SOM Faculty Profile : Braxton D Mitchell

Braxton D Mitchell

Braxton D Mitchell Ph.D., M.P.H.

Academic Title: Professor

Primary Appointment: Medicine

Secondary Appointments: Epidemiology and Preventive Medicine

Additional Title(s): Track Leader, Human Genetics and Genomic Medicine, Program in Molecular Medicine, Graduate Program in Life Sciences

bmitchel@medicine.umaryland.edu

Location: Howard Hall Room 492

Phone: (410) 706-0161

Fax: (410) 706-1622

Research Interests

There is a substantial genetic contribution for susceptibility to most common diseases, although for many of these diseases, specific DNA polymorphisms related to disease susceptibility have yet to be identified. My research program utilizes a variety of genetic epidemiologic methods to try to dissect the genetic and environmental determinants of a variety of complex diseases, including type-2 diabetes, cardiovascular disease, stroke, hypertension, osteoporosis and obesity. The goal of these efforts is to detect and identify common gene variants that may influence susceptibility to one or more of these disorders, and to determine how these variants may interact with other gene variants and/or with lifestyle factors to influence disease risk.

The bulk of our research is carried out in large population studies. For example, we work extensively with the Old Order Amish population of Lancaster County, Pennsylvania, in whom we are currently studying the genetics of diabetes, cardiovascular disease, hypertension, osteoporosis and longevity. The unique ancestral history of this population makes it exceptionally well-suited for studies of genetics.

Publications

Search my publications in Pub Med

HIGHTLIGHTED PUBLICATIONS

Streeten EA, McBride DJ, Lodge AL, Pollin TI, Stinchcomb DG, Agarwala R, Schäffer AA, Shapiro JR, Shuldiner AR, Mitchell BD. Reduced incidence of hip fracture in the Old Order Amish. J Bone Miner Res 19:308-313, 2004.

Pollin TI, Hsueh W-C, Steinle NI, Snitker S, Shuldiner AR, Mitchell BD. A genome-wide scan of lipid levels in the Old Order Amish. Atherosclerosis 173:89-96, 2004.

Langefeld CD, Wagenknecht LE, Saad MF, Hokanson JE, Rotter JI, Williams AH, Norris JM, Rich SS, Mitchell BD. Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families. The IRAS Family Study. Diabetes 53:1170-1174, 2004.

Mitchell BD, Zaccaro D, Wagenknecht LE, Scherzinger AL, Bergman RN, Haffner SM, Hokanson J, Norris JM, Rotter JI, Saad M. Insulin sensitivity, body fat distribution, and family history of diabetes: The IRAS Family Study. Obesity Res 12:831-839, 2004.

Kammerer CM, Dualan AA, Samollow PB, Périssé ARS, Bauer RL, MacCluer JW, O’Leary DH, Mitchell BD. Bone mineral density, carotid artery intimal medial thickness, and the Vitamin D Receptor BsmI polymorphism in Mexican American women. Calcified Tissue Internat 75:292-298, 2004.

Brown LB, Streeten EA, Shuldiner AR, Almasy LA, Peyser PA, Mitchell BD. Assessment of sex-specific genetic and environmental effects on bone mineral density. Genetic Epid 27:153-161, 2004

Fu M, Damcott C, Sabra M, Pollin TI, Ott S, Wang J, Garant M, O’Connell J, Mitchell BD, Shuldiner AR. Polymorphism in the Calsequestrin 1 gene on chromosome 1q21 is associated with type 2 diabetes in the Old Order Amish. Diabetes 53:3292-3299, 2004.

Cole JW, Roberts SC, Gallagher M, Giles WH, Mitchell BD, Steinberg KK, Wozniak MA, Macko RF, Reinhardt LJ, Kittner SJ. Thrombomodulin Ala455Val polymorphism and the risk of cerebral infarction in a biracial population: The Stroke Prevention in Young Women Study. BMC Neurology 4:21, 2004.

Damcott C, Hoppman N, Reinhart LJ, Wang J, O’Connell JR, Mitchell BD, Shuldiner AR. Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. Diabetes 53:3337-3341, 2004.

Pollin TI, Tanner K, O’Connell JR, Ott SH, Damcott CM, Shuldiner AR, McLenithan JC, Mitchell BD. Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 54:268-274, 2005.

Johnson L, Luke A, Adeyemo A, Deng H-W, Mitchell BD, Comuzzie AG, Cole SA, Blangero J, Perola M, Teare MD. Genome scan meta-analysis of obesity reveals significant evidence for linkage on chromosome 8p. Int J Obesity Relat Metab Disord 29:413-419, 2005.

Silver K, Tolea M, Wang J, Pollin TI, Yao F, Mitchell BD. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. Diabetes 54:1179-1184, 2005.

Wonodi I, Hong LE, Avila MT, Buchanan RW, Carpenter WT Jr, Stine OC, Mitchell BD, Thaker GK. Association between polymorphism of the SNAP29 gene promoter region and schizophrenia. Schizophrenia Research 78:339-341, 2005.

Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O’Connell JR, Mitchell BD, Shuldiner AR. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes 54:2245-50, 2005.

Kao WHL, Hsueh W-C, Rainwater DL, O’Leary DH, Imumorin IG, Stern MP, Mitchell BD. Family history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican Americans. Diab Care 28:1882-1889, 2005.

Streeten EA, Ryan KA, McBride D, Pollin TI, Shuldiner AR, Mitchell BD. The relation between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity. J Clin Endocrinol Metab 90:4536-4541, 2005.

Brown LB, Streeten EA, Shapiro JR, McBride D, Shuldiner AR, Peyser PA, Mitchell BD. Genetic and environmental influences on bone mineral density in pre- and post-menopausal women. Osteoporosis Internat 16:1849-1856, 2005.

McArdle PF, Pollin TI, O’Connell JR, Sorkin JD, Agarwala R, Schäffer AA, Streeten EA, King TM, Shuldiner AR, Mitchell BD. Does having children extend lifespan? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci 61:190-195, 2006.

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