Our Approach
We are a consultative service committed to using a comprehensive and evidence-based approach for all patients with difficult-to-treat depression (also known as treatment-resistant depression).
Our Services
Our range of services includes:
- Psychiatric/psychopharmacological assessment (second opinion)
- Transcranial Magnetic Stimulation (TMS) treatment
- Intranasal esketamine (Spravato) treatment
- Outpatient Electroconvulsive Therapy (ECT)
Further considerations may also include exploring the following options:
- Vagus Nerve Stimulation (VNS)
- Additional evidenced-based treatments and research
How We Can Help
Difficult-to-treat depression is often defined as a failure to adequately respond to at least two antidepressant trials of adequate dose and duration. Twenty-one million individuals in the U.S. are affected by depression, with 50 percent (10.5 million) failing to respond to an initial antidepressant trial. Moreover, successive trials, including augmentation or switching antidepressants, have resulted in successively lower response rates with each added trial.
New FDA-approved antidepressant and adjunctive (add-on) agents continue to update our antidepressive armamentarium. Interventions — like TMS and intranasal esketamine — have also received FDA approval as additional treatments to help combat the challenges of depression.
Our experienced and expert providers will focus on psychopharmacological as well as interventional strategies in a consultative process with the patient. We will discuss our recommendations with the referring provider and the referred patient.
Division Director
Christopher Marano, MD
Assistant Professor, Psychiatry
Contact Us
To refer a patient or to obtain additional information about the ADepT Center at the University of Maryland Medical Center, please call us and one of our program coordinators will facilitate the referral process.
The Advanced Depression Treatment Center (ADepT)
University of Maryland Department of Psychiatry
701 West Pratt Street
Baltimore, MD 21201
Phone: 410-328-8415
Fax: 410-328-1854
Hours: Monday – Friday, 8 a.m. – 5 p.m.