Update Your ProfileAcademic Title:
Professor Emeritus
Primary Appointment:
Radiation Oncology
Additional Title:
President and CEO of Xcision Medical Systems, LLC
Email:
Location:
UMH, GGJ-01
Phone (Primary):
410-328-0324
Fax:
410-328-5279
Education and Training
- B.Eng., Tianjin University, Tianjin, China, 1982
- M.Sc., Washington University, St. Louis, MO, 1985
- Biomedical Engineering Certificate, Washington University, St. Louis, MO, 1988
- D.Sc., Washington University, St. Louis, MO, 1989
Biosketch
Dr. Yu holds the Carl M. Mansfield, MD, Endowed Professorship in Radiation Oncology in the Department of Radiation Oncology. A scientist/entrepreneur, Dr. Yu has contributed to international recognition of the department’s pioneering developments in radiation treatment technology. He holds more than 20 patents on radiation and related technologies. In 2006 he patented a dedicated breast radiation therapy method, now called the GammaPod system, which was developed with the help of $3.5 million in Small Business Innovation Research grants from the National Institutes of Health. With support from the university’s technical development experts, Dr. Yu founded Xcision Medical Systems, LLC, to pursue production and regulatory approval of this high-precision, noninvasive system for treating breast cancer. He was named the 2010 University of Maryland Baltimore Entrepreneur of the Year. He also serves as a faculty member in the Bioengineering Graduate Program in the School of Engineering at the University of Maryland College Park.
Research/Clinical Keywords
Medical physics, radiation safety, education, technology research and development.
Highlighted Publications
Paganetti H, Yu CX. Photon radiotherapy has reached its limit in terms of catching up dosimetrically with proton therapy. Med Phys. 2016 Aug;43(8):4470. doi: 10.1118/1.4954790. PubMed PMID: 27487862.
Yu CX, Shao X, Zhang J, Regine W, Zheng M, Yu YS, Deng J, Duan Z. GammaPod-a new device dedicated for stereotactic radiotherapy of breast cancer. Med Phys. 2013 May;40(5):051703. doi: 10.1118/1.4798961. PubMed PMID: 23635251; PubMed Central PMCID: PMC3637326.
Mutaf YD, Zhang J, Yu CX, Yi BY, Prado K, D'Souza WD, Regine WF, Feigenberg SJ. Dosimetric and geometric evaluation of a novel stereotactic radiotherapy device for breast cancer: the GammaPod™. Med Phys. 2013 Apr;40(4):041722. doi: 10.1118/1.4794477. PubMed PMID: 23556892.
Betzel GT, Yi BY, Niu Y, Yu CX. Is RapidArc more susceptible to delivery uncertainties than dynamic IMRT? Med Phys. 2012 Oct;39(10):5882-90. doi: 10.1118/1.4749965. PubMed PMID: 23039627; PubMed Central PMCID: PMC3461049.
Yang X, Han-Oh S, Gui M, Niu Y, Yu CX, Yi BY. Four-dimensional dose distributions of step-and-shoot IMRT delivered with real-time tumor tracking for patients with irregular breathing: constant dose rate vs dose rate regulation. Med Phys. 2012 Sep;39(9):5557-66. doi: 10.1118/1.4745562. PubMed PMID: 22957622; PubMed Central PMCID: PMC3436918.
Additional Publication Citations
Neuner G, Mohiuddin MM, Vander Walde N, Goloubeva O, Ha J, Yu CX, Regine WF. High-dose spatially fractionated GRID radiation therapy (SFGRT): a comparison of treatment outcomes with Cerrobend vs. MLC SFGRT. Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1642-9. doi: 10.1016/j.ijrobp.2011.01.065. PubMed PMID: 21531514.
Yu CX, Tang G. Intensity-modulated arc therapy: principles, technologies and clinical implementation. Phys Med Biol. 2011 Mar 7;56(5):R31-54. doi: 10.1088/0031-9155/56/5/R01. Epub 2011 Feb 4. Review. PubMed PMID: 21297245.
Rong Y, Tang G, Welsh JS, Mohiuddin MM, Paliwal B, Yu CX. Helical tomotherapy versus single-arc intensity-modulated arc therapy: a collaborative dosimetric comparison between two institutions. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):284-96. doi: 10.1016/j.ijrobp.2010.10.059. PubMed PMID: 21236598.
Zhou B, Yu CX, Chen DZ, Hu XS. GPU-accelerated Monte Carlo convolution/superposition implementation for dose calculation. Med Phys. 2010 Nov;37(11):5593-603. Erratum in: Med Phys. 2011 Mar;38(3):1732. PubMed PMID: 21158271; PubMed Central PMCID: PMC2967714.
Nichols EM, Dhople AA, Mohiuddin MM, Flannery TW, Yu CX, Regine WF. Comparative analysis of the post-lumpectomy target volume versus the use of pre-lumpectomy tumor volume for early-stage breast cancer: implications for the future. Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):197-202. doi: 10.1016/j.ijrobp.2009.04.063. PubMed PMID: 20394853.
Tang G, Earl MA, Luan S, Wang C, Mohiuddin MM, Yu CX. Comparing radiation treatments using intensity-modulated beams, multiple arcs, and single arcs. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1554-62. doi: 10.1016/j.ijrobp.2009.04.003. PubMed PMID: 20338482; PubMed Central PMCID: PMC2846542.
Tang G, Earl MA, Yu CX. Variable dose rate single-arc IMAT delivered with a constant dose rate and variable angular spacing. Phys Med Biol. 2009 Nov 7;54(21):6439-56. doi: 10.1088/0031-9155/54/21/001. PubMed PMID: 19820268.
Lerma FA, Liu B, Wang Z, Yi B, Amin P, Liu S, Feng Y, Yu CX. Role of image-guided patient repositioning and online planning in localized prostate cancer IMRT. Radiother Oncol. 2009 Oct;93(1):18-24. doi: 10.1016/j.radonc.2009.06.011. PubMed PMID: 19592122.
Yu CX, Amies CJ, Svatos M. Planning and delivery of intensity-modulated radiation therapy. Med Phys. 2008 Dec;35(12):5233-41. Review. PubMed PMID: 19175082.
Tang G, Earl MA, Luan S, Wang C, Cao D, Yu CX, Naqvi SA. Stochastic versus deterministic kernel-based superposition approaches for dose calculation of intensity-modulated arcs. Phys Med Biol. 2008 Sep 7;53(17):4733-46. doi: 10.1088/0031-9155/53/17/018. PubMed PMID: 18701770.
Ha JK, Perlow DB, Yi BY, Yu CX. On the sources of drift in a turbine-based spirometer. Phys Med Biol. 2008 Aug 21;53(16):4269-83. doi: 10.1088/0031-9155/53/16/004. PubMed PMID: 18653925.
D'Souza WD, Nazareth DP, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, Regine WF. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Med Dosim. 2007 Summer;32(2):92-101. PubMed PMID: 17472888.
Earl MA, Afghan MK, Yu CX, Jiang Z, Shepard DM. Jaws-only IMRT using direct aperture optimization. Med Phys. 2007 Jan;34(1):307-14. PubMed PMID: 17278516.
Ha JK, Zhang G, Naqvi SA, Regine WF, Yu CX. Feasibility of delivering grid therapy using a multileaf collimator. Med Phys. 2006 Jan;33(1):76-82. PubMed PMID: 16485412.
D'Souza WD, Kwok Y, Deyoung C, Zacharapoulos N, Pepelea M, Klahr P, Yu CX. Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry. Med Phys. 2005 Dec;32(12):3641-9. PubMed PMID: 16475763.
Jiang Z, Earl MA, Zhang GW, Yu CX, Shepard DM. An examination of the number of required apertures for step-and-shoot IMRT. Phys Med Biol. 2005 Dec 7;50(23):5653-63. PubMed PMID: 16306659.
D'Souza WD, Naqvi SA, Yu CX. Real-time intra-fraction-motion tracking using the treatment couch: a feasibility study. Phys Med Biol. 2005 Sep 7;50(17):4021-33. PubMed PMID: 16177527.
Li K, Yu CX, Ma L. Improving a scissor-action couch for conformal arc radiotherapy and radiosurgery. J Appl Clin Med Phys. 2004 Summer;5(3):62-5. PubMed PMID: 15753940.
Sarfaraz M, Kennedy AS, Lodge MA, Li XA, Wu X, Yu CX. Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma. Med Phys. 2004 Sep;31(9):2449-53. PubMed PMID: 15487724.
Sarfaraz M, Wul X, Lodge MA, Yu CX. Automatic CT-SPECT registration of livers treated with radioactive microspheres. Phys Med Biol. 2004 May 21;49(10):N131-7. PubMed PMID: 15214547.
Wu X, Dibiase SJ, Gullapalli R, Yu CX. Deformable image registration for the use of magnetic resonance spectroscopy in prostate treatment planning. Int J Radiat Oncol Biol Phys. 2004 Apr 1;58(5):1577-83. PubMed PMID: 15050339.
Renner WD, Sarfaraz M, Earl MA, Yu CX. A dose delivery verification method for conventional and intensity-modulated radiation therapy using measured field fluence distributions. Med Phys. 2003 Nov;30(11):2996-3005. PubMed PMID: 14655947.
Wang JZ, Li XA, Yu CX, DiBiase SJ. The low alpha/beta ratio for prostate cancer: what does the clinical outcome of HDR brachytherapy tell us? Int J Radiat Oncol Biol Phys. 2003 Nov 15;57(4):1101-8. PubMed PMID: 14575842.
Ma L, Phaisangittisakul N, Yu CX, Sarfaraz M. A quality assurance method for analyzing and verifying intensity modulated fields. Med Phys. 2003 Aug;30(8):2082-8. PubMed PMID: 12945974.
Earl MA, Shepard DM, Naqvi S, Li XA, Yu CX. Inverse planning for intensity-modulated arc therapy using direct aperture optimization. Phys Med Biol. 2003 Apr 21;48(8):1075-89. PubMed PMID: 12741503.
Sarfaraz M, Kennedy AS, Cao ZJ, Sackett GD, Yu CX, Lodge MA, Murthy R, Line BR, Van Echo DA. Physical aspects of yttrium-90 microsphere therapy for nonresectable hepatic tumors. Med Phys. 2003 Feb;30(2):199-203. PubMed PMID: 12607837.
Yu CX, Li XA, Ma L, Chen D, Naqvi S, Shepard D, Sarfaraz M, Holmes TW, Suntharalingam M, Mansfield CM. Clinical implementation of intensity-modulated arc therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 1;53(2):453-63. PubMed PMID: 12023150.
Ma L, Yu CX, Earl M, Holmes T, Sarfaraz M, Li XA, Shepard D, Amin P, DiBiase S, Suntharalingam M, Mansfield C. Optimized intensity-modulated arc therapy for prostate cancer treatment. Int J Cancer. 2001 Dec 20;96(6):379-84. PubMed PMID: 11745509.
Naqvi SA, Sarfaraz M, Holmes T, Yu CX, Li XA. Analysing collimator structure effects in head-scatter calculations for IMRT class fields using scatter raytracing. Phys Med Biol. 2001 Jul;46(7):2009-28. PubMed PMID: 11474941.
Wang R, Li XA, Yu CX. Evaluation of EGS4/PRESTA multiple-scattering algorithms for 90Sr/90Y intravascular brachytherapy dosimetry. Phys Med Biol. 2000 Aug;45(8):2343-52. PubMed PMID: 10958198.
Ma L, Li XA, Yu CX. An efficient method of measuring the 4 mm helmet output factor for the Gamma knife. Phys Med Biol. 2000 Mar;45(3):729-33. PubMed PMID: 10730967.
Awards and Affiliations
2016 Medical Physics “Hall of Fame” Award, North America Chinese Medical
Physicist Association.
2010 Entrepreneur of the Year, University of Maryland, Baltimore
2007 Endowed Carl M. Mansfield, M.D. Professor in Radiation Oncology
2002 Fellow,American Association of Physicists in Medicine (AAPM)
1997 Travel award, American Society for Therapeutic Radiology and Oncology.
1985 2nd Prize in the Young Investigator's Symposium, AAPM Annual Meeting,
Seattle, WA