Academic Title:
Associate Professor
Primary Appointment:
Anesthesiology
Location:
UMMC, S11C00
Phone (Primary):
(410) 328-3990
Phone (Secondary):
(410) 328-9813
Fax:
(410) 328-3092
Education and Training
Education | |
2003-2007 | B.S., Biology, The American University |
2007-2011 | M.D., State University of New York, Upstate Medical University |
2011-2012 | Internship, University of Maryland Medical Center, Baltimore, MD |
2012-2015 | Residency, Department of Anesthesiology, University of Maryland Medical Center, Baltimore, MD |
2015-2016 | Fellowship, Cardiothoracic Anesthesiology, University of Maryland Medical Center, Baltimore, MD |
Faculty Appointments | |
2016-2022 | Assistant Professor, Department of Anesthesiology, University of Maryland School of Medicine |
2022-present | Associate Professor, Department of Anesthesiology, University of Maryland School of Medicine |
Research/Clinical Keywords
Cardiopulmonary Bypass Associated Coagulopathy Sepsis Induced Coagulopathy
Highlighted Publications
- Milam AJ, Bonner TJ, Burton BN, Williams B, Youssef MR, Smith RN, Cannesson M, Troianos C, Pittet J. The Difficulty Implementing Evidence-Based Practice in the Perioperative Setting. Anesth Analg. 139(4), 874-880. PMID: 39052524. 2024
- Suen AO, Chen F, Wang S, Li Z, Zhu J, Yang Y, Conn O, Lopez K, Cui P, Wechsler L, Cross A, Fiskum G, Kozar R, Hu P, Miller C, Zou L, Williams B, Chao W. Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma. J Immunol. 210(12), 1990-2000. PMID: 37133342. 2023
- Strauss ER, Odonkor PN, Williams B, Choi S, Mueller J, Taylor B, Shah A, Goerlich CE, Mohiuddin MM, Griffith BP. Intraoperative Management of an Orthotopic Porcine-to-Human Cardiac Xenotransplant. Ann Thorac Surg. 115(3), 784-786. PMID: 36621667. 2023
- Bartels K, Howard-Quijano K, Prin M, Shaefi S, Steppan J, Sun E, Williams B, Fox AA, Namuyonga J, Shaw AD, Vavilala MS, Sessler D. Meeting Report: First Cardiovascular Outcomes Research in Perioperative Medicine Conference. Anesth Analg. 136(2), 418-420. PMID: 36638519. 2023
- Strauss ER, Dahmane E, Judd M, Guo D, Williams B, Meyer MS, Gammie JS, Taylor BS, Mazzeffi MA, Gobburu JA, Tanaka KA. A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic acid regimen designed for the context of cardiac surgery with cardiopulmonary bypass. J Cardiothor Vasc Anesth. 35(2), 406-417. PMID: 2811752. 2022
- Morita Y, Williams B, Yamada Y, Kariya T. Effect of Anesthesia Machine Ventilator and ICU Ventilator on Intraoperative Oxygenation and Ventilation. J Cardiothorac Vasc Anesth. 36(8 Pt B), 3175-3185. PMID: 35624038. 2022
- Williams B, Kozar R, Chao W. Emerging Role of Extracellular RNA in Innate Immunity, Sepsis, and Trauma. Shock. 59(2), 190-199. PMID: 36730864. 2022
- Odonkor PN, Strauss E, Williams B. Ethical considerations during a pioneering surgical procedure: porcine cardiac xenotransplantation. Br J Hosp Med (Lond). 83(6), 1-7. PMID: 35787171. 2022
- Williams B, Zhu J, Chao W. Innate immune TLR7 signaling mediates platelet activation and platelet-leukocyte aggregate formation in murine bacterial sepsis. Platelets. 33(8), 1251-1259. PMID: 35920588. 2022
- Bartels K, Howard-Quijano K, Prin M, Shaefi S, Steppan J, Sun EC, Williams B, Fox AA, Namuyonga J, Shaw AD, Vavilala MS, Sessler DI. Meeting Report: First Cardiovascular Outcomes Research in Perioperative Medicine Conference. Anesth Analg. 136(2), 418-420. PMID: 36638519. 2022
- Yang S, Williams B, Kaczorowski D, Mazzeffi M. Overt Disseminated Intravascular Coagulation with Severe Hypofibrinogenemia During Veno-Venous Extracorporeal Membrane Oxygenation. J Extra Corpor Technol. 54(2), 148-152. 2022
- Strauss ER, Odonkor PN, Williams B. Porcine Orthotopic Cardiac Xenotransplantation: The Role and Perspective of Anesthesiologists. J Cardiothorac Vasc Anesth. 36(8 Pt B), 2847-2850. PMID: 35537973. 2022
- Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation. 29, e12744. PMID: 35357044. 2022
- Mazzeffi MA, Henderson R, Powell E, Strauss E, Williams B, Tanaka K, Yang S, Deatrick K, Madathil R. Thrombopoietin, Soluble CD40 Ligand, and Platelet Count During Veno-arterial Extracorporeal Membrane Oxygenation. ASAIO J. 68(5), e77-e79. PMID: 34081052. 2022
- Huang H, Zhu J, Gu L, Hu J, Feng Z, Huang W, Wang S, Yang Y, Cui P, Lin S, Suen A, Shimada BK, Williams B, Kane MA, Ke Y, Chen C, Birukova AA, Birukov KG, Chao W, Zou L. TLR7 Mediates Acute Respiratory Distress Syndrome in Sepsis by Sensing Extracellular miR-146a. Am J Respir Cell Mol Biol. 67(3), 375-388. PMID: 35679261. 2022
- Goerlich CE, Griffith B, Avneesh S, Mohamed A, Shreya S, Kolesnik I, Lewis B, Sentz F, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Tabatabai A, Bhutta A, Ayares D, Kaczorowski D, Mohiuddin M. Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation. Frontiers in Immunology. 12, 667093. PMID: 34177906. 2021
- Wang S, Yang Y, Suen A, Zhu J, Williams B, Hu J, Chen F, Kozar R, Shen S, Li Z, Jeyaram A, Jay S, Zou L, Chao W. Extracellular microRNA-146a-5p Regulates Innate Immune Response and Plays a Pivotal Role in Polymicrobial Sepsis. iScience. 24(12), 103441. PMID: 34877498. 2021
- Mondal S, Hollander KN, Ibekwe SO, Williams B, Tanaka KA. Heyde Syndrome-Pathophysiology and Perioperative Implications. J Cardiothorac Vasc Anesth. 35(11), 3331-3339. PMID: 33132021. 2021
- Lopez K, Suen A, Yang Y, Wang S, Williams B, Zhu J, Hu J, Fiskum G, Cross A, Kozar R, Miller C, Zou L, Chao W. Hypobaria Exposure Worsens Cardiac Function and Endothelial Injury in an Animal Model of Polytrauma: Implications for Aeromedical Evacuation. Shock. 56(4), 601-610. PMID: 33394971. 2021
- Wang J, Yang Y, Suen A, Zhu J, Williams B, Hu J, Chen F, Kozar R, Shen S, Li Z, Jeyaram A, Jan SM, Zou L, Chao W. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. iScience. 24(12), 103441. PMID: 34877498. 2021
- Chen F, Zou L, Williams B, Chao W. Targeting Toll-Like Receptors in Sepsis - From Bench to Clinical Trials. Antioxid Redox Signal. 35(15), 1324-1339. PMID: 33588628. 2021
- DiChiacchio L, Singh AK, Lewis B, Zhang T, Hardy N, Pasrija C, Morales D, Odonkor P, Strauss E, Williams B, Deatrick KB, Kaczorowski DJ, Ayares D, Griffith BP, Bartlett ST, Mohiuddin MM. Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program. Ann Thorac Surg. 109(5), 1357-1361. doi: 10.1016/j.athoracsur.2019.08.09. [Epub 2019 Oct 4]. PMID: 31589847. 2020
- Williams B, Henderson RS, Reformato VS, Pham T, Taylor BS, Tanaka KA. Hemostasis Management of Patients Undergoing Emergent Cardiac Surgery After Ticagrelor Loading. Case Report. J Cardiothorac Vasc Anesth. 34(1):168-174. PMID: 31375405. 2020
- Goerlich CE, Kaczorowski D, Singh A, Abdullah M, Lewis B, Zhang T, Tatarov I, Sentz F, Hershfeld A, Odonkor P, Williams B, Strauss E, Ayares D, Griffith B, Mohiuddin M. Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation. J Heart Lung Transplant. 39(4), S145. 2020
- Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. Lack of Human Thrombomodulin Gene Expression in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation Models Accelerate Antibody Mediated Rejection. Transplantation. 104(S3), S635. 2020
- Tanaka KA, Mondal S, Morita Y, Williams B, Strauss ER, Cicardi M. Perioperative Management of Patients With Hereditary Angioedema With Special Considerations for Cardiopulmonary Bypass. Anesth Analg. 131(1), 155-169. PMID: 32102012. 2020
- Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. The Use of Minimally Ischemic Cardiac Preservation Techniques to Overcome Perioperative Cardiac Xenograft Dysfunction (PCDX) in Life-Supporting Cardiac Xenotransplantation Model. Transplantation. 104(S3), S636. 2020
- Tanaka KA, Bharadwaj S, Hasan S, Judd M, Abuelkasem E, Henderson R, Chow JH, Williams B, Mazzeffi MA, Crimmins SD, Malinow AM. Elevated fibrinogen, von Willebrand factor, and Factor VIII confer resistance to dilutional coagulopathy and activated protein C in normal pregnant women. Br J Anaesth. 122(6), 751-759. doi: 10.1016/j.bja.2019.02.012. PMID: 30916034. 2019
- Tanaka KA, Henderson R, Williams B. Heparin-Induced Thrombocytopenia and Cardiac Surgery: Can We Do It All With Cangrelor?. A A Pract. 13(9), 366. doi: XAA.0000000000001094. PMID: 31567127. 2019
- Henderson RA, Mazzeffi MA, Strauss ER, Williams B, Wipfli C, Dawood M, Taylor BS, Tanaka KA. Impact of intraoperative high-volume autologous blood collection on allogeneic transfusion during and after cardiac surgery: a propensity score matched analysis. Transfusion. 59(6), 2023-2029. doi: 10.1111/trf.15253. Epub 2019 Mar 18. PMID: 30882929. 2019
- Jian W, Gu L, Williams B, Feng Y, Chao W, Zou L. Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis. Anesthesiology. 131(1), 105-118. doi: 10.1097/ALN.0000000000002706. PMID: 31045897. 2019
- Williams B, Neder J, Cui P, Suen A, Tanaka K, Zou L, Chao W. Toll-like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis. J Thromb Haemost. 17(10), 1683-1693. PMID: 31211901. 2019
- Williams B, Wehman B, Mazzeffi MA, Odonkor P, Harris RL, Kon Z, Tanaka K. Acute Intracardiac Thrombosis and Pulmonary Thromboembolism After Cardiopulmonary Bypass: A Systematic Review of Reported Cases. Anesth Analg. 126(2), 126(2):425-434. doi: 10.1213/ANE.0000000000002259. PMID: 28682954. 2018
- Hasan S, Abuelkasem E, Williams B, Henderson R, Mazzeffi MA, Tanaka KA. Factor IX From Prothrombin Complex Concentrate Augments Low Dose Tissue Factor-triggered Thrombin Generation - an in vitro study. Brit J Anaesth. 121(4), 936-943. doi: 10.1016/j.bja.2018.05.063. Epub 2018 Jul 4. PMID: 30236256. 2018
- Mazzeffi MA, See JM, Williams B, Richards J, Zimmerman D, Galvagno S, Fontaine M, Tanaka K. Five-year trends in perioperative red blood cell transfusion from index cases in five surgical specialties: 2011 to 2015. Transfusion. 58(5), 1271-1278. doi: 10.1111/trf.14559. Epub 2018 Mar 14. PMID: 29542136. 2018
- Williams B, Chriss E, Kaplan J, Cartron A, Taylor B, Gammie J, Tanaka K, Mazzeffi M. Hypothermia, pH and Postoperative Red Blood Cell Transfusion in Massively Transfused Adult Cardiac Surgery Patients: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. 32(4), 1642-1647. PMID: 29290382. 2018
- Williams B, Sikorski R, Anders M, Galvagno S, Rock P, Mazzeffi M. Should We Use Perioperative Transesophageal Echocardiography More in Non-Cardiac Surgery?. J Cardiothorac Vasc Anesth. 32(3), e71-e73. PMID: 27474334. 2018
- Tanaka KA, Mazzeffi MA, Williams B. Acute Traumatic Coagulopathy: Thrombin Is the Driver!. Anesthesiology. 127(3), 585. PMID: 28816786. 2017
- Williams B, Mazzeffi MA, Sanchez PG, Pham SM, Kon Z, Tanaka KA. Case Report of Severe Antithrombin Deficiency During Extracorporeal Membrane Oxygenation and Therapeutic Plasma Exchange for Double Lung Transplantation. A A Case Rep. 8(1), 11-13. PMID: 28036320. 2017
- Henderson RS, Deshpande S, Williams B, Taylor BS, Tanaka KA. Idarucizumab for Dabigatran Reversal in Emergency Type-A Aortic Dissection. J Cardiothorac Vasc Anesth. 31(6), e80-e81. doi: 10.1053/j.jvca.2016.04.027. Epub 2016 May 13. PMID: 27498256. 2017
- Odonkor P, Srinivas A, Strauss E, Williams B, Mazzeffi M, Tanaka KA. Perioperative Coagulation Management of a Hemophilia A Patient During Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 21(4), 312-320. doi: 10.1177/1089253217702747. Epub 2017 Apr 7. PMID: 28388863. 2017
- Strauss ER, Mazzeffi MA, Williams B, Key NS, Tanaka KA. Perioperative management of rare coagulation factor deficiency states in cardiac surgery. Brit J Anesth. 119(3), 354-368. PMID: 28969316. 2017
- Williams B, McNeil J, Crabbe A, Tanaka KA. Practical Use of Thromboelastometry in the Management of Perioperative Coagulopathy and Bleeding. Transfus Med Rev. 31(1), 11-25. PMID: 27622549. 2016
- Williams B, Bernstein W. Review of Venoarterial Extracorporeal Membrance Oxygenation and Development of Intracardiac Thrombosis in Adult Cardiothoracic Patients. J Extra Corpor Technol. 48(4), 162-167. PMID: 27994255. 2016
- Hu Y, Williams B, Galai I, Nathan N, Smallman B. Tongue protrusion as an extubation criterion in pediatric surgery. Paediatr Anaesth. 24(9), 1021-2. PMID: 25092454. 2014
Research Interests
- Cardiopulmonary Bypass Associated Coagulopathy
- Sepsis Induced Coagulopathy
Awards and Affiliations
2015 | 2015 Dripps Awards Recipient, UMSOM |
2018 | 2018 Kosaka Best of Meeting Abstract Award, UMSOM, IARS-Annual Meeting |
2019 | 2019 Best Basic Science Abstract, UMSOM, Anesthesiology Spring Research Retreat |
Grants and Contracts
Active Grants | |
9/1/2020-5/31/2025 |
(PI, 75%) Role of miRNA-TLR7 signaling in platelet activation and dysfunction in sepsis NIH K08 Mentored Research Award Award Total: $808,965.00 Annual Direct Cost: $150,300.00 |
Completed Grants | |
1/1/2018-12/31/2019 |
(PI,60%) Targeting Inflammation in Sepsis-induced Coagulopathy STAR DRIF Fund, No Salary Support Award Total: $50,849.00 Annual Direct Cost: $50,849.00 |
2/1/2019-1/31/2020 |
Targeting Inflammation in Sepsis-induced Coagulopathy STAR DRIF Fund, No Salary Support Award Total: $50,849.00 Annual Direct Cost: $50,849.00 |
3/1/2020-9/1/2020 |
(PI,75%) Role of TLR7 in platelet activation and dysfunction in sepsis Foundation for Education and Anesthesia Research (FAER) Mentored Research Training Grant Award Total: $250,000.00 Annual Direct Total: $125,000.00 |
Professional Activity
Institution - Departmental | |
2014-present | Member, Education Committee, Anesthesiology, University of Maryland School of Medicine |
2016-present | Member, Research Committee, Anesthesiology, University of Maryland School of Medicine |
2021-present | Member, Inclusion, Diversity, Equity and Antiracism (IDEA) Taskforce, Anesthesiology, University of Maryland School of Medicine |
National | |
2020-2020 | Member, International Collaboration for Transfusion Medicine, Platelet Transfusion Guideline Development Group |
2021-2022 | Member, Society of Cardiovascular Anesthesiologists (SCA), Cardiovascular Outcomes Research in Perioperative Medicine (COR-PM) |
2021-2023 | Member, Society of Cardiovascular Anesthesiologists (SCA), Echo Week Planning Committee |