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Brittney Williams, MD

Academic Title:

Associate Professor

Primary Appointment:

Anesthesiology

Email:

brittney.williams@som.umaryland.edu

Location:

UMMC, S11C00

Phone (Primary):

(410) 328-3990

Phone (Secondary):

(410) 328-9813

Fax:

(410) 328-3092

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Education and Training

Education
2003-2007 B.S., Biology, The American University
2007-2011 M.D., State University of New York, Upstate Medical University
2011-2012 Internship, University of Maryland Medical Center, Baltimore, MD
2012-2015 Residency, Department of Anesthesiology, University of Maryland Medical Center, Baltimore, MD
2015-2016 Fellowship, Cardiothoracic Anesthesiology, University of Maryland Medical Center, Baltimore, MD
Faculty Appointments
2016-2022 Assistant Professor, Department of Anesthesiology, University of Maryland School of Medicine
2022-present Associate Professor, Department of Anesthesiology, University of Maryland School of Medicine

Research/Clinical Keywords

Cardiopulmonary Bypass Associated Coagulopathy Sepsis Induced Coagulopathy

Highlighted Publications

  1. Milam AJ, Bonner TJ, Burton BN, Williams B, Youssef MR, Smith RN, Cannesson M, Troianos C, Pittet J. The Difficulty Implementing Evidence-Based Practice in the Perioperative Setting. Anesth Analg. 139(4), 874-880. PMID: 39052524. 2024
  2. Suen AO, Chen F, Wang S, Li Z, Zhu J, Yang Y, Conn O, Lopez K, Cui P, Wechsler L, Cross A, Fiskum G, Kozar R, Hu P, Miller C, Zou L, Williams B, Chao W. Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma. J Immunol. 210(12), 1990-2000. PMID: 37133342. 2023
  3. Strauss ER, Odonkor PN, Williams B, Choi S, Mueller J, Taylor B, Shah A, Goerlich CE, Mohiuddin MM, Griffith BP. Intraoperative Management of an Orthotopic Porcine-to-Human Cardiac Xenotransplant. Ann Thorac Surg. 115(3), 784-786. PMID: 36621667. 2023
  4. Bartels K, Howard-Quijano K, Prin M, Shaefi S, Steppan J, Sun E, Williams B, Fox AA, Namuyonga J, Shaw AD, Vavilala MS, Sessler D. Meeting Report: First Cardiovascular Outcomes Research in Perioperative Medicine Conference. Anesth Analg. 136(2), 418-420. PMID: 36638519. 2023
  5. Strauss ER, Dahmane E, Judd M, Guo D, Williams B, Meyer MS, Gammie JS, Taylor BS, Mazzeffi MA, Gobburu JA, Tanaka KA. A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic acid regimen designed for the context of cardiac surgery with cardiopulmonary bypass. J Cardiothor Vasc Anesth. 35(2), 406-417. PMID: 2811752. 2022
  6. Morita Y, Williams B, Yamada Y, Kariya T. Effect of Anesthesia Machine Ventilator and ICU Ventilator on Intraoperative Oxygenation and Ventilation. J Cardiothorac Vasc Anesth. 36(8 Pt B), 3175-3185. PMID: 35624038. 2022
  7. Williams B, Kozar R, Chao W. Emerging Role of Extracellular RNA in Innate Immunity, Sepsis, and Trauma. Shock. 59(2), 190-199. PMID: 36730864. 2022
  8. Odonkor PN, Strauss E, Williams B. Ethical considerations during a pioneering surgical procedure: porcine cardiac xenotransplantation. Br J Hosp Med (Lond). 83(6), 1-7. PMID: 35787171. 2022
  9. Williams B, Zhu J, Chao W. Innate immune TLR7 signaling mediates platelet activation and platelet-leukocyte aggregate formation in murine bacterial sepsis. Platelets. 33(8), 1251-1259. PMID: 35920588. 2022
  10. Yang S, Williams B, Kaczorowski D, Mazzeffi M. Overt Disseminated Intravascular Coagulation with Severe Hypofibrinogenemia During Veno-Venous Extracorporeal Membrane Oxygenation. J Extra Corpor Technol. 54(2), 148-152. 2022
  11. Strauss ER, Odonkor PN, Williams B. Porcine Orthotopic Cardiac Xenotransplantation: The Role and Perspective of Anesthesiologists. J Cardiothorac Vasc Anesth. 36(8 Pt B), 2847-2850. PMID: 35537973. 2022
  12. Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation. 29, e12744. PMID: 35357044. 2022
  13. Mazzeffi MA, Henderson R, Powell E, Strauss E, Williams B, Tanaka K, Yang S, Deatrick K, Madathil R. Thrombopoietin, Soluble CD40 Ligand, and Platelet Count During Veno-arterial Extracorporeal Membrane Oxygenation. ASAIO J. 68(5), e77-e79. PMID: 34081052. 2022
  14. Huang H, Zhu J, Gu L, Hu J, Feng Z, Huang W, Wang S, Yang Y, Cui P, Lin S, Suen A, Shimada BK, Williams B, Kane MA, Ke Y, Chen C, Birukova AA, Birukov KG, Chao W, Zou L. TLR7 Mediates Acute Respiratory Distress Syndrome in Sepsis by Sensing Extracellular miR-146a. Am J Respir Cell Mol Biol. 67(3), 375-388. PMID: 35679261. 2022
  15. Goerlich CE, Griffith B, Avneesh S, Mohamed A, Shreya S, Kolesnik I, Lewis B, Sentz F, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Tabatabai A, Bhutta A, Ayares D, Kaczorowski D, Mohiuddin M. Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation. Frontiers in Immunology. 12, 667093. PMID: 34177906. 2021
  16. Mondal S, Hollander KN, Ibekwe SO, Williams B, Tanaka KA. Heyde Syndrome-Pathophysiology and Perioperative Implications. J Cardiothorac Vasc Anesth. 35(11), 3331-3339. PMID: 33132021. 2021
  17. Lopez K, Suen A, Yang Y, Wang S, Williams B, Zhu J, Hu J, Fiskum G, Cross A, Kozar R, Miller C, Zou L, Chao W. Hypobaria Exposure Worsens Cardiac Function and Endothelial Injury in an Animal Model of Polytrauma: Implications for Aeromedical Evacuation. Shock. 56(4), 601-610. PMID: 33394971. 2021
  18. Wang J, Yang Y, Suen A, Zhu J, Williams B, Hu J, Chen F, Kozar R, Shen S, Li Z, Jeyaram A, Jan SM, Zou L, Chao W. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. iScience. 24(12), 103441. PMID: 34877498. 2021
  19. Chen F, Zou L, Williams B, Chao W. Targeting Toll-Like Receptors in Sepsis - From Bench to Clinical Trials. Antioxid Redox Signal. 35(15), 1324-1339. PMID: 33588628. 2021
  20. DiChiacchio L, Singh AK, Lewis B, Zhang T, Hardy N, Pasrija C, Morales D, Odonkor P, Strauss E, Williams B, Deatrick KB, Kaczorowski DJ, Ayares D, Griffith BP, Bartlett ST, Mohiuddin MM. Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program. Ann Thorac Surg. 109(5), 1357-1361. doi: 10.1016/j.athoracsur.2019.08.09. [Epub 2019 Oct 4]. PMID: 31589847. 2020
  21. Williams B, Henderson RS, Reformato VS, Pham T, Taylor BS, Tanaka KA. Hemostasis Management of Patients Undergoing Emergent Cardiac Surgery After Ticagrelor Loading. Case Report. J Cardiothorac Vasc Anesth. 34(1):168-174. PMID: 31375405. 2020
  22. Goerlich CE, Kaczorowski D, Singh A, Abdullah M, Lewis B, Zhang T, Tatarov I, Sentz F, Hershfeld A, Odonkor P, Williams B, Strauss E, Ayares D, Griffith B, Mohiuddin M. Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation. J Heart Lung Transplant. 39(4), S145. 2020
  23. Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. Lack of Human Thrombomodulin Gene Expression in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation Models Accelerate Antibody Mediated Rejection. Transplantation. 104(S3), S635. 2020
  24. Tanaka KA, Mondal S, Morita Y, Williams B, Strauss ER, Cicardi M. Perioperative Management of Patients With Hereditary Angioedema With Special Considerations for Cardiopulmonary Bypass. Anesth Analg. 131(1), 155-169. PMID: 32102012. 2020
  25. Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. The Use of Minimally Ischemic Cardiac Preservation Techniques to Overcome Perioperative Cardiac Xenograft Dysfunction (PCDX) in Life-Supporting Cardiac Xenotransplantation Model. Transplantation. 104(S3), S636. 2020
  26. Tanaka KA, Bharadwaj S, Hasan S, Judd M, Abuelkasem E, Henderson R, Chow JH, Williams B, Mazzeffi MA, Crimmins SD, Malinow AM. Elevated fibrinogen, von Willebrand factor, and Factor VIII confer resistance to dilutional coagulopathy and activated protein C in normal pregnant women. Br J Anaesth. 122(6), 751-759. doi: 10.1016/j.bja.2019.02.012. PMID: 30916034. 2019
  27. Tanaka KA, Henderson R, Williams B. Heparin-Induced Thrombocytopenia and Cardiac Surgery: Can We Do It All With Cangrelor?. A A Pract. 13(9), 366. doi: XAA.0000000000001094. PMID: 31567127. 2019
  28. Henderson RA, Mazzeffi MA, Strauss ER, Williams B, Wipfli C, Dawood M, Taylor BS, Tanaka KA. Impact of intraoperative high-volume autologous blood collection on allogeneic transfusion during and after cardiac surgery: a propensity score matched analysis. Transfusion. 59(6), 2023-2029. doi: 10.1111/trf.15253. Epub 2019 Mar 18. PMID: 30882929. 2019
  29. Jian W, Gu L, Williams B, Feng Y, Chao W, Zou L. Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis. Anesthesiology. 131(1), 105-118. doi: 10.1097/ALN.0000000000002706. PMID: 31045897. 2019
  30. Williams B, Neder J, Cui P, Suen A, Tanaka K, Zou L, Chao W. Toll-like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis. J Thromb Haemost. 17(10), 1683-1693. PMID: 31211901. 2019
  31. Williams B, Wehman B, Mazzeffi MA, Odonkor P, Harris RL, Kon Z, Tanaka K. Acute Intracardiac Thrombosis and Pulmonary Thromboembolism After Cardiopulmonary Bypass: A Systematic Review of Reported Cases. Anesth Analg. 126(2), 126(2):425-434. doi: 10.1213/ANE.0000000000002259. PMID: 28682954. 2018
  32. Hasan S, Abuelkasem E, Williams B, Henderson R, Mazzeffi MA, Tanaka KA. Factor IX From Prothrombin Complex Concentrate Augments Low Dose Tissue Factor-triggered Thrombin Generation - an in vitro study. Brit J Anaesth. 121(4), 936-943. doi: 10.1016/j.bja.2018.05.063. Epub 2018 Jul 4. PMID: 30236256. 2018
  33. Mazzeffi MA, See JM, Williams B, Richards J, Zimmerman D, Galvagno S, Fontaine M, Tanaka K. Five-year trends in perioperative red blood cell transfusion from index cases in five surgical specialties: 2011 to 2015. Transfusion. 58(5), 1271-1278. doi: 10.1111/trf.14559. Epub 2018 Mar 14. PMID: 29542136. 2018
  34. Williams B, Chriss E, Kaplan J, Cartron A, Taylor B, Gammie J, Tanaka K, Mazzeffi M. Hypothermia, pH and Postoperative Red Blood Cell Transfusion in Massively Transfused Adult Cardiac Surgery Patients: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. 32(4), 1642-1647. PMID: 29290382. 2018
  35. Williams B, Sikorski R, Anders M, Galvagno S, Rock P, Mazzeffi M. Should We Use Perioperative Transesophageal Echocardiography More in Non-Cardiac Surgery?. J Cardiothorac Vasc Anesth. 32(3), e71-e73. PMID: 27474334. 2018
  36. Tanaka KA, Mazzeffi MA, Williams B. Acute Traumatic Coagulopathy: Thrombin Is the Driver!. Anesthesiology. 127(3), 585. PMID: 28816786. 2017
  37. Williams B, Mazzeffi MA, Sanchez PG, Pham SM, Kon Z, Tanaka KA. Case Report of Severe Antithrombin Deficiency During Extracorporeal Membrane Oxygenation and Therapeutic Plasma Exchange for Double Lung Transplantation. A A Case Rep. 8(1), 11-13. PMID: 28036320. 2017
  38. Henderson RS, Deshpande S, Williams B, Taylor BS, Tanaka KA. Idarucizumab for Dabigatran Reversal in Emergency Type-A Aortic Dissection. J Cardiothorac Vasc Anesth. 31(6), e80-e81. doi: 10.1053/j.jvca.2016.04.027. Epub 2016 May 13. PMID: 27498256. 2017
  39. Odonkor P, Srinivas A, Strauss E, Williams B, Mazzeffi M, Tanaka KA. Perioperative Coagulation Management of a Hemophilia A Patient During Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 21(4), 312-320. doi: 10.1177/1089253217702747. Epub 2017 Apr 7. PMID: 28388863. 2017
  40. Strauss ER, Mazzeffi MA, Williams B, Key NS, Tanaka KA. Perioperative management of rare coagulation factor deficiency states in cardiac surgery. Brit J Anesth. 119(3), 354-368. PMID: 28969316. 2017
  41. Williams B, McNeil J, Crabbe A, Tanaka KA. Practical Use of Thromboelastometry in the Management of Perioperative Coagulopathy and Bleeding. Transfus Med Rev. 31(1), 11-25. PMID: 27622549. 2016
  42. Williams B, Bernstein W. Review of Venoarterial Extracorporeal Membrance Oxygenation and Development of Intracardiac Thrombosis in Adult Cardiothoracic Patients. J Extra Corpor Technol. 48(4), 162-167. PMID: 27994255. 2016
  43. Hu Y, Williams B, Galai I, Nathan N, Smallman B. Tongue protrusion as an extubation criterion in pediatric surgery. Paediatr Anaesth. 24(9), 1021-2. PMID: 25092454. 2014

 

Research Interests

  • Cardiopulmonary Bypass Associated Coagulopathy 
  • Sepsis Induced Coagulopathy

Awards and Affiliations

2015 2015 Dripps Awards Recipient, UMSOM
2018 2018 Kosaka Best of Meeting Abstract Award, UMSOM, IARS-Annual Meeting
2019 2019 Best Basic Science Abstract, UMSOM, Anesthesiology Spring Research Retreat

Grants and Contracts

Active Grants
9/1/2020-5/31/2025

(PI, 75%)

Role of miRNA-TLR7 signaling in platelet activation and dysfunction in sepsis

NIH K08 Mentored Research Award

Award Total: $808,965.00

Annual Direct Cost: $150,300.00
Completed Grants
1/1/2018-12/31/2019

(PI,60%)

Targeting Inflammation in Sepsis-induced Coagulopathy 

STAR DRIF Fund, No Salary Support

Award Total: $50,849.00

Annual Direct Cost: $50,849.00
2/1/2019-1/31/2020

Targeting Inflammation in Sepsis-induced Coagulopathy 

STAR DRIF Fund, No Salary Support

Award Total: $50,849.00

Annual Direct Cost: $50,849.00
3/1/2020-9/1/2020

(PI,75%)

Role of TLR7 in platelet activation and dysfunction in sepsis

Foundation for Education and Anesthesia Research (FAER) Mentored Research Training Grant

Award Total: $250,000.00

Annual Direct Total: $125,000.00

Professional Activity

 

Institution - Departmental 
2014-present Member, Education Committee, Anesthesiology, University of Maryland School of Medicine
2016-present Member, Research Committee, Anesthesiology, University of Maryland School of Medicine
2021-present Member, Inclusion, Diversity, Equity and Antiracism (IDEA) Taskforce, Anesthesiology, University of Maryland School of Medicine
National
2020-2020 Member, International Collaboration for Transfusion Medicine, Platelet Transfusion Guideline Development Group
2021-2022 Member, Society of Cardiovascular Anesthesiologists (SCA), Cardiovascular Outcomes Research in Perioperative Medicine (COR-PM)
2021-2023 Member, Society of Cardiovascular Anesthesiologists (SCA), Echo Week Planning Committee
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