Bingbing Wang, PhD

1989                  MD, Wuhan University School of Medicine, Wuhan, China

2003                  PhD, Pathobiology, University of Washington, Seattle, WA

2003-2005       Post-Doctoral Fellow, Medical Genetics, University of Washington, Seattle, WA

2005-2010       Post-Doctoral Fellow, Pathology & Immunology, Harvard Medical School and Dana-Farber Cancer Institute, Boston, MA

Academic Appointments

1989-1997  Resident and Attending Physician, Hubei Cancer Hospital & Institute, Wuhan, China

2010-2020  Assistant Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, NJ

I joined the faculty of Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine in 2021.  With use of various state-of-the-art methods including spatial transcriptomics or single-cell RNA-sequencing analysis, my research interests focus on dissecting epigenetic and genetic mechanism of adverse obstetric outcomes including preterm delivery and congenital disorders because of non-infectious or infectious cause. It is expected that these studies will significantly facilitate deciphering of molecular heterogeneity,  discovery of novel biomarkers and druggable targets, and in turn, development of selective and viable therapies including RNA-based therapeutics for these diseases while providing personalized medicine.

Maternal-fetal biology, placental (patho-)physiology, RNA biology, exosomes, drug screening, computational biology

Wang B, Yanez A, and Novina, CD.  MicroRNA-repressed mRNAs contain 40S but no 60S components.  Proc Natl Acad Sci USA 105:5343-5348, 2008

Wang B, Li S, Qi HH, Chowdhury D, Shi Y, and Novina CD. Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.  Nat Struct Mol Biol. 16:1259-1266, 2009

Wang B, Parobchak N, and Rosen T. RelB/NF-κB2 regulates corticotropin-releasing hormone in the human placenta. Mol Endocrinol. 26:1356-1369, 2012

Wang B, Parobchak N, Rosen M, Roche, N, and Rosen T. Negative effects of progesterone receptor isoform-A on human placental activity of the non-canonical NF-κB signaling. J Clin Endocrinol Metab.  99:E320-328, 2014

DiStefano V, Wang B, Parobchak N, Roche N, Rosen T. RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta. Sci Signal. 8(391):ra85. doi: 10.1126/scisignal.aaa9806. 2015

Wang B, Parobchak N, Martin A, Rosen M, Yu LJ, Nguyen M, Gololobova K, Rosen T. Screening a small molecule library to identify inhibitors of NF-κB inducing kinase and pro-labor genes in human placenta.  Sci Rep.  8(1):1657. doi: 10.1038/s41598-018-20147-0. 2018

Wang B, Wang P, Parobchak N, Treff N, Tao X, Wang J, Rosen T. Integrated RNA-seq and ChIP-seq analysis reveals a feed-forward loop regulating H3K9ac and key labor drivers in human placenta. Placenta 76:40-50. doi: 10.1016/j.placenta.2019.01.010. 2019

Ithier MC, Parobchak N, Yadava S, Cheng J, Wang B, Rosen T. Fetal lung C4BPA induces p100 processing in human placenta.  Sci Rep. 9(1):5519. doi: 10.1038/s41598-019-42078-0. 2019

Wang B, Shen WB, Yang P, Turan S. SARS-CoV-2 infection induces activation of ferroptosis in human placenta. Front Cell Dev Biol. 10:1022747. doi: 10.3389/fcell.2022.1022747. eCollection 2022