Update Your ProfileAcademic Title:
Associate Professor
Primary Appointment:
Microbiology and Immunology
Additional Title:
Member, Marlene and Stewart Greenebaum Comprehensive Cancer Center
Email:
Location:
HH 332
Phone (Primary):
4107066916
Education and Training
Nevil Singh is a graduate of the Tata Institute of Fundamental Research (TIFR, Bombay, India) where his thesis work focused on vaccine-antigens against the malarial parasite, Plasmodium falciparum. He then joined Ron Schwartz’s group at the NIAID, NIH for a post-doctoral fellowship, examining T cell tolerance to self-proteins. Subsequently, as a Research Scientist at the NIAID, he studied the mechanisms controlling the responsiveness and frequency of helper T cells. He joined the faculty of UMDSOM in 2013.
See http://nevillab.org for updated information about the current research in the lab.
Biosketch
See http://nevillab.org for updated information about the current research in the lab.
Research/Clinical Keywords
T cell activation & differentiation, Immunological tolerance, Immunological Memory, Neuroimmunology, Adaptive immunity to infections, Dendritic cell activation, IL-12 family cytokines, Tumor Immunology, Cancer Immunology
Highlighted Publications
Selected relevant publications:
Gerber AN, Abdi K & Singh NJ. (2021) The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo. (Cell Rep. 2021 Oct 12;37(2):109816. doi: 10.1016/j.celrep.2021.109816.) PubMed PMID: 34644571
Matson CA & Singh NJ. (2020) Manipulating the TCR signaling network for cellular immunotherapy: Challenges & opportunities. (Mol Immunol. 2020 Jul;123:64-73. doi: 10.1016/j.molimm.2020.04.007. Review). PubMed PMID: 32422416; PubMed Central PMCID: PMC8105766.
Matson CA, Choi S, Livak F, Zhao B, Mitra A, Love PE & Singh NJ. (2020) CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation. (Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14342-14353. doi: 10.1073/pnas.1922525117). PubMed PMID: 32513716; PubMed Central PMCID: PMC7322041.
Rosenberg KM & Singh NJ. (2019) Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner. Brain Behav Immun. 2019 Aug;80:275-285. doi: 10.1016/j.bbi.2019.04.002. PubMed PMID: 30953766; PubMed Central PMCID: PMC6660347.
Singh, N. J., Bando, J.K. and Schwartz, R.H. (2012) Subsets of non-clonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells (Immunity. 2012 Oct 19;37(4):735-46., - featured on the cover of October 2012). PubMed
Research Interests
The Nevil Lab is interested in understanding how T cells respond to pathogens, tumors and self-antigens. Projects in the lab examine how T cells discriminate between these different sources of antigen and modulate their responses accordingly.
- Negative regulatory signaling pathways in T cells restrain self-reactive T cells from causing autoimmune pathology. Conversely, these pathways also limit the ability of tumor-specific T cells to robustly reject tumors. The lab has used molecular genetic approaches to identify new molecules involved in such pathways. The lab is characterising how these regulators function and how such pathways can be modified in vivo to supress or enhance T cell responses.
- The kind of response a T cell makes is tailored precisely to the pathogen (or tumor) affecting the host but also strongly adapted to the specific tissue that is affected. Projects in the lab examine how this dual information (pathogen type plus tissue niche) is conveyed to T cells.
- It has been known for a long time that the nervous system and immune system interact often both in the steady state and during infections. The lab is examining the mechanisms by which specific neurotransmitters regulate T cell function.
For more details and up to date information about current projects, please visit our Laboratory pages at http://nevillab.org