Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Medicine
Administrative Title:
Director, Section of Hepatology - Division of Gastroenterology & Hepatology
Additional Title:
Director of General and Transplant Hepatology
Location:
UMMC, North Hospital, N3W50
Phone (Primary):
410-328-1358
Phone (Secondary):
410-328-0159
Fax:
410-328-8315
Education and Training
- 1989: MBBS, Christian Medical College, Vellore, India
- 1991: - MD, Stanley Medical College, Madras, India
- 1994-1997: Resident, Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH
- 1997-2000: Fellow, Gastroenterology, University of Connecticut, Farmington, CT
- 2000-2001: Fellow, Transplant Hepatology, Mount Sinai Medical Center, New York, NY
Biosketch
Dr. Kirti Shetty is a Professor of Medicine, and serves as Director of the Section of General and Transplant Hepatology. Her career has combined a broad experience in the management of liver diseases, with the administration of multidisciplinary programs in Hepatology and Transplantation. Her current area of research focuses on biomarker discovery and biological characteristics of hepatocellular carcinoma (HCC) in cirrhosis.
She is currently the PI on a NCI funded multi-PI U01 entitled "Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer". This research will investigate the predictive value of candidate biomarkers for HCC in cirrhosis and provides an opportunity to combine her clinical expertise in advanced liver disease, translational work in hepatocarcinogenesis, and experience with biomarker discovery.
Dr. Shetty views the education of future academic hepatologists as a priority. In her past positions, she initiated and directed Fellowship programs in Transplant Hepatology, and currently participates in the Pilot and 4th year Hepatology fellowship programs at UMSOM.
Research/Clinical Keywords
Hepatocellular carcinoma, cirrhosis, hepatitis C, non alcoholic fatty liver disease
Highlighted Publications
Mishra L, Shetty K, Tang Y, Stuart A, Byers SW. The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene. 2005; 24(37):577-589
Shetty K, Kim SS, Katuri V, Kitsin K, Baek HJ, Tang Y, Marshall B, Johnson LB, Mishra B, Mishra L. TGF-β Signaling Pathway Inactivation and Cell Cycle Deregulation in the Development of Gastric Cancer: Role of the β-Spectrin, ELF. Biochem Biophys Res Commun. 2006; 344(4):1216-1223.
Kitisin K, Shetty K, Mishra L, Johnson LB. Hepatocellular stem cells. Ca Biomark. 2007; 3(4-5):251-62.
Shetty K, Chen J, Shin JH, Jogunoori W, Mishra L. Pathogenesis Of Hepatocellular Carcinoma Development In Non Alcoholic Fatty Liver Disease. Curr Hepatol Rep. 2015;14(2):119-127.
Jesudian A, Desale S, Julia J, Landry E, Maxwell C, Kallakury B, Laurin J, Shetty K. Donor Factors Including Donor Risk Index Predict Fibrosis Progression, Allograft Loss, and Patient Survival following Liver Transplantation for Hepatitis C Virus. J Clin Experimen Hepatol. 2016; 6(2):109-14.
A complete list of Dr. Shetty's Publications can be found on PubMed.gov.
Additional Publication Citations
Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability.Hepatol. 2017; 65(2):678-693.
Di Poto C, Ferrarini A, Zhao Y, Varghese RS, Tu C, Zuo Y, Wang M, Nezami Ranjbar MR, Luo Y, Zhang C, Desai CS, Shetty K, Tadesse MG, Ressom HW. Metabolomic Characterization of Hepatocellular Carcinoma in Patients with Liver Cirrhosis for Biomarker Discovery. Ca Epidemiol Biomarkers Prev.2017;26(5):675-683.
Gu S, Nguyen BN, Rao S, Li S, Shetty K, Rashid A, Shukla V, Deng CX, Mishra L, Mishra B. Alcohol, stem cells and cancer. Genes Cancer. 2017 Sep;8(9-10):695-700.
Chen J, Zaidi S, Rao S, Chen JS, Phan L, Farci P, Su X, Shetty K, White J, Zamboni F, Wu X, Rashid A, Pattabiraman N, Mazumder R, Horvath A, Wu RC, Li S, Xiao C, Deng CX, Wheeler DA, Mishra B, Akbani R, Mishra L. Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-beta Pathway. Gastroenterology. 2018 Jan;154(1):195-210. doi: 10.1053/j.gastro.2017.09.007. Epub 2017 Sep 15
Block TM, Alter H, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten TF, Guo JT, Hoshida Y, Kowdley KV, Li W, Lok AS, McMahon B, Mehta A, Perrillo R, Rice CM, Rinaudo J, Schinazi RF, Shetty K. Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop. Antiviral Res. 2018;150:93-100. doi: 10.1016/j.antiviral.2017.12.006. Epub 2017 Dec 14.
Alter H, Block T, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Guo H, Guo JT, Hoshida Y, Hu J, Kowdley KV, Li W, Liang J, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo J, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F. A research agenda for curing chronic hepatitis B virus infection. Hepatology 2018; 67(3):1127-1131. doi: 10.1002/hep.29509. Epub 2018
A complete list of Dr. Shetty's Publications can be found on PubMed.gov.
Awards and Affiliations
- 2000: American Association for the Study of Liver Diseases ( AASLD) Advanced Hepatology Award
- 2002: American College of Gastroenterology Career Development Award
- 2008: Fellow of the American College of Gastroenterology (FACG)
- 2014: Fellow of the American Association for the Study of Liver Diseases (FAASLD)
Grants and Contracts
U01 Multicenter Grant Application: National Cancer Institute.
"Pathway Specific Functional Biomarkers for The Early Detection of Liver Cancer"
Professional Activity
Editorial Board Appointments
2006–2011
Member, Editorial Board, Hepatology
2008–2011
Member, Editorial Board, Clinical Gastroenterology and Hepatology
Advisory Committees
2012-2014
Organ Procurement Transplant Network / United Network for Organ Sharing (OPTN/UNOS)
Liver and Intestinal Transplantation Committee: Member At Large
2016-present
US Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) Peer Reviewed Cancer Research Program (PRCRP)
Liver Cancer review panel
2017-present
US Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP)
Viral Hepatitis Panel
2018-present
Organ Procurement Transplant Network / United Network for Organ Sharing (OPTN/UNOS)
Membership and Professional Standards Committee: Member