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Shabnam Salimi, MD, MSc

Academic Title:

Adjunct Assistant Professor

Primary Appointment:

Epidemiology & Public Health

Email:

ssalimi@som.umaryland.edu

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Education and Training

Kermanshah Univerity of Medical Sciences, MD, 2003

Umea Univerity, MSc, 2008

University of Maryland Baltimore, Postdoctoral Study, Genetic Epidemiology, 2015

Fellowship American Heart Association

University of Maryland Baltimore, Postdoct oral Study,Epidemiology of Aging, 2017

Biosketch

Dr. Salimi is currently an Assistant Professor at the University of Maryland, Baltimore. She is a physician-scientist with extensive experience as a genetic epidemiologist, and computational biologist focusing on chronic diseases and aging and implementations in public health. She has participated in the designing and implementation of several research projects that have built the foundation for her epidemiological, computational and biological skills, culminating in several publications and grants. 

Research/Clinical Keywords

Biomarkers of Chronic diseases, aging, system biology, genetic epidemiology

Highlighted Publications

 

  1. Salimi S, Nawi N, Seliger S, Parsa A. Periodontal disease, renal dysfunction and heightened leukocytosis. Analysis of NHANES data. Nephron Clin Pract 2014; 28(1-2):107-14.
  2. Murigi FN, Mohindra P, Hung C, Salimi S, Goetz W, Pavlovic R, Jackson IL, Vujaskovic Z. Dose Optimization Study of AEOL 10150 as a Mitigator of Radiation-Induced Lung Injury in CBA/J Mice. Radiat Res 2015; 184:422-32.
  3. Seliger SL, Salimi S, Pierre V, Giffuni J, Katzel L, Parsa A. Microvascular endothelial dysfunction is associated with albuminuria and CKD. BMC 2016; 13:17-82.
  4. Salimi S, Lewis JP, Yerges-Armstrong LM, Mitchell BD, Saeed F, O'Connell JR, Perry JA, Ryan KA, Shuldiner AR, Parsa A. Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons with Heightened Platelet Aggregation. J Am Heart Assoc 2016; 31:5.
  5. Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Böger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW; FIND Consortium., Groop PH, Forsblom C, Freedman BI, Lipkowitz M, Fox CS, Winkler CA, Feldman HI; and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study. J Am Soc Nephrol 2017; 28:923-934.
  6. Salimi S, Guralnik J, Shardell M, Huang Y, Orwig D, Gruber-Baldini A, Magaziner J. Trajectories of inflammation and frailty following hip fracture: Baltimore Hip Fracture Study. J Am Geriatr Soc 2018;66:804-811.
  7. Choi CS, Lim W, Salimi S, YEJ, Lee-Kwon W, Lee HH, Lee JH, Mitchell BD, Sanada S,Parsa A, Kwon MH. TonEBP mediates hyperglycemia-induced inflammation, vascular and renal injury. J Am Soc Nephrol. 2018;29:492-504.
  8. Salimi S, Shardell M, Miller R, Gruber-Baldini AL, Orwig D, Fedarko N, Hochberg MC, Guralnik JM, Magaziner J. Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption, and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies. J Bone Miner Res. 2018 Sep;33(9):1649-1656.
  9. Wang X, Salimi S, Deng Z, Perry J, Ryan KA, Li Z, Liu D, Streeten E, Shuldiner AR, Fu M. Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish. Sci Rep. 2018;8:7141.
  10. Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, Miller A, Correa A, BowlerRP, Bis JC, Salimi S, Jenny NS, Pankratz N, Wang B, Preuss MH, Zhou L, Moscati A, Nadkarni GN, Loos RJF, Zhong X, Li B, Johnsen JM, Nickerson DA, Reiner AP, Auer PL; NHLBI Trans-Omics for Precision Medicine Consortium. Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans. Hum Mol Genet. 2019;28:515-523.
  11. NHLBI TOPMed Lipid working Group. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018;9:3391.
  12. NHLBI TOPMed Lipids Working Group. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018;9:2606.
  13. Snyder JM, Snider TA, Ciol MA, Wilkinson JE, Imai DM, Casey KM, Vilches-Moure JG, Pettan-Brewer C, Pillai SPS, Carrasco SE, Salimi S, Ladiges W. Validation of a geropathology grading system for aging mouse studies. Geroscience 2019; 41(4):455-465.
  14. Ferrucci L, Gonzalez-Freier M, Fabbri E, Simonsick E, Tanaka T, Moore Z, Salimi S, Sierra F, de Cabo R. Measuring biological aging in humans: A quest. Aging Cell 2020; 19(2):e13080
  15. Raffield LM, Iyengar AK, Wang B, Gaynor SM, Spracklen CN, Zhong X, Kowalski MH, Salimi S, et al. Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts. Am J Hum Genet 2020; 2;106.
  16. Salimi S, Yanosky JD, Huang D, Montressor-Lopez J, Vogel R, Reed RM, Mitchell BD, Puett RC. Long-term Exposure to Particulate Air Pollution and Brachial Artery Flow-Mediated Dilation in the Old Order Amish. Environ Heath 2020;14; 19:50.
  17. Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium. De Novo Mutations Across 1,465 Diverse Genomes Reveal Mutational Insights and Reductions in the Amish Founder Population. Proc Natl Acad Sci USA, 2020, 4;117(5):2560-2569.
  18. Kachroo P, Hecker J, Chawes BL, Ahluwalia TS, et al. National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest 2019; 156:1068-1079.
  19. NHLBI TOPMed NeuroCognitive Working Group. Whole-genome sequence analyses of brain imaging measures in the Framingham Study. Neurology 2018;16;90:e188-e196
  20. Salimi S, Hamlyn JM. COVID-19 and Crosstalk With the Hallmarks of Aging. J Gerontol A Biol Sci Med Sci; 2020 Jun 16;glaa149.
  21. Salimi S, Vehtari A, Salive Body Clock: Matching Personalized Multimorbidity and Fast Aging Using Information Entropy

 

 

 

 

Additional Publication Citations

 

  1. Jafarian S, Gorouhi F, Salimi S, Lotfi J. Sumatriptan for prevention of acute mountain sickness: a randomized clinical trial. Ann Neurol. 2007; 62:273-7.
  2. Kashkouli MB, Salimi S, Aghaee H, Naseripour M. Bilateral pseudomonas aeruginosa endophthalmitis following bilateral simultaneous cataract surgery. Indian J Ophthalmol 2007; 55:374-5.
  3. Kashkouli MB, Salimi S, Bakhtiari P, Parvaresh MM, Sanjari MS, Naseripour M. EMLA cream application without occlusive dressing before upper facial botulinum toxin injection a randomized, double-blind, placebo-controlled Trial. Ann Plast Surg 2008; 60:353-6.
  4. Kashkouli MB, Rezaee A, Nilforoushan N,Salimi S, Foroutan A, Naseripour M. Topical antiglaucoma medication and lacrimal drainage system. Ophthal Plast Reconstr Surg 2008; 24:172-5.
  5. Dolan K, Salimi S, Nassirimanesh B, Mohsenifar S, Allsop D, Mokri A. The establishment of a methadone treatment clinic for women in Tehran, Iran. J Public Health Policy. 2011; 32:219-30.
  6. Dolan K, Salimi S, Nassirimanesh B, Mohsenifar S, Allsop D, Mokri A. Characteristics of Iranian Women Seeking Drug Treatment. J of Women’s Health 2011; 20:1687-1691.
  7. Mohsenifar S, Ghasemzadeh H, Salimi S, Arjmand M. A preliminary study on categorization type (rule-based versus family resemblance judgment) in a group of Iranian students. J Cogn Cult 2011;49-59.
  8. Dolan K, Salimi S, Nassirimanesh B, Mohsenifar S, Allsop D, Mokri A Six-month follow-up of Iranian women in methadone treatment: drug use, social functioning, crime and HIV and HCV. Substance Abuse and Rehabilitation 2012; 3:37- 43.
  9. Clausen F, Lindh T, Salimi S, Erlandsson A. Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration. Brain Res 2014; S0006-8993(14) 1118-4.
  10. Salimi S, Nawi N, Seliger S, Parsa A. Periodontal disease, renal dysfunction and heightened leukocytosis. Analysis of NHANES data. Nephron Clin Pract 2014; 28(1-2):107-14.
  11. Sadeghian S, Darvish S, Salimi S, Esfehani FA, Fallah N, Mahmoodian M, Salarifar M, Karimi A. Metabolic Syndrome: stronger association with coronary artery disease in young men in comparison to higher prevalence in young women. Coron Artery Dis 2007;18:163-8.

  12.  Jafarian S, Gorouhi F, Salimi S, Lotfi J. Low-dose gabapentin in treatment of high-altitude headache. Cephalalgia. 2007; 27: 1274-7.

Research Interests

Biomarkers of chronic disease in older adults and aging using state-of-the-art “omics” data and clinical application.

Awards and Affiliations

2011                            National Institute on Drug Abuse, Travel Award

2011                            World Health Organization, Travel Award

2014                            National Institute on Drug Abuse, Travel Award 

2014                            Radiation Research Society, Young Investigator Award, Society

                                   of Irradiation Training

2016                            American Heart Association Fellowship

2017                            Outstanding Presentation, Geriatrics and Gerontology Education

                                    and Research Program

2017                            Scientific Presentation, 10th Annual Aging ShowCase, Johns Hopkins

                                   University 2018 Scientific Best Presentation, The Claude D. Pepper Older Americans

                                   Independence Centers (OAIC) Annual Meeting

Grants and Contracts

 PI: Pilot Principal Investigator with small funding 10K to further measure inflammatory markers in association with bone loss in men following hip fracture “Serum Metabolomic Profiles in association with chronic outcomes in older adults, two months and six months after hip fracture in men. University of Maryland Claude D. Pepper Older American Independence Center (UM-OAIC)

In the News

  https://www.nytimes.com/2020/09/08/health/covid-aging-immune-system.html

Lab Techniques and Equipment

Western blot, cell culture, histology,  genome function

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