Academic Title:
Research Associate
Primary Appointment:
Anesthesiology
Phone (Primary):
(410) 328-6120
Fax:
(410) 328-5531
Education and Training
1994-1999 Master’s degree in Biochemistry, Bashkir State University, Ufa, Russian Federation
1999-2003 Ph.D. in Molecular Biology, Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Russian Federation
Post-Graduate Training and experience
2010-2014 Postdoctoral fellow, Shock, Trauma and Anesthesiology Research (STAR) Center, Department of Anesthesiology, School of Medicine, University of Maryland, Baltimore, MD (P.I.: Dr. Alan Faden)
2004-2010 Postdoctoral fellow, Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD (P.I.: Dr. Timothy G. Clark - deceased)
2014-present Faculty Research Associate, Shock, Trauma and Anesthesiology Research (STAR) Center, Department of Anesthesiology, School of Medicine, University of Maryland, Baltimore, MD
Research/Clinical Keywords
Brain trauma, neuronal cell death, apoptosis
Highlighted Publications
- miR-711 upregulation induces neuronal cell death after traumatic brain injury. Sabirzhanov B, Stoica BA, Zhao Z, Loane DJ, Wu J, Dorsey SG, Faden AI. Cell Death Differ. 2016 Apr;23(4):654-68. doi: 10.1038/cdd.2015.132. Epub 2015 Oct 16. PMID: 26470728
- Voluntary Exercise Preconditioning Activates Multiple Antiapoptotic Mechanisms and Improves Neurological Recovery after Experimental Traumatic Brain Injury. Zhao Z, Sabirzhanov* B, Wu J, Faden AI, Stoica BA. J Neurotrauma. 2015 Sep 1;32(17):1347-60. doi: 10.1089/neu.2014.3739. Epub 2015 May 7. PMID: 25419789 * First coauthor
- Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. Sabirzhanov B, Zhao Z, Stoica BA, Loane DJ, Wu J, Borroto C, Dorsey SG, Faden AI. J Neurosci. 2014 Jul 23;34(30):10055-71. doi: 10.1523/JNEUROSCI.1260-14.2014. PMID: 25057207
- Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. Wu J, Sabirzhanov* B, Stoica BA, Lipinski MM, Zhao Z, Zhao S, Ward N, Yang D, Faden AI. Cell Cycle. 2015;14(23):3698-712. doi: 10.1080/15384101.2015.1104436. PMID: 26505089 * First coauthor
Research Interests
My current research interest is mechanisms and modulation of neuronal cell death, including in vitro studies using primary neuronal cultures and in vivo studies using rodent models of experimental traumatic brain injury. Particularly, I am interested in investigation of post-transcriptional and epigenetic regulation of genes expression in neuronal apoptosis. Another area of my research is identification of microRNAs (miRs) biomarkers for detection of neurological injuries.