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Marcela F. Pasetti, PhD

Academic Title:

Professor

Primary Appointment:

Pediatrics

Secondary Appointment(s):

Microbiology and Immunology

Email:

mpasetti@som.umaryland.edu

Location:

HSFII S361

Phone (Primary):

(410) 706-5328

Fax:

(410) 706-6205

Education and Training

University of Buenos Aires, Orientation, Microbiology and Immunology, 1990

University of Buenos Aires, Ph.D., Immunology, 1994

Année Universitaire, Institute Pasteur, Diplome d’Immunologie Générale, 1994-1995

Postdoctoral Fellow, University of Maryland School of Medicine Center for Vaccine Development, 1996-2001

Biosketch

Dr. Pasetti researches vaccines and immunology to understand how protective immunity can be induced in animal models and in humans following infection and vaccination, and the mechanisms involved. Her primary areas of interests are pediatric vaccines, neonatal and infant immunology, and maternal immunization. She investigates novel vaccine strategies, antigen delivery systems, adjuvants, and immunization regimens for protection against pathogens that affect young children, as well as the influence of maternal immunity on infant immune responses to vaccines, and the impact of vaccine combination on long-term health and protection. Such knowledge is critical for successful pediatric immunization and to inform effective public health interventions.

Dr. Pasetti is particularly interested in vaccines that include live attenuated Salmonella and Shigella (alone or encoding foreign antigens), protein subunit vaccines, and polysaccharide conjugates. She is working in a new concept for a broadly protective pediatric vaccine against Salmonella, Shigella, and Yersinia based on conserved Type III secretion proteins, evaluating immunogenicity and protective efficacy in  adult, neonatal, and maternal-infant animal models.

Research/Clinical Keywords

Immunology, vaccines, immune responses, neonatal immunity, maternal-infant immunization, vaccine development, mucosal immunology, adjuvant, vaccine delivery systems.

Highlighted Publications

Levine MM, Pasetti MF. Serological monitoring is key to sustain progress of the maternal and neonatal tetanus elimination initiative. Clin Vaccine Immunol. 2016 Jul 5;23(7):532-4.

Tapia MD, Sow SO, Tamboura B, Tégueté I, Pasetti MF, Kodio M, Onwuchekwa U, Tennant SM, Blackwelder WC, Coulibaly F, Traoré A, Keita AM, Haidara FC, Diallo F2, Doumbia M, Sanogo D, DeMatt E, Schluterman NH, Buchwald A, Kotloff KL, Chen WH, Orenstein EW, Orenstein LA, Villanueva J, Bresee J, Treanor J, Levine MM. Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: A prospective, active-controlled, observer-blind, randomised phase 4 trial. Lancet Infect Dis. 2016 Sep; 16(9):1026-35.

Mohan VK, Varanasi V, Singh A, Pasetti MF, Levine MM, Venkatesan R, Ella KM. Safety and immunogenicity of a Vi polysaccharide-tetanus toxoid conjugate vaccine (Typbar-TCV) in healthy infants, children, and adults in typhoid endemic areas: a multicenter, 2-cohort, open-label, double-blind, randomized controlled phase 3 study. Clin infect Dis. 2015 Aug 1;61(3):393-402.

Heine SJ, Diaz-McNair J, Andar AU, Drachenberg CB, van de Verg L, Walker R, Picking WL, Pasetti MF. Intradermal delivery of Shigella IpaB and IpaD Type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity and protection across serotypes. J Immunol. 2014 Feb 15;192(4):1630-40.

Muhsen K, Pasetti MF, Reymann MK, Graham DY, Levine MM. Helicobacter pylori infection affects immune responses following vaccination of typhoid-naive U.S. adults with attenuated Salmonella typhi oral vaccine CVD 908-htrA. J infect Dis. 2014 May1; 209(9):1452-8.

Additional Publication Citations

Research Interests

Grants and Contracts

Lab Techniques and Equipment

Laboratory Methods

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