Academic Title:
Associate Professor
Primary Appointment:
Neurology
Additional Title:
Medical Director, UMMC Neuro Critical Care Unit
Location:
UMMC Neuro Critical Care Unit
Phone (Primary):
(410) 328-4515
Education and Training
- The University of Texas at Austin, BA, Biochemistry
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Texas A&M College of Medicine, MD
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St. Vincent's Hospital - Manhattan, Intern, Internal Medicine
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Barrow Neurological Institute at Saint Joseph's Hospital and Medical Center, Resident, Neurology
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Barrow Neurological Institute at Saint Joseph's Hospital and Medical Center, Chief Resident, Neurology
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Columbia University Medical Center / Weill Cornell Medical Center, Clinical Fellow, Neurocritical Care/Vascular Neurology
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National Institutes of Heatlh, NINDS Research Fellow, Neuroimaging
Biosketch
My career has been focused on merging principles of clinical neurology and critical care medicine. My research focus is to identify biomarkers during the resuscitation phase of patients with acute brain injuries that are determinants of lesion repair, restoration of function, and recovery of consciousness. This has led to both in vivo & ex vivo investigations characterizing the MRI signature of primary microvascular injury after head trauma and other acute brain injuries.
Research/Clinical Keywords
High Reliability, Safety, Quality, Patient Experience, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage, Traumatic Brain Injury, Translational Neuroscience, Multimodality Monitoring, Neuroimaging, Triage and Interhospital transfer of Neuroscience Patients
Highlighted Publications
1. Griffin AD, Turtzo LC, Parikh GY, Tolpygo A, Lodato Z, Moses AD, Nair G, Perl DP, Edwards NA, Dardzinski BJ, Armstrong RC, Ray-Chaudhury A, Mitra PP, Latour LL. Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Brain. 2019 Nov 1;142(11):3550-3564. doi: 10.1093/brain/awz290. PMID: 31608359; PMCID: PMC6821371.
2. Turtzo L, Jikaria N, Cota M, Williford J, Uche V, Davis T, MacLaren J, Moses A, Parikh G, Castro M, Pham D, Butman J, Latour L. Meningeal Blood-Brain Barrier Disruption in Acute Traumatic Brain Injury. Brain Communications. 2020;2(2):fcaa143.
3. Khan IR, Gu Y, George BP, Malone L, Conway KS, Francois F, Donlon J, Quazi N, Reddi A, Ho CY, Herr DL, Johnson MD, Parikh GY. Brain Histopathology of Adult Decedents After Extracorporeal Membrane Oxygenation. Neurology. 2021 Mar 2;96(9):e1278-e1289. PMID: 33472914; PMCID: PMC8055323.
4. Podell JE, Krause EM, Rector R, Hassan M, Reddi A, Jaffa MN, Morris NA, Herr DL, Parikh GY. Neurologic Outcomes After Extracorporeal Cardiopulmonary Resuscitation: Recent Experience at a Single High-Volume Center. ASAIO J. 2021 Apr 21. PMID: 33927083.
5. Turtzo LC, Luby M, Jikaria N, Griffin A, Greenman D, Bokkers RPH, Parikh G, Peterkin N, Whiting M, Latour LL. Cytotoxic edema associated with hemorrhage predicts poor outcome after traumatic brain injury. J Neurotrauma. 2021 Nov 15; 38(22), pp. 3107-3118.
6. Salasky V, Jaffa MN, Motta M, Parikh GY. Neurocritical Care Recovery Clinics: An Idea Whose Time Has Come. Current Neurology and Neuroscience Reports. 2023 Apr; 23(4), pp. 159-166.
7. Zimmerman WD, Pergakis M, Ahmad G, Morris NA, Podell J, Chang WT, Motta M, Chen H, Jindal G, Bodanapally U, Simard JM, Badjatia N, Parikh GY. Iodine-based dual-energy CT predicts early neurological decline from cerebral edema after large hemispheric infarction. Research Square. 2023 Nov 10.
8. Woodward MR, Wells CL, Arnold S, Dorman F, Ahmed Z, Morris NA, Ciryam P, Podell JE, Chang WT, Zimmerman WD, Motta M, Butt B, Pergakis MB, Labib M, Wang TI, Edlow BL, Badjatia N, Braun R, Parikh GY. Behavioral Assessment With the Coma Recovery Scale—Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness. Critical Care Explorations. 2024 Jul 1;6(7):e1101.
Additional Publication Citations
Research Interests
I focus on the pathobiology of acute brain injury and hemorrhagic stroke through the use of advanced methods (e.g. MRI and multimodality monitoring) that can be translated to the care of critically-ill patients and used as outcome measures in clinical trials of new drugs and rehabilitation-based strategies to treat aspects of brain injury—such as demyelination and neurodegeneration—for which there is currently no therapy.
Awards and Affiliations
Fellow of the Neurocritical Care Society (2024)
Member, American Academy of Neurology
Member, Neurocritical Care Society
Member, National Neurotrauma Society
Grants and Contracts
09/30/2020 – 9/29/2025 Site Co-PI; MPI – Natalia Rost
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery (DISCOVERY)
NINDS/NIA U19 NS115388
07/01/2022 – 11/30/2026 SubK site-PI, MPI Jonathan Rosand
Race / Ethnicity, Hypertension and Prevention of VCID and Stroke after Intracerebral Hemorrhage (REACH-ICH)
NINDS/NIH 5R01NS093870-08