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Patrick N. Odonkor, MB,ChB

Academic Title:

Professor

Primary Appointment:

Anesthesiology

Administrative Title:

Anesthesiology Chief for the Cardiothoracic Division

Email:

podonkor@som.umaryland.edu

Location:

UMMC, S8D

Phone (Primary):

(410) 328-9971

Phone (Secondary):

(410)-328-9813

Fax:

(410) 328-3092

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Education and Training

Education
1985-1991 M.B.,Ch.B., University of Ghana Medical School, Accra, Ghana
1995-1996 Internship, Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York
1996-1999 Residency, Department of Anesthesiology, University of Maryland, Baltimore, MD
1998-1999 Chief Resident, Department of Anesthesiology, University of Maryland, Baltimore, MD
1999-2000 Fellowship, Department of Anesthesiology, Cardiothoracic Anesthesia University of Maryland, Baltimore, MD
Faculty Appointments
2000-2018 Assistant Professor, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD
2018-2024 Associate Professor, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD
2024-present Professor, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD
Additional Appointments
1991-1992 House Officer, Department of Pediatrics & Surgery, University of Ghana Medical School, Accra, Ghana
1992-1995 Medical Officer, Department of Anesthesiology, University of Ghana Medical School, Accra, Ghana

Highlighted Publications

  1. Strauss ER, Odonkor PN, Williams B, Choi S, Mueller J, Taylor B, Shah A, Goerlich CE, Mohiuddin MM, Griffith BP. Intraoperative Management of an Orthotopic Porcine-to-Human Cardiac Xenotransplant. Ann Thorac Surg. 2023; 115(3):784-786.   PMID: 36621667.
  2. Shah A, Goerlich CE, Pasrijah C, Hirsch J, Fisher S, Odonkor P, Strauss E, Ayares D, Mohiuddin M, Griffith BP. Anatomical Differences Between Human and Pig Hearts and Their Relevance for Cardiac Xenotransplantation Surgical Technique. JACC Case Rep. 2022;4(16):1049-1052. PMID: 36062051.
  3. Smith Bergbower EA, Odonkor PN. Con: Acute Normovolemic Hemodilution Should not be used in Infective Endocarditis. J Cardiothorac Vasc Anesth. 2022;36(8):2815-2818. PMID: 35501262.
  4. Odonkor P, Strauss E, Williams B. Ethical considerations during a pioneering surgical procedure: porcine cardiac xenotransplantation. Br J Hosp Med. 2022;83(6):1-7. PMID: 35787171.
  5. Strauss ER, Odonkor PN, Williams B. Porcine Orthotopic Cardiac Xenotransplantation: The Role and Perspective of Anesthesiologists. J Cardiothorac Vasc Anesth. 2022;36(8):2847-2850. PMID: 35537973.
  6. Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Odonkor P. Progressive Genetic Modifications of Porcine Cardiac Xenografts Extend Survival to 9 Months. Xenotransplantation. 2022;29(3):e12744. PMID: 35357044.
  7. Silverman H, Odonkor P. Reevaluating the Ethical Issues in Porcine-to-Human Heart Xenotransplantation. Hastings Center Report. 2022;52(5):32-42. PMID: 36226875.
  8. Grewal A, Odonkor P, Ghoreishi M, Deshpande SP. Anesthetic Considerations in Endovascular Repair of the Ascending Aorta. J Cardiothorac Vasc Anesth. S1053-2021;0770(21):00348-7. PMID: 34059437.
  9. Goerlich CE, Griffith B, Singh AK, Abdullah M, Singireddy S, Kolesnik I, Lewis B, Sentz F, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Tabatabai A, Bhutta A, Ayares D, Kaczorowski DJ, Mohiuddin MM. Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation. Front Immunol. 2021;12: 667093. PMID: 34177906.
  10. Brown JM, Hajjar-Nejad MJ, Dominique G, Gillespie M, Siddiqui I, Romaine H, Odonkor P, Dawood M, Gammie JS. A Failed Cardiac Surgery Program in an Underserved Minority Population County Reimagined: The Power of Partnership. J Am Heart Assoc. 2020;9(23):e018230. PMID: 33213254.
  11. DiChiacchio L, Singh AK, Lewis B, Zhang T, Hardy N, Pasrija C, Morales D, Odonkor P, Strauss E, Williams B, Deatrick KB, Kaczorowski DJ, Ayares D, Griffith BP, Bartlett ST, Mohiuddin MM. Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program. Ann Thorac Surg. 2020;109(5):1357-1361. PMID: 31589847.
  12. Goerlich CE, Kaczorowski D, Singh A, Abdullah M, Lewis B, Zhang T, Tatarov I, Sentz F, Hershfeld A, Odonkor P, Williams B, Strauss E, Ayares D, Griffith B, Mohiuddin M. Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation. J Heart Lung Transplant. 2020;39(4):S145.
  13. Goerlich C, Singh a, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. Lack of Human Thrombomodulin Gene Expression in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation Models Accelerate Antibody Mediated Rejection. Transplantation. 2020;104(S3):S635.
  14. Goerlich C, Singh A, Kaczorowski D, Abdullah M, Lewis B, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Ayares D, Griffith B, Mohiuddin M. The Use of Minimally Ischemic Cardiac Preservation Techniques to Overcome Perioperative Cardiac Xenograft Dysfunction (PCDX) in Life-Supporting Cardiac Xenotransplantation Model. Transplantation. 2020;104(S3):S636.
  15. Odonkor P, Deshpande S, Malinow A. An Impacted Epidural Catheter. Anesthesiology. 2019;131(3):664. PMID: 31008765.
  16. Williams B, Wehman B, Mazzeffi M, Odonkor P, Harris RL, Kon Z, Tanaka K. Acute Intracardiac Thrombosis and Pulmonary Thromboembolism After Cardiopulmonary Bypass: A Systematic Review of Reported Cases. Anesth Analg. 2018;126(2):425-434. doi: 10.1213/ANE.0000000000002259. PMID: 28682954.
  17. Deshpande SP, Chow JH, Odonkor P, Griffith B, Carr SR. Misadventures of a Pigtail: Case Report of Accidental Insertion of a Chest Tube into the Left Atrium During Interventional Radiology-Guided Placement. A&A Pract. 2018;11(10):273-275. doi: 10.1213/XAA.0000000000000807. PMID: 29894345.
  18. Odonkor P, Srinivas A, Strauss E, Williams B, Mazzeffi M, Tanaka KA. Perioperative Coagulation Management of a Hemophilia A Patient During Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 2017;21(4):312-320. doi: 10.1177/1089253217702747. Epub 2017 Apr 7. PMID: 28388863.
  19. Banayan JM, Roberts JD, Chaney MA, Odonkor PN, Hosseinian L, Torregrossa G. CASE 7-2016 Choice of Percutaneous Mechanical Assistance During Cardiopulmonary Instability: Heart, Lungs, or Both? J Cardiothorac Vasc Anesth. 2016;30(4):1104 - 1171. PMID: 26755437.
  20. Mazzeffi M, Lund L, Wallace K, Herrera AV, Tanaka K, Odonkor P, Strauss E, Rock P, Fiskum G. Effect of cardiopulmonary bypass on platelet mitochondrial respiration and correlation with aggregation and bleeding: a pilot study. Perfusion. 2016;31(6):508 - 515. PMID: 26916901.
  21. Mazzeffi M, Stafford P, Wallace K, Bernstein W, Deshpande S, Odonkor P, Grewal A, Strauss E, Stubbs L, Gammie J, Rock P. Intra-abdominal hypertension and postoperative kidney dysfunction in cardiac surgery patients. J Cardiothorac Vasc Anesth. 2016;30(6):1571-1577. doi: 10.1053/j.jvca.2016.05.028. Epub 2016 May 19. PMID: 27590464.
  22. Strauss E, Taylor B, Mazzeffi M, Tanaka K, Odonkor P. The Auscultation of a Carbon Dioxide Embolization Event during Endoscopic Vein Harvest. Case Rep Anesthesiol. 2016;doi: 10.1155/2016/6947679. Epub 2016 May 31. PMID: 27340571.
  23. Hollis AL, Heil EL, Nicolau DP, Odonkor P, Dowling TC, Thom KA. Validation of a dosing strategy for cefazolin for surgery requiring cardiopulmonary bypass. Surg Infect (Larchmt). 2015;16(6):829-32. PMID: 26291478.
  24. Odonkor PN, Grigore AM. Patients with ischemic heart disease. Med Clin North Am. 2013;97(6):1033-50. PMID: 24182718.
  25. Odonkor PN, Stansbury L, Garcia JP, Rock P, Deshpande SP, Grigore AM. Perioperative management of adult surgical patients on extracorporeal membrane oxygenation support. J Cardiothorac Vasc Anesth. 2013;27(2):329-44. PMID: 23276594.
  26. Deshpande SP, Lehr E, Odonkor P, Bonatti JO, Kalangie M, Zimrin DA, Grigore AM. Anesthetic management of robotically assisted totally endoscopic coronary artery bypass surgery (TECAB). J. Cardiothorac. Vasc. Anesth. 2012;27(3):586-99. PMID: 23672862.
  27. Odonkor P, Stansbury LG, Gammie JS, Rock P, Fitzpatrick M, Grigore AM. Anesthetic management of patients undergoing aortic valve bypass (apicoaortic conduit) surgery. J. Cardiothorac. Vasc. Anesth. 2010;26(1):148-60. PMID: 21724415.
  28. Lehr EJ, Zimrin D, Vesely M, Odonkor P, Griffith B, Bonatti J. Axillary-coronary sequential vein graft for total endoscopic triple coronary artery bypass. Ann Thorac Surg. 2010;90(5):e79-81. PMID: 20971229.
  29. Kon ZN, Lehr E, Odonkor P, Fitzpatrick M, Zimrin D, Griffith B, Bonatti J. Is an intraaortic balloon pump a contraindication to robotic totally endoscopic coronary artery bypass? Heart Surg Forum. 2010;13(6):E399-401. PMID: 21169153.
  30. Lehr EJ, Odonkor P, Reyes P, Bonatti J. Minimized extracorporeal circulation for the robotic totally endoscopic coronary artery bypass grafting hybrid procedure. Can J Cardiol. 2010;26(7):e286-7. PMID: 20847981.
  31. Bonatti J, Garcia J, Rehman A, Odonkor P, Haque R, Zimrin D, Griffith B. On-pump beating-heart with axillary artery perfusion: A solution for robotic totally endoscopic coronary artery bypass grafting? Heart Surg Forum. 2009;12(3):E131-3. PMID: 19546060.
  32. Rehman A, Garcia J, Deshpande S, Fitzpatrick M, Odonkor P, Zimrin D, Griffith B, Bonatti J. Poor left ventricular function is not a contraindication for robotic totally endoscopic coronary artery bypass grafting. Heart Surg Forum. 2009;12(3):E152-4. PMID: 19546067.
  33. Rehman A, Garcia J, Deshpande S, Odonkor P, Reicher B, Vesely M, Zimrin D, Griffith B, Bonatti J. Totally endoscopic coronary artery bypass grafting is feasible in morbidly obese patients. Heart Surg Forum. 2009;12(3):E134-6. PMID: 19546061.
  34. Gammie JS, Krowsoski LS, Brown JM, Odonkor PN, Young CA, Santos MJ, Gottdiener JS, Griffith BP. Aortic valve bypass surgery: Midterm clinical outcomes in a high-risk aortic stenosis population. Circulation. 2008;118(14):1460-6. PMID: 18794389.
  35. Reicher B, Poston RS, Mehra MR, Joshi A, Odonkor P, Kon Z, Reyes PA, Zimrin DA. Simultaneous "Hybrid" percutaneous coronary intervention and minimally invasive surgical bypass grafting: feasibility, safety, and clinical outcomes. Am Heart J. 2007;155(4):661-7. PMID: 18371473.
  36. Gammie JS, Griffith BP, Brown JM, Santos MJ, Roberts K, Odonkor PN, Gottdiener JS. Hemodynamic Efficacy of the Aortic Valve Bypass (Apicoaortic Conduit): Assessment by 2D-Doppler Echocardiography: MP9. Innovations:Technology and Techniques in Cardiothoracic and Vascular Surgery. 2006;1(4):188-189.
  37. Gammie JS, Brown JW, Brown JM, Poston RS, Pierson RN, Odonkor PN, White CS, Gottdiener JS, Griffith. Aortic valve bypass for the high-risk patient with aortic stenosis. Ann Thorac Surg. 2005;81(5):1605-10. PMID: 16631642.
  38. Fahy BG, Hasnain JU, Flowers JL, Plotkin JS, Odonkor P, Ferguson MK. Transesophageal echocardiographic detection of gas embolism and cardiac valvular dysfunction during laparoscopic nephrectomy. Anesth Analg. 1999;88(3):500-4. PMID: 10071994.

Additional Publication Citations

Book Articles/Chapters
 
  1. Herr D, Odonkor P. Taking the First Breath: ICU Care of the Lung Transplant Patient. Barac YD, Silvestry SC, Daneshmand MA, Goldstein DJ, eds. In Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease. Wiley Blackwell: https://doi.org/10.1002/9781119633884.ch88. 2023
  2. Odonkor P, Mondal S. Anesthesia considerations in global cardiac surgery capacity development in emerging countries. In: Kpodonu, J, eds. Global Cardiac Surgery Capacity Development in Low and Middle Income Countries. Cham. Springer: 257-277. 2021
  3. Odonkor P, Passannante AN, Rock P. When should pulmonary function tests be performed preoperatively?. Fleischer L, eds. Evidence-Based Practice of Anesthesiology. 3rd ed. Elsevier: Chapter 14. 2013

Research Interests

2005-2006

Research Team Member in a multicenter clinical trial assessing the efficacy and safety of Palonosetron in the treatment of post-operative nausea and vomiting. This trial was sponsored by Helsinn Healthcare SA (Helsinn Healthcare SA Palo-04-06/7)

2005-2007

Research Team Member in a Multicenter, Parallel Group, Comparative, Phase IIIa Trial to Compare the Efficacy, Safety, and Pharmacokinetics of Org 25969 in Elderly Subjects. I administered the trial medication and took measurements of the effect of the trial drug. This trial was sponsored by Organaon Pharmaceuticals

2011-2012

Research Team Member in Edwards Lifesciences Partner I and II Trial for Transcutaneous Aortic Valve Implantation (TAVI) at the University of Maryland Medical Center

2014-2015

Research Team Member in University of Maryland participation in COAPT clinical trial for Mitral Regurgitation and commercial use of Mitra Clip procedure in management of degenerative mitral regurgitation

2017-present

Research Team Member in University of Maryland Program in Cardiac Xenotransplantation. My role has been in the perioperative anesthetic management of baboons undergoing cardiac xenotransplantation

2018-present

Research Team Member in Transcatheter Mitral Valve Replacement with the Medtronic TMVR System in Patients with severe symptomatic Mitral Regurgitation - APOLLO Trial (HP-00077255)

2022-present

Principle Investigator on approved IRB protocol for study "Effect of Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels: an Acute Kidney Injury Biomarker (HP-00099231)" 

2023

Research Team member in multicenter trial "Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II)". Site enrollment and IRB approval pending
  • Cardiac Xenotransplantation
  • Improvement in peri-operative management of major cardiovascular surgical procedures and in patients with major comorbidities
  • Improvement in peri-operative Coagulation management during cardiac surgery
  • Potential effects of autologous normovolemic hemodilution on cardiac surgery associated acute kidney injury

Clinical Specialty Details

Proficiency in Cardiothoracic and major Vascular Anesthesiology:
Anesthesia for Heart and Lung Transplantation
Anesthesia for Placement of Ventricular Assist Devices
Anesthesia for Minimally Invasive Mitral and Aortic Valve Surgery, (including Transcatheter aortic valve implantation and Mitraclip placement)
Anesthesia for Placement of Apico-Aortic Conduit (Aortic Valve Bypass Surgery)
Anesthesia for Endoscopic Cardiac Surgery using Robotics
Anesthesia for Major Vascular Surgery, (Ascending and descending aorta, and aortic arch surgery)
Transesophageal Echocardiography (TEE)
Placement of Coronary Sinus Catheters Under TEE Guidance,
Anesthesia for Thoracic Surgical Procedures, (including Placement of Thoracic Epidural Catheters and their Management, placement and management of double lumen endotracheal tubes and other lung isolation techniques)
Anesthetic management for initiation of Extracorporeal Membrane Oxygenation (ECMO) and anesthetic management of patients on ECMO having surgical procedures

Proficiency in Adult Multispecialty Anesthesiology:
Neurosurgery
Orthopedic Surgery
Oral and maxillofacial Surgery
Ear Nose and Throat Surgery
General Surgery
Obstetrics and Gynecological Surgery
Genitourinary Surgery
Surgical and interventional procedures requiring Non-operating room anesthetic management

 

Awards and Affiliations

1999-2000 Robert Dripps Memorial Award for Outstanding Resident in Anesthesiology, Department of Anesthesiology, UMSOM
2016 Baltimore Top Doctor

Grants and Contracts

Active Grants

2023-2024

(PI, No Salary Support; PI - Patrick Odonkor)

Effect of a Low-volume Fluid Replacement Strategy during Acute Normovolemic Hemodilution in Cardiac Surgery on the Incidence of Cardiac Surgery-associated Acute Kidney Injury

Department of Anesthesiology, University of Maryland School of Medicine Seed Grant

Award Total: $16,566.00

Total Direct Cost: $16,566.00

Community Service

2019, 2021 Presentation on Anesthesiology to High School Students, Edmondson Westside High School Introduction to Careers in Health Care, University of Maryland Medical Center

Professional Activity

Institution - Departmental
2000-present Mentor, Mentorship Program, Department of Anesthesiology, University of Maryland School of Medicine. My role has been to mentor one anesthesiology resident every year.
2014-present Member, Professional Review and Performance Committee, Department of Anesthesiology, University of Maryland School of Medicine
2016-present Facilitator, Administration of individual simulated mock oral board examinations for graduates of the Anesthesiology residency program and other junior faculty of the Department of Anesthesiology preparing for oral board examinations
2021 Member, Focused Professional Practice Evaluation Committee, Department of Anesthesiology, University of Maryland School of Medicine
Institutional Service
2009-2010 Acting Chief, Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, University of Maryland School of Medicine
2013-2014 Acting Chief, Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, University of Maryland School of Medicine
2014-2016 Member, Cardiac Surgery Blood Conservation Workgroup, Division of Cardiac Surgery, Departments of Cardiac Surgery, Anesthesiology and Hematology, UMB
2014-2016 Member, Cardiac Surgery Surgical Site Infection Control Committee, University of Maryland Medical Center, University of Maryland Medical System
2014-2021 Clinical Director, Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, University of Maryland School of Medicine
2014-present Member, Resuscitation Committee, University of Maryland Medical Center
2014-present Initiation and Management of Cardiac Anesthesiology Program, Capital Region Medical Center, University of Maryland Medical System
2014-present Member, Infection Control Executive Committee, University of Maryland Medical Center
2014-present Member, Cardiac Surgery Quality Improvement Group; Division of Cardiac Surgery, UMB
2014-present Member, University of Maryland School of Medicine Council, University of Maryland School of Medicine
2014-2021 Clinical Director, Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, University of Maryland School of Medicine
2016 Department of Cardiac Surgery Quality Assurance and Performance Improvement, University of Maryland Medical Center, Anesthesiology Representative
2016-2020 Member, University of Maryland Faculty Senate, University of Maryland, Baltimore
2018-2019 Member, Cardiac Room Readiness and scheduling Workgroup, University of Maryland Medical Center
2018-2019 Member, TogetherMD Cardiovascular Executive Steering Committee, University of Maryland Medical Center
2018-present Member, Cardiac Performance Improvement Workgroup, University of Maryland Medical Center
2021 Cardiac Surgery ERAS program, University of Maryland Medical Center, University of Maryland School of Medicine
2021-present Member, Continuous Quality Improvement Committee, Heart and Vascular Institute, Capital Region Medical Center
2021-2022 Interim Chief, Division of Cardiothoracic Anesthesiology, University of Maryland School of Medicine
2021-2022 Mentor to Deborah Brooks, Assistant Professor, Dept of Psychiatry, University of Maryland School of Medicine. Serve as mentor for junior faculty to guide their academic progress towards promotion.
2021-2022 Mentor to Julie Hurvitz, Assistant Professor, Dept of Obstetrics and Gynecology, University of Maryland School of Medicine. Serve as mentor for junior faculty to guide their academic progress towards promotion.
2022-present Member, Cardiac Surgery Enhanced Recovery After Surgery Workgroup, University of Maryland Medical Center
2022-present Member, Prolonged Ventilation and Sternal Wound Infection Improvement - Cardiac Surgery Performance Improvement Workgroup, University of Maryland School of Medicine
National Service
2000 Member, American Society of Anesthesiologists
2000 Member, Society of Cardiovascular Anesthesiologists
2015 Junior Editor, MOCA Minute Committee, American Board of Anesthesiology
2015-present Examiner, American Board of Anesthesiology's Standardized Oral Board Examination and Objective Standardized Clinical Examination, American Board of Anesthesiologists, Administer oral examination for the American Board of Anesthesiology's Standardized Oral Examination and Objective Standardized Clinical Examination.
2015-present Question Author for the MOCA Minute Anesthesiology Committee, American Board of Anesthesiologists, Development of questions for the Maintenance of Certification in Anesthesiology program of the American Board of Anesthesiology (Average of 12 questions per year)
2016-present Member, Perfusion Advisory Committee, Department of Health and Mental Hygiene, Maryland Board of Physicians
2021-present Question author for the Standardized Oral Exam (SOE) Committee, American Board of Anesthesiology, Development of questions for the standardized oral board examination of the American Board of Anesthesiology
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