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Sina Mossahebi, PhD

Academic Title:

Associate Professor

Primary Appointment:

Radiation Oncology

Email:

sinamossahebi@umm.edu

Location:

Maryland Proton Treatment Center

Phone (Primary):

410-369-5315

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Education and Training

Education

1999-2004       B.S., Physics, University of Tehran, Iran      

2005-2007       M.S., Physics, University of Tehran, Iran 

2008-2010       M.A., Physics, Washington University in St. Louis

2008-2014       Ph.D., Physics, Washington University in St. Louis

2014-2015       Certificate in Medical Physics, University of Chicago

 

Training

2015-2017       Medical Physics Residency, Department of Radiation Oncology, University of Maryland Medical Center

 

Biosketch

Dr. Mossahebi was born and raised in Tehran, Iran. He received his bachelor's and master's degrees in Physics from University of Tehran, Iran.  He moved to the Unites States in 2007, where he earned his PhD in Physics/Biophysics from Washington University in St. Louis, MO. Dr. Mossahebi’s research focused on kinematic characterization of left ventricular chamber stiffness and relaxation  to quantify diastolic physiology and facilitate the development of mechanistic indexes for diastolic function.  Following his PhD, Dr. Mossahebi completed his Therapeutic Medical Physics residency at the University of Maryland School of Medicine. In 2017, he joined Maryland Proton Treatment Center as an Assistant Professor at the Department of Radiation Oncology.

 

Research/Clinical Keywords

Radiation Therapy, Quality Assurance, Treatment Planning, Proton Therapy

Highlighted Publications

  1. Mossahebi S, Byrne K, Jiang K,  Gerry A, Deng W, Repetto C, Jackson IL, Sawant A,  Poirier Y. A high-throughput focused collimator for OAR-sparing preclinical proton FLASH studies: Commissioning and validation. PMB. 2024. [In Press]
  2. Modiri A, Mossahebi S, Sawant A, Chen S, Zhang B, Yi BY. Sectored Single-Energy Volumetric-Modulated Proton Arc Therapy (VPAT): a preliminary multi-disease-site concept study. Phys Med. 2024. [In Press]
  3. Mossahebi S, Molitoris JK, Poirier Y, Jatczak J, Zhang B, Mohindra P, Ferris M, Regine WF, Yi BY. Clinical Implementation and Dosimetric Evaluation of a Robust Proton Lattice Planning Strategy Using Primary and Robust Complementary Beams. Int J Radiat Oncol Biol Phys. 2024 S0360-3016(24)00742-9
  4. Sabouri P, Molitoris JM, Ranjbar M, Moreau J, Simone II CB, Mohindra P, Langen K, Mossahebi S. Dosimetric Evaluation and Reproducibility of Breath-hold Plans in Intensity Modulated Proton Therapy: An Initial Clinical Experience. Adv Radiat Oncol. 2023 21;9(3):101392
  5. Li H, Mayr NA, Griffin RJ, Zhang H, Pokhrel D, Grams M, Penagaricano J, Chang S, Spraker MB, Kavanaugh J, Lin L, Sheikh K, Mossahebi S, Simone II CB, Roberge D, Snider JW, Sabouri P, Molineu A, Xiao Y, Benedict SH. Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy (SFRT) Clinical Trials. Int J Radiat Oncol Biol Phys. 2024 119(3):737-749
  6. Chhabra AM, Snider JW, Kole A, Stock M, Holtzman A, Press R, Wang CJ, Li H, Lin H, Shi C, McDonald M, Soike M, Zhou J, Sabouri P, Mossahebi S, Colaco R, Albertini F, Simone II CB. Proton Therapy for Spinal Tumors: A Consensus Statement from the Particle Therapy Cooperative Group. Int J Radiat Oncol Biol Phys. 2024 S0360-3016(24)00507-8
  7. Yi BY, Jatczak J, Deng W, Poirier Y, Yao W, Witek ME, Molitoris JM, Zakhary MJ, Zhang B, Biswal NC, Ferris MJ, Mossahebi S. Is Non-coplanar Plan More Robust to Setup Variations in Treating Bilateral HN Tumors with Pencil-beam Scanning Proton Beams? J Appl Clin Med Phys. 2024 25(2):e14186
  8. Spruijt K, Mossahebi S, Lin H, Lee E, Kraus J, Dhabaan A, Poulsen P, Lowe M, Ayan A, Spiessens S, Godart J, Hoogeman M. Multi‐institutional Consensus on Machine QA for Isochronous Cyclotron‐based Systems Delivering Ultra-high Dose Rate (FLASH) Pencil Beam Scanning Proton Therapy in Transmission Mode. Med Phys. 2023 51(2):786-798.
  9. DeCesaris CM, Mossahebi S, Jatczak J, Rao AD, Zhu M, Mishra MV, Nichols EM. Outcomes of and Treatment Planning Considerations for A Novel Technique Delivering Proton Pencil-Beam Scanning Radiation to Women with Metal-Containing Tissue Expanders Undergoing Post-Mastectomy Radiation. Radiotherapy and Oncology. 2021 164:289-298.
  10. Rao AD, Sun K, Zhu M, Mossahebi S, Sabouri P, Houser T, Jatczak J, Zakhary MJ, Regine WF, Miller R, Bentzen S, Mishra MV. Plan quality effects of maximum monitor unit constraints in pencil beam scanning proton therapy for central nervous system and skull base tumors. Radiother Onco. 2021;160:18-24.
  11. Mossahebi S, Sabouri P, Chen H, Mundis M, O’Neil M, Maggi P, Polf JC. Initial Validation of Proton Dose Calculations on Stopping Power Ratio Images Constructed From Dual-Energy CT with A Clinical Treatment Planning System. Int J Particle Ther. 2020;7(2):51-56.
  12. Diwanji T, Mohindra P, Vyfhuis M, Snider JW, Kavalagunta C, Mossahebi S, Yu J, Feigenberg SJ, Badiyan S. Advances in Radiotherapy Techniques and Delivery for NSCLC: Benefits of IMRT, Proton Therapy, and SBRT. Transl Lung Cancer Res. 2017;6(2):131–147.
  13. Mossahebi S,  Kovács SJ, “Fractionating E-wave deceleration time into its stiffness and relaxation components distinguishes pseudonormal from normal filling”, Circulation: Cardiovascular Imaging 8: e002177, 2015
  14. Mossahebi S, Kovács SJ, “The Isovolumic Relaxation to Early Rapid Filling Connection: Kinematic Model Prediction with in-vivo Validation”, Physiological Reports 2(3): E00258, 2014
  15. Mossahebi S, Zhu S, Chen H, Shmuylovich L, Ghosh E, Kovács SJ, “Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism”, Journal of Visualized Experiment. 91: e51471, 2014 
  16. Mossahebi S, Kovács SJ, “Diastolic Function in Normal Sinus Rhythm vs. Chronic Atrial Fibrillation: Comparison by Fractionation of E-wave Deceleration Time into Stiffness and Relaxation Components”, Journal of Atrial Fibrillation, 6(5): 13-19, 2014
  17. Mossahebi S, Kovács SJ, “Decomposition of E-wave Deceleration Time into Stiffness and Relaxation Components”, Cardiovascular Engineering & Technology, 5(1): 25-34, 2014
  18. Mossahebi S, Shmuylovich L, Kovács SJ, “Echocardiographic Assessment of Chamber Stiffness in Chronic Atrial Fibrillation vs. Normal Sinus Rhythm”, Journal of Atrial Fibrillation, 6(3): 45-50, 2013
  19. Mossahebi S, Kovács SJ, “Kinematic Modeling-based Left Ventricular Diastatic (Passive) Chamber Stiffness Determination with In-Vivo Validation”, Annals Biomedical Engineering, 40(5): 987-995, 2012
  20. Mossahebi S, Shmuylovich L, Kovács SJ, “The Thermodynamics of Diastole: Kinematic Modeling based Derivation of the P-V Loop to Transmitral Flow Energy Relation, with In-Vivo Validation”, American Journal of Physiology – Heart and Circulatory Physiology 300:H514-H521, 2011

Additional Publication Citations

  1. Mossahebi S, Xu H, Guerrero M, Yi BY, Prado KL, Aryal P, Warren D'Souza WD, Chen S, “Feasibility of Monitor Unit Calculation Using a Commercial Monte Carlo Algorithm for Electrons”, Med. Phys. 44(6): 2841, 2017
  2. Mossahebi, Snider JW, Dilmanian FA, Krishnan S, Eley JG, “Importance of Secondary Particles Produced in a Tungsten Multislit Collimator for Proton Minibeam Therapy”, Med. Phys. 44(6): 2872-2873, 2017
  3. Mossahebi S, Xu H, Aryal P, Lamichhane N, Guerrero, Yi BY, Prado KL, Chen S, “Feasibility of Using Monte-Carlo Based Treatment Planning System to Calculate Output Factors for Patients Receiving Electron Radiation Therapy”, Med. Phys. 44(6): 2841, 2017
  4. Lee M, Mossahebi S, Prado KL, Cifter F, Yi BY, “Dosimetric Impact of Rotational Shift in the Lung SBRT”, Med. Phys. 44(6): 2973, 2017
  5. Xu H, Mossahebi S, Guerrero M, Chen S, Aryal P, Prado KL, Yi BY, “An Effective Methodology To Reduce TG-71 Based Electron Data Set Measurement For Different Varian Machines”, Med. Phys. 44(6): 2840, 2017
  6. Fellows Z, Chen S, Guerrero M, Snider JW, Mossahebi S, Spaeth K, Lamichhane N, “Dosimetric Comparison of Multi-Criteria Optimization and Direct Machine Parameters Optimization Generated VMAT Plans for Head and Neck”, Med. Phys. 44(6): 2931, 2017
  7. Sabouri P, Foote M, Ranjbar M, Tajdini M, Mossahebi, Joshi S, Sawant A, “A Novel Method Using Surface Monitoring to Capture Breathing-Induced Cycle-To-Cycle Variations with 4DCT”, Med. Phys. 44(6): 2720, 2017
  8. Chung H, Gopal A, Lasio GM, Xu H, Mossahebi S, Polf JC, “Feasibility Studies of the Use of An Averaged HU-To-SPR Calibration Curve of Multiple CT Scanners for Dose Calculations in Proton Radiotherapy”, Med. Phys. 44(6): 2874, 2017
  9. Mossahebi S, Guerrero M, Prado KL, Langen KM, Yi BY, Chen S, “Potential implications of CT-to-density relationships on dose calculations”, AAPM Spring Clinical Meeting, 2017
  10. Mossahebi S, Feigenberg S, Nichols EM, Niu Y, Becker SJ, Prado KL, Yi BY, Yu CX, Mutaf YD, “Development of Safe and Effective Clinical Workflows for a Novel Stereotactic Breast Radiotherapy Technology: GammaPod™”, Int J Radiat Oncol Biol Phys. 96(2S):E543, 2016
  11. Mutaf YD, Niu Y, Yi BY, Yu CX, Becker SJ, Mossahebi S, Nichols SM, Feigenberg SJ, Prado KL, Regine WF, “Development of Safe and Effective Clinical Workflows for a Novel Stereotactic Breast Radiotherapy Technology: GammaPod™”,  Int J Radiat Oncol Biol Phys. 96(2S):E640-641, 2016
  12. Mossahebi S, Feigenberg SJ, Nichols EM, Niu Y, Becker SJ, Prado KL, Yi BY, Yu CX, Mutaf YD, “Failure Mode and Effects Analysis in the First Clinical Implementation of a Novel Stereotactic Breast Radiotherapy Device: GammaPod™”, Med. Phys. 43(6): 3840, 2016
  13. Mossahebi S, Langen KM, Guerrero M, Yi BY, Lu W, Kalavagunta C, Prado KL, Chen S, “Calculation-Based Patient Specific IMRT QA Detects Potential Errors That Measurement-Based QA Does Not”, Med. Phys. 43(6): 3528, 2016
  14. Chen S, Guerrero M, Zhang B, Yi BY, Mossahebi S,  Prado KL, D'Souza WD, Langen KM, “Implementation of a Non-Measurement-Based Patient-Specific IMRT QA Program”, Med. Phys. 43(6): 3687, 2016
  15. Kalavagunta C, Yang X, Xu H, Zhang B, Mossahebi S, Sawant A, Yi BY, “Is Weekly MLC QA Necessary? Two Year EPID-Based Weekly MLC QA Experience at the University of Maryland”, Med. Phys. 43(6): 3753, 2016
  16. Becker SJ, Niu Y, Mossahebi S, Yi BY, Yu CX, Prado KL, Mutaf YD, “Verifications of Absolute and Relative Dosimetry of a Novel Stereotactic Breast Device: GammaPod™”, Med. Phys. 43(6): 3634, 2016
  17. Mossahebi S, Lin M, Chen S, Xu H, Guerrero M, “Evaluation of Electron Monte Carlo Dose Calculation of RayStation Treatment Planning System in Heterogeneous Media”, AAPM Spring Clinical Meeting, 2016
  18. Mossahebi S, Kovács SJ, “Distinguishing Pseudonormalized from Normal Filling by Fractionating E-wave Deceleration Time into Its Stiffness and Relaxation Components”, Journal of American College of Cardiology 63(12_S): A1191, 2014
  19. Mossahebi S, Kovács SJ, “Diastolic Function in Normal Sinus Rhythm vs. Chronic Atrial Fibrillation: Quantitative Comparison by Fractionation of E-wave Deceleration Time into Stiffness and Relaxation Components” Circulation 128: A10604, 2013
  20. Mossahebi S, Kovács SJ, “Decomposition of E-wave Deceleration Time into Stiffness and Relaxation Components”, Journal of American College of Cardiology 61(10): E866, 2013
  21. Mossahebi S, Shmuylovich L, Kovács SJ, “Echocardiographic Assessment of Chamber Stiffness - Contrasting Normal Sinus Rhythm and Chronic Atrial Fibrillation”, Circulation 126: A12095, 2012
  22. Mossahebi S, Kovács SJ, “The Isovolumic Relaxation to Early Rapid Filling Connection: Model Prediction and in-vivo Validation”, Biomedical Engineering Society 2012-001072, 2012
  23. Mossahebi S, Kovács SJ, “Echocardiographic Determination of Left Ventricular Diastatic Chamber Stiffness: Kinematic Modeling-Based Derivation With in-vivo Validation”, Circulation 124: A13595, 2011
  24. Mossahebi S, Shmuylovich L, Kovács SJ, “The Thermodynamics of Diastole: Diastolic Function Assessment Using E-wave Derived Energy, with In-Vivo Validation”, Journal of American College of Cardiology 57(14): E660, 2011

Research Interests

Proton Therapy

Flash Radiation Therapy

Dual Energy CT

Radiotherapy Treatment Planning

Awards and Affiliations

2021     The Karl Prado Physics Educator of the Year, Department of Radiation Oncology, University of Maryland School of Medicine

2017    Finalist, AAPM Spring Clinical Meeting Young Investigator Symposium, New Orleans, LA

2016    Finalist, AAPM Spring Clinical Meeting Young Investigator Symposium, Salt Lake City, UT

2013    Best Poster Nomination, ACC 62nd Annual Scientific Sessions, San Francisco, CA

2008    Hughes Fellowship, Washington University in St. Louis, St. Louis, MO

2007    Chancellor's Golda Meir Library Scholar Awards, University of Wisconsin-Milwaukee, Milwaukee, WI

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