Update Your ProfileAcademic Title:
Assistant Professor
Primary Appointment:
Psychiatry
Administrative Title:
Director, Division of Geriatric Psychiatry & Adult Acute Care
Additional Title:
Associate Director of Residency Training, University of Maryland / Sheppard Pratt Psychiatry Residency
Location:
University of Maryland Medical Center
Phone (Primary):
(410) 328-6610
Phone (Secondary):
(410) 328-6325
Fax:
(410) 328-2672
Education and Training
• University of Virginia, B.S., Civil Engineering, 1992
• Towson University, Post-Baccalaureate Premedical Program, 1996
• University of Maryland School of Medicine, M.D., 2000
• University of Maryland / Sheppard-Pratt Psychiatry Residency Training Program, General Psychiatry Residency, 2004
• University of Mayland Medical Center, Geriatric Psychiatry and Research Fellowship, 2006
Biosketch
Dr. Chris Marano is an Assistant Professor in the Division of Geriatric Psychiatry and an Associate Director of Psychiatry Residency Training. Dr. Marano is a board-certified geriatric psychiatrist. Clinically, he cares for patients on the Older Adult Inpatient Psychiatry Unit at the University of Maryland Medical Center. Dr. Marano also performs Electroconvulsive Therapy at UMMC. Dr. Marano has particular expertise in the treatment of the neuropsychiatric symptoms of dementia and psychiatric disorders medically complex older adults. Dr. Marano’s research interests include the neuropsychiatric symptoms of dementia, the neurobiology of late-life depression, and the relationship between late-life depression and dementia. He completed a career development award evaluating the role of insulin resistance in the cognitive impairment of late-life depression. Furthermore, he participated in clinical trials of pharmacologic treatments for the behavioral disturbances of dementia as well as multimodal imaging studies of late-life depression and mild cognitive impairment.
Research/Clinical Keywords
Geriatric psychiatry, dementia, neurocognitive disorders, late-life depression, Alzheimer's disease, insulin resistance, electroconvulsive therapy, integrated behavioral health, residency education
Highlighted Publications
Marano CM, Phatak P, Vemulapalli UR, Sassan A, Nalbandyan MR, Ramanujam S, Soekadar S, Demosthenous M, Regenold WT. Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression. Journal of Clinical Psychiatry. 2007; 68(4):512-7.
Pellegrino LD, Peters ME, Lyketsos CG, Marano CM. Depression in cognitive impairment. Current Psychiatry Reports. 2013 Sep;15(9):384.
Marano CM, Workman CI, Lyman CH, Munro CA, Kraut MA, Smith GS. Structural Imaging in Late Life Depression: Association with Mood and Cognitive Responses to Antidepressant Treatment. American Journal of Geriatric Psychiatry. 2015 Jan;23(1):4-12.
Marano CM, Workman CI, Lyman CH, Kramer E, Hermann CR, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith GS. The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. Psychiatry Research. 2014 Apr 30;222(1-2):84-90.
McClam TD, Marano CM, Rosenberg PB, Lyketsos CG. Interventions for neuropsychiatric symptoms in neurocognitive impairment due to Alzheimer's disease: A review of the literature. Harvard Review of Psychiatry. 2015 Sep-Oct;23(5):377-93.
Additional Publication Citations
Peer-reviewed journal articles
Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV. Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar 1 affective and schizoaffective disorders. Journal of Affective Disorders. 2002; 70(1):19-26.
Dixon LB, Kreyenbuhl JA, Dickerson FB, Donner TW, Brown CH, Wolheiter K, Postrado L, Goldberg RW, Fang L, Marano C, Messias E. A comparison of type 2 diabetes outcomes among persons with and without severe mental illnesses. Psychiatric Services. 2004; 55(8):892-900.
Regenold WT, Hisley KC, Obuchowski A, Lefkowitz DM, Marano C, Hauser P. Relationship of white matter hyperintensities to cerebrospinal fluid glucose polyol pathway metabolites—a pilot study in treatment-resistant affective disorder patients. Journal of Affective Disorders. 2005; 85(3):341-50.
Marano CM, Phatak P, Vemulapalli UR, Sassan A, Nalbandyan MR, Ramanujam S, Soekadar S, Demosthenous M, Regenold WT. Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression. Journal of Clinical Psychiatry. 2007; 68(4):512-7.
Regenold WT, Phatak P, Marano CM, Gearhart L, Viens CH, Shapiro PC, Hisley CK.. Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression. Psychiatry Research. 2007; 151(3):179-88.
Regenold WT, Hisley KC, Phatak P, Marano CM, Obuchowski A, Lefkowitz DM, Sassan A, Ohri S, Phillips TL, Dosanji N, Conley RR, and Gullapalli R. Relationship of cerebrospinal fluid glucose metabolites to MRI deep white matter hyperintensities and treatment resistance in bipolar disorder patients. Bipolar Disorders. 2008; 10(7):753-64.
Regenold WT, Phatak P, Marano CM, Sassan A, Conley RR, Kling MA. Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biological Psychiatry. 2009; 65(6):489-94.
Drye LT, Ismail Z, Porsteinsson AP, Rosenberg PB, Weintraub D, Marano C, Pelton G, Frangakis C, Rabins PV, Munro CA, Meinert CL, Devanand DP, Yesavage J, Mintzer JE, Schneider LS, Pollock BG, Lyketsos CG, for the CitAD Research Group. Citalopram for agitation in Alzheimer's disease: Design and methods. Alzheimer’s and Dementia. 2012;8(2):121-30.
Marano CM, Workman CI, Kramer E, Hermann CR, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith GS. Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. International Journal of Geriatric Psychiatry. 2013 Apr;28(4):417-23.
Thambisetty M, Metter EJ, Yang A, Dolan H, Marano C, Zonderman AB, Troncoso JC, Zhou Y, Wong DF, Ferrucci L, Egan J, Resnick SM, O'Brien RJ. Glucose Intolerance, Insulin Resistance, and Pathological Features of Alzheimer Disease in the Baltimore Longitudinal Study of Aging. JAMA Neurology. 2013 Sep 1;70(9):1167-72.
Pellegrino LD, Peters ME, Lyketsos CG, Marano CM. Depression in cognitive impairment. Current Psychiatry Reports. 2013 Sep;15(9):384.
Marano CM, Workman CI, Lyman CH, Munro CA, Kraut MA, Smith GS. Structural Imaging in Late Life Depression: Association with Mood and Cognitive Responses to Antidepressant Treatment. American Journal of Geriatric Psychiatry. 2015 Jan;23(1):4-12.
Marano CM, Workman CI, Lyman CH, Kramer E, Hermann CR, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith GS. The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. Psychiatry Research. 2014 Apr 30;222(1-2):84-90
Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014 Feb 19;311(7):682-91.
Drye LT, Spragg D, Devanand DP, Frangakis C, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group. Changes in QTc interval in the citalopram for agitation in Alzheimer's disease (CitAD) randomized trial. PLoS One. 2014 Jun 10;9(6):e98426
Weintraub D, Drye LT, Porsteinsson AP, Rosenberg PB, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Yesavage J, Lyketsos CG; CitAD Research Group. Time to response to citalopram treatment for agitation in Alzheimer Disease. American Journal of Geriatric Psychiatry. 2015 Nov;23(11):1127-33. Epub 2015 May 19.
Rosenberg PB, Drye LT, Porsteinsson AP, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Weintraub D, Newell J, Yesavage J, Lyketsos CG; CitAD Research Group. Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial. International Psychogeriatrics. 2015 Dec;27(12):2059-67. Epub 2015 Aug 25.
McClam TD, Marano CM, Rosenberg PB, Lyketsos CG. Interventions for neuropsychiatric symptoms in neurocognitive impairment due to Alzheimer's disease: A review of the literature. Harvard Review of Psychiatry. 2015 Sep-Oct;23(5):377-93.
Oh ES, Marano CM, Leoutsakos JM, Lee RW, Rissman RA, Smith GS, Craft S, Lyketsos CG. Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker. Alzheimer’s and Dementia: Diagnosis, Assessment & Disease Monitoring. 2015 Sep;1(3):311-315.
Schneider LS, Frangakis C, Drye LT, Devanand DP, Marano CM, Mintzer J, Mulsant BH, Munro CA, Newell JA, Pawluczyk S, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rein L, Rosenberg PB, Shade D, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group. Heterogeneity of treatment response to citalopram for patients with Alzheimer's disease with aggression or agitation: The CitAD randomized clinical trial. American Journal of Psychiatry. 2016 May 1;173(5):465-72. Epub 2016 Jan 15
Barrett FS, Workman CI, Sair HI, Savonenko AV, Kraut MA, Sodums DJ, Joo JH, Nassery N, Marano CM, Munro CA, Brandt J, Zhou Y, Wong DF, Smith GS. Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment. Hum Brain Mapping. 2017 Apr 5. [Epub ahead of print]
Smith GS, Barrett FS, Joo JH, Nassery N, Savonenko A, Sodums DJ, Marano CM, Munro CA, Brandt J, Kraut MA, Zhou Y, Wong DF, Workman CI. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of Disease. 2017 Sep;105:33-41. Epub 2017 May 13
Book Chapters
Regenold WT, Marano C: Glucose metabolism in bipolar disorder, in Trends in Bipolar Disorder Research, Edited by Malcomb R. Brown. Nova Science Publishers, Hauppauge, NY, 2004.
Marano CM, Rosenberg PB, Lyketsos CG: Depression in dementia, in Late-Life Mood Disorders, Edited by Helen Lavretsky, Martha Sajatovic, and Charles Reynolds. Oxford University Press, New York, NY, 2013.
Marano, CM, Rabins PB, Lyketsos, CG: Neurocognitive disorder due to Alzheimer’s disease, in Gabbard’s Treatments of Psychiatric Disorders, Fifth Edition, Edited by Glen O. Gabbard. American Psychiatric Publishing, Arlington, VA 2014.
Marano CM, Rabins PB: Disease specific therapies and symptomatic cognitive enhancement, in Practical Dementia Care, Third Edition, Edited by Peter V. Rabins, Constantine G. Lyketsos, and Cynthia D. Steele. Oxford University Press, New York, NY, 2016.
Marano CM, Rabins PB: Pharmacologic treatments for neuropsychiatric symptoms, in Practical Dementia Care, Third Edition, Edited by Peter V. Rabins, Constantine G. Lyketsos, and Cynthia D. Steele. Oxford University Press, New York, NY, 2016.
Marano CM, Driving Considerations, in Cognitive Impairment and Depression in Older Patients. Edited by Martin Steinberg and Paul B. Rosenberg. Oxford University Press, New York, NY, 2017.