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Brajesh K. Lal, MBBS

Academic Title:

Professor

Primary Appointment:

Surgery

Additional Title:

Director - NIH Vascular Imaging Core Facility, Director - Center for Vascular Research, Director - UMMC Center for Vascular Diagnostics, President - American Venous Forum Chief - Baltimore VA Medical Center Vascular Surgery

Email:

blal@som.umaryland.edu

Location:

UMMC S10-B00

Phone (Primary):

410-328-5840

Download CV

Education and Training

Undergraduate

  • 1982-1988       Medical School, All India Institute of Medical Sciences, Delhi, India                
  • 1988-1992       M.S., Surgery, All India Institute of Medical Sciences, Delhi, India                

Post-Graduate Education and Training

  • 1992-1994       Fogarty Research Fellowship, National Institutes of Health, Bethesda, MD            
  • 1994-1999       Surgery Residency, Rutgers-New Jersey Medical School (NJMS), Newark, NJ 
  • 1999-2001       Vascular Surgery Fellowship, Rutgers-NJMS, Newark, NJ  

Certifications

  • 2006-present   Vascular Surgery  
  • 2001-present   Fellow of the American College of Surgeons

Biosketch

A clinician-scientist in the field of cerebrovascular disease and stroke, Dr. Lal launched the new field of cognitive-mobility function in carotid stenosis through his ground-breaking research and pioneering leadership in this field. He has fundamentally changed our understanding of the range of morbidity associated with carotid atherosclerosis, well beyond stroke. His collective work over a decade has made sustained and transformational changes to our understanding of cerebrovascular disease. His current research is an integral part of the stroke-prevention drive of the National Institute of Neurological Disorders and Stroke, NIH, and is focused on how the structure and biomechanics of atherosclerotic plaque in the carotid artery affects brain function, and impacts plaque disruption, stroke, cognitive function and mobility function; and how these adverse outcomes respond to interventions such as pharmacotherapy, rehabilitation and surgical revascularization.

As co-Principal Investigator of the largest randomized trial in stroke-prevention funded by the NINDS-NIH, Dr Lal will be instrumental in determining the optimal treatment approach for over 10 million individuals in the United States with carotid atherosclerosis, and many more world-wide. As Principal Investigator of the National Carotid Stenting Registry, with its administrative center here at the School of Medicine, he is working with the NIH and the Centers for Medicare and Medicaid, to establish national physician credentialing, clinical performance and reimbursement standards for carotid artery stenting. As Director of the Center for Vascular Diagnostics, he manages one of the largest clinical vascular laboratories in the country with over 15,000 tests performed every year. The center adjudicates imaging data from several NIA, NINDS, DOD and the VA funded studies, during which he has developed several novel diagnostic vascular tests for vascular disease.

From 2004 to date, Dr. Lal has been a highly cited investigator worldwide in the field of carotid atherosclerosis. He has authored more than 125 publications including the Society for Vascular Surgery guidelines for carotid occlusive disease management. He serves on the Advisory Board of JCAHO for Stroke Center policy development, and is the President of the national venous disease society. He has also led numerous collaborations with investigators in vascular disease epidemiology, mechanisms, diagnostics and therapeutics. 

Additional Publication Citations

Peer-reviewed journal articles (*Senior Author)

  1. Kumar A, Lal BK, Singh MK, Kapur BML. Angiosarcoma of the gall bladder. American Journal of Gastroenterology. 1989:84(11):1431-3.
  2. Lal BK, Kumar A, Kapur BML. Surgery in the Elderly. South Indian Surgical Clinics. 1989; 3(2-4):89-93.
  3. Kumar A, Lal BK, Singh MK, Kapur BML. Adult Wilms tumor: A case report and review of world literature. Japanese Journal of Surgery. 1990;20(5):585-9.
  4. Kumar A, Lal BK, Thomas S. Local and distant chemical burns due to cetrimide injection in a massive dose. Indian Journal of Dermatology and Venereology. 1990;56(2):139-41.
  5. Kumar A, Lal BK, Chattopadhyay TK. Hydatid disease of the liver, surgical options. Tropical Gastroenterology. 1992;13(3):102-5.
  6. Kumar A, Lal BK, Chattopadhyay TK. Radiological diagnosis of hydatid disease of the liver. Tropical Gastroenterology. 1992;13(2):52-5.
  7. Lal BK, Kumar A, Chattopadhyay TK. Hydatid disease of the liver- non surgical options. Journal of Association of Physicians of India. 1993;41(7):437-8.
  8. Lal BK, Kumar A, Tushar K, Chattopadhyay TK. Hydatid jaundice - an overview. Tropical Gastroenterology. 1993;14(1):10-15.
  9. McVicar DW, Lal BK, Kawamura M, Staples JE, Blake T, Ortaldo JR, O’Shea JJ. Novel protein tyrosine kinases (PTKs) in natural killer (NK) cells and activated T-lymphocytes – clinical research meeting. Journal of Clinical Research. 1994;42(2):206.
  10. Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(14):6374-8.
  11. McVicar DW, Lal BK, Lloyd A, Kawamura M, Chen YQ, Zhang X, Staples JE, Ortaldo JR, O’Shea JJ. Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes. Oncogene. 1994;9(7):2037-44.
  12. McVicar DW, Lal BK, Musso T, Loyd A, Kawa M, Chen YQ, Zhang X, Ortaldo J, O’Shea JJ. Lymphocyte activation: structure and expression of the novel CSK like tissue specific Tyrosine Kinase, LSK. Journal of Cellular Biochemistry. 1994;57(18D):406.
  13. Lal BK, Tortolani J, Riva A, Johnston J, Chen YQ, Reaman G, Beckwith M, Longo D, Ortaldo JR, Bhatia K, McGrath I, Kehrl J, Tuscano J, McVicar DW, O'Shea JJ. Tortolani J and Lal BK contributed equally to the paper. Regulation of JAK3 expression and activation in human B Cells and B cell malignancies. Journal of Immunology. 1995;155(11):5220-6.
  14. Kumar S, Lal BK, Misra MC. Post-mastectomy seroma: a new look into the etiology of an old problem. Journal of the Royal College of Surgeons of Edinburgh. 1995;40(5):292-4.
  15. Donahoo JS, Miller JA, Lal BK, Rosario PG. Chest wall hamartoma in an adult: an unusual chest wall tumor. Journal of Thoracic Cardiovascular Surgery. 1996;44(2):110-1.
  16. Reidy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O’Shea JJ, Johnston JA. Genomic sequence, organization, and chromosomal localization of human JAK3. Genomics. 1996;37(1):57-61.
  17. Lal BK, Hobson II RW. Carotid artery occlusive disease. Current Treatment Options in Cardiovascular Medicine. 2000; 2(3):243-254.
  18. Chakhtoura EY, Hobson II RW, Goldstein J, Simonian GT, Lal BK, Haser PB, Silva, MB, Padberg FT, Pappas PJ, Jamil Z. In‑stent restenosis after carotid angioplasty‑stenting: incidence and management. Journal of Vascular Surgery. 2001;33(2):220‑6.
  19. Lal BK*, Varma S, Pappas PJ, Hobson II RW, Durán WN. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric oxide synthase, and MAP kinase pathways. Microvascular Research. 2001;62(3):252-62.
  20. Saito S, Trovato M, You R, Lal BK, Fasehun F, Padberg FT, Hobson II RW, Durán WN, Pappas PJ. Role of matrix metalloproteinase 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency. Journal of Vascular Surgery. 2001; 34(5):930-8.
  21. Hobson II RW, Lal BK, Chakhtoura EY, Goldstein J, Jamil Z, Kubicka R. Carotid artery closure for endarterectomy does not influence results of CAS for restenosis. Journal of Vascular Surgery. 2002;35(3):435-8.
  22. Varma S, Breslin JB, Lal BK, Pappas PJ, Hobson II RW, Durán WN. P 42/44 MAPK regulates baseline permeability and cGMP‑induced hyperpermeability in endothelial cells. Microvascular Research. 2002;63(2):172-8.
  23. Lal BK*, Hobson II RW, Pappas PJ, Kubicka R, Hameed M, Chakhtoura EY, Jamil Z, Padberg Jr. FT, Haser PB, Durán WN. Pixel distribution analysis of B‑mode ultrasound images predicts histologic features of atherosclerotic carotid plaques. Journal of Vascular Surgery. 2002;35(6):1210-17.
  24. Padberg Jr. FT, Cerveira JJ, Lal BK, Pappas PJ, Varma S, Hobson II RW. Does severe venous insufficiency have a different etiology in the morbidly obese? Is it venous? Journal of Vascular Surgery. 2003;37(1):79-85.
  25. Cerveira JJ, Lal BK, Padberg FT, Pappas PJ. Methicillin-resistant Staphylococcus aureus infection does not adversely affect clinical outcome of lower extremity amputations. Annals of Vascular Surgery. 2003;17(1):80-5.
  26. Lal BK*, Saito S, Pappas PJ, Padberg FT, Cerveira JJ, Hobson II RW, Durán WN. Altered proliferative responses of dermal fibroblasts to TGF beta 1 may contribute to chronic venous stasis ulcers. Journal of Vascular Surgery. 2003;37(6):1285-93. 
  27. Hobson II RW, Lal BK, Chakhtoura E, Goldstein J, Haser P, Kubicka R, Cerveira J, Pappas P, Padberg FT, Jamil Z. Carotid artery stenting: analysis of data for 105 patients at high risk. Journal of Vascular Surgery. 2003;37(6):1234-9. 
  28. Lal BK*, Hobson II RW, Goldstein J, Geohagan M, Chakhtoura E, Pappas PJ, Jamil Z, Haser PB, Varma S, Padberg FT, Cerveira JJ. In-stent recurrent stenosis after carotid artery stenting: incidence and clinical relevance. Journal of Vascular Surgery. 2003;38(6)1162-9.
  29. Choi HM, Lal BK*, Cerveira JJ, Padberg FT, Silva II MB, Hobson II RW, Pappas PJ. Durability and cumulative functional patency of transposed and non-transposed arteriovenous fistulae. Journal of Vascular Surgery. 2003;38(6):1206-12.
  30. Lal BK*, Hobson II RW, Goldstein J, Chakhtoura E, Durán WN. Carotid artery stenting: Is there a need to revise ultrasound velocity criteria for stenosis? Journal of Vascular Surgery. 2004;39(1):58-66.
  31. Lal BK*, Cerveira JJ, Seidman C, Haser PB, Kubicka R, Jamil Z, Padberg FT, Hobson II RW, Pappas PJ. Observer variability of iliac artery measurements in the endovascular repair of abdominal aortic aneurysms. Annals of Vascular Surgery. 2004;18(6):644-52.
  32. Choi HM, Hobson II RW, Goldstein J, Chakhtoura E, Lal BK, Haser PB, Cuadra SA, Padberg FT, Jamil Z.  Technical challenges in a program of carotid artery stenting. Journal of Vascular Surgery. 2004;40(4):746-51.          
  33. Pappas PJ, Lal BK, Cerveira JJ, Padberg FT, Durán WN. Causes of severe chronic venous insufficiency. Seminars in Vascular Surgery. 2005;18(1):30-5.
  34. Lal BK*, Varma S, Zheng R, Breslin JW, Saito S, Hobson II RW, Pappas PJ, Durán WN. Lal BK and Varma S contributed equally to the manuscript. Hyperglycemia alters P13k and Akt signaling and leads to endothelial cell proliferative dysfunction. American Journal of Physiology - Heart and Circulatory Physiology. 2005;289(4):H1744-51.
  35. Zickler RW, Padberg FT Jr, Lal BK, Pappas PJ. When is a more proximal amputation needed? Clinics of Podiatric Medicine and Surgery. 2005;22(3):429-46.
  36. Lal BK*, Hobson II RW, Hameed M, Pappas PJ, Padberg FT, Jamil Z, Durán WN. Non-invasive identification of the unstable carotid plaque. Annals of Vascular Surgery. 2006; 20(2):167-74.
  37. Sánchez FA, Savalia NB, Durán RG, Lal BK, Boric MP, Durán WN. Functional significance of differential eNOS translocation and function. American Journal of Physiology - Heart and Circulatory Physiology. 2006;291(3):H1058-64.
  38. Lal BK*, Hobson II RW. Pixel distribution analysis to identify unstable carotid plaques: is carotid plaque morphology ready for prime time? Endovascular Today. 2006;5(8):26-31.
  39. Lal BK*, Hobson II RW. Management of carotid restenosis. Journal of Cardiovascular Surgery (Torino). 2006; 47(2):153-60.
  40. Lal BK*. Impact of plaque characterization on carotid interventions. Expert commentary. Perspectives in Vascular Surgery. 2006;18(4):316-7.
  41. Lal BK*, Choi HM, Silva MB, Hobson II RW, Pappas PJ, Durán WN. Creation of arteriovenous fistulas up-regulates venous eNOS. Vascular & Endovascular Surgery. 2007; 40(6):475-81.
  42. Lal, BK*, Hobson RW. Treatment of carotid artery disease: stenting or surgery. Current Neurology and Neuroscience Reports. 2007;7(1):49-53.
  43. Lal, BK*. Cognitive function after carotid artery revascularization. Vascular Endovascular Surgery. 2007;41(1):5-13.
  44. Abai B, Zickler RW, Pappas PJ, Lal BK, Padberg FT. Lymphorrhea responds to negative pressure wound therapy. Journal of Vascular Surgery. 2007;45(3):610-3.
  45. Lal BK*, Kaperonis EA, Cuadra S, Kapadia I, Hobson II RW. Patterns of in-stent restenosis after carotid artery stenting: classification and implications for long-term outcome. Journal of Vascular Surgery. 2007;46(5):833-40.
  46. Lal BK*. Recurrent carotid stenosis after CEA and CAS: diagnosis and management. Seminars in Vascular Surgery. 2007;20(4):259-66.
  47. Lal BK*, Hobson II RW, Tofighi B, Kapadia I, Cuadra S, Jamil Z. Duplex ultrasound velocity criteria for the stented carotid artery. Journal of Vascular Surgery. 2008;47(1):63-73.
  48. Hobson II RW, Mackey WC, Ascher E, Murad MH, Calligaro KD, Comerota AJ, Montori VM, Eskandari MK, Massop DW, Bush RL, Lal BK, Perler BA. Management of atherosclerotic carotid artery disease: clinical practice guidelines of the Society for Vascular Surgery. Journal of Vascular Surgery. 2008;48(2):480-6.
  49. Cuadra SA, Hobson II RW, Lal BK*, Goldstein J, Chakhtoura E, Jamil Z. Outcome of carotid artery stenting for primary versus restenotic lesions. Annals of Vascular Surgery. 2009;23(3):330-4.
  50. Sánchez FA, Rana R, Kim DD, Iwahashi T, Zheng R, Lal BK, Gordon DM, Meininger CJ, Durán WN. Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. Proceedings of the National Academy of Sciences of the USA. 2009;106(16):6849-53.
  51. Lal, BK*. Optimal carotid duplex velocity criteria for defining the severity of carotid in-stent restenosis. Expert Commentary. Perspectives in Vascular Surgery and Endovascular Therapy. 2009;21(3):200-1.
  52. Padberg FT, Hauck K, Lal BK, Pappas PJ. Screening for abdominal aortic aneurysm with electronic clinical reminders. American Journal of Surgery. 2009; 198(5):670-674.
  53. Lal BK*, Brott TG. The Carotid Revascularization Endarterectomy vs. Stenting Trial completes randomization: lessons learned and anticipated results. Journal of Vascular Surgery. 2009;50(5):1224-31.
  54. Pappas PJ, Lal BK, Ohara N, Saito S, Zapiach L, Durán WN. Regulation of matrix contraction in chronic venous disease. European Journal of Vascular and Endovascular Surgery. 2009;38(4):518-29.
  55. Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT, Matsumura JS, Kohler TR, Lin PH, Jean-Claude JM, Cikrit DF, Swanson KM, Peduzzi PN, Lal BK; Open Versus Endovascular Repair (OVER) Veterans Affairs cooperative study group. Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial. Journal of the American Medical Association. 2009;302(14):1535-42.
  56. Hopkins LN, Roubin GS, Chakhtoura ES, Gray WA, Ferguson RD, Katzen BA, Rosenfield K, Goldstein J, Cutlip DE, Morrish W, Lal BK, Sheffet AJ, Tom M, Hughes S, Voeks J, Kathir K, Meschia JF, Hobson II RW, Brott TG. The Carotid Revascularization Endarterectomy vs. Stenting Trial: credentialing of interventionalists and final results of lead-in phase. Journal of Stroke and Cerebrovascular Diseases. 2010;19(2):153-62.
  57. Brott TG, Hobson II RW, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Meschia JF. Stenting versus endarterectomy for treatment of carotid-artery stenosis: CREST investigators. New England Journal of Medicine. 2010;363(1):11-23.
  58. Henke P; Writing Group I of the Pacific Vascular Symposium 6, Vandy F, Comerota A, Kahn SR, Lal BK, Lohr J, Meissner M, Caprini J, McLafferty R, Bender D, Jarvis G, Meyer P, Wu D, Wakefield T. Prevention and treatment of the postthrombotic syndrome. Journal of Vascular Surgery. 2010;52(5 Suppl):21S-28S.
  59. Lal BK*, Younes M, Cruz G, Kapadia I, Jamil Z, Pappas P. Cognitive changes after surgery vs. stenting for carotid artery stenosis. Journal of Vascular Surgery. 2011;54(3):691-8.
  60. Lal BK*, Beach KW, Sumner DS. Intracranial collateralization determines hemodynamic forces for carotid plaque disruption. Journal of Vascular Surgery. 2011;54(5):1461-71.
  61. Ricotta JJ, Aburahma A, Ascher E, Eskandari M, Faries P, Lal BK; Society for Vascular Surgery. Updated Society for Vascular Surgery guidelines for management of extracranial carotid disease: Executive Summary. Journal of Vascular Surgery. 2011;54(3):832-6.
  62. Ricotta JJ, Aburahma A, Ascher E, Eskandari M, Faries P, Lal BK; Society for Vascular Surgery. Updated Society for Vascular Surgery guidelines for management of extracranial carotid disease. Journal of Vascular Surgery. 2011;54(3):e1-31.
  63. Voeks JH, Howard G, Roubin GS, Malas MB, Cohen DJ, Sternbergh III WC, Aronow HD, Eskandari MK, Sheffet AJ, Lal BK, Meschia JF, Brott TG; CREST Investigators. Age and outcomes after carotid stenting and endarterectomy: the carotid revascularization endarterectomy versus stenting trial. Stroke. 2011;42(12):3484-90.
  64. Lal BK*, Sikdar S, Zhao L, Beach K, Leotta D. Ultrasonic monitoring of three-dimensional carotid atherosclerotic plaque structure. Journal of Vascular Surgery. 2011;53(6):3S.
  65. Hill MD, Brooks W, Mackey A, Clark WM, Meschia JF, Morrish WF, Mohr JP, Rhodes JD, Popma JJ, Lal BK, Longbottom ME, Voeks JH, Howard G, Brott TG; CREST Investigators. Stroke after carotid stenting and endarterectomy in the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST). Circulation. 2012;126(25):3054-61.
  66. Lal BK*, Beach KW, Roubin GS, Lutsep HL, Moore WS, Malas MB, Chiu D, Gonzales NR, Burke JL, Rinaldi M, Elmore JR, Weaver FA, Narins CR, Foster M, Hodgson KJ, Shepard AD, Meschia JF, Bergelin RO, Voeks JH, Howard G, Brott TG; CREST Investigators. Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial. Lancet Neurology. 2012;11(9):755-63.
  67. Stroupe KT, Lederle FA, Matsumura JS, Kyriakides TC, Jonk YC, Ge L, Freischlag JA; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness of open versus endovascular repair of abdominal aortic aneurysm in the OVER trial. Journal of Vascular Surgery. 2012;56(4):901-9.
  68. Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT Jr, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM; OVER Veterans Affairs Cooperative Study Group. Long-term comparison of endovascular and open repair of abdominal aortic aneurysm. New England Journal of Medicine. 2012;367(21):1988-97.
  69. Lederle FA, Stroupe KT; Open versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness at two years in the VA Open Versus Endovascular Repair Trial. European Journal of Vascular Surgery. 2012;44(6):543-8
  70. Caldwell KJ, Prior SJ, Kampmann M, Zhao L, McEvoy S, Lal BK*. Upper body exercise increases lower extremity venous blood flow. Journal of Vascular Surgery. 2012;55(6):S64.
  71. Lal BK*, Brott TG. Restenosis after carotid endarterectomy and stenting--authors' reply. Lancet Neurology. 2013;12(2):130-1.
  72. Zhao L, Prior SJ, Kampmann M, Sorkin JD, Caldwell K, Braganza M, McEvoy S, Goldberg A, Lal BK*. Three-dimensional ultrasound assessment of DVT volume: a clinical protocol and description of the time0course of thrombus resolution. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2013;1(1):113.
  73. Timaran C, Moore W, Lal BK, Mantese VA, Malas M, Brown OW, Voeks JH, Brott TG; CREST Investigators. Differential outcomes of carotid stenting and endarterectomy performed exclusively by vascular surgeons in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Journal of Vascular Surgery. 2013;57(2):303-8.
  74. Caldwell K, Prior SJ, Kampmann M, Zhao L, McEvoy S, Goldberg AP, Lal BK*. Upper body exercise increases lower extremity venous blood flow in deep vein thrombosis. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2013;1(2):126–33.
  75. Lal BK*, Meschia JF, Brott TG. Guiding Treatments for Asymptomatic Carotid Disease: Examining stenting and endarterectomy in the context of intensive medical management (CREST-2). Endovascular Today. 2013;9(1):73-6.
  76. Zierler RE, Beach KW, Bergelin RO, Lal BK, Moore WS, Roubin GS, Voeks JH, Brott TG; CREST Investigators. Agreement between site-reported and ultrasound core laboratory results for duplex ultrasound velocity measurements in the Carotid Revascularization Endarterectomy versus Stenting Trial. Journal of Vascular Surgery. 2014;59(1):2-7.
  77. Zhao L, Prior SJ, Kampmann M, Sorkin JD, Caldwell K, Braganza M, McEvoy S, Goldberg A, Lal BK*. Measurement of thrombus resolution using three-dimensional ultrasound assessment of deep vein thrombosis volume. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2014;2(2):140-7.
  78. Zhao L. Kampmann M, Prior SJ, Sorkin MJ, Braganza M, McEvoy S, Lal BK. Freehand 3D Ultrasound to Measure Thrombus Volume in Patients with Acute Deep-Vein        Thrombosis. Journal for Vascular Ultrasound. 2014;38(1):23-8.
  79. AlMuhanna, K, Hossain M, Zhao L, Kowalewski G, Sikdar S, Lal BK. 3D Ultrasonic Tissue Characterization for Asymptomatic Carotid Atherosclerosis. Journal of Vascular Surgery. 2014;60(3):818–9.
  80. Shishehbor MH, Venkatachalam S, Gray WA, Metzger C, Lal BK, Peng L, Omran HL, Blackstone EH. Experience and outcomes with carotid artery stenting: an analysis of the CHOICE study (Carotid Stenting for High Surgical-Risk Patients; Evaluating Outcomes through the Collection of Clinical Evidence). Journal of the American College of Cardiology - Cardiovascular Interventions. 2014;7(11):1307-17.
  81. Chabasse C, Siefert SA, Chaudry M, Hoofnagle MH, Lal BK, Sarkar R. Recanalization and flow regulate venous thrombus resolution and matrix metalloproteinase expression in vivo. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2015;3(1):64-74.
  82. Malas M, Glebova NO, Hughes SE, Voeks JH, Qazi U, Moore WS, Lal BK, Howard G, Llinas R, Brott TG. Effect of patching on reducing restenosis in the Carotid Revascularization Endarterectomy Versus Stenting Trial. Stroke. 2015;46(3):757-61.
  83. Hossain MM, AlMuhanna K, Zhao L, Lal BK, Sikdar S. Semiautomatic segmentation of atherosclerotic carotid artery wall volume using 3D ultrasound imaging. Journal of Medical Physics. 2015;42(4):2029-43.
  84. Miller LE, Razavi MK, Lal BK. Suprarenal versus infrarenal stent graft fixation on renal complications after endovascular aneurysm repair. Journal of Vascular Surgery. 2015; 61(5):1340-9.
  85. Matsumura JS, Stroupe KT, Lederle FA, Kyriakides TC, Ge L, Freischlag JA; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Costs of repair of abdominal aortic aneurysm with different devices in a multicenter randomized trial. Journal of Vascular Surgery. 2015;61(1):59-65.
  86. AlMuhanna K, Hossain MM, Zhao L, Fischell J, Kowalewski G, Dux M, Sikdar S, Lal BK. Carotid plaque morphometric assessment with three-dimensional ultrasound imaging. Journal of Vascular Surgery. 2015;61(3):690-7.
  87. Howard G, Hopkins L, Moore W, Katzen B, Chakhtoura E, Morrish W, Ferguson RH, Shawl F, Harrigan M, Voeks JH, Howard V, Lal BK, Meschia J, Brott T. Temporal changes in periprocedural events in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). 2015;46(8):2183-9.
  88. Barrett KM, Lal BK, Meschia JF. Stroke: Advances in medical therapy and acute stroke intervention. Current Cardiology Reports. 2015;17(10):79.
  89. Lal BK. Venous ulcers of the lower extremity: Definition, epidemiology, and economic and social burdens. Seminars in Vascular Surgery. 2015;28(1):3-5.
  90. Almeida JI, Wakefield T, Kabnick LS, Onyeachom UN, Lal BK. Use of the clinical, etiologic, anatomic, and pathophysiologic classification and venous clinical severity score to establish a treatment plan for chronic venous disorders. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2015;3(4):456-60.
  91. Starnes BW, Dwivedi AJ, Giglia JS, Woo K, Yeh C; TRANSFIX Study Investigators. Endovascular repair for blunt thoracic aortic injury using the Zenith Alpha low-profile device. Journal of Vascular Surgery. 2015;62(6):1495-1503.
  92. Lal BK*, Zhou W, Li Z, Kyriakides T, Matsumura J, Lederle FA, Freischlag J; OVER Veterans Affairs Cooperative Study Group. Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of abdominal aortic aneurysms. Journal of Vascular Surgery. 2015; 62(6):1394-404.
  93. Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA, Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks JH, Hobson II RW; CREST Investigators. Long-term results of stenting versus endarterectomy for carotid-artery stenosis. New England Journal of Medicine. 2016;374(11):1021-31.
  94. Chaturvedi S, Chimowitz M, Brown RD, Lal BK, Meschia JF. The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis. Neurology. 2016;87(21):2271-8.
  95. Lederle FA, Stroupe KT, Kyriakides TC, Ge L, Freischlag JA. Long-term cost-effectiveness in the Veterans Affairs Open vs. Endovascular Repair Study of aortic abdominal aneurysm: a randomized clinical trial. JAMA Surgery. 2016;151(12)1139-44.
  96. Lal BK*, Meschia JF, Howard G, Brott TG. Carotid stenting versus carotid endarterectomy: What did the carotid revascularization endarterectomy versus stenting trial show and where do we go from here? Angiology. 2017;68(8):675-82.
  97. Addison O, Ryan AS, Prior SJ, Katzel LI, Kundi R, Lal BK, Gardner AW. Changes in function after a 6-month walking intervention in patients with intermittent claudication who are obese or nonobese. Journal of Geriatric Physical Therapy. 2017;40(4):190-6.
  98. Aziz F, Raffetto JD, Diaz JA, Myers DD Jr, Ozsvath KJ, Carman TL, Lal BK; American Venous Forum (AVF) Research Committee. Practice patterns of adjunctive therapy for venous leg ulcers. Phlebology. 2017;32(1):19-26.
  99. Lal BK, Mallick R, Wright D. Improvement in patient-reported outcomes of varicose veins following treatment with polidocanol endovenous microfoam. Phlebology. 2017;32(5):342-54.
  100. Obi AT, Sutzko DC, Almeida JI, Kabnick L, Cronenwett JL, Osborne NH,Lal BK, Wakefield TW. First 10-month results of the Vascular Quality Initiative Varicose Vein Registry. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2017;5(3):312-20.
  101. Heck DV, Roubin GS, Rosenfield KG, Gray WA, White CJ, Jovin TG, Matsumura JS,Lal BK, Katzen BT, Dabus G, Jankowitz BT, Brott TG. Asymptomatic carotid stenosis: medicine alone or combined with carotid revascularization. Neurology. 2017;88(21):2061-5.
  102. Crawford JM,Lal BK, Durán WN, Pappas PJ. Pathophysiology of venous ulceration. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2017;5(4):596-605.
  103. Khan A, Koudelka C, Goldstein C, Zhao L, Yokemick J, Dux M, Sikdar S, Lal BK*. Semi-automatic quantification of carotid plaque volume with three-dimensional ultrasound imaging. Journal of Vascular Surgery. 2017;65(5):1407-17.
  104. Khan AA, Sikdar S, Hatsukami T, Cebral J, Jones M, Huston J, Howard G, Lal BK*. Non-invasive characterization of carotid plaque strain. Journal of Vascular Surgery. 2017; 65(6)1653-63.
  105. Menon N, Khalifeh A, Drucker CB, Sahajwani S, Garrido D, Kalsi R, Lal BK, Toursavadkohi S. Transcervical carotid artery stenting using a prosthetic arterial conduit: case series of a novel surgical technique. Annals of Vascular Surgery. 2017;47(7):279.
  106. Gloviczki P, Dalsing M, Henke P, Lal BK, O’Donnell II TF, Huang H, Markovic J, Shortell CK, Wakefield TW. Report of the Society for Vascular Surgery and the American Venous Forum on the July 20, 2016 meeting of the medicare evidence development and coverage advisory committee panel on lower extremity chronic venous disease. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2017;5(3):378-98.
  107. Howard VJ, Meschia JF,Lal BK, Turan TN, Roubin GS, Brown II RD, Voeks JH, Barrett KM, Demaerschalk BM, Huston III J, Lazar RM, Moore WS, Wadley VG, Chaturvedi S, Moy CS, Chimowitz M, Howard G, Brott TG; CREST-2 investigators. Carotid revascularization and medical management for asymptomatic carotid stenosis: protocol of the CREST-2 clinical trials. International Journal of Stroke. 2017;12(7):770-8.
  108. Kumar R, Batchelder A, Saratzis A, AbuRahma AF, Ringleb P,Lal BK, Mas JL, Steinbauer M, Naylor AR. Restenosis after carotid interventions and its relationship with recurrent ipsilateral stroke: a systematic review and meta-analysis. European Journal of Vascular and Endovascular Surgery. 2017;53(6):766-75.
  109. Powell JT, Sweeting MJ, Ulug P, Blankensteijn JD, Lederle FA, Becquemin JP, Greenhalgh RM; EVAR-1, DREAM, OVER, and ACE Trialists. Meta-anaylsis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal of Surgery. 2017;104(3):166-78.
  110. Brott TG, Meschia JF,Lal BK. Duplex velocity criteria for carotid endarterectomy. Journal of Vascular Surgery. 2017;65(4):938-9.
  111. Mallick R,Lal BK, Daugherty C. Relationship between patient-reported symptoms, limitations in daily activities, and psychological impact in varicose veins. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2017;5(2):224-37.
  112. Kundi R, Prior SJ, Addison O, Lu M, Ryan AS, Lal BK*. Contrast-enhanced ultrasound reveals exercise-induced perfusion deficits in claudicants. Journal of Vascular and Endovascular Surgery. 2017;2(1):9.
  113. Lal BK*, Meschia J, Brott T. Clinical need, design, and goals for the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial. Seminars in Vascular Surgery. 2017;30(1):2-7.
  114. Cires-Drouet RS, Mozafarian M, Ali A, Sikdar S, Lal BK*. Imaging of high-risk carotid plaques: ultrasound. Seminars in Vascular Surgery. 2017;30(1):44-53
  115. Lal BK*, Dux M, Sikdar S, Goldstein C, Khan AA, Yokemick J, Zhao L. Asymptomatic carotid stenosis is associated with cognitive impairment. Journal of Vascular Surgery. 2017; 66(4):1083-92.
  116. Demaerschalk BM, Brown II RD, Roubin GS, Howard VJ, Cesko E, Barrett KM, Longbottom ME, Voeks JH, Chaturvedi S, Brott TG, Lal BK, Meschia JF, Howard G; CREST-2 investigators. Factors associated with time to site activation, randomization, and enrollment performance in a stroke prevention trial. Stroke. 2017;48(9):2511-8.
  117. Addison O, Kundi R, Ryan AS, Goldberg AP, Patel R, Lal BK, Prior SJ. Clinical relevance of the modified physical performance test versus the short physical performance battery for detecting mobility impairments in older men with peripheral arterial disease. Disability and Rehabilitation. 2018;40(25):3081-3085.
  118. Lichtman JH, Jones MR, Leifheit EC, Sheffet AJ, Howard G, Lal BK, Howard VJ, Wang Y, Curtis J, Brott TG. Carotid endarterectomy and carotid artery stenting in the US medicare population, 1999-2014. Journal of the American Medical Association. 2017;318(11):1035-46.
  119. Crawford JM, Gasparis A, Almeida J, Elias S, Wakefield T, Lal BK, Osborne N, Amery S, Labropoulos N. United States Endovenous ablation practice trends: a 4-year review of the United States Medicare data utilization and payment database. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2018;6(2):288.
  120. Kundi R, Prior S, Addison O, Ryan A, Lal BK. A history of successful revascularization is not associated with superior functional ability in peripheral arterial disease patients. Journal of Vascular and Endovascular Therapy. In Press 2018.
  121. Lal BK, Roubin GS, Jones M, Clark W, Mackey A, Hill MD, Voeks JH, Howard G, Hobson II G, Brott TG. Influence of multiple stents on periprocedural stroke after carotid artery stenting in CREST. Journal of Vascular Surgery. 2019;69(3):800-806.
  122. Zierler ER, Jordan WD, Lal BK, Mussa F, Leers S, Fulton J, Pevec W, Hill A, Murad MH. The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures. Journal of Vascular Surgery. 2018;68(1):256-284.
  123. Marshall RS, Lazar RM, Liebeskind DS, Connolly ES, Howard G, Lal BK, Huston III J, Meschia JF, Brott TG – on behalf of the CREST-H study investigators. Carotid revascularization and medical management for asymptomatic carotid stenosis – hemodynamics (CREST-H): study design and rationale. International Journal of Stroke. 2018;13(9):985-991.
  124. Norling AM, Marshall RS, Pavol MA, Howard G, Howard V, Liebeskind D, Huston III J, Lal BK, Brott TG, Lazar RM. Is hemispheric hypoperfusion a treatable cause of cognitive impairment? Current Cardiology Reports. 2019;21(1):4.
  125. Diaz J, Saha P, Cooley B, Palmer O, Grover S, Henke P, Wakefield T, Mackman N, Smith A, Lal BK. Choosing a mouse model of venous thrombosis: A consensus assessment of utility and application. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019;39(3):311-318.
  126. Lurie F, Lal BK, Killewich L, Rooke T, Jacobowitz G, Caprini JA, Kalodiki E, Davies A, Partsch H, Antignani PL, Blebea J, Ma H, Lohr J, Mosti G, Forrestal M, Bush R, Wakefield TW. Compression therapy after invasive treatment of superficial veins of the lower extremities: clinical practice guidelines of the American Venous Forum (AVF), Society for Vascular Surgery (SVS), American College of Phlebology (ACP), Society for Vascular Medicine (SVM), and International Union of Phlebology (UIP). Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2019;7 (1):17-28.
  127. Jones MR, Howard G, Roubin GS, Blackshear JL, Cohen DJ, Cutlip DE, Leimgruber PP< Rhodes, D, Prinease RJ, Glasser SP, Lal BK, Voeks JH, Brott TG. Periprocedural stroke and myocardial infarction as risks for long-term mortality in CREST. Circulation: Cardiovascular Quality and Outcomes. 2018;11 (11):1-9.
  128. Sharma J, Dosi G, Ayers JD, Padberg FT Jr, Pappas PJ, Lal BK. Reliability and accuracy of duplex ultrasound vein mapping for dialysis access. American Journal of Surgery. 2018;pii:S00002-9610(18):31270-4.
  129. Talaie T, Drucker C, Aicher B, Khalifeh A, Lal BK, Sarkar R, Toursavadkohi S. Endovascular Thrombectomy of Septic Thrombophlebitis of the Inferior Vena Cava: Case Report and Review of the Literature. Vascular and Endovascular Surgery. 2018;52(8):641-647.
  130. Cires-Drouet R, Sharma J, McDonald T, Sorkin JD, Lal BK. Variability in the management of line-related upper extremity deep vein thrombosis. Phlebology. In press 2019.
  131. Chrencik MT, Khan AA, Luther L, Anthony L, Yokemick J, Patel J, Sorkin JD, Sikdar S, Lal BK. Quantitative assessment of carotid plaque morphology (geometry and tissue composition) using computed tomography angiography. Journal of Vascular Surgery. 2019; pii: S0741-5214(19)30141-7.
  132. Farivar BS, Toursavadkohi S, Monahan TS, Sharma J, Ucuzian AA, Kundi R, Sarkar R, Lal BK. Prospective study of cryopreserved placental tissue wound matrix in the management of chronic venous leg ulcers. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2019;7(2):228-233.
  133. Nenezic D, Aqyguasanosa J, Menhei G, Holjencsik T, Matyas L, Muluk S, Courtney K, Ibanez J, Chen J. A prospective, single-blind, randomized, phase III study to evaluate the safety and efficacy of Fibrin Sealant Grifols as an adjunct to hemostasis compared to manual compression in vascular surgery. Journal of Vascular Surgery. 2019;S0741-5214(19):30214-9.
  134. Diaz J, Saha P, Cooley B, Palmer O, Grover S, Henke P, Wakefield T, Mackman N, Smith A, Lal BK. Choosing a mouse model of venous thrombosis: A consensus assessment of utility and application. Journal of Thrombosis and Haemostasis. 2019;17(4):699-707.
  135. Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT Jr, Matsumura JS, Huo Z, Johnson GR, OVER Veterans Affairs Cooperative Study Group. Open versus endovascular repair of abdominal aortic aneurysm. New England Journal of Medicine. 2019;380(22):1216-2135.
  136. Lal BK, Meschia JF, Roubin GS, Jankowitz B, Heck D, Jovin T, White CJ, Rosenfieldx K, Katzen B, Dabus G, Gray W, Matsumara J, Hopkins LN, Luke S, Sharma J, Voeks JH, Howard G, Brott TG, for the CREST-2 Investigators. Factors influencing credentialing of interventionists in the CREST-2 trial. Journal of Vascular Surgery. In press, 2019.
  137. Crawford JM, Gasparis A, Almeida J, Elias S, Wakefield T, Lal BK, Osborne N, Amery S, Labopoulos N. A review of United States endovenous ablation practice trends from the Medicare Data Utilization and Payment Database. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2019;7(4):471-479.

Books

  1. Handbook for Surgical Residents-Resident Survival Guide. Editor: Lal BK. Published by UMDNJ -New Jersey Medical School. Editions 1996, 1997, 1998, 1999.
  2. Annual Report of the American Venous Registry. Editor: Lal BK. Published by Dendrite Corp, London, England, 2012.

Book Chapters

  1. Lal BK and Padberg FT Jr. Non Operative Management of Deep Vein Thrombosis. In: Current Therapy in Vascular Surgery. Calvin B Ernst & James C Stanley (Editors). Edition 1999. Mosby Year Book, Philadelphia, Pennsylvania pages 212-220.
  2. Lal BK and Silva MB. Vascular Access for Hemodialysis. In: Decision Making in Vascular Surgery. Robert B Rutherford & Jack Cronenwett (Editors). Edition 2000. Mosby Yearbook, Philadelphia, Pennsylvania pages 354-359.
  3. Lal BK and RW II Hobson. Carotid Artery Occlusive Disease. In: Current Treatment in Cardiovascular Medicine. Edition 2000. Current Science Inc. Philadelphia, Pennsylvania pages 243-254.
  4. Lal BK and Hobson II RW. Management of Carotid and Vertebral Artery Disease. In: Textbook of Vascular Medicine. Peter Lanzer (Editor). Edition 2001. Springer-Verlag Heidelberg GmbH & Company. Germany pages 1316-1329.
  5. Hobson II RW and Lal BK. Carotid Angioplasty and Stenting for Carotid Restenosis after Carotid Endarterectomy, in: Advances in Vascular Surgery. WH Pearce and J ST Yao (Editors). Edition 2002. Precept Press, Chicago, Illinois pages 159-166.
  6. Lal BK and Hobson II RW. Carotid Angioplasty and Stenting: Clinical Experience and Role for Clinical Trials. In: Angioplasty and Stenting of Carotid and Supra-Aortic Trunks, A. Polydorou and D. Kiskinis (Editors). Edition 2002. Greece pages 175-182.
  7. Cerveira JJ, Lal BK, Pappas PJ. Decision making for dialysis access. In: Textbook of Vascular Diagnosis. Editors: Ashraf Mansour, MD, Nicols Labropoulos, MD. Elsevier Science, Philadelphia, Pennsylvania. Edition 2003 pages 230-235.
  8. Lal BK and Hobson II RW. Current status of clinical trials and implication of anti-emboli protection. In: Carotid Artery Stenting. Al-Mubarak, Gary S Roubin, Sriram S Iyer and Jiri J Vitek (Editors). Edition 2003. Lippincott Williams & Wilkins, Philadelphia, Pennsylvania pages 150-169.
  9. Chakhtoura E, Lal BK, Hobson II RW. Management of carotid in-stent restenosis. In: Carotid Artery Stenting. Al-Mubarak, Gary S Roubin, Sriram S Iyer and Jiri J Vitek (Editors). Edition 2003. Lippincott Williams & Wilkins, Philadelphia, Pennsylvania pages 181-192.
  10. Pappas PJ, Lal BK, Cerveira JJ. Management of patients with chronic venous ulceration.  In; Advances in Vascular Surgery. E Stanley, JST Yao (Editors). Edition 2003. Precept Press, Chicago, Illinois pages 293-303. 
  11. Cerveira JJ, Padberg FT, Pappas PJ, Lal BK. Prevention and Management of Complications Relating to Hemo-access. Trends in Vascular Surgery 2004, Eds. Pearce, Yao, and Matsumura.
  12. Pappas PJ, Lal BK, Cerveira JJ, Padberg FT, Duran WN. Causes of Severe Chronic Venous Insufficiency. Seminars in Vascular Surgery, January 2005.
  13. Pappas PJ, Lal BK, Padberg FT, Zickler RW, Duran WN. (2005). Pathophysiology of leg ulceration. In: Venous and Lymphatic Disorders. Labropoulos N. and Stansby G. (Eds.), New York, New York:  Taylor & Francis Group.  
  14. Pappas PJ, Lal BK, Cerveira JJ, Duran WN. (2005). Pathophysiology of Chronic Venous Insufficiency. In: Rutherford’s Textbook of Vascular Surgery. Fifth Edition. Vlovizki P, et al. (Eds.) (2220-2229). Philadelphia, Pennsylvania: W.B. Saunders.
  15. Zickler RW, Padberg FT. Lal BK, Pappas PJ. (2005). When is a more proximal amputation needed. In: Clinics in Podiatric Medicine. Wallace GF, Mandracchia VJ. (Eds).  429-446. Philadelphia, Pennsylvania, Elsevier/Saunders.
  16. Lal BK. (2006). Sonographic evaluation in carotid stenosis. In: State-of-the-art-imaging in carotid stenosis. Schaller B (ed). Springer, Wien, Sweden
  17. Lal BK. (2006). Duplex ultrasound velocity criteria after carotid artery stenting. In: Noninvasive Vascular Diagnosis 2nd Edn: A Practical Guide to Therapy. AbuRahma A and Bergan J (Eds). Springer, New York, NY
  18. Lal BK, Abai, Babak, Hobson II RW (2007). Diagnosis and Management of In-Stent Restenosis after Carotid Artery Stenting. In: Textbook of Vascular Surgery (Eds.) Sumaira McDonald, Springer-Verlag (London) Ltd.
  19. Lal BK, (2008). Venous Physiologic Assessment. In: Rutherford 7th edition, in the “Patient Evaluation”. (Eds.) Jack Cronenwett, K. Wayne Johnston. Elsevier, Chicago, IL
  20. Pappas PJ, Lal BK, Padberg FT, Zickler RW, Duran WN (2008). Pathogenesis of varicose veins and cellular pathophysiology of chronic venous insufficiency. In: Handbook of Venous Disorders. 3RD edition (Eds) Peter Gloviczki & Michael Dalsing. Hodder & Stoughton, London, England.
  21. Lal BK, (2009). Carotid Artery Disease. In: Imaging of the Cardiovascular System. 1st edition (Eds) Ho & Reddy. Elsevier. Philadelphia, Pennsylvania.
  22. Lal BK. (2012). Duplex ultrasound velocity criteria after carotid artery stenting. In: Noninvasive Vascular Diagnosis 3rd Edn: A Practical Guide to Therapy. AbuRahma A and Bandyk D (Eds). Springer, New York, NY
  23. Lal BK, (2013). Venous Physiologic Assessment. In: Rutherford 8th edition, in “Patient Evaluation”. (Eds.) Jack Cronenwett, K. Wayne Johnston. Elsevier, Chicago, IL
  24. Lal BK, Chander R and Cires-Druet R. Cerebrovascular disease in the elderly. In: Vascular disease in older adults. Edition 2017. Rabih Chander (Editor). Edition 2017. Springer International Publishing pages 113-125.
  25. Lal BK, Marshall R, Lazar R, (2019). Carotid artery disease. In: Neurovascular Neuropsychology, 2nd Ronald Lazar, PhD. Springer Verlag, Philadelphia, PA.

Abstracts and/or Proceedings

  1. Varma S, Lal BK, Pappas PJ, Hobson II RW, Durán WN. VEGF increases permeability of endothelial cell monolayers by activating PKB/akt, NOS and MAP kinases pathways. Federation of American Societies for Experimental Biology. 2001;15(4):A55.
  2. Breslin JW, Varma S, Lal BK, Hobson II RW, Pappas PJ, Durán WN. Mitogen activated protein (MAP) kinases mediate vascular endothelial growth factor (VEGF) and cyclic GMP (cGMP)-induced endothelial hyperpermeability in vitro. Federation of American Societies for Experimental Biology. 2001;15(4):A43.
  3. Breslin JW, Varma S, Lal BK, Hobson II RW, Pappas PJ, Durán WN. The MAP kinase cascade is involved in the signal transduction of histamine-induced microvascular hyperpermeability in vitro. Federation of American Societies for Experimental Biology. 2001;15(4):A43.
  4. Lal BK*, Hobson II RW, Pappas PJ, Hameed M, Jamil Z, Padberg FT, Durán WN. Pixel distribution analysis of B-mode ultrasound images predicts differences in lipid cores of symptomatic vs. asymptomatic carotid plaques. Stroke. 2002;33(1):59-64.
  5. Varma S, Breslin JB, Lal BK, Pappas PJ, Hobson II RW, Durán WN. PI3k and Akt regulate cell proliferation of endothelial cells cultured under conditions of increased glucose concentrations. Federation of American Societies for Experimental Biology. 2002;16(4): A512-513.
  6. Saito S, Zapaiach L, Lal BK, Hobson II RW, Durán WN, Pappas PJ. Mitogen activated protein kinases regulate TGF beta1 mediated fibroblast gel contraction. Federation of American Societies for Experimental Biology. 2002;16(4):A514-515.
  7. Ohara N, Hatakeyama T, Lal BK, Pappas PJ, Hobson II RW, Durán WN. Phosphatase inhibition enhances eNOS phosphorylation and increases microvascular transport. FASEB Journal. 2004;18(5):A245.
  8. Kanetaka T, Duran RG, Lal BK, Pappas PJ, Durán WN. eNOS-derived NO promotes microvascular hyperpermeability in ischemia-reperfusion (I-R) injury. FASEB. 2006;20(5): A1151-52.
  9. Zheng R, Durán WN, Lal BK*. Hyperglycemia decreases endothelial cell proliferation by inhibiting insulin signaling pathway. FASEB. 2006;21:A245.
  10. Sanchez FA, Kim DD, Durán RG, Lal BK, Durán WN. eNOS internalization mediated by caveolar endocytosis regulates microvascular permeability. FASEB 2007, 21(5):A490-1.
  11. Lal BK, Hill J, Yunes M, Cruz G, Jamil Z. Cognitive changes after surgery versus stenting for carotid artery stenosis. Journal of Vascular Surgery. 2009;50(4):S965.
  12. Schor J, Kapadia I, Jamil Z, Lal BK. Prior cervical radiation predicts reduced durability of CAS. Journal of Vascular Surgery. 2009;49(5):
  13. AlMuhanna K, Zhao L, Kowalewski G, Beach KW, Lal BK, Sikdar S. Investigation of cerebral hemodynamics and collateralization in asymptomatic carotid stenoses. Engineering in Medicine and Biology Society Conference Proceedings. 2012:5618-5621.
  14. Lal BK, Beach KW, Roubin GS. Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST: a randomised controlled trial. Journal of Vascular Surgery. 2013;58(1).
  15. Lal BK*, JI Almeida, L Kabnick, TW Wakefield, RB McLafferty, PJ Pappas, JD Raffetto, S Raju, J Blebea, MC Dalsing, M Meissner, J Rectenwald, DL Gillespie, U Onyeachom, R Kinsman. American Venous Registry - the first national registry for the treatment of varicose veins. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2013;1(1):105.
  16. Kabnick L,Wakefield T, Almeida J, Raffetto J, McLafferty R, Pappas P, Rectenwald J, Blebea J, Gillespie D, Onyeachom U, Kinsman R, Lal BK*. Use of compression therapy in patients with chronic venous insufficiency undergoing ablation therapy: a report from the American Venous Registry. Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2013;(1):107.
  17. Almeida J, Kabnick L, Wakefield T, Raffetto J, McLafferty R, Pappas P, Rectenwald J, Blebea J, Gillespie D, Onyeachom U, Kinsman R, Lal BK*. Management trends for chronic venous insufficiency across the United States: a report from the American Venous Registry.  Journal of Vascular Surgery - Venous and Lymphatic Disorders. 2013;1(1):100.
  18. Khalid A, Hossain M, Khosravi A, Zhao L, Fischell J, Kowalowski G, Sikdar S, Lal BK. Measurement of carotid plaque volume by 3D Ultrasound. Journal of Vascular Surgery. 2014;59(6):54S–55S.
  19. Lal BK, Dux MC, Sikdar S, Zhao L, AlMuhanna K, Kowalewski G, Hossian M, Asymptomatic carotid stenosis impairs cognitive function: preliminary results of the ACCOF study. Journal of Vascular Surgery. 2014;59(6):
  20. Toursavadkohi S, Kundi R, Kowalewski G, Monahan TS, Smith-MaMacchia R, Binnick M, Sarkar R, Lal BK. A prospective study of human viable wound matrix in the management of chronic venous ulcers. Journal of Vascular Surgery. 2014;60(3):828–829.
  21. Divakaruni S, Dosi G, Kidwell P, Lal BK. Dilation of Ipsilateral Extremity Veins: A beneficial effect of dialysis access procedures. Journal of Vascular Surgery. 2014;59(6):
  22. Hossain M, AlMuhanna K, Zhao L, Lal BK, Sikdar S. Three dimensional level set based semiautomatic segmentation of atherosclerotic carotid artery wall volume using 3D   ultrasound imaging. SPIE 2014 Proceedings. 2014;9034.
  23. Lal BK, Zhou W, Li Ziyi, Kyriakides T, Matsumura J, Lederle FA, Freischlag J. Predictors and outcome of endoleaks in the OVER Trial. Journal of Vascular Surgery. 2014; 59(6):21S-22S.
  24. AlMuhanna K, Hossain M, Khosravi A, Zhao L, Fischell J, Kowalowski G, Sikdar S, Lal BK. Measurement of carotid plaque volume by 3D Ultrasound. Journal of Vascular Surgery. 2014;59(6).
  25. Dux MC, Kowalewski G, Zhao L, AlMuhanna K, Sikdar S, Lal BK. Asymptomatic carotid stenosis is associated with cognitive dysfunction. Neurology. 2014;83(2).
  26. Lal BK, Dux MC, Sikdar S, Zhao L, AlMuhanna K, Kowalewski G, Murad H. Asymptomatic carotid stenosis impairs cognitive function: preliminary results of the ACCOF study. Journal of Vascular Surgery. 2014;59(6).
  27. Lal BK, Rosenfield K, Furaln T, Heck D, Tunis S, Brott TG. Crest -2 Companion Registry Update. Journal of Vascular Interventional Radiology. 2015;26(1):e7.
  28. Kundi R, Addison O, Patel R, Goldberg AP, Ryan AS, Prior SJ, Lal B K. Paradoxical association between asymptomatic carotid stenosis and functional mobility in patients with peripheral arterial disease. Journal of Vascular Surgery. 2015;61(6):87S-8S.
  29. Meschia JF, Lal BK, Howard G, Roubin GS, Brown II RD, Barrett KM, Huston III J. Carotid revascularization and medical management for asymptomatic carotid stenosis: CREST-2 Status Update. Annals of Neurology. 2015;78:S29.
  30. Meschia J, Lal BK, Howard G, Roubin G, Brown RD, Barrett KM, Huston J. Carotid revascularization and medical management for asymptomatic carotid stenosis: CREST-2 Status Update. Circulation. 2015;132(S3):A17291.
  31. Lichtman JH, Jones MR, Sheffet AJ, Howard G, Wang Y, Leifheit-Limson E, Lal BK, Brott TG. Trends in performance and outcomes of carotid endarterectomy among elderly medicare beneficiaries, 2003-2010. Stroke. 2016;47(S1):A15.
  32. Roubin GS, Lal BK, Voeks JH, Heck DV, Brooks WH, Bozorgchami H, Brott TG. Degree of stenosis by angiography does not influence risk of endarterectomy or stenting in patients with severe asymptomatic carotid stenosis. Stroke. 2016;47(S1):ATP131.
  33. John PR, Anandagoda LP, Farivar BS, Lal BK. Venous thromboembolism prophylaxis in surgical patients: compression device use on the upper extremity. Journal of the American College of Surgeons. 2016;223(4):e115-e116.
  34. Khan AA, Hecker JC, Hatsukami T, Sikdar S, Lal BK. Carotid plaque strain characterization in clinical B-mode ultrasound image sequences. Journal of Vascular Surgery. 2016;64(3): 846-7.
  35. Lal BK, Cires-Drouet RS, Morrish H, Yokemick J, Startzel M, Liu F, Panghat L. High prevalence of chronic venous disease among hospital workers in the United States. Journal of Vascular Surgery. 2016;63(6):212S.
  36. Kundi R, Prior S, Addison O, Lu M, Lal BK. Contrast ultrasound quantification of exercise-induced gastrocnemial perfusion deficits in patients with peripheral arterial disease. Journal of Vascular Surgery. 2016;63(6):182S-3S.
  37. Lal BK, Khan AA, Koudelka C, Zhao L, Dux M, Goldstein CB, SikdarS. Semiautomatic quantification of carotid plaque volume with 3D ultrasonography. Journal of Vascular Surgery. 2016;63(6):186S.
  38. Khan AA, Hecker JC, Lal BK, Sikdar S.Clinical viability of carotid plaque strain estimation using B-mode ultrasound image sequences. Engineering in Medicine and Biology Society IEEE 38th Annual International Conference. 2016;2877-80.
  39. Lal BK, Rosenfeld K, Heck D, Tunis S, Furlan A, Roubin G, Meschia J, Howard G, Moy C, Conley R, Brott TG. CREST-2 companion registry: quality control for carotid stenting and pathway reimbursement. Stroke. 2017; in press.
  40. Lal BK, Rosenfeld K, Heck D, Tunis S, Furlan A, Roubin G, Meschia J, Howard G, Moy C, Conley R, Brott TG. Crest-2 registry: ensures carotid stenting quality while supporting trial. Stroke. 2017; in press.
  41. Barrett K, Meschia J, Lal BK, Howard G, Roubin G, Brown R, Chaturvedi S, Chimowitz M, Demaerschalk B, Howard V, Huston J, Lazar R, Moore W, Moy C, Turan T, Voeks J, Brott TG. Carotid revascularization and medical management for asymptomatic carotid stenosis: CREST-2 Update. Neurology. 2017;88(16):279.
  42. Demaerschalk BM, Brown RD, Roubin G, Howard VJ, Tom M, Barrett K , Longbottom ME, Voeks JH, Cesko E, Brott TG, Lal BK, Meschia JF, Howard G; CREST-2 investigators. Predictors of time to site activation and randomization, and enrollment performance in a large multi-center randomized clinical trial. Stroke. 2017; in press.
  43. Demaerschalk BM, Brown R, Howard VJ, Tom M, Longbottom ME, Voeks JH, Kadiric E, Lal BK, Meschia JF, Brott TG. Selection and activation of sites in a large multi-center randomized clinical trial. Stroke. 2017;48:ATP132.
  44. Roubin GS, Heck DV, White CJ, Rosenfeld K, Dabus G, Jovin TG, Jankowitz BT, Katzen BT, Gray WA, Matsumura JS, Hopkins LN, Gamble DM, Voeks JH, Luke SM, Lal BK, Meschia JF, Brott TG. Credentialing of interventionists in a large randomized trial. Stroke. 2017;48:ATP119.
  45. Meschia JF, Barrett KM, Roubin GS, Lal BK, Brott TG. Control of Vascular Risk Factors at Baseline in CREST-2. Stroke. 2018;49(Suppl_1).
  46. Meschia JF, Lal BK, Howard GH, Roubin GS, Brown, RD, Barrett MD, Chaturvedi S, Chimowitz MI, Demaerschalk BM, Howard VJ, Huston III J, Lazar RM, Moore WS, Scala Moy C, Turan TN, Voeks JF, Brott TG, for the CREST-2 Investigators. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis: CREST-2 Update. Stroke. In press 2018.
  47. Wadley V, Howard V, Knopman D, Lal BK,  Meschia J,  Howard G,  Brott T,  Lazar Carotid Plaque Characterization In A Large Randomized Trial: Results From CREST-2. Journal of Vascular Surgery. 2018;68(2):e18.
  48. Wadley V, Howard V, Knopman D, Lal BK, Meschia J, Howard G, Brott T, Lazar R. Centralized cognitive assessment in a multicenter trial of treatment modes for asymptomatic carotid artery disease. Journal of Gerontology - Innovation in Aging. 2018;2(suppl_1):702.
  49. Turan TN, Voeks JH, Barrett KM, Lal BK, Brott T. Relationship between risk factor control and physician specialty in the CREST2 Trial. Stroke. 2018;49(Suppl_1).
  50. Chaturvedi S, Meschia J, Lal BK, Turan TN, Howard G, Brott T. Expanding access to cholesterol lowering drugs. New York Times. Letter. In press.
  51. Lal BK, Chrencik M, Khan AA, Jones M, Huston J, Sternbergh C, Rapp J, Mukherjee D, Henke P, Yokemick J, Moore W, Sikdar S, Voeks J, Howard G, Meschia J, Brott T. Carotid plaque characteristics correlated to baseline vascular risk factors in a large randomized trial: results from CREST-2. Stroke. 2019;50:ATMP96.
  52. Crawford JM, Gasparis A, Almeida J, Elias S, Wakefield T, Lal BK, Osborne N, Amery S, Labropoulos N. Endovenous ablation practice trends: a 4-year review of the United States Medicare data utilization and payment database. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2018;6(2):288.
  53. Ucuzian AA, Sharma J, Flentje A, Makkar G, Karwowski J, Monahan T, Toursavadkohi S, Lal BK. The predictive value of duplex ultrasound and ankle brachial index screening after prosthetic infrainguinal bypasses. Journal of Vascular Surgery, In press 2019.
  54. Chaturvedi S, Voeks J, Turan T, Gordon N, Chimowitz M, Meschia J, Lal BK, Howard G, Roubin GS, Brown RD, Barrett KM, Demaerschalk BM, Howard VJ, Huston III J, Lazar RM, Moore WS, Moy CS, Brott TG, for the CREST-2 Investigators. Baseline physical activity profiles in the CREST-2 randomized trial. Stroke. 2019;50(Suppl_1).
  55. Conway R, Almeida J, Kabnick L, Wakefield T, Buchwald A, Leekha S, Lal BK. Clinical response to combination therapy in the treatment of varicose veins. Journal of Vascular Surgery – Venous and Lymphatic Disorders. 2019;7(2):303-304.
  56. Chrencik M, Caraballo B, Yokemick J, Pappas PJ, Lal BK, Nagarsheth K. Infrapopliteal arterial pseudoaneurysm development after blunt trauma: case series and literature review. Journal of Vascular Surgery. 2019;69(6):e262.

Clinical Specialty Details

  • Aortic Aneurysm
  • Aortic dissection
  • Cerebrovascular Disease
  • Chronic Venous Insufficiency
    • Varicose veins
    • Venous obtstruction
    • Post thrombotic syndrome
    • Venous ulcers
  • Deep vein thrombosis
  • Dialysis access
    • Autogenous
    • Prosthetic
    • Peritoneal
  • Lower extremity arterial occlusive disease
  • Mesenteric ischhemia
  • Pulmonary embolism
  • Renal artery disease

Awards and Affiliations

  • 1982-1984, National Talent Scholarship, National Council of Educational Research, India   
  • 1982, All India Merit List (top 25 students of India) Premed Program, Indian School Certificate Examination                                                                     
  • 1988, Ranked 1st in Surgery in medical school, All India Institute of Medical Sciences, New Delhi, India                               
  • 2000, JOBST Vascular Research Award, American Venous Forum                                 
  • 2000, Best Research Paper, New Jersey Vascular Society                                     
  • 2000, 2001, Best Research Paper, National Vascular Fellows Competition, New York           
  • 2002, Young Investigator’s Award, Eastern Vascular Society                               
  • 2003, Faculty Research Award, American College of Surgeons                            
  • 2006, 2008, Best Research Paper (mentor), National Vascular Fellows Competition
  • 2006, 2007, Best Research Paper (mentor), New Jersey Vascular Society                      
  • 2009, Best Research Paper (mentor), New Jersey Vascular Society                      
  • 2012, Top 5% of Research papers presented at the American Academy of Neurology (AAN) Annual Meeting, New Orleans, LA  
  • 2012, Top 5% of Research papers presented at the American Heart Association Annual (AHA) meeting, San Francisco, CA
  • 2019, Student Research Fellowship Award (mentor), SVS Foundation
  • 2019, Best Abstract (mentor), SVS Vascular Annual Meeting

Grants and Contracts

Active Grants, Principal Investigator

P30AG028747-13S2 (Brajesh K Lal) 10.1.2018-9.30.2019, 2% effort, NIA- National Institutes of Health, Periodontitis Cognition and Atherosclerosis. This study examines the effects of intensive therapy for periodontitis (PD) to prevent the progression of cognitive impairment to dementia in high-risk older people with asymptomatic carotid stenosis. Results could highlight PD as a readily modifiable risk factor for dementia and inform a larger clinical trial to prevent dementia.

HP-00059915 (Brajesh K Lal) 8.1.2017- 7.30.2020, 1% effort, Maryland Industrial Partnerships Grant, $200,000 (total), Novel imaging approaches to peripheral arterial disease. The major goals of this project are to gather data on physical function in patients with PAD who are receiving conservative treatment as well as those who have undergone an endovascular intervention for lower extremity arterial disease. We also seek to gather data on muscle perfusion while walking in PAD patients using ultrasound imaging with stabilized microbubbles.

NS097876 (Brajesh K Lal) 8.1.2017-7.30.2022, 2% effort, NINDS-National Institutes of Health, Vascular Imaging Core facility for CREST-Hemodynamics. The major goals of this project are to 1) review and adjudicate imaging studies performed in CREST-H (MR angiograms, MR brain perfusion scans and MR brain scans) 2) credential vascular ultrasound technologists at the >150 CREST-2 clinical centers, and 3) provide infrastructure to receive and archive all images obtained in the CREST-H trial. The major goals of CREST-H is to determine whether cognition can be improved by revascularization among a subset of CREST-2 patients with hemodynamic impairment at baseline.

I01CX001621 (Brajesh K Lal) 6.1.2017- 5.30.2021, 5% effort, VA Merit Award-CSR&D, Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates – 2. The major goal of this project is to perform a systematic, adequately powered study to measure the magnitude of cognitive improvement in asymptomatic carotid stenosis patients undergoing carotid revascularization, its impact on quality of life, and its potential pathophysiological mechanisms.

HP-00063876 (Brajesh K Lal) 1.1.2015- 12.31.2022, 17% effort, NIH, CMS, FDA, Industry, C2R- National Carotid Registry. The major goals of this project 1) Promote rapid initiation and completion of enrollment in the CREST-2 trial, 2) Ensure that CAS is performed by adequately experienced operators within CREST-2 and C2R, 3) Closely monitor clinical outcomes of C2R patients, and 4) Prevent inappropriate use of CAS outside of C2R.

U01NS080168 (Co-PIs: Thomas G Brott , James Meschia, Brajesh K Lal) 3.14.2014- 3.13.2022, 10% effort, NINDS-National Institutes of Health UO1, Carotid Revascularization endarterectomy versus Stent trial-2 (CREST-2). The major goals of this project are to assess whether intensive medical management is superior to CEA and to CAS with respect to a composite end-point of stroke and death at 4 years follow-up. Secondary assessments will assess if the CEA or CAS vs. intensive medical management difference is affected by age, sex, severity or carotid stenosis, restenosis, or the level of control of cardiovascular risk factors, and whether recurrent stenosis after CAS or CEA is significantly higher than stenosis progression during intensive medical management.

 I01RX000995 (Brajesh K Lal) 6.1.2014- 6.1.2020, 10% effort, VA Merit Award-RR&D, Exercise induced flow mediated thrombus resolution (EFFORT Trial). The major goal of this project is to assess whether increased blood flow across a thrombus (induced by supervised exercise) will accelerate thrombus resolution and decrease the prevalence and severity of Post Thrombotic Syndrome (PTS).

HP-00062121 (Brajesh K Lal) 3.1.2014- 2.28.2022, 5% effort, NINDS-National Institutes of Health, NIH-designated Vascular Imaging Core Lab for CREST-2. The major goals of this project are to 1) review and adjudicate carotid imaging studies performed in CREST-2 (ultrasound, CT angiograms, MR angiograms, MR brain scans, catheter angiograms) 2) credential vascular ultrasound technologists at the >150 CREST-2 clinical centers, and 3) provide infrastructure to receive and archive all images obtained in the CREST-2 trial.

AG000513 (Brajesh K Lal) 7.1.2013- 6.30.2019, 5% effort, NIA-National Institutes of Health, NIH-designated Vascular Imaging Core Lab for HANDLS. The major goal of this project is the evaluation of intimal medial thickness measurement in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) Study

 

Active Grants, Co-Investigator

(Jay Magaziner, PI) 7.1.2016-6.30.2021, 2% effort, NIA-National Institutes of Health, $8,000,000, Role: Develop and implement novel vascular imaging protocols for PAD, Claude D. Pepper Older Americans Independence Center

(Steven Prior, PI) 4.1.2016-3.31.2019, 1% effort, NIH-R21, NMES in PAD patients, Role: Provide scientific and clinical support to the PI

(Steven Prior, PI) 9.1.2015- 9.1.2019, 1% effort, VA SPiRe Award, Angiogenesis in PAD patients, Role: Provide scientific and clinical support to the PI 

 

Active Grants, Mentor

(Brajesh K Lal Mentor, Odessa Addison PI) 7.1.2016- 6.30.2020, 1% effort, VA Mentored Career Development Award, PAD in obese patients –effect of a weight loss program, Role: Provide scientific and clinical guidance to the PI 

(Brajesh K Lal Mentor, Shahab Toursavadkohi PI) 7.1.2015- 6.30.2019, 1% effort, Endologix Corporation, Endografts (LEOPARD trial) Randomized trial of endologix versus other FDA- approved aortic, Role: Provide scientific and clinical guidance to the PI 

(Brajesh K Lal Mentor, Odessa Adison PI) 9.1.2015- 9.1.2019, 1% effort, NIH Pepper Center Junior Investigator Award, PAD in obese patients – effect of a weight loss program, Role: Provide scientific and clinical guidance to the PI

                                 

Active Grants, Industry-funded Clinical Trials

(Brajesh K Lal Co-Investigator, Robert Crawford Site PI) 8.1.2012-7.31.2019, Cook Inc., Zenith aortic dissection study

(Brajesh K Lal Site PI) 8.1.2012-7.31.2019, Cook Inc., Zenith TX2 thoracic aortic trauma study

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