Academic Title:
Associate Professor
Primary Appointment:
Medicine
Secondary Appointment(s):
Psychiatry
Administrative Title:
Associate Director of the Kahlert Institute for Addiction Medicine.
Additional Title:
Co-Director, Research Initiative on Infectious Disease and Substance Use Disorder
Location:
725 West Lombard St Baltimore, MD 21201
Phone (Primary):
443-691-4638
Fax:
301-451-5799
Education and Training
2000-2004 BS, Biology and BS, Psychology, Virginia Commonwealth University
2005-2009 MD, Eastern Virginia Medical School
2010-2012 Residency, Internal Medicine, George Washington University
2012-2013 Chief Resident, Internal Medicine, George Washington University
2018-2022 Master of Public Health, Epidemiology, University of Maryland SOM
Biosketch
I am an academic clinician investigator, with expertise in hepatitis C (HCV) and opioid use disorder (OUD). In 2013, I served as a clinician within the National Institute of Allergy and Infectious Disease, Laboratory of Immunoregulation clinic, gaining experience in advanced HIV treatment and the use of directly-acting antiviral therapy for HCV. In 2014, I transitioned to the Institute of Human Virology, where I now serve as Assistant Professor in the University of Maryland School of Medicine, and simultaneously lead the Partnership for HIV/AIDS Progress' (PFAP) Research Initiative in Infectious Disease and Substance Use (RIIS) as Baltimore Site Director.
In these positions, I provide both research-related and clinical care in community-based settings, serving an urban cohort representative of the HCV and OUD epidemics. I served as the lead investigator of the SYNERGY (G,H,F) study, evaluating the limits of short duration combination DAA therapy and predictors of successful treatment, and the ASCEND study, which explored the impact of provider type on HCV treatment outcomes in community-based settings.
My current research focus is on implementation-based improvements in the care of individuals with HCV and OUD. I serve as senior investigator of ANCHOR, a unique study designed to evaluate integrated HCV treatment, OUD treatment, and harm reduction in a high-risk population of persons with OUD, HCV, and active drug use.
Research/Clinical Keywords
Hepatitis C, Opioid Use Disorder, Implementation Science
Highlighted Publications
- Rosenthal ES, Silk R, Mathur P, Gross C, Eyasu R, Nussdorf L, Hill K, Brokus C, D'Amore A, Sidique N, Bijole P, Jones M, Kier R, McCullough D, Sternberg D, Stafford K, Sun J, Masur H, Kottilil S, Kattakuzhy S. Concurrent Initiation of Hepatitis C and Opioid Use Disorder Treatment in People Who Inject Drugs. Clin Infect Dis. 2020 Feb 3;PubMed PMID: 32009165.
- Schwetz TA, Calder T, Rosenthal E, Kattakuzhy S, Fauci AS. Opioids and Infectious Diseases: A Converging Public Health Crisis. J Infect Dis. 2019 Jul 2;220(3):346-349. PubMed PMID: 30941402; PubMed Central PMCID: PMC6941614.
- Kattakuzhy S, Gross C, Emmanuel B, Teferi G, Jenkins V, Silk R, Akoth E, Thomas A, Ahmed C, Espinosa M, Price A, Rosenthal E, Tang L, Wilson E, Bentzen S, Masur H, Kottilil S. Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial. Ann Intern Med. 2017 Sep 5;167(5):311-318. PubMed PMID: 28785771; PubMed Central PMCID: PMC5736381.
- Kattakuzhy S, Wilson E, Sidharthan S, Sims Z, McLaughlin M, Price A, Silk R, Gross C, Akoth E, McManus M, Emmanuel B, Shrivastava S, Tang L, Nelson A, Teferi G, Chavez J, Lam B, Mo H, Osinusi A, Polis MA, Masur H, Kohli A, Kottilil S. Moderate Sustained Virologic Response Rates With 6-Week Combination Directly Acting Anti-Hepatitis C Virus Therapy in Patients With Advanced Liver Disease. Clin Infect Dis. 2016 Feb 15;62(4):440-447. PubMed PMID: 26503379; PubMed Central PMCID: PMC4725378.
Additional Publication Citations
Wilson EM, Kattakuzhy S, Sidharthan S, Sims Z, Tang L, McLaughlin M, Price A, Nelson A, Silk R, Gross C, Akoth E, Mo H, Subramanian GM, Pang PS, McHutchison JG, Osinusi A, Masur H, Kohli A, Kottilil S. Successful Retreatment of Chronic HCV Genotype-1 Infection With Ledipasvir and Sofosbuvir After Initial Short Course Therapy With Direct-Acting Antiviral Regimens. Clin Infect Dis. 2016 Feb 1;62(3):280-288. PubMed PMID: 26521268; PubMed Central PMCID: PMC4706633.
Faldetta KF, Kattakuzhy S, Wang HW, Sereti I, Sheikh V. Cytomegalovirus immune reconstitution inflammatory syndrome manifesting as acute appendicitis in an HIV-infected patient. BMC Infect Dis. 2014 Jun 9;14:313. PubMed PMID: 24910267; PubMed Central PMCID: PMC4057562.
Hadigan C, Kattakuzhy S. Diabetes mellitus type 2 and abnormal glucose metabolism in the setting of human immunodeficiency virus. Endocrinol Metab Clin North Am. 2014 Sep;43(3):685-96. PubMed PMID: 25169561; PubMed Central PMCID: PMC4159723.
Wilson EM, Rosenthal ES, Kattakuzhy S, Tang L, Kottilil S. Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C. Clin Microbiol Rev. 2017 Jan;30(1):23-42. PubMed PMID: 27795306; PubMed Central PMCID: PMC5217793.
Tang LS, Masur J, Sims Z, Nelson A, Osinusi A, Kohli A, Kattakuzhy S, Polis M, Kottilil S. Safe and effective sofosbuvir-based therapy in patients with mental health disease on hepatitis C virus treatment. World J Hepatol. 2016 Nov 8;8(31):1318-1326. PubMed PMID: 27872683; PubMed Central PMCID: PMC5099584.
Gross C, Akoth E, Price A, Kattakuzhy S, Silk R, Rosenthal E. HIV/HCV Co-infection: Overcoming Barriers to Treatment. J Assoc Nurses AIDS Care. 2016 Jul-Aug;27(4):524-9. PubMed PMID: 26996983.
Akoth E, Gross C, Silk R, Rosenthal E, Kattakuzhy S. A Practical Approach and Model of Care for HCV Treatment With Direct Acting Antivirals in an Urban Setting. J Assoc Nurses AIDS Care. 2017 Sep - Oct;28(5):680-684. doi: 10.1016/j.jana.2017.04.007. Epub 2017 Apr 26. PubMed PMID: 28506435.
Research Interests
My current research focus is on implementation-based improvements in the care of individuals with HCV and OUD. I serve as senior investigator of ANCHOR, a unique study designed to evaluate integrated HCV treatment, OUD treatment, and harm reduction in a high-risk population of persons with OUD, HCV, and active drug use.
Clinical Specialty Details
Internal Medicine
Grants and Contracts
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