Mohammad S. Islam, PhD

2016-    Ph.D., Molecular Biology and Oncology, Chiba University, Japan

Thesis Title: Molecular Mechanism of cellular signaling related to spontaneous regression of neuroblastoma 

2009-    M.Sc., Biochemistry and Molecular Biology, Dhaka University, Bangladesh

Thesis Title: A Computational and experimental approach for developing jute ESTs from genomic clones

2007-    B.Sc. (Honors), Biochemistry and Molecular Biology, Dhaka University, Bangladesh

I graduated from the University of Dhaka, Bangladesh with a bachelors in Biochemistry and Molecular biology. After my graduation, I have started my career in infectious disease in virology laboratory International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) a renowned international research institute in Bangladesh in 2009. My research involves the extraction and purification of different microorganisms including virus, bacteria and other pathogens by cutting-edge bacteriological and immunological techniques. I have completed my Ph.D. from the department of Molecular Biology and Oncology, School of Medicine, Chiba University, Japan in 2016.

During my Ph.D. my research interest was to study the molecular mechanism of signaling related to spontaneous regression of neuroblastoma occurred in human. After my first postdoc in Bangladesh, I worked as an assistant professor in the Department of Biochemistry and Molecular Biology, Jagannath University, Dhaka, Bangladesh. At the present time, I am working as a postdoctoral fellow in the Department of Obstetrics, Gynecology and Reproductive Sciences at University of Maryland, Baltimore (UMB). My current work focuses in the cellular signaling pathway to understand the cause of diabetic embryopathy and structural birth defects. I dream of succeeding in life science and making a positive impact on the world's health.

Cancer Biology, Infectious disease, Molecular Biology, Neural tube defects, Congenital heart defects

1. Mohammad Sazzadul Islam†, Ryo Takano†, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara and Yasutoshi Tatsumi. Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells. BMC Cancer. 2019; 19: 542. Available at: https://doi.org/10.1186/s12885-019-5772-4 
2. Md Tarikul Islam†, Suprovath Kumar Sarkar1†, Nusrat Sultana, Mst. Noorjahan Begum, Golam Sarower Bhuyan,Shezote Talukder, A. K. M. Muraduzzaman, Md Alauddin1, Mohammad Sazzadul Islam, Pritha Promita Biswas,Aparna Biswas, Syeda Kashfi Qadri, Tahmina Shirin, Bilquis Banu, Salma Sadya, Manzoor Hussain,Golam Sarwardi, Waqar Ahmed Khan, Mohammad Abdul Mannan, Hossain Uddin Shekhar,Emran Kabir Chowdhury, Abu Ashfaqur Sajib, Sharif Akhteruzzaman, Syed Saleheen Qadri, Firdausi Qadriand Kaiissar Mannoor. High resolution melting curve analysis targeting the HBB gene mutational hotspot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh. BMC Genetics. 2018; 19:1. Available at: https://doi.org/10.1186/s12863-017-0594-3 
3. Golam Sarower Bhuyan, Mohammad Amir Hossain, Suprovath Kumar Sarker, Asifuzzaman Rahat, Md Tarikul Islam, Tanjina Noor Haque, Noorjahan Begum, Syeda Kashfi Qadri, A. K. M. Muraduzzaman, Nafisa Nawal Islam, Mohammad Sazzadul Islam, Nusrat Sultana, Manjur Hossain Khan Jony, Farhana Khanam, Golam Mowla, Abdul Matin, Firoza Begum, Tahmina Shirin, Dilruba Ahmed, Narayan Saha, Firdausi Qadri, Kaiissar Mannoor. Bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in Dhaka city. PLoS ONE. 2017, 12(3): e0174488. Available at: https://doi.org/10.1371/journal.pone.0174488 
4. Mohammad Sazzadul Islam, Yasutoshi Tatsumi, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Toshinori Ozaki, Yohko Nakamura, Miki Ohira and Akira Nakagawara. Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells. Biocem Biophys Res Commun. 2016, 478(1):81-86. Available at: https://doi.org/10.1016/j.bbrc.2016.07.089 
5. Yasutoshi Tatsumi, Ryo Takano, Mohammad Sazzadul Islam, Tomoki Yokochi, Makiko Itami, Yohko Nakamura and Akira Nakagawara. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell Death and Disease. 2015, 22; 6:e1607. doi: 10.1038/cddis.2014.568. Available: https://doi.org/10.1038/cddis.2014.568
6. Jesmin Akter, Atsushi Takatori, Mohammad Sazzadul Islam, Atsuko Nakazawa, Toshinori Ozaki, Hiroki Nagase and Akira Nakagawara. Intracellular fragment of NLRR3 (NLRR3-SCD) stimulated ATRA-dependent neuroblastoma differentiation. Biocem Biophys Res Commun. 2014, 453(1):86-93. Available at: https://doi.org/10.1016/j.bbrc.2014.09.065