Academic Title:
Assistant Professor
Primary Appointment:
Biochemistry and Molecular Biology
Location:
108 N. Greene St, Baltimore, MD, 21201
Phone (Primary):
(410) 706-5787
Education and Training
1994-2000 M.D. General Medicine. School of Medicine, National Autonomous University of Mexico. Mexico.
1999-2000 Internship (Surgery, Internal Medicine, and Emergency Medicine) at the Institute of Medical Sciences and Nutrition, Dr. Salvador Zubirán, Mexico.
2001-2007 Ph.D. in Biomedical Sciences, Subject: Physiology and Biophysics, School of Medicine, National Autonomous University of Mexico, Mexico.
2004-2007 Scholar Fellow, Department of Biochemistry and Molecular Biology School of Medicine, University of Maryland, Baltimore, MD, USA. Mentor: Dr. Martin F. Schneider.
2007-2010 Post-doctoral fellow, Department of Biochemistry and Molecular Biology School of Medicine, University of Maryland, Baltimore, MD, USA. Mentor: Dr. Martin F. Schneider.
Biosketch
I am a physician-physiologist fascinated by studying the human body and disease mechanisms. My undergraduate, graduate, and early postdoctoral research focused on peripheral sympathetic nervous system physiology. The sympathetic division of the autonomic nervous system is classically known for mediating the ‘fight or flight’ response. Still, it is also indispensable for body homeostasis during daily activities such as exercise, eating a meal, and regulating body temperature and immune responses. My research has included studying the mechanisms of voltage-gated calcium channel modulation mediated by G-protein coupled receptors. Voltage-gated calcium channels are critical mediators of depolarization-induced calcium influx into excitable cells, playing pivotal roles in various physiological responses. In recent years, my research has focused on skeletal muscle physiology and pathophysiology, focusing on myopathies induced by chronic diseases such as diabetes and heart failure. In recent collaborative multi-institutional projects, we are eager to unravel the role of calcium dysregulation in neurodegenerative conditions such as Huntington's disease and Alzheimer's disease with the hope of finding biomarkers, novel diagnostic tools, and new alternative therapies.
Research/Clinical Keywords
Excitability, calcium signals, voltage-gated ion channels, neurons, skeletal muscle cells. Calcium channel regulation, calcium dysregulation, Calcium binding proteins, S100A1. Calcium release channels, RyR1 and RyR3. Diabetic myopathy, skeletal muscle diseases, and heart failure-induced skeletal myopathy. Neurons derived from human pluripotent stem cells
Highlighted Publications
Perry ML, Varney KM, Tiwary P, Weber DJ, Hernández-Ochoa EO. Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on "Structural insights into the regulation of RyR1 by S100A1". Cell Calcium. 2024 Nov;123:102947.
Peña-Pichicoi A, Fernández M, Navarro-Quezada N, Alvear-Arias JJ, Carrillo CA, Carmona EM, Garate J, Lopez-Rodriguez AM, Neely A, Hernández-Ochoa EO, González C. N-terminal region is responsible for mHv1 channel activity in MDSCs. Front Pharmacol. 2023 Oct 17;14:1265130.
Bibollet H, Bennett DF, Schneider MF, Hernández-Ochoa EO. Functional Site-Directed Fluorometry in Native Cells to Study Skeletal Muscle Excitability. J Vis Exp. 2023 Jun 2;(196). doi: 10.3791/65311.
Bibollet H, Nguyen EL, Miranda DR, Ward CW, Voss AA, Schneider MF, Hernández-Ochoa EO. Voltage sensor current, SR Ca(2+) release, and Ca(2+) channel current during trains of action potential-like depolarizations of skeletal muscle fibers. Physiol Rep. 2023 May;11(9):e15675.
Velasquez FC, Roman B, Hernández-Ochoa EO, Leppo MK, Truong SK, Steenbergen C, Schneider MF, Weiss RG, Das S. Contribution of skeletal muscle-specific microRNA-133b to insulin resistance in heart failure. Am J Physiol Heart Circ Physiol. 2023 May 1;324(5):H598-H609.
Bibollet H, Kramer A, Bannister RA, Hernández-Ochoa EO. Advances in Ca(V)1.1 gating: New insights into permeation and voltage-sensing mechanisms. Channels (Austin). 2023 Dec;17(1):2167569.
Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL Jr, Colecraft HM. Selective posttranslational inhibition of Ca(V)β(1)-associated voltage-dependent calcium channels with a functionalized nanobody. Nat Commun. 2022 Dec 9;13(1):7556.
Banks Q, Bibollet H, Contreras M, Bennett DF, Bannister RA, Schneider MF, Hernández-Ochoa EO. Voltage sensor movements of Ca(V)1.1 during an action potential in skeletal muscle fibers. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40).
Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021 May 26;12(1):3175.
Hernández-Ochoa, E. O. and M. F. Schneider. Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis. Skelet Muscle. 2018 8(1): 22.
Hernández-Ochoa EO, Pratt SJ, Lovering RM, Schneider MF. Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease. Front Physiol. 2016.
Hernández-Ochoa EO, Robison P, Contreras M, Shen T, Zhao Z, Schneider MF. Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood). 2012 Sep;237(9):1068-83.
Hernández-Ochoa EO, Schachter TN, Schneider MF. Elevated nuclear Foxo1 suppresses excitability of skeletal muscle fibers. Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C643-53.
Hernández-Ochoa EO, Schneider MF. Voltage clamp methods for the study of membrane currents and SR Ca(2+) release in adult skeletal muscle fibres. Prog Biophys Mol Biol. 2012 Apr;108(3):98-118.
Hernández-Ochoa EO, Contreras M, Cseresnyés Z, Schneider MF. Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials. Cell Calcium. 2007 Jun;41(6):559-71.
García DE, Li B, García-Ferreiro RE, Hernández-Ochoa EO, Yan K, Gautam N, Catterall WA, Mackie K, Hille B. G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels. J Neurosci. 1998 Nov 15;18(22):9163-70.
Additional Publication Citations
- Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021 May 26;12(1):3175.
- Pratt SJP, Hernández-Ochoa E, Martin SS. Calcium signaling: breast cancer's approach to manipulation of cellular circuitry. Biophys Rev. 2020 Dec 18;12(6):1343-1359.
- Pratt, S.J.P., R. M. Lee, O. Hernández-Ochoa, E.C. Ory, K. N. Thompson, P.C. Bailey, T.J. Mathias, M.I. Vitolo, M.F. Schneider, J.P. Stains, C.W. Ward and S. S. Martin (2020) “Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas” PNAS, 117(42):26008-26019.
- Zhao, Z., L. Cao, Hernández-Ochoa, M. F. Schneider and E. A. Reece (2019). "Disturbed intracellular calcium homeostasis in neural tube defects in diabetic embryopathy." Biochem Biophys Res Commun 514(3): 960-966.
- Banks, Q., S. J. P. Pratt, S. R. Iyer, R. M. Lovering, O. Hernández-Ochoa and M. F. Schneider (2018). "Optical Recording of Action Potential Initiation and Propagation in Mouse Skeletal Muscle Fibers." Biophys J 115(11): 2127-2140.
- Au, D. T., Z. Ying, O. Hernández-Ochoa, W. E. Fondrie, B. Hampton, M. Migliorini, R. Galisteo, M. F. Schneider, A. Daugherty, D. L. Rateri, D. K. Strickland and S. C. Muratoglu (2018). "LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca(2+) Signaling and Expression of Cytoskeleton-Related Proteins." Arterioscler Thromb Vasc Biol 38(11): 2651-2664.
- Hernández-Ochoa, E. O., Z. Melville, C. Vanegas, K. M. Varney, P. T. Wilder, W. Melzer, D. J. Weber and M. F. Schneider (2018). "Loss of S100A1 expression leads to Ca(2+) release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1." Physiol Rep 6(15): e13822.
- Hernández-Ochoa, E. O. and M. F. Schneider (2018). "Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?" Skelet Muscle 8(1): 22.
- Pratt, S. J. P., O. Hernández-Ochoa, R. M. Lee, E. C. Ory, J. S. Lyons, H. C. Joca, A. Johnson, K. Thompson, P. Bailey, C. J. Lee, T. Mathias, M. I. Vitolo, M. Trudeau, J. P. Stains, C. W. Ward, M. F. Schneider and S. S. Martin (2018). "Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding." Oncotarget 9(38): 25008-25024.
- Robison, P., T. E. Sussan, H. Chen, S. Biswal, M. F. Schneider and O. Hernández-Ochoa (2017). "Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD." Muscle Nerve 56(2): 282-291.
- Melville, Z., O. Hernández-Ochoa, S. J. P. Pratt, Y. Liu, A. D. Pierce, P. T. Wilder, K. A. Adipietro, D. H. Breysse, K. M. Varney, M. F. Schneider and D. J. Weber (2017). "The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP." Biochemistry 56(17): 2328-2337.
- Iyer, S. R., S. B. Shah, A. P. Valencia, M. F. Schneider, O. Hernández-Ochoa, J. P. Stains, S. S. Blemker and R. M. Lovering (2017). "Altered nuclear dynamics in MDX myofibers." J Appl Physiol (1985) 122(3): 470-481.
- Hernández-Ochoa, E. O., P. Llanos and J. T. Lanner (2017). "The Underlying Mechanisms of Diabetic Myopathy." J Diabetes Res 2017: 7485738.
- Hernández-Ochoa, E. O., Q. Banks and M. F. Schneider (2017). "Acute Elevated Glucose Promotes Abnormal Action Potential-Induced Ca(2+) Transients in Cultured Skeletal Muscle Fibers." J Diabetes Res 2017: 1509048.
- Iyer, S. R., A. P. Valencia, O. Hernández-Ochoa and R. M. Lovering (2016). "In Vivo Assessment of Muscle Contractility in Animal Studies." Methods Mol Biol 1460: 293-307.
- Hernández-Ochoa, E. O., C. Vanegas, S. R. Iyer, R. M. Lovering and M. F. Schneider (2016). "Alternating bipolar field stimulation identifies muscle fibers with defective excitability but maintained local Ca(2+) signals and contraction." Skelet Muscle 6: 6.
- Hernández-Ochoa, E. O. and C. Vanegas (2015). "Diabetic Myopathy and Mechanisms of Disease." Biochem Pharmacol (Los Angel) 4(5).
- Hernández-Ochoa, E. O., S. J. P. Pratt, R. M. Lovering and M. F. Schneider (2015). "Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease." Front Physiol 6: 420.
- Hernández-Ochoa, E. O., S. J. P. Pratt, K. P. Garcia-Pelagio, M. F. Schneider and R. M. Lovering (2015). "Disruption of action potential and calcium signaling properties in malformed myofibers from dystrophin-deficient mice." Physiol Rep 3(4).
- Robison, P., O. Hernández-Ochoa and M. F. Schneider (2014). "Atypical behavior of NFATc1 in cultured intercostal myofibers." Skelet Muscle 4(1): 1.
- Hernández-Ochoa, E. O., R. O. Olojo, R. T. Rebbeck, A. F. Dulhunty and M. F. Schneider (2014). "β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers." Biophys J 106(3): 535-547.
- Hernández-Ochoa, E. O., T. N. Schachter and M. F. Schneider (2013). "Elevated nuclear Foxo1 suppresses excitability of skeletal muscle fibers." AJP Cell Physiol 305(6): C643-653.
- Wu, F., W. Mi, O. Hernández-Ochoa, D. K. Burns, Y. Fu, H. F. Gray, A. F. Struyk, M. F. Schneider and S. C. Cannon (2012). "A calcium channel mutant mouse model of hypokalemic periodic paralysis." J Clin Invest 122(12): 4580-4591.
- Hernández-Ochoa, E. O., P. Robison, M. Contreras, T. Shen, Z. Zhao and M. F. Schneider (2012). "Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle." Exp Biol Med (Maywood) 237(9): 1068-1083.
- Hernández-Ochoa, E. O. and M. F. Schneider (2012). "Voltage clamp methods for the study of membrane currents and SR Ca(2+) release in adult skeletal muscle fibres." Prog Biophys Mol Biol 108(3): 98-118.
- Liu, Y., O. Hernández-Ochoa, W. R. Randall and M. F. Schneider (2012). "NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers." AJP Cell Physiol 303(3): C334-347.
- Olojo, R. O., A. P. Ziman, O. Hernández-Ochoa, P. D. Allen, M. F. Schneider and C. W. Ward (2011). "Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling." PLoS One 6(12): e27036.
- Olojo, R. O., O. Hernández-Ochoa, N. Ikemoto and M. F. Schneider (2011). "Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers." Biophys J 100(10): 2367-2377.
- Yamaguchi, N., B. L. Prosser, F. Ghassemi, L. Xu, D. A. Pasek, J. P. Eu, O. Hernández-Ochoa, B. R. Cannon, P. T. Wilder, R. M. Lovering, D. Weber, W. Melzer, M. F. Schneider and G. Meissner (2011). "Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1." AJP Cell Physiol 300(5): C998-C1012.
- Robison, P., O. Hernández-Ochoa and M. F. Schneider (2011). "Adherent primary cultures of mouse intercostal muscle fibers for isolated fiber studies." JB Biotechnol 2011: 393740.
- Prosser, B. L., O. Hernández-Ochoa and M. F. Schneider (2011). "S100A1 and calmodulin regulation of ryanodine receptor in striated muscle." Cell Calcium 50(4): 323-331.
- Shen, T., Y. Liu, M. Contreras, O. Hernández-Ochoa, W. R. Randall and M. F. Schneider (2010). "DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers." Histochem Cell Biol 134(4): 387-402.
- Prosser, B. L., O. Hernández-Ochoa, R. M. Lovering, Z. Andronache, D. B. Zimmer, W. Melzer and M. F. Schneider (2010). "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle." AJP Cell Physiol 299(5): C891-902.
- Prosser, B. L., O. Hernández-Ochoa, D. B. Zimmer and M. F. Schneider (2009). "Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres." J Physiol 587(Pt 18): 4543-4559.
- Prosser, B. L., O. Hernández-Ochoa, D. B. Zimmer and M. F. Schneider (2009). "The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1." J Physiol 587(Pt 18): 4523-4541.
- Hernández-Ochoa, E. O., B. L. Prosser, N. T. Wright, M. Contreras, D. J. Weber and M. F. Schneider (2009). "Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons." AJP Cell Physiol 297(4): C955-970.
- Prosser, B. L., N. T. Wright, O. Hernandez-Ochoa, K. M. Varney, Y. Liu, R. O. Olojo, D. B. Zimmer, D. J. Weber and M. F. Schneider (2008). "S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling." J Biol Chem 283(8): 5046-5057.
- Hernández-Ochoa, E. O., R. E. García-Ferreiro and D. E. García (2007). "G protein activation inhibits gating charge movement in rat sympathetic neurons." AJP Cell Physiol 292(6): C2226-2238.
- Hernández-Ochoa, E. O., M. Contreras, Z. Cseresnyés and M. F. Schneider (2007). "Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials." Cell Calcium 41(6): 559-571.
- Brown, L. D., G. G. Rodney, Hernández-Ochoa, C. W. Ward and M. F. Schneider (2007). "Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibers." AJP Cell Physiol 292(3): C1156-1166.
- García-Ferreiro, R. E., O. Hernández-Ochoa and D. E. García (2001). "Modulation of N-type Ca2+ channel current kinetics by PMA in rat sympathetic neurons." Pflugers Arch 442(6): 848-858.
- García, D. E., B. Li, R. E. García-Ferreiro, O. Hernández-Ochoa, K. Yan, N. Gautam, W. A. Catterall, K. Mackie and B. Hille (1998). "G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels." J Neurosci 18(22): 9163-9170.
Research Interests
Neuronal and muscular physiology. Calcium signals and voltage-gated ion channels in excitable cells.
Alterations of voltage-gated ion channels function and calcium signaling in neurons and muscle.
Pathophysiology of Diabetes, Denervation and Skeletal Muscle diseases.
- One of the primary focuses of my research interest is the function of the sympathetic nervous system. During my PhD studies and early during my postdoctoral career, I studied mechanisms of ion channel regulation mediated by neurotransmitters, calcium signaling, and the role of extracellular S100A1. I demonstrated that different neurotransmitters and hormones can control the activity of ion channels via the modulation of the voltage sensing apparatus. Our group also discovered that specific patterns of electrical activity control the activation of NFATc1, a transcription factor that regulates myriad neuronal functions. I also identified a novel regulation mechanism of sympathetic neurons when S100A1 is added extracellularly. This form of regulation may occur during or after a heart attack and the accompanying ischemic damage or during neuronal damage. My scientific findings from this initial stage of my research career have been cited numerous times in peer-reviewed journals and book chapters.
- Improving our understanding of skeletal muscle functions constitutes a prerequisite for better treating skeletal muscle diseases. Over the years, my colleagues and I have developed a range of research strategies to allow a vastly improved understanding of muscle physiology and disease conditions.
Clinical Specialty Details
Medical Licensure
2000-present Active, México City, México.
USMLE Board Certification
2019, USMLE STEP 1, pass, May.
2020, USMLE STEP 2 CK, pass, July.
ECFMG Certification
2020 OET, pass, October.
Awards and Affiliations
Awards
2010 Member, National Researchers System (level 1), granted by The National Council on Science and Technology (CONACYT-Mexico).
2015 Chair, Gordon Research Seminar, preceding Gordon Research Conference: Muscle Excitation/Contraction Coupling.
2023 Nominated as Chair, Gordon Research Conference: Muscle Excitation/Contraction Coupling.
Affiliations
2001-present Member, Biophysical Society
2004-present Member, Latin American Biophysicists Society
2014-present Member, Society of General Physiology
Grants and Contracts
Ongoing Research Support
Active Grants
04/01/21-03/31/26 Hernandez-Ochoa, EO (PI, 40%)
Voltage sensor domain movements in skeletal muscle fiber activation
NIH/NIAMS, R01 AR075726
$220,000 FY Direct costs
In the News
Muscle Protein That Makes Vertebrates More Fit Linked to Limited Lifespan
Protein That Enhances Physical Fitness Reduces Lifespan
Community Service
Administrative Service
2015-present Member: Graduate Program in Biochemistry and Molecular Biology, Graduate Program in Life Science, University of Maryland School of Medicine, University of Maryland Baltimore County.
2015-present Member: Interdisciplinary Training Program in Muscle Biology. University of Maryland School of Medicine.
2018-Present Admission Committee: Cellular and Molecular Biomedical Science (CMBS) MS Program, Graduate Program in Life Science, University of Maryland, Baltimore
2019-present Admission Committee: Graduate Program in Biochemistry and Molecular Biology, Graduate Program in Life Science, University of Maryland School of Medicine, University of Maryland Baltimore County.
2023-present Admission Committee: Graduate Program in Molecular Medicine, Graduate Program in Life Science, University of Maryland School of Medicine.
2023-present Member: Graduate Program in Membrane Biology, Graduate Program in Life Science, University of Maryland School of Medicine.
2023-present Co-Director: Medical Spanish, University of Maryland School of Medicine.
PhD program Teaching/Training/Mentoring
2007-2010 Research Co-Mentor. PhD Student: Benjamin L. Prosser, Program in Molecular Medicine (University of Maryland School of Medicine), 4-6 hours per week. (Current position: Assistant Professor, Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania).
2007 Laboratory Rotation Co-Mentor. PhD Student: Dushon D. Riley, Program in Neuroscience (University of Maryland School of Medicine), 1-2 hours/week for 2 months. (Current position: ORISE Fellow at Food and Drug Administration).
2008-2012 Research Co-Mentor. PhD Student: Patrick Robison, Program in Biochemistry (University of Maryland School of Medicine), 4-6 hours per week. (Current position: Postdoctoral Fellow, Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania)
2011-2013 Research Co-Mentor. PhD Student: Tova Neustadt Schachter, Program in Biochemistry, (University of Maryland School of Medicine) 4-6 hours per week. (Current position: Adjunct Professor at Maalot Baltimore).
2011-2013 Research Co-Mentor. PhD Student: Jeremiah Brown, Program in Biochemistry (University of Maryland School of Medicine), 4-6 hours per week. (Current position: QC Chemist at SPI Pharma).
2014-2020 Research Co-Mentor. PhD Student: Sarah Russell, Program in Biochemistry (University of Maryland School of Medicine), 1-2 hours per week.
2014-2018 Research Co-Mentor. PhD Student: Camilo Venegas, Program in Molecular Medicine (University of Maryland School of Medicine), 2-4 hours per week.
2015 Laboratory Rotation Co-Mentor. PhD Student: Stephen Pratt, Program in Biochemistry (University of Maryland School of Medicine), 1-2 hours/week for 2 months. (Postdoctoral Fellow at Genomics Institute of the Novartis Research Foundation).
2016-2020 Research Co-Mentor. PhD Student: Quinton Banks, Program in Biochemistry (University of Maryland School of Medicine), 4-5 hours per week. (Current position: Biomedical Associate at Milken Institute, D.C.).
2020-present Research Co-Mentor. PhD Student: Hugo Bibollet, Program in Biochemistry (University of Maryland School of Medicine), 4-8 hours per week.
Post-Graduate Teaching (role/student name/program, current position)
2007-2009 Research co-advisor, Henrietta Passanoz PhD. Interdisciplinary Training Program in Muscle Biology (University of Maryland School of Medicine), 1-2 hours per week. (Latest position: Research Associate at Department of Physiology and Biophysics, Robert Wood Johnson Medical School, NJ).
2009-2013 Research co-advisor, Rotimi Olojo, PhD. Interdisciplinary Training Program in Muscle Biology (University of Maryland School of Medicine), 4-6 hours per week. (Current position: Assistant Professor, Baltimore City Community Colleague, Baltimore, MD).
2021-2022 Research co-advisor, Audra Kramer, PhD. Interdisciplinary Training Program in Muscle Biology (University of Maryland School of Medicine), 2-4 hours per week. (Current position: Postdoctoral Fellow Department of Physiology, University of Maryland School of Medicine).
2023-present Research advisor, Giovanni Rosales, PhD. (University of Maryland School of Medicine), 4-6 hours per week.
Undergraduate Student Teaching/Mentoring
2010 Co-Mentor: National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), STEP-UP summer program.
Student: Ashwin Kadambi, daily interaction and training for the summer. (Current position: enrolled in Master of Public Health, Eastern Virginia Medical School, VA).
2011 Co-Mentor: Towson University Research Summer Program.
Student: Moses Demehin, daily interaction and training for the summer. (Current position: enrolled in Doctor of Pharmacy Program at University of Maryland School of Pharmacy).
Professional Activity
Editorship and Peer reviewing
2012-present Ad hoc Reviewer, Frontiers in Cell and Developmental Biology
2015-present Ad hoc Reviewer, Journal of Physiology
2015-present Ad hoc Reviewer, Journal of General Physiology
2015-present Ad hoc Reviewer, Frontiers in Physiology
2015-present Ad hoc Reviewer, Journal of Visual Experimentation
2015-present Ad hoc Reviewer, Frontiers in Cell Neuroscience
2015-present Ad hoc Reviewer, Physiological Reports
2016-present Ad hoc Reviewer, Skeletal Muscle
2016-present Guest Editor, Journal of Diabetes Research
2021-present Ad hoc Reviewer, Communications Biology
2021-present Ad hoc Reviewer, American Journal of Physiology
2021 Ad hoc Reviewer, International Journal of Molecular Sciences
2021 Ad hoc Reviewer, Frontiers in Pediatrics
2021 Ad hoc Reviewer, PLOS ONE
2021-present Ad hoc Reviewer, FASEB
2022 Ad hoc Reviewer, Frontiers in Surgery
2022 Ad hoc Reviewer, Aging and Disease
2022 Ad hoc Reviewer, Journal of Cell Physiology
2022-present Review Editor, Frontiers in Striated Muscle Physiology
2022-present Associate Editor, Frontiers in Stem Cell Research
2023-present Ad hoc Reviewer, FASEB BioAdvances
Reviewing Grants:
2018 Grant Reviewer, Medical Research Council, United Kingdom.
2022 NIH-Center for Scientific Review, Division of Neuroscience, Development and Aging (DNDA); Basic Neuroscience Review Branch: Neuronal Communications Study Section.
2023 French Muscular Dystrophy Association (AFM-Telethon). The Molecular and Physiopathological basis of other Neuro-Muscular Diseases Committee.
2024 NIH-Center for Scientific Review, Division of Musculoskeletal, Skin and Oral Sciences (MSOS); Review Branch: Skeletal Muslce Biology and Exercise Physiology (SMEP).
Organizer of Academic Meetings
2015 Chair: Gordon Research Seminar, preceding Gordon Research Conference: Muscle Excitation/Contraction Coupling.
Lab Techniques and Equipment
-Primary skeletal muscle cells and neuronal cultures
-iPSC neuronal cultures
-heterologous (HEK cells) and homologous (GLT myoblasts) expression systems
-Ca2+ imaging
-Electrophysiology
-Ultrafast confocal imaging
-Functional Site-Directed fluorometry in native and expression systems
-In vitro skeletal muscle functional assays
-In vivo muscle gene transfer
-Cellular microinjection and micromanipulation
Current and Past Laboratory Members
Current members
Megan Perry (PhD Student)
Hugo Bibollet (PhD Candidate)
Giovanni Rosales-Soto, PhD. (Postdoctoral Fellow)
Previous members
Daniel Bennett (Research Specialist)
Isabella Sterner (Research Assistant)