Daniel M. Harrison, MD

Dr. Harrison received his medical degree from the Albert Einstein College of Medicine in the Bronx, New York and completed a neurology residency at the Columbia University Medical Center in New York City, where he was chief resident. He holds board certification in neurology from the American Board of Psychiatry and Neurology and he received subspecialty training by completing a fellowship in neuroimmunology and neuroinfectious disease at the Johns Hopkins University School of Medicine.

Dr. Harrison is a Professor of Neurology at the University of Maryland School of Medicine. He has been on faculty here at UMSOM since 2015. Prior to that he was on faculty at the Johns Hopkins University School of Medicine from 2010 through 2015. Dr. Harrison directs an active research program focused on the development and validation of new techniques for imaging of the brain and spinal cord for application to multiple sclerosis research and clinical trials. Dr. Harrison's research program is currently focused on utilization of novel MRI techniques, including high-field, 7-tesla MRI for visualization of cortical pathology, neurodegeneration, and meningeal inflammation in multiple sclerosis. His lab also works on utilization of novel imaging techinques of the retina and visual pathways in MS and on machine learning based approaches to image analysis. Dr. Harrison is also an active investigator in the Maryland Center for MS clinical trials program.

Multiple Sclerosis, MRI, Neuroimaging, Clinical Trials

1. Harrison DM, Caffo B, Shiee N, Farrell JAD, Bazin PL, Farrell SK, Ratchford JN, Calabresi PA, Reich DS.  Longitudinal changes in diffusion-tensor-based quantitative MRI in multiple sclerosis.  Neurology.  2011;Jan 11;76(2):179-86.
2. Harrison DM, Gladstone DE, Hammond E, Cheng J, Jones RJ, Brodsky RA, Kerr D, McArthur JC, Kaplin A.  Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance.  Multiple Sclerosis.  2012 February;18(2):202-209.
3. Harrison DM, Oh J, Roy S, Wood ET, Whetstone A, Seigo M, Jones CK, Pham D, van Zijl P, Reich DS, Calabresi PA. Thalamic Lesions in multiple sclerosis by 7T MRI: clinical implications and relationship to cortical pathology. Multiple Sclerosis 2014: 21(9):1139-50.
4. Harrison DM, Roy S, Oh J, Izbudak I, Pham D, Courtney S, Caffo B, Jones CK, van Zijl P, Calabresi PA. Association of cortical lesion burden on 7T MRI with cognition and disability in multiple sclerosis. JAMA Neurology 2015; 72(9):1004-12.
5. Harrison DM, Li X, Liu H, Jones CK, Caffo B, Calabresi PA, van Zijl P. Lesion heterogeneity on high-field susceptibility MRI is associated with multiple sclerosis severity. Am J Neuroradiol 2016; 37(8):1447-53. PMID: 26939635
6. Harrison DM, Wang KY, Fiol J, Naunton K, Royal III W, Hua J, Izbudak I. Leptomeningeal enhancement at 7T in multiple sclerosis: frequency, morphology, and relationship to cortical volume. Journal of Neuroimaging 2017: 2017 Sep;27(5):461-468.
7. Jonas SN, Izbudak I, Frazier AA, Harrison DM. Longitudinal persistence of meningeal enhancement on postcontrast 7T 3D-FLAIR MRI in multiple sclerosis. AJNR Am J Neuroradiol. 2018 Oct;39(10):1799-1805. 
8. Ontaneda D, Raza PC, Mahajan KR, Arnold DL, Dwyer MG, Gauthier SA, Greve DN, Harrison DM, Henry RG, Li DKB, Mainero C, Moore W, Narayanan S, Oh J, Patel R, Pelletier D, Rauscher A, Rooney WD, Sicotte NL, Tam R, Reich DS, Azevedo CJ; North American Imaging in Multiple Sclerosis Cooperative (NAIMS). Deep grey matter injury in multiple sclerosis: A NAIMS consensus statement. Brain. 2021 Mar 23:awab132. doi: 10.1093/brain/awab132. Online ahead of print. 
9. Choi S, Spini M, Hua J, Harrison DM. Blood-brain barrier breakdown in non-enhancing multiple sclerosis lesions detected by 7-Tesla MP2RAGE ΔT1 mapping. PLoS One. 2021 Apr 26;16(4):e0249973. doi: 10.1371/journal.pone.0249973. eCollection 2021. 
10. Mizell R, Chen H, Lambe J, Saidha S, Harrison DM. Association of retinal atrophy with cortical lesions and leptomeningeal enhancement in multiple sclerosis on 7T MRI. Mult Scler. 2021 Jun 14:13524585211023343. doi: 10.1177/13524585211023343. 
11. Patel LD, Raghavan P, Tang S, Choi S, Harrison DM. Imaging of the meningeal lymphatic network in healthy adults: a 7T MRI study. Journal of Neuroradiology. 2023 Jun;50(4):369-376. 
12. Hammer DX, Kovalick K, Liu Z, Chen C, Saeedi OJ, Harrison DM. Cellular-level visualization of retinal pathology in multiple sclerosis with adaptive optics. Invest Ophthalmol Vis Sci. 2023;64(14):21. 
13. Harrison DM, Allette YM, Zeng Y, Cohen A, Dahal S, Choi S, Zhuo J, Hua J. Meningeal contrast enhancement in multiple sclerosis: assessment of field strength, acquisition delay, and clinical relevance. PLoS One. 2024 May 29;19(5):e0300298. doi: 10.1371/journal.pone.0300298. PMID: 38809920; PMCID: PMC11135724.