Update Your ProfileAcademic Title:
Associate Professor
Primary Appointment:
Medicine
Administrative Title:
Clinical Co-Director of Cardiovascular Medicine
Location:
Paca Pratt, 7-S-162
Phone (Primary):
(410) 328-9098
Fax:
(410) 328-1717
Education and Training
1994 B.A. Biology, Johns Hopkins University, Baltimore, MD
1998 M.D., University of Maryland School of Medicine, Baltimore, MD
1998 – 2001 Internship/Residency, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
2001 - 2003 Fellowship, Weill Medical College, Cornell University, New York, NY
Howard Gilman Institute for Valvular Heart Disease Cardiovascular Research Fellow, Division of Cardiovascular Pathophysiology, Department of Medicine
2003 - 2006 Cardiology Fellowship, Temple University Hospital
2006 – 2008 Fellowship, Interventional Cardiology, New York Presbyterian Hospital, Columbia University Medical Center
Biosketch
Anuj Gupta, MD, is an Associate Professor at the University of Maryland School of Medicine. An interventional cardiologist, he serves as clinical co-director of the Division of Cardiovascular Medicine at the University of Maryland School of Medicine. His primary focus is on the treatment of severe aortic stenosis in patients who are eligible for transcatheter aortic valve replacement (TAVR). In his role evaluating TAVR and related therapies, he is the site principal investigator for the PARTNER 2 trial, Early TAVR Trial, Galileo Trial, and the Medtronic low-risk, randomized trial for TAVR. In addition, he is involved in renal denervation studies, including the SYMPLICITY-HTN3 trial and Reduce HTN: Reinforce trial.
He is a past Governor of the Maryland Chapter of the American College of Cardiology, the professional society for cardiologists and related cardioavascular specialists. He is a principal in the Maryland Academic Consortium for Percutaneous Coronary Intervention Appropriateness and Quality (MACPAQ), a joint initiative between Johns Hopkins University School of Medicine and the University of Maryland School of Medicine to create a system of external peer review for PCI in the state of Maryland. External peer review, a state requirement for providing PCI services, demonstrates that hospitals in Maryland are providing appropriate, high-quality PCI services.
Research/Clinical Keywords
Aortic Stenosis TAVR Aortic Balloon Valvuloplasty Acute Coronary Syndrome
Highlighted Publications
Guo L, Akahori H, Harari E1, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R1, Mori H1, Kutyna MD1, Torii S1, Sakamoto A1, Choi CU2, Cheng Q1, Grove ML6, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV. CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. J Clin Invest. 2018 Feb 19.
Gupta A, Yeh R, Tamis-Holland JE, Patel SH, Guyton RA, Klein LW, Rab T, Kirtane AJ. Implications of Public Reporting of Risk-Adjusted Mortality following PCI: Misperceptions and Potential Consequences for High-Risk Patients including the Non-Surgical Patient. J Am Coll Cardiol Intv. 2016;9(20):2077-2085
Ghasemi Z, Jeon W, Kim CS, Gupta A, Rajamani R, Hahn JO. Observer-Based Deconvolution of Deterministic Input in Coprime Multichannel Systems With Its Application to Noninvasive Central Blood Pressure Monitoring. Journal of Dynamic Systems, Measurement and Control. Sept 2020, Vol 142 ; 091006-1
Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW. Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation. 2009 Jun 30;119(25):3198-3206
Gupta A, Mancini D, Kirtane AJ, Kaple RK, Apfelbaum MA, Kodali SK, Marboe C, Leon MB, Moses JW, Rabbani LE. Value of drug-eluting stents in cardiac transplant recipients. Am J Cardiol. 2009 Mar 1;103(5):659-66
Torii S, Jinnouchi H, Sakamoto A, Kutyna M, Cornelissen A, Kuntz S, Guo L, Mori H, Harari E, Paek KH, Fernandez R, Chahal D, Romero ME, Kolodgie FD, Gupta A, Virmani R, Finn AV. Drug-eluting coronary stents: insights from preclinical and pathology studies. Nat Rev Cardiol. 2019 Jul 25. doi: 10.1038/s41569-019-0234-x
Additional Publication Citations
Borer JS, Truter S, Herrold EM, Supino PG, Carter JN, Gupta A. The cellular and molecular basis of heart failure in regurgitant valvular diseases: the myocardial extracellular matrix as a building block for future therapy. Advances in Cardiology 2002; 39: 7-14.
Jain VK, Gupta A, Magrath IT. A rapid screening method for bacteria containing firefly luciferase plasmids. Biotechniques, 1993 Oct; 15(4): 600-2
Borer JS, Truter SL, Gupta A, Herrold EM, Carter JN, Lee E, Pitlor L. Heart failure in aortic regurgitation: the role of primary fibrosis and its cellular and molecular pathophysiology. Adv Cardiol. 2004; 41: 16-24.
Gupta A, Carter JN, Truter SL, Leer EH, Herrold EM, Borer JS. Cellular response of human cardiac fibroblasts to mechanically simulated aortic regurgitation. Am J Ther. 2006 Jan-Feb; 13 (1): 8-11.
Gupta A, Burke JA, and Bove A. Coronary Artery Revascularization—Past, Present Future. Part 1: Historical Trials. Clin. Cardiol. 29, 341–344 (2006)
Gupta A, Burke JA, and Bove A. Coronary Artery Revascularization—Past, Present Future. Part 2: Newer Technologies. Clin. Cardiol. 29, 290–294 (2006)
Supino PG, Borer JS, Schuleri K, Gupta A, Hochreiter C, Kligfield P, Herrold EM, Preibisz JJ. Prognostic value of exercise tolerance testing in asymptomatic chronic nonischemic mitral regurgitation. Am J Cardiol. 2007 Oct 15;100(8):1274-81
Solinas E, Dangas G, Kirtane AJ, Lansky AJ, Franklin-Bond T, Boland P, Syros G, Kim YH, Gupta A, Mintz G, Fahy M, Collins M, Kodali S, Stone GW, Moses JW, Leon MB, Mehran R. Angiographic patterns of drug-eluting stent restenosis and one-year outcomes after treatment with repeated percutaneous coronary intervention. Am J Cardiol. 2008 Aug 1;102(3):311-315
Truter SL, Catanzaro DF, Supino PG, Gupta A, Carter J, Herrold EM, Dumlao TF, Borer JS. Differential expression of matrix metalloproteinases and tissue inhibitors and extracellular matrix remodeling in aortic regurgitant hearts. 2009;113(3):161-168
Truter SL, Catanzaro DF, Supino PG, Gupta A, Carter J, Ene AR, Herrold EM, Dumlao TF, Beltran F, Borer JS. Fibronectin gene expression in aortic regurgitation: relative roles of mitogen-activated protein kinases. 2009;113(4):291-298
Gupta A, Mancini D, Kirtane AJ, Kaple RK, Apfelbaum MA, Kodali SK, Marboe C, Leon MB, Moses JW, Rabbani LE. Value of drug-eluting stents in cardiac transplant recipients. Am J Cardiol. 2009 Mar 1;103(5):659-662
Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW. Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. 2009 Jun 30;119(25):3198-3206
Cilingiroglu M, Gupta A. The laa occlusion paradigm: are we there yet? Catheter Cardiovasc Interv. 2011 Nov 15;78(6):974-5
Sanidas EA, Maehara A, Mintz GS, Kubo T, Gupta A, Apfelbaum MA, Hakim D, Moses JW, Mancini DM, Rabbani LE. Volumetric intravascular ultrasound assessment of mechanisms and results of stent expansion in heart transplant patients. Catheter Cardiovasc Interv. 2012 Mar 28
Remo BF, Preminger M, Bradfield J, Mittal S, Boyle N, Gupta A, Shivkumar K, Steinberg JS, Dickfeld T. Safety and Efficacy of Renal Denervation as a Novel Treatment for Ventricular Tachycardia Storm in Patients with Cardiomyopathy. Heart Rhythm 2014 Apr;11(4):541-546
Godiwala T, Srivastava M, Gupta A. Reperfusion Strategies and Systems of Care in ST- Elevation Myocardial Infarction. Cardiology Clinics 2012: 30 (4), 629-637
Motwani M, Motlagh M, Gupta A, Berman DS, Slomka P. Reasons and implications of agreements and disagreements between coronary flow reserve, fractional flow reserve, and myocardial perfusion imaging. Journal of Nuclear Cardiology. Online December 29, 2015
Rollor J, Feldmeier R, Jerome S, Gupta A. Reconciling discordant myocardial perfusion imaging and coronary angiography. Journal of Nuclear Cardiology. Accepted December 18th, 2015
Gupta A, Rajagopalan S. Letter by Gupta regarding article, "Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011: Evidence for Stagnation in Young Adults, Especially Women". Accepted November 29th, 2015
Gupta A, Yeh R, Tamis-Holland JE, Patel SH, Guyton RA, Klein LW, Rab T, Kirtane AJ. Implications of Public Reporting of Risk-Adjusted Mortality following PCI: Misperceptions and Potential Consequences for High-Risk Patients including the Non-Surgical Patient. J Am Coll Cardiol Intv. 2016;9(20):2077-2085
Lingel J, Srivastava M, Gupta A. Management of coronary artery disease and acute coronary syndrome in the chronic kidney disease population-A review of the current literature. Hemodial Int.2017 Jan 17
George P, Srivastava MC, Ludmir J, Reed RM, Tewelde SZ, Gupta A, McCurdy MT. “Augmenting Function for Infarction from Infection: Impella 2.5 for Ischemic Cardiogenic Shock Complicating Sepsis,” Case Reports in Cardiology, vol. 2017, Article ID 8407530, 4 pages, 2017
Mori H, Gupta A, Torii S, Harari E, Jinnouchi H, Virmani R, Finn AV. Clinical Implications of Blood- Material Interaction and Drug Eluting Stent Polymers in Review. Expert Rev Med Devices. 2017 Aug 11 :1-10.
Mori H, Otsuka F, Gupta A, Jinnouchi H, Torii S, Harari E, Virmani R, Finn AV. Revisiting the role of durable polymers in cardiovascular devices. Expert Rev Cardiovasc Ther. 2017 Nov;15(11):835-846
Sakamoto A, Virmani R, Finn AV, Gupta A. Calcified Nodule as the Cause of Acute Coronary Syndrome: Connecting Bench Observations to the Bedside. 2018 Jan 5;139(2):101-104
Guo L, Akahori H, Harari E1, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R1, Mori H1, Kutyna MD1, Torii S1, Sakamoto A1, Choi CU2, Cheng Q1, Grove ML6, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV. CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. J Clin Invest. 2018 Feb 19.
Ludmir J, Liu X, Gupta A, Ramani GV, Liu SS, Zakaria S, Verceles AC, Shah NG, McCurdy MT, Dammeyer JA, Netzer G. Cardiologist perceptions of family-centered rounds in cardiovascular clinical care. Open Heart. 2018 Sep 5;5(2):e000834
Jinnouchi H, Mori H, Cheng Q, Kutyna M, Torii S, Sakamoto A, Guo L, Acampado E, Gupta A, Kolodgie FD, Virmani R, Finn AV. Thromboresistance and Functional Healing in the COBRA PzF Stent versus Competitor DES: Implications for Dual Anti-Platelet Therapy. 2018 Oct 30
Harari E, Guo L,Smith SL, Paek KH, Fernandez R, Sakamoto A, Mori H, Kutyna MD, Habib A, Torii S, Cornelissen A, Jinnouchi H, Gupta A, Kolodgie FD, Virmani R, Finn AV. Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2217-2224
Srivastava M, Varrichio C, Gupta A. Same-Day Discharge After Percutaneous Coronary Intervention—An Elusive Bargain. JAMA Cardiol. 2019;4(5):495-496
Zhang J, Khalifeh A, Dominguez RS, Bruno D, Gupta A, Toursavadkohi S. Endovascular Reconstruction of the Hepatic Arteries for the Management of Mycotic Hepatic Artery Pseudoaneurysm in a Liver Transplant Patient. Annals of Vascular Surgery. 2019 Nov; 61: e7-473
Torii S, Jinnouchi H, Sakamoto A, Kutyna M, Cornelissen A, Kuntz S, Guo L, Mori H, Harari E, Paek KH, Fernandez R, Chahal D, Romero ME, Kolodgie FD, Gupta A, Virmani R, Finn AV. Drug-eluting coronary stents: insights from preclinical and pathology studies. Nat Rev Cardiol. 2019 Jul 25. doi: 10.1038/s41569-019-0234-x
Aghdassi A, Gupta A. Endomyocardial Biopsy : Examining Indications and Trends in Use—More Native Heart Biopsies to Come? Cardiology 142 (2), 102-104, 2019
Mondal S, Dawood M, Bandyopadhyay D, Taylor B, Tanaka K, Gupta A. Transcatheter aortic valve replacement: A potential option for aortic insufficiency management in patients with left ventricular assist device. IJC Heart & Vasculature, Volume 26, 2020, 100425.
Restrepo AJ, Chahal D, Gupta A. Roadmap to Success : 3D Printing in Pre-Procedural Planning. J Am Coll Cardiol Case Rep. 2020 Mar, 2 (3) 358-360.
Ahmed T, Shkullaku M, Chahal D, Dawood M, Gupta A. Triple Valve Replacement in a Patient with Severe Combined Aortic and Mitral Stenosis. Cureus 12 (3), 2020
Ahmed T, Chahal D, Shkullaku M, Gupta A. Extensive coil embolization of a giant coronary artery aneurysm in an octogenarian: a case report. European Heart Journal Case Reports. 03 May 2020
Ghasemi Z, Jeon W, Kim CS, Gupta A, Rajamani R, Hahn JO. Observer-Based Deconvolution of Deterministic Input in Coprime Multichannel Systems With Its Application to Noninvasive Central Blood Pressure Monitoring. Journal of Dynamic Systems, Measurement and Control. Sept 2020, Vol 142 ; 091006-1
Ahmed T, Chahal D, Madathil R, Kaczorowski D, Gupta A. Percutaneous Coronary Intervention (PCI) Strategies under Hemodynamic Support for Cardiogenic Shock: A Single-Center Experience with Two Patients. Case Reports in Cardiology. Volume 2020. Article ID 6260239
Ghoreishi M, Shah A, Jeudy J, Pasrija C, Lebowitz J, Kaczorowski D, Gupta A, Toursavadkohi S, Taylor B. Endovascular Repair of Ascending Aortic Disease in High-Risk Patients Yields Favorable Outcome. Annals of Thoracic Surgery. Volume 109, Issue 3, March 2020 ; 678-685
Research Interests
Multicenter clinical trials evaluating the efficacy of transcatheter aortic valve replacement systems for the treatment of severe, symptomatic aortic stenosis in patients at various risk for surgical aortic valve replacement forms the bulwark of my research efforts.
In addition, efforts to reduce renal toxicity by contrast preservation methods in patients being evaluated for TAVR has formed a secondary interest. These patients, often elderly with renal dysfunction, benefit from efforts to reduce contrast exposure.
As external peer review establishes itself in the state of Maryland, future efforts will evaluate Appropriate Use Criteria in the context of interventional cardiology reviewed PCI procedures.
Clinical Specialty Details
My main clinical specialties include treatment of coronary disease for acute coronary syndrome, cardiogenic shock, and cardiac arrest, as well as patients declined by cardiac surgery due to patient's high surgical risk. In addition, I have established, since its inception and along with my surgical colleagues, the Transcatheter Aortic Valve Replacement program at the University of Maryland.
Awards and Affiliations
2001 Outstanding Achievement in the Teaching of Medical Students, Leo M. Davidoff Society of the Albert Einstein College of Medicine of Yeshiva University
2012 Teacher of the Year Award, University of Maryland Division of Cardiology
2008-Present Fellow of the American College of Cardiology
2008-Present Fellow of the Society for Coronary Angiography and Intervention