Stephen S. Gottlieb, MD

• AB, Brown University, Providence, RI
• MD, Brown University Program in Medicine, Providence, RI
• Internship and Residency, Internal Medicine, University of Chicago Hospital and Clinics, Chicago, IL
• Fellowship, Cardiology, Mount Sinai Medical Center, New York, NY

Board Certification

• Internal Medicine
• Cardiovascular Disease
• Advanced Heart Failure and Transplant Cardiology

Dr. Gottlieb’s investigations center on the physiology of congestive heart failure (CHF). This has included a particular interest in neurohormonal activation in CHF patients. Dr. Gottlieb was the United States principal investigator for MERIT, an international beta blocker survival trial in heart failure patients. He was also co-chairman of the mortality committee of BEST, a National Institutes of Health (NIH) and Veterans Affairs (VA) sponsored study of a different beta blocker. In addition, with the support of the local AHA, he is looking at the mechanism by which beta blockers may be effective. Other neurohormonal interests include investigation of vasopressin antagonists, adenosine antagonists, and endothelin antagonists.

Dr. Gottlieb is particularly interested in the interaction of heart failure and renal dysfunction, having studied the impact of various medications on renal function and the physiology of renal function in heart failure patients. Similarly, he is investigating the best ways to treat fluid overload, a common problem in patients with heart failure. He is actively involved in the investigation of left ventricular assist devices, investigational agents, and home telemonitoring in heart failure patients. In addition, he evaluates sleep abnormalities and the interaction of physiology and psychology in heart failure patients. He also works on the detection and treatmentof amyloidosis.

Cardiorenal syndrome, Cardiac Amyloidosis, Cardiomyopathy, Heart Failure

• Gottlieb SS, Ahmed T. Perfection is the Enemy of Good: Consider Everything When Prescribing Sacubitril/Valsartan.,  J Am Coll Cardiology. 2020;  76:1049-1050
• Ton VK, Patel S, Gottlieb SS. Carpal Tunnel Syndrome and Future Amyloidosis: Time to Heed the Warning Sign. J Am Coll Cardiol. 2019; 74(1):24-25. 10.1016/j.jacc.2019.04.055.
• Husam Abdel-Qadir H, Gottlieb SS. Trajectories of Renal Function During Heart Failure Hospitalization: Beware the Bumpy Ride! J Card Fail. 2019
• Psotka MA, Gottlieb SS, Francis GS, Allen LA, Teerlink JR, Adams KF Jr, Rosano GMC, Lancellotti P. Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. J Am Coll Cardiol. 2019;73:2345-2353.
• Oates CP, Ananthram M, Gottlieb SS. Management of Sleep Disordered Breathing in Patients with Heart Failure. Curr Ht Fail Rep; 2018. 15:123-130.
• Laliberte B, Reed BN, Devabhakthuni S, Watson K, Ivaturi V, Liu T, Gottlieb SS. Observation of Patients Transitioned to an Oral Loop Diuretic Prior to Discharge and Risk of Readmission for Acute Decompensated Heart Failure. J Card Failure. 2017; 23:746-752.
• Gottlieb SS. The Risks of Big Databases: Why Do Married People Drown in Kentucky? J Card Fail; 2018. Jul;24(7):451-452.
• Wawrzyniak AJ, Dilsizian V, Krantz, DS, Harris KM, Smith MF, Shankovich A, Whittaker KS, Rodriguez GA, Gottdiener J, Shuying Li S, Kop W, Gottlieb SS. High concordance between mental stress-induced and adenosine-induced myocardial ischemia assessed using SPECT in heart failure patients: Hemodynamic and biomarker correlates. J Nucl Med 2015; 56:1527-33.
• Blum Q, Gottlieb SS. The Effect of a Randomized Trial of Home Telemonitoring on Medical Costs, 30-Day Readmissions, Mortality and Health Related Quality of Life in a Cohort of Community Dwelling Heart Failure Patients.  J Card Failure. 2014;  20:513-21.