Update Your ProfileAcademic Title:
Professor Emeritus
Primary Appointment:
Anesthesiology
Secondary Appointment(s):
BioChemistry&Molecular Biology, Pharmacology
Administrative Title:
Vice Chair
Research/Clinical Keywords
pathophysiology of both ischemic and traumatic brain injury, relationships between injury to the brain and multiple organ failure
Highlighted Publications
Suen AO, Chen F, Wang S, Li Z, Zhu J, Yang Y, Conn O, Lopez K, Cui P, Wechsler L, Cross A, Fiskum G, Kozar R, Hu P, Miller C, Zou L, Williams B, Chao W. Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma. J Immunol. 2023 May 3. PMID: 37133342.
Brammer J, Wolf G, Baliban SM, Allen JC, Choi M, Kambouris AR, Simon R, Fiskum G, Chao W, Lopez K, Miller C, Singh NJ, Cross AS. A non-lethal full-thickness flame burn produces a seroma beneath the forming eschar thereby promoting Pseudomonas aeruginosa sepsis in mice. J Burn Care Res. PMID: 34739051. 2021
Lopez K, Suen A, Yang Y, Wang S, Williams B, Zhu J, Hu J, Fiskum G, Cross A, Kozar R, Miller C, Zou L, Chao W. Hypobaria Exposure Worsens Cardiac Function and Endothelial Injury in an Animal Model of Polytrauma: Implications for Aeromedical Evacuation. Shock. 2020 Dec 23; PMID: 33394971.
Tchantchou F, Puche AA, Leiste U, Fourney W, Blanpied TA, Fiskum G. Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs. J Neurotrauma. 2018;35(10):1192-1203.
Malinow AM, Schuh RA, Alyamani O, Kim J, Bharadwaj S, Crimmins SD, Galey JL, Fiskum G, Polster BM. Platelets in preeclamptic pregnancies fail to exhibit the decrease in mitochondrial oxygen consumption rate seen in normal pregnancies. Biosci Rep. 2018;38(3):BSR20180286.
Additional Publication Citations
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolanos JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Dussmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordan J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018;25(3):542-572.
Choi M, Tamrakar P, Schuck PF, Proctor JL, Moore A, Asbury K, Fiskum G, Coksaygan T, Cross AS. Effect of hypobaria and hyperoxia during sepsis on survival and energy metabolism. J Trauma Acute Care Surg. 2018;Publish Ahead of Print.
Proctor JL, Mello KT, Fang R, Puche AC, Rosenthal RE, Fourney WL, Leiste UH, Fiskum G. Aeromedical evacuation-relevant hypobaria worsens axonal and neurologic injury in rats after underbody blast-induced hyperacceleration. J Trauma Acute Care Surg. 2017;83(1 Suppl 1):S35-S42.
Chandrasekaran K, Muragundla A, Demarest TG, Choi J, Sagi AR, Najimi N, Kumar P, Singh A, Ho C-Y, Fiskum G, Koch LG, Britton SL, Russell JW. mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. Annals of clinical and translational neurology. 2017;4(12):844-858.
DeVience SJ, Lu X, Proctor J, Rangghran P, Melhem ER, Gullapalli R, Fiskum GM, Mayer D. Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate. Sci Rep. 2017;7(1):1907.
Brix KA, Brody DL, Grimes JB, Yitzhak A, Agoston D, Aldag M, Armstrong R, Arun P, Audette M, Babcock D, Balaban C, Banton R, Bellgowan P, Borkholder D, Broglio S, Brokaw E, Cantu R, Carr W, Chapman S, Cmarik J, Colder B, Colombe J, Cook D, Cozzarelli T, Da Silva UO, Daphalapurkar N, Dardzinski B, DeGraba T, DeMar J, DeWitt D, Dickstein D, Duckworth J, Elder G, Fazel-Rezai R, Fine M, Fiskum G, et al. Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations. J Neurotrauma. 2017;34(S1):S18-S25.
Tang S, Xu S, Fourney WL, Leiste UH, Proctor JL, Fiskum G, Gullapalli RP. Central Nervous System Changes Induced by Underbody Blast-Induced Hyperacceleration: An in Vivo Diffusion Tensor Imaging and Magnetic Resonance Spectroscopy Study. J Neurotrauma. 2017;34(11):1972-1980.
Demarest TG, Waite EL, Kristian T, Puche AC, Waddell J, McKenna MC, Fiskum G. Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia-ischemia. Neuroscience. 2016;335:103-113.
Tchantchou F, Fourney WL, Leiste UH, Vaughan J, Rangghran P, Puche A, Fiskum G. Neuropathology and neurobehavioral alterations in a rat model of traumatic brain injury to occupants of vehicles targeted by underbody blasts. Exp Neurol. 2017;289:9-20.
Andreyev A, Tamrakar P, Rosenthal RE, Fiskum G. Calcium uptake and cytochrome c release from normal and ischemic brain mitochondria [Internet]. Neurochemistry International. 2017. Available from: http://www.sciencedirect.com/science/article/pii/S0197018617304473
Research Interests
The primary goal of the Fiskum lab is to improve the understanding of the pathophysiology of both ischemic and traumatic brain injury and relationships between injury to the brain and multiple organ failure.