Montasir Elahi, D.Eng.

Alzheimer's disease, Tauopathy, Diabetes, Protein, Protein aggregation

 1Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Koichi Ishiguro, Yuzuru Imai, Nobutaka Hattori “Serum/Glucocorticoid Regulated Kinase 1 activated by high fat diet is involved in the etiology of Alzheimer's disease through the acceleration of Tau pathology”. Human Molecular Genetics-in pres, https://doi.org/10.1093/hmg/ddab115

2.Mohammad Nasir Uddin, Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori “Clearance of Seed-Dependent Tau Aggregation by Lithium-Induced Autophagy: Implications of Strain-Specificity” (Biochemical, biophysical research communication-BBRC in press)

3. Tetsuo Hayashi; Shotaro Shimonaka; Montasir Elahi; Shin-Ei Matsumoto; Koichi Ishiguro; Nobutaka Hattori; Yumiko Motoi “Learning deficits accompanied by microglial proliferation after the long-term post-injection of Alzheimer’s brain extract in mouse brains” (Journal of Alzheimer’s disease in press)

4.Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori “The Asn³⁶⁸ in the fourth repeat region of tau is a key residue to determine strain-specific tau aggregation in different tauopathies” (Journal of Biological Chemistry-2020 Aug 5;jbc.RA120.013271. doi: 10.1074/jbc.RA120.013271. Online ahead of print)

5.Sachiko Nakayama, Shotaro Shimonaka, Montasir Elahi, Kenya Nishioka, Yutaka Oji, Shin-Ei Matsumoto, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Taku Hatano, Takeshi Sato, Teikichi Ikura, Nobutoshi Ito, Yumiko Motoi, Nobutaka Hattori.” Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism”.” Neurobiology of Aging”, Volume 84,2019, Pages 240-249, DOI: 10.1016/j.neurobiolaging.2019.02.016, PMID: 31027853 (https://www.ncbi.nlm.nih.gov/pubmed/31027853)

6.Aya Ikeda, Kenya Nishioka, Hongrui Meng, Masashi Takanashi, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Yuanzhe Li, Kei-ichi Ishikawa, Masato Hasegawa, Montasir Elahi, Manabu Funayama, Hideyuki Okano,Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori “Mutations in CHCHD2 accelerate α-synuclein aggregation” -Human molecular Genetics- Volume 28, Issue 23, December 2019, Pages 3895–3911, DOI: 10.1093/hmg/ddz241, PMID: 31600778

7.Monastir Elahi, Yumiko Motoi, Koichi Ishiguro, Nobutaka Hattori.” Serum/Glucocorticoid Regulated Kinase 1 (SGK1), Tau Pathology and Cognitive Dysfunction in High-Fat Diet-Fed Tauopathy Model Mice”.” Alzheimer’s and Dementia”, Volume 13, Issue 7,2017, Page 1504

8.Montasir Elahi, Hassan Zafrul, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattori (2015). “Region-specific vulnerability of Neuroinflammation, Oxidative Stress and Tau Hyperphosphorylation in Experimental Diabetes Mellitus mice”　“Journal of Alzheimer’s disease (JAD)”- Volume 51 Number4, 2016, Pages 1209-1224, DOI: 10.3233/JAD-150820, PMID:26923011(http://www.ncbi.nlm.nih.gov/pubmed/26923011)

9. Montasir Elahi,　Yumiko Motoi, Shin-Ei Matsumoto, Zafrul Hasan, Koichi Ishiguro, Nobutaka Hattori (2015). “Short-term Treadmill Exercise Increased Tau Insolubility and Neuroinflammation in Tauopathy Model Mice”-Neuroscience letters- DOI:10.1016/j.neulet.2015.11.010 Volume 610,January 2016, Pages 207–212, PMID: 26592481. (http://www.ncbi.nlm.nih.gov/pubmed/26592481)\

10. Yuko Hara, Yumiko Motoi, Keigo Hikishima, Hirotaka Onoe, Shin-Ei Matsumoto, Montasir Elahi, Hideyuki Okano, Shigeki Aoki, Nobutaka Hattori,(2016) ”Selective Involvement of the Septo-hippocampal Fiber Tract and Upregulation of Acetylcholinesterase in Tauopathy model mice” Current Alzheimer’s Research. DOI: 2174/1567205013666160602235800, Volume 13, Issue 12, June 2016, Pages, PMID: 27335039,

11.Manjiri R. Kulkarni, Monirul M. Islam, Nobutaka Numoto, Montasir Elahi, Mamunur R. Mahib, Nobutoshi Ito and Yutaka Kuroda (2015) “Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants” Biochim Biophys Acta: Proteins and Proteomics.-DOI:10.1016/j.bbapap.2015.07.004, Volume 1854, Issue 10, October 2015, Pages 1438–1443 PMID: 26160751. (http://www.ncbi.nlm.nih.gov/pubmed/26160751)

12. Montasir Elahi, Monirul M. Islam, Keiichi Noguchi, Masafumi Yohda, Hiroyuki Toh, Yutaka Kuroda.(2014).“Computational prediction and experimental characterization of a “size switch type repacking” during the evolution of dengue envelope protein domain III (ED3)” “Biochim Biophys Acta: Proteins and Proteomics”, DOI: 10.1016/j.bbapap.2013.12.013, Volume 1844, Issue 3, March 2014, Pages 585–592, PMID: 24373879.( http://www.ncbi.nlm.nih.gov/pubmed/24373879 )

13.Montasir Elahi, Monirul M. Islam, Keiichi Noguchi, Masafumi Yohda, Yutaka Kuroda (2013). “High resolution crystal structure of dengue-3 envelope protein domain III (ED3) suggests possible molecular mechanisms for serospecific antibody recognition.”Proteins: Structure function and Bioinformatics. DOI:10.1002/ prot. 24237,Volume 81, Issue 6, pages 1090–1095, June 2013, PMID: 23239402.( http://www.ncbi.nlm.nih.gov/pubmed/23239402 )

14.Shakhinur Islam Mondal, Montasir Elahi, Zabed Mahmud, Arzuba Akter, Nurnabi Azad Jewel, Md. Muzahidul Islam, Sabiha Ferdous “Intra-inter species protein interactions revealed the potential drug targets and the effective drug design for Escherichia coli O104:H4 C277-11 (Broad)”- (Equal contribution and corresponding author) “In silico Pharmacology”- 2016 Dec;5(1):1. DOI: 10.1007/s40203-017-0021-5. Epub 2017 Apr 11, PMID: 28401513.