Update Your ProfileAcademic Title:
Research Associate
Primary Appointment:
Microbiology and Immunology
Location:
Health Sciences Facility III, 670 W. Baltimore Street, Baltimore, MD - 21201
Phone (Primary):
(410) 706-6782
Education and Training
2021 - 2023 Staff scientist, Bioinformatics Analyst II, Institute for Genome Sciences, University of Maryland School of Medicine (UMSOM), Baltimore, Maryland, USA (Advisor: Joana C. Silva, Ph.D.)
2017 - 2021 Postdoctoral researcher, Comparative genomics and population genetics, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA (Advisor: Joana C. Silva, Ph.D.)
2013 - 2016 Ph.D., Health Biology (Parasitology and Bioinformatics), Institut de Biologie Computationnelle (IBC) / Institut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, Montpellier, France (Advisors: Emmanuel Cornillot, Ph.D. & Christelle Reynes, Ph.D.)
2007 - 2012 BS-MS Dual Degree, Applied Mathematics and Biology, Indian Institute of Science Education and Research - Pune, Pune, Maharashtra, India (Advisor: Pranay Goel, Ph.D.)
Biosketch
I am a computational biologist, developing tools and implementing population genetics and evolutionary genomics approaches to understand evolution and transmission of infectious disease pathogens. My prime research focus is Malaria, specifically Plasmodium falciparum (Pf) Malaria, which represents a major health burden for developing countries. In addition to studying evolution of Pf and its populations, I identify targets to be validated for vaccine design and efficacy. I have been working in the field of Pf malaria for more than 10 years. During my graduate research I worked on characterizing Pf parasite populations of Cambodia in the context of anti-malarial drug resistance (Artemisinin derivatives and partner drugs) and identifying causative mutations and the metabolic pathways to which mutated genes belong. Since my training as a post-doctoral researcher, my research is focused on identifying selection pressure shaping the evolution of Pf populations and use of comparative genomics approaches to identify the genetic basis of a variety of Pf phenotypic traits. The developed analyses approaches are transferrable to study of other parasite genera, like Babesia.
I am involved in development and implementation of a variety of bioinformatics pipelines and have worked with high-throughput genomic and transcriptomics data from different malaria transmission settings to identify targets contributing to drug resistance mechanism, host-vector interactions and associated with vaccine-induced protection. I have exposure in the fields of epidemiology, immunology, biostatistics and analysis of sequencing data from clinical samples and vaccine trials.
My research objective is to understand the evolution and transmission of infectious disease pathogens worldwide.
Research/Clinical Keywords
Malaria, Plasmodium falciparum, Plasmodium, Babesia, Evolution, Population genetics, Genomics
Highlighted Publications
Mbambo G, Dwivedi A, Ifeonu OO, Munro JB, Shrestha B, Bromley RE, Hodges T, Adkins RS, Kouriba B, Diarra I, Niangaly A, Kone AK, Coulibaly D, Traore K, Dolo A, Thera MA, Laurens MB, Doumbo OK, Plowe CV, Berry AA, Travassos M, Lyke KE, Silva JC. Immunogenomic profile at baseline predicts host susceptibility to clinical malaria. Front Immunol. 2023;14:1179314. doi: 10.3389/fimmu.2023.1179314. eCollection 2023. PubMed PMID: 37465667; PubMed Central PMCID: PMC10351378.
Molina-Cruz A, Canepa GE, Dwivedi A, Liu W, Raytselis N, Antonio-Nkondjio C, Hahn BH, Silva JC, Barillas-Mury C. Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213626120. doi: 10.1073/pnas.2213626120. Epub 2023 Jan 23. PubMed PMID: 36689648; PubMed Central PMCID: PMC9945982.
Silva JC, Dwivedi A, Moser KA, Sissoko MS, Epstein JE, Healy SA, Lyke KE, Mordmüller B, Kremsner PG, Duffy PE, Murshedkar T, Sim BKL, Richie TL, Hoffman SL. Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa. Nat Commun. 2022 Jun 13;13(1):3390. PubMed Central PMCID: PMC9189790.
Moser KA, Drábek EF, Dwivedi A, Stucke EM, Crabtree J, Dara A, Shah Z, Adams M, Li T, Rodrigues PT, Koren S, Phillippy AM, Munro JB, Ouattara A, Sparklin BC, Dunning Hotopp JC, Lyke KE, Sadzewicz L, Tallon LJ, Spring MD, Jongsakul K, Lon C, Saunders DL, Ferreira MU, Nyunt MM, Laufer MK, Travassos MA, Sauerwein RW, Takala-Harrison S, Fraser CM, Sim BKL, Hoffman SL, Plowe CV, Silva JC. Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential. Genome Med. 2020 Jan 8;12(1):6. PubMed Central PMCID: PMC6950926.
Dwivedi A, Reynes C, Kuehn A, Roche DB, Khim N, Hebrard M, Milanesi S, Rivals E, Frutos R, Menard D, Mamoun CB, Colinge J, Cornillot E. Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia. Malar J. 2017 Dec 19;16(1):493. PubMed Central PMCID: PMC5735551.
Additional Publication Citations
E. Potter, V. Callier, B. Shrestha, S. Joshi, A. Dwivedi, J. C. Silva, M. B. Laurens, D. A. Follmann, G. A. Deye, Can incorporating genotyping data into efficacy estimators improve efficiency of early phase malaria vaccine trials?, Malaria Journal, 22:383, December 2023.
Moita, T. G. Maia, M. Duarte, C. M. Andrade, I. S. Albuquerque, A. Dwivedi, J. C. Silva, L. González-Céron, C. J. Janse, A. M. Mendes, M. Prudêncio, A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria, npj Vaccines, 7, 163, December 2022.
C. Stabler, A. Dwivedi, B. Shrestha, S. Joshi, T. Schindler, A. Ouattara, G. A. Garcia, C. Daubenberger, J. C. Silva, Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparum, Malaria Journal, 21, 357, November 2022.
Ouattara, A. Dwivedi, M. Adams, A. Niangaly, M. B. Laurens, M. M. Nyunt, C. V. Plowe, A. Djimde, S. Takala-Harrison, J. C. Silva, An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes, Microorganisms, 10(6), 1090, May 2022.
Ayithan, A. Ghosh, A. Dwivedi, J. J. Wallin, S. K. Tan, D. Chen, S. Kottilil, B. Poonia, Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans, Viruses, 13(12), 2400, November 2021.
M. Stucke, A. Dara, A. Dwivedi, T. K. Hodges, S. Ott, D. Coulibaly, A. K. Koné, K. Traoré, B. Guindo, B. M. Tangara, A. Niangaly, M. Daou, I. Diarra, Y. Tolo, M. Sissoko, L. Tallon, L. Sadzewicz, A. E. Zhou, M. B. Laurens, A. Ouattara, B. Kouriba, O. K. Doumbo, S. Takala-Harrison, D. Serre, C. V. Plowe, M. A. Thera, M. A. Travassos, and J. C. Silva, Successful Profiling of Plasmodium falciparum var Gene Expression in Clinical Samples via a Custom Capture Array, mSystems, e00226-21, November 2021.
Molina-Cruz, N. Raytselis, R. Withers, A. Dwivedi, P. D. Crompton, B. Traore, G. Carpi, J. C. Silva, and C. Barillas-Mury, A genotyping assay to determine geographic origin and transmission potential of Plasmodium falciparum malaria cases, Nature Communications Biology, 4, Article number: 1145, September 2021.
Oberstaller, L. Zoungrana, C. D. Bannerman, S. Jahangiri, A. Dwivedi, J. C. Silva, J. H. Adams, and S. Takala-Harrison, Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum, International Journal for Parasitology: Drugs and Drug Resistance, Volume 16: Pages 119-128, August 2021.
Shah, M. T. Naung, K. A. Moser, M. Adams, A. G. Buchwald, A. Dwivedi, A. Ouattara, K. B. Seyde, D. P. Mathanga, A. E. Barry, D. Serre, M. K. Laufer, J. C. Silva, and S. Takala-Harrison, Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies targets of allele-specific immunity to clinical malaria, PLOS Genetics, 17(5): e1009576, May 2021.
M. Mendes, M. Machado, N. Gonçalves-Rosa, I. J. Reuling, L. Foquet, C. Marques, A. M. Salman, A. SP. Yang, K. A. Moser, A. Dwivedi, C. C. Hermsen, B. Jiménez-Díaz, S. Viera, J. M. Santos, I. Albuquerque, S. N. Bhatia, J. Bial, I. Angulo-Barturen, J. C. Silva, G. Leroux-Roels, C. J. Janse, S. M. Khan, M. M. Mota, R. W. Sauerwein, and M. Prudêncio, A Plasmodium berghei sporozoite-based vaccination platform against human malaria, NPJ Vaccines, 3(1):33, August 2018.
Agrawal, K. A. Moser, L. Morton, M. P. Cummings, A. Parihar, A. Dwivedi, A. C. Shetty, E. F. Drabek, C. G. Jacob, P. P. Henrich, C. M. Parobek, K. Jongsakul, R. Huy, M. D. Spring, C. A. Lanteri, S. Chaorattanakawee, C. Lon, M. M. Fukuda, D. L. Saunders, D. A. Fidock, J. T. Lin, J. J. Juliano, C. V. Plowe, J. C. Silva, and S. Takala-Harrison, Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity, The Journal of Infectious Diseases, 216(4): 468-476, July 2017.
N. Duy, P. Ravel, A. Dwivedi, O. M. Sessions, Y. Hou, R. Chua, G. Kister, A. Afelt, C. Moulia, D. J. Gubler, V. D. Thiem, N. T. H. Thanh, C. Devaux, T. N. Duong, N. T. Hien, E. Cornillot, L. Gavotte, and R. Frutos, Valine/isoleucine variants drive selective pressure in the VP1 sequence of EV-A71 enteroviruses, BMC Infectious Diseases, 17(1):333, May 2017.
C. Silva, E. Cornillot, C. McCracken, S. Usmani-Brown, A. Dwivedi, O. Ifeonu, J. Crabtree, H. Gotia, A. Virji, C. Reynes, J. Colinge, V. Kumar, L. Lawres, J. Pazzi, J. Pablo, C. Hung, J. Brancato, P. Kumari, J. Orvis, K. Tretina, M. Chibucos, S. Ott, L. Sadzewicz, N. Sengamalay, A. Shetty, Q. Su, L. Tallon, C. Fraser, R. Frutos, D. Molina, P. Krause, and C. B. Mamoun, Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions, Scientific reports, 6:35284, October 2016.
Carpi, K. S. Walter, C. B. Mamoun, P. J. Krause, A. Kitchen, T. Leopore, A. Dwivedi, E. Cornillot , A. Caccone, and M. Diuk-Wasser, Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States, BMC Genomics, 17(1):888, September 2016.
A. Dwivedi, N. Khim, C. Reynes, P. Ravel, L. Ma, M. Tichit, C. Bourchier, S. Kim, D. Dourng, C. Khean, P. Chim, S. Siv, R. Frutos, S. Lekdy, O. Puijalon, F. Ariey, D. Menard, and E. Cornillot, Plasmodium falciparum parasite population structure and gene flow associated to anti-malarial drugs resistance in Cambodia, Malaria Journal, 15(1):319, June 2016.
Garg, A. Stein, W. Zhao, A. Dwivedi, R. Frutos, E. Cornillot, and C. B. Mamoun, Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti, PLoS One, 9(10): e107939, October 2014.
A. Dwivedi, Sponsor: Dr. Pranay Goel, A stochastic version of the Pederson-Sherman insulin secretion model, SIURO, volume 7, January 2014.
Awards and Affiliations
2013 - 2016 Erasmus Mundus Action 2 project - Svaagata.eu: India scholarship, European Commission, EU
2007 - 2012 INSPIRE scholarship, Government of India, Department of Science and Technology, India