Allan Doctor, MD

• University of Virginia, BA, Neurobiology, 1980-1984
• University of Virginia School of Medicine, MD, 1985-1989
• University of Pittsburgh, Resident, Emergency Medicine, 1989-1992
• Children’s Hospital, Boston, Fellow, Pediatric Emergency Medicine, 1992–1994
• Children’s Hospital, Boston, Resident, Pediatrics, 1994–1996
• Children’s Hospital, Boston, Fellow, Pediatric Critical Care, 1996-1999

Allan Doctor, MD is Professor of Pediatrics at the University of Maryland School of Medicine, where he directs the Center for Blood Oxygen Transport and Hemostasis. He is a Pediatric Intensivist and previously led Pediatric Critical Care at Washington University and St Louis Children’s Hospital for 10 years, stepping down and then transitioning to UMB to focus on a rapidly expanding research program and on development of a novel bio-synthetic artificial red cell.

His laboratory studies the role of red blood cell-based signaling in the control of regional blood flow, related pathophysiology arising from acquired red cell injuries, blood substitute design, and on translational transfusion medicine in critical illness.

pediatric critical care medicine, pediatric emergency medicine, red blood cell-based signaling, blood substitute, resuscitation, nitric oxide, metabolomics, translational transfusion medicine

Doctor A, Platt R, Sheram ML, Eischeid A, McMahon T, Maxey T, Doherty J, Axelrod M, Kline J, Gurka M, Gow A and Gaston B. Hemoglobin conformation couples S-nitrosothiol content in erythrocytes to O2 gradients Proc Natl Acad Sci. 2005;102:5709-14. PMID:15824313

Rogers S, Said A, Corcuera D, Kanter J, McLaughlin D, Kell P, Doctor A. Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance. FASEB J. 2009;23(9):3159-70. PMID:19417084

Rogers S, Ross J, Gibbons L, McLaughlin D, Hassan M, Griffin S, Neumayr T, DeBaun M and Doctor A. Sickle hemoglobin disturbs normal coupling between erythrocyte O₂content, glycolysis and antioxidant capacity. Blood. 2013;121(9):1651-62. PMID: 23297128

Guilliams K, Fields M, Ragan D, Eldeniz C, Binkley M, Doctor A, Hulbert M, Shimony J, Vo K, McKinstry R, An H, Lee J and Ford A. Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell disease. Blood. 2018;131(9):1012-1021. PMID: 29255068.

Mistry N, Mazer J, Lazarus A, Cahill L, Solish M, Zhou Y, Romanova N, Hare A, Doctor A, Fisher J, Brunt K, Simpson J, and Hare G. Cardiovascular and Hypoxic Cellular Responses to Moderate Anemia Induced by a Red Blood Cell-Specific Antibody. Am J Physiol. 2018;314(4):R611-R622. PMID: 29351418