Meagan E. Deming, MD, PhD

• Bolles M*, Deming D*, Long K, Agnihothram S, Whitmore A, Ferris M, Funkhouser W, Gralinski L, Totura A, Heise M, Baric RS. A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.J Virol. 2011 Dec;85(23):12201-15. doi: 10.1128/JVI.06048-11. Epub 2011 Sep 21. PMID: 21937658; PMC3209347.
• Bolles M, Donaldson E, Baric R. SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.Curr Opin Virol. 2011 Dec;1(6):624-34. doi: 10.1016/j.coviro.2011.10.012. Review. PMID: 22180768; PMC3237677.
• Rani M, Bolles M, Donaldson EF, Van Blarcom T, Baric R, Iverson B, Georgiou G. Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus.J Virol. 2012 Sep;86(17):9113-21. doi: 10.1128/JVI.00233-12. Epub 2012 Jun 13. PMID: 22696652; PMC3416138.
• Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.Nat Med. 2012 Dec;18(12):1820-6. doi: 10.1038/nm.2972. Epub 2012 Nov 11. PMID: 23142821; PMC3518599.
• Gralinski LE, Bankhead A 3rd, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury.MBio. 2013 Aug 6;4(4). pii: e00271-13. doi: 10.1128/mBio.00271-13. PMID: 23919993; PMC3747576.
• Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A 3rd, Bolles M, Carter V, Chang J, Clauss TRW, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josse L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, SC Tilton, Totura T, Wang J, Webb-Robertson B, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG Scheuermann RH. A comprehensive collection of systems biology data characterizing the host response to viral infection.Sci Data. 2014 Oct 14;1:140033. doi: 10.1038/sdata.2014.33. eCollection 2014. PMID: 25977790; PMC4410982.
• Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA. Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness.J Virol. 2014 Dec;88(23):13769-80. PMID: 25231316; PMC4248992.
• Graham RL, Deming DJ, Deming ME, Yount BL, Baric RS. Evaluation of a recombination-resistant coronavirus as a broadly applicable rapidly implementable vaccine platform. Commun Biol. 2018 Oct 29;1(179):1-10. PMID: 30393776; PMCID: PMC6206136.
• Deming M, Mark A, Nyemba V, Heil EL, Palmeiro RM, Schmalzle SA. Cognitive biases and knowledge deficits leading to delayed recognition of cryptococcal meningitis. IDCases 2019;18:e00588. PMID 31360635; PMC6639654
• Edelman R, Deming ME, Toapanta FR, Heuser MD, Chrisley L, Barnes RS, Wasserman SS, Blackwelder WC, Handwerger BS, Pasetti M, Siddiqui KM, Sztein MB. The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route. Immun Ageing. 2020;17(9):1–16. PMID 32355503; PMC7187507
• Deming ME, Chen WH. COVID-19 and Lessons to be Learned from Prior Coronavirus Outbreaks. Ann Am Thorac Soc. 2020;17(7): 790-794. PMID: 32267164; PMC7328171
• Deming ME, Michael NL, Robb M, Cohen MS, Neuzil KM. Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models. NEJM 2020;383(10):e63.DOI: 10.1056/NEJMp20200761. PMID: 32610006; PMC7968616
• Niang M*, Deming ME*, Goudiaby D, Diop OM, Dia N, Diallo A, Ortiz JR, Diop D, Lewis KDC, Lafond KE, Widdowson M, Victor JC, Neuzil KM. Immunogenicity of seasonal inactivated influenza and inactivated polio vaccines among children in Senegal: results from a cluster-randomized trial. Vaccine 2020 Nov 3;38(47):7526-7532. DOI:10.1016/j.vaccine.2020.09.059. PMID: 33012603; PMC7936169
• Deming ME, Lyke KE. A ‘mix and match’ approach to SARS-CoV-2 vaccination. Nature Med (2021) DOI:10.1038/s41591-021-01463-x. PMID: 34312555
• Barnabas R V., Brown ER, Bershteyn A, Stankiewicz Karita HC, Johnston C, Thorpe LE, Kottkamp A, Neuzil KM, Laufer MK, Deming M, Paasche-Orlow MK, Kissinger PJ, Luk A, Paolino K, Landovitz RJ, Hoffman R, Schaafsma TT, Krows ML, Thomas KK, Morrison S, Haugen HS, Kidoguchi L, Wener M, Greninger AL, Huang M-L, Jerome KR, Wald A, Celum C, Chu HY, Baeten JM. Hydroxychloroquine as Postexposure Prophylaxis to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Ann Intern Med. 2021; 174(3):344-352. doi:10.7326/M20-6519. PMID: 33284679; PMC7732017
• So JY, O’Hara NN, Kenaa B, Williams JG, deBorja CL, Slejko JF, Zafari Z, Sokolow M, Paul Zimand P, Deming M, Marx J, Pollak AN, Reed Decline in COPD Admissions During the COVID-19 Pandemic Associated with Lower Burden of Community Respiratory Viral Infections. Am J Med. 2021;134(10):1252-1259. DOI:10.1016/j.amjmed.2021.05.008. PMID 34126098; PMC8196237.
• Strohmeier S, Amanat F, Zhu X, McMahon M, Deming M, Pasetti M, Neuzil K, Wilson I, Krammer F. A novel recombinant influenza virus neuraminidase vaccine candidate stabilized by a measles virus phosphoprotein tetramerization domain provides robust protection from virus challenge in the mouse model. mBio. 2021; DOI: 10.1128/mBio.02241-21. PMID 34809451; PMC8609353
• Stankiewicz Karita HC, Dong TQ, Johnston C, Neuzil KM, Paasche-Orlow MK, Kissinger PJ, Bershteyn A, Thorpe LE, Deming M, Kottkamp A, Laufer M, Landovitz RJ, Luk A, Hoffman R, Roychoudhury P, Magaret CA, Greninger AL, Huang M-L, Jerome KR, Wener M, Celum C, Chu HY, Baeten JM, Wald A, Barnabas R V., Brown ER. Trajectory of Viral RNA Load Among Persons With Incident SARS-CoV-2 G614 Infection (Wuhan Strain) in Association With COVID-19 Symptom Onset and Severity. JAMA Netw Open. 2022 Jan 10;5(1):e2142796. PMID: 35006245
• Atmar RL, Lyke KE, Deming ME, Jackson LA, Branche AR, Sahly HM El, Rostad CA, Martin JM, Johnston C, Rupp RE, Mulligan MJ, Brady RC, Frenck Jr RW, Bäcker M, Kottkamp AC, Babu TM, Rajakumar K, Edupuganti S, Dobrzynski D, Coler RN, Posavad CM, Archer JI, Crandon S, Nayak SU, Szydlo D, Zemanek JA, Dominguez Islas CP, Brown ER, Suthar MS, McElrath MJ, McDermott AB, O’Connell SE, Montefiori DC, Eaton A, Neuzil KM, Stephens DS, Roberts PC, Beigel JH, DMID 21-0012 Study Group. Homologous and Heterologous Covid-19 Booster Vaccinations. NEJM. 2022 DOI: 10.1056/NEJMoa2116414. PMID 35081293
• Friedman-Klabanoff DJ, Fitzpatrick MC, Deming ME, Agrawal V, Sitar S, Schaafsma T, Brown E, Neuzil KM, Barnabas R V, Laufer MK, Team HC-19 PEPS. Risk of SARS-CoV-2 acquisition is associated with individual exposure but not community-level transmission. J Infect Dis. 2022 Feb 2;jiac029. PMID 35134185
• Bershteyn A, Dahl AM, Dong TQ, Deming ME, Celum CL, Chu HY, Kottkamp AC, Greninger AL, Hoffman RM, Jerome KR, Johnston CM, Kissinger PJ, Landovitz RJ, Laufer MK, Luk A, Neuzil KM, Paasche-Orlow MK, Pitts RA, Schwartz MD, Stankiewicz Karita HC, Thorpe LE, Wald A, Zheng CY, Wener MH, Barnabas R V, Brown ER. Self-Assessed Severity as a Determinant of COVID-19 Symptom Specificity: A Longitudinal Cohort Study. Clin Infect Dis. 2022 Feb 13. DOI: 10.1093/cid/ciac129 PMID: 35152299
• Deming ME, Dong TQ, Agrawal V, Mills MG, Huang M-LW, Greninger AL, Jerome KR, Wener MH, Paasche-Orlow MK, Kissinger P, Luk A, Hoffman RM, Stewart J, Kottkamp AC, Bershteyn A, Chu HY, Stankiewicz Karita HC, Johnston CM, Wald A, Barnabas R, Brown E, Neuzil K. Detection and kinetics of subgenomic SARS-CoV-2 RNA viral load in longitudinal diagnostic RNA positive samples. J Infect Dis. 2022 Feb 12;jiac048. DOI: 10.1093/infdis/jiac048. PMID 35150571
• Lyke KE, Atmar RL, Dominguez Islas C, Posavad CM, Szydlo D, PaulChourdhury R, Deming ME, Eaton A, Jackson LA, Branche AR, El Sahly HM, Rostad C, Martin JM, Johnston C, Rupp R, Mulligan MJ, Brady RC, Frenck R, Bäcker M, Kottkamp A, Babu TM, Rajakumar K, Edupuganti S, Dobrzynski D, Coler RN, Archer JI, Crandon S, Zemanek JA, Brown ER, Neuzil KM, Stephens DS, Post DJ, Nayak SU, Suthar M, Roberts PC, Beigel JH, Montefiori DC. Rapid Decline in Vaccine-Boosted Neutralizing Antibodies Against SARS-CoV-2 Omicron Variant. Cell Reports Med. 2022 Jul;3(7):100679; DOI: 10.1016/j.xcrm.2022.100679. PMID: 35798000
• Sajadi MM, Myers A, Logue J, Saadat S, Shokatpour N, Quinn J, Newman M, Deming M, Tehrani ZR, Magder LS, Karimi M, Abbasi A, Shlyak M, Baracco L, Frieman MB, Crotty S, Harris AD. Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection. mSphere. 2022;7(6):e0027922. DOI: 10.1128/msphere.00279-22 PMID: 36321826
• Lyke KE, Atmar RL, Dominguez Islas C, Posavad CM, Deming ME, Branche AR, Johnston C, El Sahly HM, Edupuganti S, Mulligan MJ, Jackson LA, Rupp RE, Rostad CA, Coler RN, Bäcker M, Kottkamp AC, Babu TM, Dobrzynski D, Martin JM, Brady RC, Frenck RW Jr, Rajakumar K, Kotloff K, Rouphael N, Szydlo D, PaulChoudhury R, Archer JI, Crandon S, Ingersoll B, Eaton A, Brown ER, McElrath MJ, Neuzil KM, Stephens DS, Post DJ, Lin BC, Serebryannyy L, Beigel JH, Montefiori DC, Roberts PC; DMID 21-0012 Study Group. Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants. NPJ Vaccines. 2023;8(1):98. DOI: 10.1038/s41541-023-00693-z. PMID: 37433788 PMCID: PMC10336079.
• Deming ME, Brown ER, McArthur MA, Schrag SJ, Arvay ML, Humphrys M, Ravel J, Adelglass JM, Essink B, Musante DB, Maguire R, Gorman R, Formentini E, Mason R, Robb ML, Neuzil KM, Rapaka RR, Wolff P, Kotloff KL; SNIFF Study Team. NVX-CoV2373 efficacy in preventing SARS-CoV-2 infection in adolescents: an ancillary study to a randomized, placebo-controlled, observer-blinded trial. Lancet Microbe. 2024. Accepted 2024-08-27.

Dr. Deming is a board-certified Infectious Disease specialist. She attends on the transplant infectious disease consult service, on which she also teaches medical students, residents, and fellows. 

• 2024 Dr. Laure Aurelian Biomedical Research Award
• 2023 IDCRC Early Career Investigator of the Year
• 2022 Passano Clinician-Scholar
• 2018-2020 T32 Vaccinology Research fellowship
• 2018 Fellow Teacher of the Year Award, Division of Infectious Diseases, University of Maryland School of Medicine

• 05/25/2023 – (4/31/2027)           PI: Dr. Meagan Deming
  • “Characterization of seasonal CoV immunity and operationalization of a novel controlled human infection model for the betacoronavirus OC43,” NIH K08AI170950.
• 02/01/2024 – (1/30/2027)           PI: Dr. Christopher Chiu
  • “MusiCC – Controlled Human Infection Models for Betacoronaviruses,” CEPI
  • Co-investigator; University of Maryland, Baltimore site PI & WP2 co-lead
• 06/01/2023 – (05/31/2028)        PI: Dr. Florian Krammer
  • “Development of a multivalent variant-proof mucosal SARS-CoV-2 vaccine;” NIH 75N93023C00019. 
  • Sub-award PI, University of Maryland, Baltimore.
• 03/15/2021-3/14/2022    PI: Dr. Meagan Deming
  • “Seasonal Coronavirus Immunity and Effects on SARS-CoV-2 Immune Response,” IDCRC New Investigator Pilot Award, UM1AI148684