Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Pathology
Additional Title:
Professor of Pathology
Location:
IHV, S215
Phone (Primary):
(410) 706-2788
Fax:
(410) 706-2789
Education and Training
|
1970 |
A.A. |
Biology |
Community College of Baltimore |
|
1973 |
B.A. |
Psychology |
University of Maryland Baltimore County |
|
1974 |
B.S. |
Medical Technology |
University of Maryland Program in Medical Technology |
|
1981 |
Ph.D. |
Pathology |
University of Maryland School of Medicine |
Biosketch
A. Personal Statement
As a professor in the Department of Pathology and Institute of Human Virology, I possess over 42 years of experience in the diagnostic arena, have acted frequently as an international consultant for laboratory strengthening activities in many countries, and have a productive track record with extramural funding and publications. In addition to teaching and research for over 35 years, I have been the Director of the Clinical Immunology Laboratory at the University of Maryland Medical Center Hospital for 25 years, have spent 3 years at the U.S. Naval Medical Research Unit #3 in Cairo Egypt establishing laboratories and providing quality assurance measures, participated in establishing laboratories and increasing laboratory capacity in Nigeria under a major PEPFAR program, and was recruited to Geneva to work with the Global AIDS Programme in the Diagnostics Unit. In 1997, I established the Laboratory of Viral Diagnostics at the Institute of Human Virology, an active research unit that develops diagnostic tests, and evaluates diagnostic methods in projects funded by the US Government. Research in the laboratory includes the development of highly sensitive analytical methods, most notably Immuno-PCR which was developed for the early detection of HIV and prions in blood. The laboratory continuously performs clinical trials and I have been the PI fornine FDA PMA clinical trials and one FDA 510K clinical trial for medical devices. My extensive experience in working in resource-limited countries for training personnel, building laboratory infrastructure, establishing capability, and monitoring quality outcome makes me well-qualified in the field of diagnostics.
B. Positions and Honors
Positions:
| 1974-1976 | Medical Technologist, Diagnostic Immunology Laboratory, JohnsHopkinsHospital, Baltimore, MD |
| 1979-1982 | Instructor, Program in Medical Technology, University of MarylandSchool of Medicine, Baltimore, MD |
| 1980-1984 | Instructor (part-time), Department of Physical Therapy, University of Maryland School of Medicine, Baltimore, MD |
| 1982 | Instructor (part-time), HowardCommunity College, Baltimore, MD |
| 1982-1983 | Instructor (part-time), University of Maryland Baltimore County, Baltimore, MD |
| 1982-1987 | Assistant Professor, Program in Medical Technology, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD |
| 1983-1987 | Instructor (part-time), EssexCommunity College, Baltimore, MD |
| 1985 | Instructor, Program in Medical Technology, MorganStateUniversity, Baltimore, MD |
| 1985-1987 | Alternate Program Coordinator, Program in Medical Laboratory Technicians, EssexCommunity College, Baltimore, MD |
| 1987-1989 | Research Assistant Professor, Program in International Health, University of MarylandSchool of Medicine, Baltimore, MD |
| 1987-1990 | Division Chief, Clinical Diagnostics Division, Virology Department, Assignment to U.S. Naval Medical Research Unit #3, Cairo, Egypt |
| 1987-1990 | Research Assistant Professor, Department of Pathology, University of Maryland, School of Medicine, Baltimore, MD |
| 1990-2015 | Director, Clinical Immunology, University of Maryland Medical Center |
| 1991-1997 | Research Associate Professor, Department of Pathology, University of Maryland, School of Medicine, Baltimore, MD |
| 1997-present | Professor, Department of Pathology, Institute of Human Virology, University of Maryland, School of Medicine, Baltimore, MD |
Other Experience and Professional Memberships
1974 Membership: American Society ofClinicalPathologists
1987-1990 Division Chief, Clinical Diagnostics Division, Virology Department, US Naval Medical
Research Unit #3, Cairo Egypt.
1990-2015 Director, Clinical Immunology Laboratory, University of Maryland Medical Center
1993 Consultant, Global AIDS Programme, Diagnostics Unit, World Health Organization, Geneva Switzerland
1995 Consultant, World Bank, “Assessment, Planning, and Recommendations for strengthening the National Laboratory System for HIV and STD; Two 2-week visits, Indonesia
2003 Consultant, U.S. Agency for International Development (USAID), “Workshop for the commercialization of rapid test technology in India.” Delhi, India; Ambala College of Engineering and Applied Research, Ambala, India
2003 Consultant, U.S. Agency for International Development (USAID), Planning a National Quality Assurance Program for HIV Thailand and The Philippines
2008 Consultant, Ministry of Health and CDC Haiti for Laboratory Strengthening, Port au Prince, Haiti
Honors
9/22/05 Innovator of the Year Award, Daily Record, Baltimore, MD
Research/Clinical Keywords
Experimental and Clinical Immunology Immunodiagnosis Retroviruses HIV-1, HIV-2, HTLV-I/II Prion Diseases Auto-immune diseases
Highlighted Publications
- Constantine, N.T., Saville, R., and Dax, E.: Retroviral Testing and Quality Assurance: Essentials for Laboratory Diagnosis. (Book) Malloy Printers, 2005
- Barletta, J., Bartolome, A., Constantine, N.T. Immunomagnetic quantitative immuno-PCR for detection of less than one HIV-1 virion. J. Virol. Meth., 157: 122-132, 2009.
- Constantine, N, Wright, PA, Saleh, A, DeMarinis, A. The impact of molecular testing on the blood bank. In Molecular Diagnostics: 14 Tests that changed everything; A volume in the series: Molecular and Personalized Medicine; WB Coleman and GJ Tsongalis (Series Eds), W Highsmith (Ed); Springer, 2014.
- Nkeze, J, Constantine, N, Zhao, RY. Laboratory testing for HIV infection: advances after 27 years. In Molecular Diagnostics: 14 Tests that changed everything; A volume in the series: Molecular and Personalized Medicine; WB Coleman and GJ Tsongalis (Series Eds), W Highsmith (Ed); Springe, 2014.
- Constantine, N, Sill, A, Paulus, S, Gudesblat, E, Saleh, A. Assessment of Two Rapid Assays for their Diagnostic Capability to Accurately Identify Infection by Treponema pallidum. Journal of Applied Laboratory Medicine, 346-356; January 2017..
Additional Publication Citations
- Hong, L., Ketema, F., Sill, A., Kreisel, K., Cleghorn, F.R., & Constantine, N.T. A simple and inexpensive particle agglutination test to distinguish recent and established HIV-1 infection. International Journal of Infectious Disease, 11:459-465, 2007.
- Sill, A.M., Kreisel, K., Deeds, B.G., Wilson, C.M., Constantine, N.T., Peralta, L., & the Adolescent Trials Network (ATN) for HIV/AIDS Intervention. Calibration and validation of an oral fluid-based S/LS assay to distinguish recent from established HIV-1 infection. Journal of Clinical Laboratory Analysis, 21:40-45, 2007.
- Constantine, N.T., Sill, A.M., Jack, N., Kreisel, K., Edwards, J., Cafarella, T., Smith, H., Bartholomew, C., Cleghorn, F., & Blattner, W.A. Improved classification of recent HIV-1 infection by employing a two-stage sensitive/less sensitive test strategy. Journal of AIDS, 32:94-103, 2003.
- Constantine, N.T. & Lana, L. Immunoassays for the diagnosis of infectious diseases. In: Murray et al. (Eds), Manual of Clinical Microbiology, 8th Edition, ASM Press, pp. 218-233, 2003.
- Highsmith, W.E., Constantine, N.T., & Friedman, K.F. Molecular diagnostics, (Chapter 48). In: L. Kaplan, A. Pesche, & Kazmierszak (Eds), Clinical Chemistry, 4rd Ed. NY: Mosby, pp. 937-959, 2003.
- Nkeze, J, Constantine, NT, Zhao, R. Laboratory Testing for HIV Infection; In HIV Clinical Manual, 2nd Edition; Singh, N, Shafer, R, Swindells, S (editors); www.antimicrobe.org, 2009.
- Sajadi, M.M., Constantine, N.T., Mann, D.L., Charurat, M., Dadzan, E., Kadlecik, P., Redfield, R.R. Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors; JAIDS, 50: 403-408, 2009.
- Rosenberg, E, Brennan, C, Claessens, C, Constantine, N, Murphy, G, Owen, S, Werner, B, Yao, J, Yen-Lieberman, B, Branson, B, Garrett, P, Howell, R. Criteria for laboratory testing and diagnosis of HIV infection. CLSI, M53-P, Vol. 30, Number 21, ISBN: 1-56238-735-9, 2011.
- Nkeze, J, Constantine, N, Zhao, RY. Laboratory testing for HIV infection: advances after 27 years. In Molecular Diagnostics: 14 Tests that changed everything; A volume in the series: Molecular and Personalized Medicine; WB Coleman and GJ Tsongalis (Series Eds), W Highsmith (Ed); Springe, 2014.
- Wei Luo, Silvina Masciotra, Kevin Delaney, Man Charurat, Taeleisha Croxton, Niel Constantine, Abdulsalami Nasidi, William Blattner, Laura Wesolowski, S. Michele Owen. Comparison of HIV Oral Fluid and Plasma Testing during Early Infection in a Longitudinal Nigerian Cohort. J Clin Virol; 58S 2013.
.
Research Interests
Diagnostic test development, including highly sensitive molecular techniques, serologic assays, rapid tests, point of care tests, and biosensor assays; Clinical trials, quality assurance.
Clinical Specialty Details
FDA Clinical Trials
| 8/99-11/00 | “MedMira Rapid HIV Screen”; MedMira Laboratories, Inc., Halifax, Nova Scotia, Canada. FDA approved. |
| 8/00-12/00 | “Assessment of the OraQuick HIV1/2 Assay for Oral Fluids, Blood, and Plasma” Epitope, Inc., Beaverton, NJ, US. |
| 10/00-12/00 | “Evaluation of a Semi-rapid, Simple Immunoassay Designed to Confirm Infection by HIV”; Bionor A/S, Norway. |
| 9/00-11/01 | “Evaluation of Simple Immunoassay to Confirm HIV”; BionorA/S, Norway |
| 12/00-5/01 | “Development of a Rapid Assay for Detection of HIV Infection in Urine” Calypte Biotech, California, US. |
| 4/02-2/03 | “Evaluation of the Uni-Gold Recombigen HIV Test”; Trinity Biotech, PLC, Bray, Co. Wicklow, Ireland. |
| 1/03-6/03 | “HIV 1/2 Hema-Strip Clinical Trial”; Saliva Diagnostics System (SDS), Massachusetts, US. |
| 1/03-6/03 | “Multispot HIV-1/HIV-2 Known Positive Population”; BioRad Laboratories, California, US. |
| 8/03-8/04 | “Clinical Evaluation of the MultiSpot HIV-1/HIV-2 Investigational Test Kit on Samples Derived from a High Risk Population”; Bio-Rad Laboratories, California, US. |
| 9/03-9/04 | “Clinical Evaluation of the MultiSpot HIV-1/HIV-2 Investigational Test Kit on Samples Derived from a Low Risk Population” Clinical Trial 01.007.3.OE, Bio-Rad Laboratories, California, US. |
| 12/03-12/04 | “HIV 1-2 Hema-Strip Clinical Trial (2)” Clinical Trial 03-HIV01, Saliva Diagnostics Systems, Inc., Massachusetts, US. |
| 3/04-2/06 | “Assessment of the Trinity Biotech Product Uni-Gold Recombigen HIV when Performed by Individuals with No Laboratory Training or Product Experience” Trinity Biotech Plc, Bray, Co. Wicklow, Ireland. |
| 5/04-12/05 | “Assessment of Chembio Rapid HIV Tests”; Chembio Diagnostics, New York, US. |
| 11/04-9/09 | “Validating Supplemental Testing to Confirm Preliminary Positive Rapid HIV Tests Study Protocol MDC-03-03”; CDC/MDC, Atlanta, US. |
| 10/07-9/08 | “Evaluation of the Insti-HIV Rapid Assay” bioLytical, Inc., Richman, British Columbia. |
| 11/07-10/08 | “Clinical Study of Clearview Complete HIV-1/2 and Clearview HIV-1/2 STAT-Pak Test in the 12-17 year old Pediatric Population”; ChemBio Diagnostic Systems, Inc.; New York, US. |
| 5/09-4/10 | “Reproducibility Study, INSTI HIV-1 Antibody Test Kit” bioLytical Laboratories, Richman, British Columbia. |
| 2/11-12/12 | “Comparison of results of plasma and SMARTplasma (using SMARTube) for identifying HIV infection in a high risk population” G & W Laboratories, New Jersey, US. |
| 7/11-7/12 | “Clinical Trial of the DPP Syphilis Screen Rapid Test” Chembio, Inc., New York, US. |
| 7/11-7/12 | “Clinical trial comparing two types of blood samples (plasma and SMARTplasma) for HIV and HCV antibody testing. 510 K, G & W Laboratories, New Jersey, US. |
| 9/11-9/12 | “Clinical Trial of the DPP Reader”; Chembio, Inc., New York, US. |
| 9/11-9/12 12/13-12/14 4/17-3/18 | “Clinical Trial of the Chembio DPP HIV 1 / 2 Screen Rapid Test on a Pediatric Population” Chembio, Inc., New York, US. Dr. Niel Constantine (PI, 10%) CHEMBIO DPP® HIV-Syphilis Rapid Test Chembio, Inc. FDA PMA Clinical Trial: : CHEMBIO DPP® HIV-Syphilis Rapid Test Chembio, Inc. Of the 22 clinical trials, 8 were PMAs for rapid HIV tests that are approved by the FDA. |
Awards and Affiliations
9/22/05: Innovator of the Year, The Daily Record
Grants and Contracts
Constantine (PI), 4/1/17-3/31/18
Chembio Diagnostic Systems, Inc.
FDA PMA Clinical Trial of the DPP HIV / Syphilis Assay
This clinical trial assess the performance characteristics of a new combination rapid test for the ability to meet manufacturer's claims for the detection of HIV and Treponemal antigens simultaneously. A novel reading device is used.
Constantine (PI), 10/25/15 -9/2/17
The USAID Global Health Supply Chain Quality Assurance Program
Proposal for Rapid Diagnostics (HIV and syphilis), and Other Laboratory Products (Point of Care Products), USAID Global Health Supply Chain‐Quality Assurance Program (USAID | GHSC – QA), FHI360.
This is an effort to assess and evaluate a large number of infectious and chemistry tests for their suitability to meet manufacturers’ claims. Test kits from over 15 resource-limited countries, and from manufacturers’ facilities are sent to our laboratory for determination of their accuracy and performance characteristics using panels of blood samples.
Constantine (PI), 8/1/16 -8/1/17
The USAID Global Health Supply Chain Quality Assurance Program, Supplement
This supplement to the above project includes provisions for international consultancy, extensive evaluation of select tests, establishing a test kit retention facility, determination of the causes of test kit failure, and providing training of individuals in resource-limited countries.
Constantine (Investigator), 9/01/15 – 2-29/17;Fabio Romerio / Lichterfeld (Co-PIs)
NIH 1RO1AI120008-01, NIAID; Quantification of the HIV Reservoir by Immuno-PCR”, NIAID
This project aims to use Immuno-PCR to determine HIV latent reservoirs by increasing the sensitivity of detection
Constantine (PI) 7/30/15 – 12/31/15
Supply Chain Management System (SCMS)
Supplement to Proposal to Establish and Implement Procedures to Assure Suitability for
Intended Use of Laboratory Supplies, and HIV/AIDS, TB, Syphilis,
Hepatitis and Pregnancy Rapid Test Kits, “Evaluation of the SD Bioline syphilis 3.0
and the Chembio Syphilis Screen and Confirm.
This project involved evaluating 2 rapid syphilis tests appropriate for resource-limited countries for their suitability to rapidly diagnose syphilis. A large panel of well-characterized samples were used and included assessment of accuracy, precision, reproducibility, lot-to lot variation, and high temperature studies.
Constantine (PI) 3/1/09-8/28/15
Supply Chain Management System (SCMS)
Proposal to Establish and Implement Procedures to Assure Suitability for Intended Use of Laboratory Supplies, and HIV/AIDS, TB, Syphilis, Hepatitis and Pregnancy Rapid Test Kits
This quality assurance project aims to evaluate 5 types of rapid tests for meeting specifications after they arrive at world-wide sites. The kits will be shipped to the US for a series of experiments to determine suitability and compliance with manufacturers’ recommendations; investigations as to cause for poor performance are included.
Constantine (PI) 12/1/13 – 12/1/15
Chembio Diagnostics Systems, Inc.
This pre-clinical trial of the CHEMBIO DPP HIV-Syphilis Rapid Test, evaluates a novel multiplex rapid test to detect both HIV and syphilis simultaneously. The trial has been successful and Chembio is planning a full FDA clinical trial before the end of 2015.
Constantine (PI) 01/01/15
Jacques Initiative, Institute of Human Virology
This effort, funded by Gilead, and known as FOCUS, aims to decrease turn-around time for HIV and HCV test results in a clinical setting (UMMC). Patients in the Emergency Department and select medical floors are recruited for testing, results are returned within 2 hours, and they are linked to care before being released. The effort includes IT support, laboratory stat testing, and result reporting.
Constantine (Investigator) 10/08/13-9/30/14
Roche Diagnostics
This project was to prospectively collect up to 500 samples from high risk group subjects to evaluate tests for hepatitis A, B, C, and E. The subjects included those at high risk (from methadone clinics) and those with symptoms compatible with hepatitis. Extensive questionnaires were used and 2-3 tubes of blood collected. Samples were processed, aliquoted, transported, and stored within well-defined time limits. All data were entered into an electronic database.
Constantine (PI) 12/1/13-11/30-14
Chembio Diagnostics
Evaluation of the DPP HIV/syphilis rapid test.
The FDA clinical trial evaluated a new and novel rapid test that can detect HIV-1/HIV-2 and syphilis simultaneously. The assessment included prospectively-collected samples and archived samples. The DPP experimental test was evaluated against reference tests.
Constantine (PI) 2/1/11-6/31/13
G & W Laboratories
Comparison of results of plasma and SMARTplasma (using SMARTube) for identifying HIV infection in a high risk population.
This effort involved the collection of blood from 400 high risk individuals, incubation of whole blood in the SMARTube, and comparing HIV test results on the resultant SMARTplasma as compared with those in routine plasma. The SMARTube contains components that activate B lymphocytes to produce specific antibodies faster and in higher quantities. Thus, this technology offers early HIV detection, and can be applied to measure HIV incidence.
Professional Activity
Local Service
| 1974-1976 | Medical Technologist, Diagnostic Immunology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland |
| 1980 | Member, Government Student Association, University of Maryland Graduate School |
| 1981 | Student Senator, University of Maryland, Baltimore |
| 1982-1987 | Course Chairman, Clinical Immunology, Clinical Pathology, Anatomy and Physiology, Program in Medical Technology, University of Maryland School of Medicine, Baltimore, MD |
| 1985-1986 | Director, Continuing Education, University of Maryland Program in Medical Technology |
| 1985-1987 | Assistant Director, Program in Medical Technology, University of Maryland School of Medicine, Baltimore, MD |
| 1990-2000 | Infection Control Subcommittee, UMMS, UMB |
| 1990-present | Director and Division Head, Clinical Immunology Laboratory, University of Maryland Medical System/Hospital, Department of Pathology, School of Medicine, Baltimore, MD |
| 1990-present | Technical Supervisor for Immunology, Associates in Pathology |
| 1991-1993 | Pharmacy and Therapeutics Committee, UMB |
| 1991-1999 | School of Medicine Council, Alternate, UMB |
| 1995-2000 | Teaching, Advanced Fellowship Program for Pathologists in the Special Field of Hematopathology |
| 1998-2000 | Biosafety Committee for MBI/UMBI |
| 1999-present | School of Medicine Council, Regular or Associate Member, UMB |
National Service
| 1981 | University of Maryland International Health Consultant (Leishmaniasis), Pakistan |
| 1995-1997 | Active Member, Training Consultation Management Resources |
| 1995-2005 | Active Board Member, Tropical Medicine Dinner Club, Baltimore, MD |
| 1996 | Education Development Center, Inc. (sponsored by the World Bank), Consultant, Developing Educational Materials for HIV Testing and Quality Assurances, Boston, MA |
| 5/96 | Inspector, College of American Pathologists, University of Pennsylvania |
| 8/98 | Inspector, College of American Pathologists, Quest Diagnostics |
| 1998-2000 | Steering Committee of the WHO Collaborating Center for Oral Infectious Diseases: Education, Research, and Care, University of Pennsylvania School of Medicine |
| 2001 | Advisor, World Health Organization, 2 days, Global Alliance for Vaccine Initiative (GAVI), NIH |
| 2008 | External Peer Review Committee, CDC, CCID/NCPDCID/Division of Laboratory Systems External Peer Review, Atlanta, GA |
| 2008 2013 | Member, Sub-committee on Criteria for Laboratory Testing and Diagnosis of HIV-1 Infection, Clinical Laboratory Standards Institute (CLSI) DHHS, National Institutes of Health, NIAID, Study section for review of “Immunology Quality Assessment Program, December 19, 2013. |
Editorial Tasks
| 2/94, 5/94, 11/95, 7/96 | Reviewer, AIDS Journal |
| 4/94, 3/98 | Reviewer, Bulletin of the Pan American Health Organization |
| 11/03 | |
| 12/94, 2/98 | Reviewer, Journal of Infectious Diseases |
| 11/94 | Reviewer, American Journal of Public Health |
| 7/97, 12/97, 10/98, 6/99, 8/01, 9/01, 5/05, 1/06, 2/07, 7/07, 10/07 | Reviewer, Journal of Acquired Immunodeficiency Syndromes and Human Retroviruses |
| 1/98, 4/98, 10/98 | Reviewer, Journal of Human Virology |
| 12/97 | Reviewer, American Medical Association |
| 6/98, 10/98 | Reviewer, Hematopathology and Molecular Hematology |
| 9/00 | Reviewer, Clinical and Diagnostic Laboratory Immunology |
| 2/02, 1/03, 4/03, 11/03 | Reviewer, Pan American Health Organization |
| 7/05 | Indian Journal of Medicine |
| 7/05 | Review of Molecular Diagnostics |
| 2/06 | Reviewer, Journal of Virological Methods |
| 6/06 | CDC Study Section, ZCD1 Internet and Opt-Out Testing in EDs |
| 6/06 | Clinical and Applied Immunology Reviews |
| 4/07 | Study Section, RFP, NIH, NIAID, DAIDS: Immunology Quality Assurance Program |
| 6/07 8/11 9/11 2/12 | Reviewer, Expert Reviews of Molecular Diagnostics Reviewer, PLOS Reviewer, Oral Diseases Future Virology |
International Service
| 1988 | Consultant, National Research Institute of Health (HIV), Addis Ababa, Ethiopia |
| 1988 | Consultant, WHO, Egypt |
| 1989 | Advisor and Course Director, WHO sponsored workshop on HIV, Pakistan |
| 1989 | Advisor, WHO sponsored workshop on AIDS, Kuwait |
| 1992 | Consultant, U.S. Agency for International Development (USAID), 3 weeks, Review of HIV Testing and Quality Assurance, Kampala, Uganda |
| 1992 | Consultant, U.S. Agency for International Development (USAID), 4 weeks, Planning a National Quality Assurance Program for HIV Thailand and The Philippines |
| 1993 | Consultant, World Health Organization, Global Programme on AIDS, 11 months, Diagnostic Unit, Geneva, Switzerland |
| 1995 | Consultant, World Bank, “Assessment, Planning, and Recommendations for strengthening the National Laboratory System for HIV and STD; Two 2-week visits, Indonesia |
| 1996 | Consultant, World Health Organization, 2 weeks, Capability Assessment of HIV Sentinal Surveillance Sites, The Philippines |
| 1996 | Consultant, U.S. Agency for International Development (USAID), 2 weeks, Strategic Planning for the National Institutes of Biologicals, New Delhi, India |
| 2003 | Temporary Advisor, WHO, Global Alliance for Vaccine Initiative (GAVI), R&D Task Force |
| 2003 | Consultant, U.S. Agency for International Development (USAID), “Workshop for the commercialization of rapid test technology in India.” Delhi, India; Ambala College of Engineering and Applied Research, Ambala, India |
| 2006 | Consultant, UNAIDS, Scaling up HIV rapid testing towards universal access to prevention, treatment, care, and support services in Ukraine, Kiev, Ukraine |
| 2008 | Advisor, WHO, Working Group on Protocol for Validation of HIV Incidence Assays, Geneva, Switzerland |
| 2008 | Advisor, PEPFAR, Clinical Laboratory Harmonization and Standardization Meeting, Maputo, Mozambique |
| 2008 2010 2011 2015 | Consultant, Ministry of Health and CDC Haiti for Laboratory Strengthening, Port au Prince, Haiti. Working Group on Incidence Testing, World Health Organization, Geneva, Switzerland Working Group on Incidence Testing, World Health Organization, Atlanta, Georgia Evaluation of the SD Bioline syphilis 3.0 test; the evaluation resulted in the placement of this test on the worldwide distribution list of USAID. |
Invited Chairman
| 10/88 | Constantine, N.T.Laboratory Diagnosis and Clinical Management in Adults. AIDS Conference, Abu Dhabi, United Arab Emirates. |
| 12/88 | Constantine, N.T.Retroviral Infections and Epidemiology. 37th Annual Meeting, Am. Soc. Trop. Med. Hyg., Washington, D.C. |
| 2/90 | Constantine, N.T.Technologic Advances in the Sero-diagnosis of AIDS. 3rd International Conference on AIDS, Kuwait. |
| 9/90 | Constantine, N.T.The Use of HIV-1/HIV-2 Combination Assays for Confirmation of HIV Infection. 5th International Conference on AIDS in Africa, Kinshasa, Zaire. |
| 7/92 | Constantine, N.T.Quality Control Techniques: Applying New Diagnostic Methods to Epidemiology: New Advances in Antibody Testing. VIII International Conference on AIDS/III World Congress, Session 89, Amsterdam, Netherlands. |
| 12/93 | Constantine, N.T.Field Evaluation of combined antibody assays for HIV-1/HIV-2. Roundtable discussion. VIII International Conference on AIDS in Africa, Marrakesh, Morocco. |
| 12/94 | Constantine, N.T.Molecular Biology. 6th International Conference on New Modalities for Diagnosis and Treatment, Cairo, Egypt. |
| 9/96 | Constantine, N.T.New Technologies for HIV Testing. AIDS Conference, Baltimore, MD. |
| 9/97 | Constantine, N.T.Emerging Technologies. Institute of Human Virology 1997 Annual Meeting. |
| 12/10/97 | Constantine, N.T.Testing Technologies and Test Algorithms (HIV). International Conference on AIDS in Africa, Cote d Ivoire. |
| 3/5/98 | Constantine, N.T.Global Epidemiology of HIV Infection, and Current Methods for HIV Testing, 22nd National Conference of Indian Association for the Study of Sexually Transmitted Diseases & AIDS. |
| 12/99 | Constantine, N.T.Perinatal Transmission of HIV, HIV and STDs in India, Mumbai, India. |
Workshops
| 6/86 | Constantine, N.T. “Current Considerations in AIDS.” Continuing Education, University of Maryland, Baltimore, MD. |
| 6/86 | Constantine, N.T. “Detection and Interpretation of Diagnostically Significant Autoantibodies.” Continuing Education, University of Maryland, Baltimore, MD. |
| 6/87 | Constantine, N.T. “Immunologic Dysregulation in AIDS.” WHO sponsored AIDS Workshop, NAMRU-3, Cairo, Egypt. |
| 5/88; 6/89 | Constantine, N.T.Workshop Coordinator, Training course for the laboratory diagnosis of HIV infection. WHO sponsored AIDS Workshop, NAMRU-3, Cairo, Egypt. |
| 10/89 | Constantine, N.T.Workshop Advisor, WHO sponsored training workshop on HIV. University of Kuwait, Kuwait. |
| 11/89 | Constantine, N.T.Workshop Director, WHO sponsored training workshop on the laboratory diagnosis of AIDS. National Institute of Health, Pakistan. |
| 9/90 | Constantine, N.T.Workshop Coordinator. World AIDS Foundation sponsored training course on AIDS. National Reference Laboratory, Kigali, Rwanda. |
| 11/9/97 | Constantine, N.T.HIV Laboratory Diagnosis: Increasing the Arsenal. American Society of Clinical Pathologists. |
| 4/99 | Constantine, N.T.Workshop Coordinator, Rapid Tests for the Diagnosis of HIV Infection, Eric Williams Medical Sciences, Sponsored by the Ministry of Health and Fogarty International, Trinidad, and Tobago. |
| 4/99 | Constantine, N.T.Workshop Coordinator, Rapid Tests for the Diagnosis of HIV Infection, Hospital Universitario Clemention Fraga Filho, Rio de Janeiro, Brazil. |
| 4/4-5/02 | Constantine, N.T.Lecturer, Nurses HIV Phase II Training, Nassau, Bahamas |
| 6/4-15/02 | Constantine, N.T.HIV Testing and Quality Control, Nigeria |
| 5/06 | Constantine, N.T. Laboratory Quality Assessment Essentials, Cairo, Egypt, National Hepatology & Tropical Medicine Research Institute |
| 11/07 | Constantine, N.T. Viral Hepatitis in Egypt, Cairo, Egypt, Swedish International Development Agency |
| 8/11 | Constantine, N.T. (invited) WHO/CDC Incidence Testing, Atlanta, GA |
Links of Interest
Current trainings:
- HIPAA training (101, 120, 125, 201).
- CITI Program in the Protection of Human Research Subjects Training.
- Good Clinical Practice and ICH.
- Blood Borne Pathogens Training.
- Biological Material and Dry Ice Shipping Training.
- Laboratory Safety Training.
- Environmental Management Training.
- DOT Infectious and Diagnostic Materials Shipping Training
- Overview of GLP and Human Subjects Protection
- Good Clinical Practices and Clinical Research Professionals
- Clinical Research billing Compliance Education
- BRAAN Training
- UPI Compliance Training for Physicians
- Unanticipated Problems Involving Risk to Research Participants or Others
- Protecting Human Research Participants, HIH Web-based training
- Investigator Training for Financial Conflict of Interest (FCOI)
- Employee Sexual Harassment Awareness