Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Medicine
Secondary Appointment(s):
BioChemistry&Molecular Biology, Epidemiology & Public Health
Administrative Title:
Senior Program Advisor
Additional Title:
Christy Chang (Other Name)
Location:
670 West Baltimore Street, HSF3 Room 4174
Phone (Primary):
(410) 706-6737 (office)
Fax:
(410) 706-1622
Education and Training
Education And Training
1984-1988 B.S. Biology with minor in Chemistry
Virginia Polytechnic Institute, Blacksburg, VA
1988-1994 Ph.D. Human Genetics and Molecular Biology
The Johns Hopkins University, Baltimore, MD
Thesis Advisors: Kirby D. Smith, Ph.D. and George J. Dover, M.D.
Post Graduate Education And Training
1995-1997 University of Cagliari, Cagliari, Italy, Post-doctoral research
Mentor: Licinio Contu, M.D.
Employment History
2005-2010 Assistant Professor Department of Medicine
University of Maryland School of Medicine
2005-2010 Assistant Professor Department of Epidemiology and Public Health
University of Maryland School of Medicine
2010-pres Associate Professor Department of Medicine
University of Maryland School of Medicine
2010-pres Associate Professor Department of Epidemiology and Public Health
University of Maryland School of Medicine
Biosketch
Trained in human genetics and molecular biology, my research in the last 10 years has centered on the genetic basis of complex diseases, with hypertension, hypercholesterolemia, and bipolar depression as the phenotypes of primary focus. I have been involved in many aspects of genetics: molecular analysis of genotype-phenotype relationships, NextGen sequencing for allele finding and for transcriptom analysis, genome-wide linkage and association studies, pharmacogenetics, comparative genomics, bioinformatics, and mouse models of human diseases. I have been continuously funded by NIH (RO1s, R21s, and ARRA) since 2007. Specifically for this grant, I am currently conducting a study to investigate the genetic basis of pain sensing. Other than research, I am passionate about graduate school eduction and contribute to numerous classes for medical and graduate students. I am also interested in various aspects of faculty development and a granting writing coach for minority faculty through the NIH sponsored National Research Mentoring Network (NRMN)
Research/Clinical Keywords
Molecular and genetic bases of complex disorders such as hypertension and hypercholesterolemia, regulatory elements (non-protein coding) in the human genome, gene regulation, bioinformatics tools for function prediction, faculty development, and graduate school education.
Highlighted Publications
- Chang YP, Liu X, Kim JD, Ikeda MA, Layton MR, Weder AB, Cooper RS, Kardia SL, Rao DC, Hunt SC, Luke A, Boerwinkle E, Chakravarti A. Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet. 2007;80(2):253-64. PMCID: 1785356.
- Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2009;106(1):226-31. PMCID: 2629209.
- Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, …, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, …,Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011; 478(7367):103-9. PMID:21909115.
- Prasad M, Bhalla K, Pan Z, O’Connell J, Weder A, Chakravarti A, Tian B, Chang YC, A polymorphic 3’UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PLoS ONE 2013:8(10): e76290
- Roy A, DonnellyBF, RonzaudC, GongF, ChangYC, ButterworthMB, Pastor-SolerN, HallowsKR, StaubO, and Subramanya AR, Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action, J Clin Invest. 2015;125(9):3433–3448.