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Donna J.. Calu, PhD

Academic Title:

Associate Professor

Primary Appointment:

Neurobiology

Location:

HSF2

Phone (Primary):

‪(443) 302-9139‬

Phone (Secondary):

410-706-5162

Education and Training

I graduated from University of Maryland, College Park with BS in Biology. I completed my PhD at University of Maryland Baltimore School of Medicine (UMSOM/UMB), Program in Neuroscience, working with Geoffrey Schoenbaum to study the role of amygdala neural activity in attention and associative learning. As a postdoc in the laboratory of Yavin Shaham at the National Institute on Drug Abuse (NIDA), I used an optogenetic approach to examine the role of prefrontal cortex in driving palatable food relapse. I started my lab as an Early Independent Scientist at NIDA, building a research program investigating the behavioral and brain basis of addiction vulnerability. I moved back across town to UMSOM Department of Anatomy and Neurobiology in September of 2015. 
 
The Calu lab conducts behavioral and systems neuroscience studies to elucidate the brain systems driving individual differences in reward learning and motivation that predict addiction vulnerability. We probe amygdala, cortical and striatal brain circuitry, prior to drug experience, to determine how engagement of these brain pathways during learning relates to addiction vulnerability phenotypes. We also examine how these brain systems are changed by voluntary drug experience and dependence to drive drug seeking and drug taking. These preclinical studies may yield new biomarkers of addiction vulnerability and identify new prevention and diagnostic strategies for treatment of addiction.
 
For more about me and current lab peronnel see: www.calulab.com

 

Biosketch

Lab website: https://www.calulab.com/

Research/Clinical Keywords

Reward, learning, motivation, attention, decision-making, addiction, obesity, individual differences, amygdala, insular cortex, striatum, dopamine, in vivo electrophysiology, optogenetics, chemogenetics, fiber photometry, dopamine sensing

Highlighted Publications

Full list of publications via PubMed

Bacharach, S.Z., Martin, DA, Stapf, CA, Sun, F, Li, Y, Cheer, JF, Calu, DJ (2023).Decreased ventral tegmental area CB1R signaling reduces sign-tracking and shifts cue-outcome dynamics in rat nucleus accumbens.The Journal of Neuroscience. 21 June 2023, 43 (25) 4684-4696; PMID: 37208179

Utsav Gyawali, David A Martin, Fangmiao Sun, Yulong Li, Donna Calu (2023)Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations.eLife 12:e81980

Moin Afshar N, Cinotti F, Martin D, Khamassi M, Calu DJ, Taylor JR, Groman SM. (2023) Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related.J Neurosci.2023 Jan 18;43(3):458-471.doi: 10.1523/JNEUROSCI.1113-22.2022.

Keefer SE, Kochli, DE, Calu, DJ. (2022)Basolateral amygdala to insular cortex projections make sign-tracking behavior insensitive to outcome value.eNeuro. 9 (5) ENEURO.0156-22.2022.

Martin, D. A., Keefer, S. E., and Calu, D. (2022)Investigating discriminative stimulus modulation of opioid seeking after conflict‑induced abstinence in sign‑ and goal‑tracking rats.Psychopharmacology. Published online Aug 16 2022.doi: 10.1007/s00213-022-06204-7

Keefer, SE, Gyawali, U., Calu, DJ. (2021). Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making. Behav. Brain Res.;409:113306. doi: 10.1016/j.bbr.2021.113306. Online ahead of print.

Kochli, DE, Keefer, SE Gyawali, U, Calu, DJ. (2020) Basolateral Amygdala to Nucleus Accumbens Communication Differentially Mediates Devaluation Sensitivity of Sign- and Goal-Tracking Rats.  Front. Behav. Neurosci. 14:593645.

Gyawali, UG, Martin, DA, Sulima, A, Rice, KC, Calu, DJ. (2020) Role of BNST CRFR1 receptors in incubation of fentanyl seeking. Front. Behav. Neurosci. 14:153. https://doi.org/10.3389/fnbeh.2020.00153

Martin, DA, Gyawali, U, Calu, DJ. (2020) Effects of 5-HT 2A Receptor Stimulation on Economic Demand for Fentanyl After Intermittent and Continuous Access Self-Administration in Male Rats. Addict Biol. 2020 May 26; e12926. doi: 10.1111/adb.12926. Online ahead of print.

Keefer SE, Bacharach, SB, Kochli, DE, Chabot, JM, Calu, DJ. (2020) Effects of limited and extended Pavlovian training on devaluation sensitivity of sign-and goal-tracking rats. Front. Behav. Neurosci., 04 February 2020 | https://doi.org/10.3389/fnbeh.2020.00003 *Featured in editors pick 2021

Bacharach, SZ*, Nasser, HM*,Zlebnik, NE, Dantrassy, HM, Cheer, JF, Calu, DJ. (2018) Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats. Psychopharmacology doi: 10.1007/s00213-018-4993-6.

Nasser, HM, Lafferty, DL, Lesser, EN, Bacharach, SZ, Calu, DJ. (2017). Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping. Neurobiology of Learning and Memory. 2017 Nov 21;147:35-45.

Nasser, HM*, Chen, YW*, Fiscella, KA, Calu, DJ. (2015) Individual variability in behavioral flexibility predicts sign-tracking tendency.Frontiers in Behavioral Neuroscience. Nov 3; published online.

Chen, YW, Fiscella, KA, Bacharach, SZ, Tanda, G, Shaham, Y, Calu, DJ. (2014) Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history. Addiction Biology. Epub ahead of print Jul 27, 2014.

Chen, YW, Fiscella, KA, Calu, DJ. (2014) Effect of cafeteria diet history on cue-, pellet-priming-, and stress-induced reinstatement of food seeking in female rats. PLoS One. Jul 15; 9(7):e102213.

 

*Authors contributed equally to the work.

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