Irina Burd, MD, PhD

Dr. Burd's publications can be found on PubMed

Board certified Maternal Fetal Medicine physician with full scope of practice, dedicating 20% to clinical care with clinical expertise in fetal neurosonology and fetal echocardiography. Development of Fetal Neurosonology program at the Johns Hopkins Hospital generated referral nationally and internationally. Research focus is in fetal programing (immune and neuroimmune) with exposure to intrauterine inflammation and infection.

• 1995 - Athenaum Honor Society Award (Rutgers University)
• 1995 - Gerard S. Weissman Memorial Prize in Biology (Rutgers University)
• 1998 - Merck/AFAR Scholarship in Pharmacology of Aging
• 2002 - Honorable Mention Manuscript, Residency Competition, Primary Care Update for Ob/Gyns
• 2002 - Research Achievement Award  (Rutgers-RWJMS)
• 2002 - President, Arnold P. Gold Foundation Humanism in Medicine Honor Society (Rutgers-RWJMS)
• 2003 - Academic Excellence in Obstetrics and Gynecology Award (Rutgers-RWJMS)
• 2003-2005 - Ob-Gyn Excellence in Teaching Awards (Thomas Jefferson University)
• 2005 - American College of Surgeons Certificate of Appreciation for Exemplary Teaching
• 2005 - Arnold P. Gold Foundation Resident Award for Humanism in Medicine and Excellence in Teaching
• 2005 - Berlex Best Teaching Resident Award
• 2006 - Administrative Chief, Department of Obstetrics and Gynecology, Thomas Jefferson Univ Hosp
• 2006 - S. Leon Israel Award for Excellence in Research (Obstetrical Society of Philadelphia)
• 2007 - Research Award, Thomas Jefferson University, Department of Ob/Gyn
• 2007 - Howard Lees Kent Memorial Prize for Outstanding Scholarship, Thomas Jefferson University, Department of Ob/Gyn
• 2009-2012 - American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation (ABOG/AAOGF) Scholar
• 2009-2011 - NIH Loan Repayment Award
• 2010 - Ikaria Early Career Investigator Award (The Perinatal Research Society)
• 2010 - Thomas Boggs Award (Philadelphia Perinatal Society)
• 2011 - Pfizer SRI President’s Presenter Award, Mentor, Society for Reproductive Investigation
• 2012 - Johns Hopkins University Clinician Scientist Award (K12)
• 2012 - Passano Foundation Clinician Scientist Award
• 2013 - Super Doctors Rising Star, Maryland, Virginia and Washington DC area, rated by Washington Post
• 2014 - Dr. John Gusdon Memorial New Investigator Award, Mentor (American Society for Reproductive Immunology)
• 2015 - Dr. John Gusdon Memorial New Investigator Award, Mentor (American Society for Reproductive Immunology)
• 2017 - Dr. John Gusdon Memorial New Investigator Award, Mentor (American Society for Reproductive Immunology)
• 2016 - Pfizer SRI President’s Presenter Award, Mentor, Society for Reproductive Investigations
• 2016 - Johns Hopkins Discovery Award
• 2017 - James W. Kennedy Award (AAOGF)
• 2018 - American Journal for Reproductive Immunology Award, American Society for Reproductive Immunology (ASRI)
• 2019 - Mead Johnson Award Speaker, Perinatal Research Society
• 2021 - President’s Achievement Award, Society for Reproductive Investigation
• 2022 - ASRI Distinguished Service Award

Active Grants

10/1/2018 - 9/30/2023

IL-1β regulation of Zika-mediated adverse perinatal outcomes
1R01HD097608-01                            
NICHD                                                          
$609,548 (total per year)
PI: Burd/Klein
PD/PI, 20%

The goal of this study is to test the hypothesis that the extent of perinatal neurologic injury following intrauterine ZIKV infection is determined by the state of placental inflammation, which can then be reversed by targeting maternal IL-1β signaling. These studies are the direct extension of my work on NICHD K08 “IL-1β regulation of perinatal brain injury.”  Unlike the K08 and 1R01HD1031240-01A1 (nanomedicine approaches) studies, employing an endotoxin, a component of gram negative bacteria, these R01 studies aim to demonstrate the generalizability of the key findings (how placental inflammatory determinants impact fetal programming) of my prior work and aim to extrapolate to a viral infections (i.e., Zika virus and SARS-Cov2, as NICHD-approved expanded aims) in utero.

4/1/18-03/31/24

IL-36 responses in Staphylococcus aureus driven skin inflammation
R01AR073665
NIH/NIAMS
PI: Archer
$360,113/year
Co-I, 5%

4/01/2019 – 3/31/2024

Intergenerational link of cardiometabolic risk: Integrate multi-omics with birth cohort

R01HD098232-01
NICHD
$465,803/year
PI: Wang X/Liang L
Co, I, 3%

04/13/21 – 03/31/26

Nanomedicine approaches for prevention of inflammation-induced preterm birth

1R01HD1031240-01A1
NICHD
$629,685 (total per year)
PI: Burd/Ensign                      
PI, 20%

The major goal of this study is to explore nanomedicine approaches to address fundamental questions regarding route of administration, pharmacokinetics, as well as validating existing drug classes that may be reformulated and repurposed for improved targeting to the female reproductive tract. If these preclinical studies progress as expected, we will have identified novel, effective methods for prevention of inflammation-induced preterm birth that also support fetal and neonatal immunological and neuro-immunological programming and development.

 6/1/2021-5/31/2023

Defining SARS-CoV-2 vaccine-induced immunity in pregnant and lactating people
FDA-CERSI
CERSI Collaborators: Burd, Klein, Cox, Pekosz, Mostafa
FDA collaborators: Sewell, Wesley
Co-PI, 2.5%

10/1/2021-9/30/2026

7/24 Healthy Brain and Child Development National Consortium
U01DA055350-01
NIDA
$969,101 (total per year)
PI: Burd/Volk/Kaufman
PI, 5%

The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

Completed grants

7/1/09 – 6/30/12

Excitotoxicity as a Mechanism of Neuronal Damage in Inflammation-Induced Preterm Birth
NO NUMBER
Foundation of the American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation
$300,000
PI: Burd
75% effort

7/1/12-4/30/17

IL1β Regulation of Perinatal Brain Injury

K08 HD073315-05
NICHD
$135,540/year
PI: Burd
75% effort

6/1/13 – 5/30/16

Towards of molecular point-of-care diagnosis: Using umbilical cord blood

[NO NUMBER]
Gerber Foundation
$270,000
PI: Yang
Co-Investigator, 5% effort

The major goal of this project is perform an exploratory validation study to evaluate performance and operational characteristics of novel PCR-HRMA assay using umbilical cord blood.

10/1/14-9/30/16

CHAP Study (multi-sites)
U01 HL120338-01A1
NHLBI
$45,644
PI: Tita
Johns Hopkins University Site PI, 5% effort

7/1/16-6/30/17

ASRI Conference
March of Dimes
NO NUMBER
$5,000
PI: Burd

9/1/2011 – 6/30/2018

Post-doctorate research training of Saudi Arabian physicians
[NO NUMBER]
Ministry of Higher Education of Saudi Arabia/Saudi Arabian Cultural Mission
$6,776,428/over 7 years (72 fellows rotated through this program)
PI: Burd
3%

The major goals of this project is to train Saudi Arabian physicians to conduct research through 1-2 year full time positions, to conduct collaborative projects through other departments within institution and other institutions in order to increase the scientific output and funding.

7/1/17-6/30/18

Novel immunomodulatory therapy to prevent fetal neurologic sequelae associated with Zika infection
AAOGF Bridge Fund
$75,000
PI: Burd

8/1/14-5/30/18

Effect of pharmacologic interventions on inflammation-induced brain injury in a preterm labor murine model: Long term neurologic implications of intrauterine magnesium sulfate and betamethasone exposure

SG5P Grant
Department of Defense
$48,000/year (to JHU)
PI: Thagard
Site PI, 5% effort

7/1/17-10/30/18

Association of Professors of Gynecology and Obstetrics (APGO) Medical Education Endowment Fund Grant Program to develop a series of short videos with companion teaching scripts covering basic sciences topics to vertically integrate into the Obstetrics and Gynecology Clerkshi
[NO NUMBER]
$50,000
PI: Hueppchen
Co-I, 2%

2/15/18-1/31/21

SRI Meeting: Training and Development in the Reproductive Sciences
1R13HD095655-01
NICHD
$6,000
PI: England
Co-I, 2%

7/1/16- 1/31/19

In-utero characterization of embryonic mouse brain development and injury using MRI
R21 NS098018
NINDS
PI: Wu
$157,392

The major goal of this project is to establish an integrated imaging platform for in utero monitoring of the embryonic mouse brain development and injury (in utero LPS model). Co-I, 10%

7/1/14 – 6/30/19

Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being
[NO NUMBER]
Hartwell-Groves Foundation
$400,000/year=
PI, 10% effort

7/1/2018-6/30/2019

Maternal stress and preterm birth: role of genome and epigenome
R03HD096136-01
NICHD
$81,850/year
PI: Hong
Co-I, 2% effort

7/1/17-06/30/19

Impact of immune changes of pregnancy on tuberculosis
R01HD081929
NICHD
PI: Gupta
$411,265
Co-I, 2.5%

10/11/16-3/31/19

Collection of samples from pregnant women for the evaluation of preeclampsia biomarkers
[NO NUMBER]
Progenity
PI: Burd$58,000
PI, 2%

4/01/2016 – 3/31/2021

Preterm birth, maternal and cord blood metabolome, and child metabolic risk
2R01HD041702-12
NICHD
$565,740
PI: Wang, X/Hu, F
Co-I, 3%

7/1/16- 6/30/21

Prenatal stress and antidepressant effects on offspring brain development
RO1 MH106806A1
NIMH
$432,017
PI: Bonnin
Site PI, 10%

4/1/2019 - 3/31/2022

Placental determinants of neonatal immune function in maternal HIV infection
1R21HD099000-01                           
NICHD
$212,510 (total per year)
PI: Burd/Mathad
PI, 10%

6/1/2020-5/31/2022

Assessing real world use of pharmaceuticals among pregnant and lactating people
FDA-CERSI
CERSI Collaborators: Burd, Ladd-Acosta, Volk, Wang, Fallin
FDA collaborators: Johnson, Leishear, Liu, Nugent
Co-PI, 3%

04/01/2018-03/31/22

Maternal-fetal AHR signaling in the pathogenesis and treatment of necrotizing enterocolitis
1R01DK117186-01
NICHD
PI: Hackam
Co-I, 1%

9/1/17-8/31/22

Early life origins of ASD: Role of maternal and cord blood metabolome, placental histology and fetal growth trajectory
HRSA126480
PI: Wang
Co-I, 3%

INTRAMURAL FUNDING  - previous

7/1/16-06/30/17

ORigins of Health and Resilience in Development (ORCHARD) cohort
NO NUMBER
JHU Discovery Award
$125,000
PI: Burd/Wills-Karp/Fallin/X.Wang

1/1/12 – 12/31/12

IL1β Regulation of Perinatal Brain Injury
NO NUMBER
Passano Foundation/JHU Clinician Scientist Award
$80,000
PI: Burd
75% effort