Boyman, Liron | University of Maryland School of Medicine

Academic Title:

Adjunct Assistant Professor

Primary Appointment:

Pharmacology, Physiology & Drug Development

Location:

Mailing Address : BioMET Building, 111 S. Penn St., Suite 104 Office: Pharmacy Hall S544

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Education and Training

B.Sc., Medical and Life Sciences, Tel Aviv University School of Medicine and the Faculty of Life Sciences, Israel, 2004
Ph.D., Physiology and Pharmacology, Tel Aviv University School of Medicine, Israel, 2010
Postdoctoral Fellowship, BioMET-Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD, 2010-2015

Biosketch

Dr. Boyman's work centers on investigating cardiac calcium signaling and has been the discoverer of important features in cardiac muscle physiology, including the regulation of calcium efflux from cardiac cells and the quantitative aspects of calcium movement in cardiac mitochondria.

He has developed and implemented novel imaging technologies, most of which are designed for investigating calcium signals at high temporal and spatial resolution in cardiac cells. This includes developing tools to carry out quantitative measurements of mitochondrial Ca²⁺ signals in real-time using genetically targeted probes, new oxygen micro sensors to investigate the effect of ischemia on mitochondrial Ca²⁺, and new biochemical fluorescent applications to quantify mitochondrial Ca²⁺ fluxes through specific ion channels and exchangers. In addition to the effort to develop new tools he has extensively collaborated with many other investigators to implement these new tools in their ongoing investigation.

Research/Clinical Keywords

Calcium Signaling, Calcium Sparks, Calcium-Dependent Arrhythmogenesis, Excitation-Contraction (EC) Coupling, Sodium Calcium Exchange Mechanisms, Cardiac Hypertrophy, Heart Failure, Cardiac Myocytes, Cardiac Mitochondria, Cardiac Cellular Physiology, Computational Biology, Super-Resolution Imaging, Confocal Imaging

Highlighted Publications

Wescott AP, Kao JPY, Lederer WJ, Boyman L. (2019). Voltage-energized calcium-sensitive ATP production by mitochondria. Nature Metabolism. 14 October 2019. Volume 1, pages 975–984. Free version at https://rdcu.be/bUfKZ.

Boyman L, Karbowski M, Lederer WJ. (2019). Regulation of Mitochondrial ATP production: Ca²⁺ signaling and quality control. Trends in Molecular Medicine. 2020 Jan;26(1):21-39. doi: 10.1016/j.molmed.2019.10.007. PMID:31767352

Boyman, L., Chikando, A.C., Williams, G.S., Khairallah, R., Kettlewell, S., Ward, C.W., Smith, G.L., Kao, J.P., Lederer, W.J. (2014). Calcium Movement in Cardiac Mitochondria. Biophys J. 107(6):1289-301. PMID: 25229137.

Boyman, L., Williams, G.S., Khananshvili, D., Sekler, I., Lederer, W.J. (2013). NCLX: The mitochondrial sodium calcium exchanger. J Mol Cell Cardiol. 59:205-213. PMID: 23538132.

Williams, G.S., Boyman, L., Chikando, A.C., Khairallah, R., Lederer, W.J. (2013) Mitochondrial Calcium Uptake. Proc Natl Acad Sci USA. 25;110(26):10479-86. PMID: 23759742.

Additional Publication Citations

Vivek Garg, Junji Suzuki, Ishan Paranjpe,Tiffany Unsulangi, Boyman L, Lorin S. Milescu, W. Jonathan Lederer and Yuriy Kirichok. (2021). The Mechanism of MICU-Dependent Gating of the Mitochondrial Ca²⁺ Uniporter.

eLife. 2021 Aug 31;10. doi: 10.7554/eLife.69312. PubMed PMID: 34463251.

Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M. (2021). Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination. J Cell Biol. Jun 7;220(6):e202006043. doi: 10.1083/jcb.202006043. PMID: 33851959.

Boyman L, Coleman AK, Zhao G, Wescott AP, Joca HC, Greiser BM, Karbowski M, Ward CW, Lederer WJ. (2019). Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events. Arch Biochem Biophys. May 15;666:31-39. doi: 10.1016/j.abb.2019.03.016. PMID: 30930285.

Boyman, L., Williams, G.S., Wescott AP, Leach JB, Kao JPY, Lederer WJ. (2019). Real-time local oxygen measurements for high resolution cellular imaging. J Mol Cell Cardiol. Feb;127:97-104. doi: 10.1016/j.yjmcc.2018.11.021. PMID: 30528909.

Shan, X., Cherok, E., Das, S., Li, S., Roelofs, BA., Ge, SX., Polster, BM., Boyman, L., Lederer, W.J., Wang, C., Karbowski, M.(2016). Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein. Mol Biol Cell. 27(2):349-59. PMID: 26564796

Sunan, L., Shan, X., Roelofs, BA., Boyman, L., Lederer, WJ., Sesaki, H., Karbowski, M., (2015). Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J Cell Biology. PMID: 25547155

Boyman, L., Williams, G.S., Lederer, W.J. (2015) The Growing Importance of Mitochondrial Calcium in Health and Disease. Proc Natl Acad Sci USA. 112(36):11150-1. PMID: 26311848.

Williams, G.S., Boyman, L., Lederer, W.J. (2015). Mitochondrial calcium and the regulation of metabolism in the heart. J Mol Cell Cardiol. 78:35-45. PMID: 25450609

Boyman, L., Hagen, B.M., Giladi, M., Hiller, R., Lederer, W.J., Khananshvili, D. (2011). Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger. J Biol Chem. 286(33):28811-28820. PMID: 21680748.Hagen, B.M., Boyman, L., Kao, J.P., Lederer. W.J. (2012). A comparative assessment of fluo Ca2+ indicators in rat ventricular myocytes. Cell Calcium. 52(2):170-181. PMID: 22721780.

Boyman, L., Mikhasenko, H., Hiller, R., Khananshvili, D. (2009). Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein. J Biol Chem. 284(10):6185- 6193. PMID: 19141619.

Book Chapters
Boyman, L., Williams, G.S., Lederer, W.J., Mitochondrial Calcium and Ischemia Reperfusion Injury in Heart, Mitochondria and Cell Death, Edited by David M, New York, Springer Science 2015, DOI 10.1007/978-1-4939-3612-0_2.

Awards and Affiliations

Affiliations:

2020 – present Assistant Professor, Department of Physiology, University of Maryland School of medicine. BioMET-Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD.

Awards:

2004 –2010: Ph.D. Stipend Award, Dr. Miriam and Sheldon G. Edelson Foundation.

2008: Katzir-Katchalsky Award, Student Travel Fellowships, For Distinguished Under Graduate Performances.

2009: Shtacher Award, For Research Excellency in the Fields of Physiology and Pharmacology.

2014: Scientist Development Grant Award, American Heart Association. AHA Award Number: 15SDG22100002.

Grants and Contracts

1/01/15 - 01/01/19 American Heart Association Award. PI: Liron Boyman. 15SDG221000020. “Mitochondrial Calcium Signaling in Heart; Physiological and Pathophysiological Implications ” .

07/01/2018 - 6/31/2021 (Collaborator) PI: Wei Chao “Extracellular RNA, Inflammation, and Sepsis” Funding agency: International Anesthesia Research Society.