Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Neurology
Secondary Appointment(s):
Anesthesiology, Neurosurgery
Administrative Title:
Executive Vice Chair
Additional Title:
Chief of Neurocritical Care, Program in Trauma
Location:
GUDELSKY 7th FL, G7K18
Phone (Primary):
410.328.4515
Education and Training
Education
M.D. Northeastern Ohio Universities College of Medicine (NEOUCOM)
M.S. Biostatistics, Mailman School of Public Health, Columbia University
MHCDS Tuck School of Business, Dartmouth College
Post Graduate Education and Training
Resident, Neurology, Emory University School of Medicine
Chief Resident, Neurology, Emory University School of Medicine
Clinical Fellow, Neurocritical Care/ Vascular Neurology, Massachusetts General Hospital
Program in Clinical Effectiveness, Harvard University School of Public Health
Biosketch
I have focused my research career on understanding the systemic sequelae of acute brain injury. As a junior investigator, I received a KL2 award to study the metabolic impact of temperature regulation after brain injury. As part of these investigations, I identified an intricate inter-relationship between inflammation, the metabolic response and neurologic recovery after subarachnoid hemorrhage. This ongoing work has shown that a modified, high-protein diet combined with neuromuscular electrical stimulation may have a beneficial impact on neurologic recovery in a critically ill subarachnoid hemorrhage population. My research group is additionally applying machine learning-based algorithms to continuous streams of vital sign data in an effort to quantify dysautonomia as a systemic marker of neurological decline after TBI and ischemic stroke. With respect to temperature regulation, I have partnered with industry to develop approaches to targeted temperature management that optimizes brain temperature while minimizing systemic effects. I lead a recently completed a multi-center phase 2 clinical trial of a novel transnasal cooling device and am on the steering committee for a multicenter, international clinical trial of targeted normothermia in cerebrovascular patients.
Research/Clinical Keywords
targeted temperature management, machine learning, nutrition and metabolism, inflammation, traumatic brain injury
Highlighted Publications
Complete List of Published Work in MyBibliography:
Grants and Contracts
Dates: 05/01/2024 - 04/30/2029
Role: Co-I (PI: H.A. Choi, MD MSc (UT-Houston))
Title: Biomarkers of Cerebral Edema after Subarachnoid Hemorrhage
Agency: NIH/NINDS: R01NS131469
Dates: 08/1/2023 – 10/31/2024
Role: PI
Title: Therapeutic Cooling of Stroke Patients
Agency: Maryland Industry Partnerships, State of Maryland (MIPS 6021.22-PI )
Dates: 05/01/2023 – 12/31/2027
Role: Co-PI (PPI: P. Hu, PhD)
Title: Shock Trauma Center Research Infrastructure for Trauma with Medical Observation (STC RITMO)
Agency: Defense Advanced Research Projects Agency (DARPA)(HR001122S0043-RITMO-PA-006)
Dates: 04/01/2022 – 3/31/2027
Role: Co-I (PPI: Jennifer Albrecht, PhD)
Title: Recovery among Older Adults Following Head Injury
Agency: NIA/NIH(1R01AG076441-01)
Dates: 01/01/2021 – 12/31/2025
Role: (PI)
Title: Interoperable Medical Automated (iMAS) Technology and Gap Assessment: Development of field triage tool for TBI.
Agency: Medical Technology Enterprise Consortium (MTEC), Department of Defense (MTEC – 20 – 13 – IMAS – 006)
Dates: 01/01/2019 – 12/31/2024
Role: (PI)
Title: Impact of NMES and HPRO on Recovery after Subarachnoid Hemorrhage (INSPIRE)(NCT03201094)
Agency: Neurocritical Care Society, INCLINE Grant
09/30/2018 – 03/31/2024
Role: (PI)
Title: Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury (RAPID- TBI)
Agency: Department of Defense (FA8650-18-23-6H18)