Graham W. Aberdeen, PhD

Education

      B.Sc., Biology, University of Alberta, Edmonton, Alberta, Canada                                  1986

      M.Sc., Physiology, McGill University, Montreal, Quebec, Canada                                   1992

      Ph.D., Physiology/Reproductive Endocrinology, University of Maryland, Baltimore       1998

Post Graduate Education

     Post-Doctoral Research Fellow                                                                                1998 - 2001

      University of Maryland School of Medicine, Baltimore

      Department Obstetrics/Gynecology & Reproductive Sciences

      Division of Perinatal Research

      Baltimore, Maryland

Estrogen regulation of placental and fetal development.

Fetal programming of fetal vascular and adrenal development.

Programming effects upon vascular development and insulin sensitivity in offspring.

Placental Spiral Artery Remodeling

Contrast-enhanced ultrasound (CEUS) and gene therapy (VEGF & sFlt-1) selective administration to the placental basal plate.

Maternal vascular dysfunction associated with an experimental model of defective placental spiral artery remodeling.

Fetal/Perinatal Endocrinology, Placental Development, Fetal Development

Aberdeen GW, Bonagura TW, Harman CR,  Pepe GJ, Albrecht ED.  Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy:  Impact on uterine and fetal blood flow dynamics.  Am  J Physiol Heart Circ Physiol. 302(10): H1936-1944, 2012.

Bonagura TW, Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED.  Prematurely elevating estrogen in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins.  Endocrinology 153(6): 2897-2906, 2012.

Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht ED, Aberdeen GW, Nathanielsz PW, Jeyasuria P, Condon JC.  Cross-Species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon.  Endocrinology 154(12): 4873-4884, 2013.

Dumitrescu A, Aberdeen GW, Pepe GJ, Albrecht ED.  Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex.  Endocrinology 155(12): 4774-4784, 2014.

Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benviz R, Aberdeen GW, Yang P.  Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome.  Diabetes, 64(3): 973-988, 2015.

Babischkin JS, Aberdeen GW, Linder JR, Bonagura TW, Pepe GJ, Albrecht ED. Vascular endothelial growth factor delivery to basal plate promotes uterine artery remodeling in the primate.   Endocrinology, 160(6):1492-1505,  PMID: 31002314

Armant DR, Aberdeen GW, Kilburn BA, Pepe GJ, Albrecht ED. Baboon placental heparin-binding epidermal growth factor-like growth factor.  , 160 (1): 31-37, 2020.  PMID: 32272450

Thompson LP, Turan S, Aberdeen GW. Sex differences and the effects of intrauterine hypoxia on growth and in vivo heart function of fetal guinea pigs.  Am J Physiol Regul, Integr, & Comp Physiol.,  Sep 1;319(3):R243-R254, 2020.  PMID: 32639864

Albrecht ED, Babischkin JS, Aberdeen GW, Burch MA, Pepe GJ. Maternal systemic vascular dysfunction in a primate model of defective uterine spiral artery remodeling.  Am J Physiol Heart Circ Physiol. Apr 1;320(4):H1712-H1723, 2021.  PMID: 33666502

Turan MO, Babischkin JS, Aberdeen GW, Turan S, Harman CR, Pepe GJ, Albrecht ED. B-flow/Spatio-Temporal Image Correlation M-mode:  A Novel Ultrasound Method that Detects a Decrease in Spiral Artery Luminal Diameter in the First Trimester in a Primate Model of Impaired Spiral Artery Remodeling.  Ultrasound Obstet Gynecol. 59:358-364, 2022.  PMID: 34358371

Aberdeen GW, Babischkin JS, Lindner JR, Pepe GJ, Albrecht ED. Placental sFlt-1 Gene Delivery in Early Primate Pregnancy Suppresses Uterine Spiral Artery Remodeling.  Endocrinology, 163(4): 1-10, 2022. PMID: 35134145