Update Your ProfileAcademic Title:
Research Associate
Primary Appointment:
Radiation Oncology
Location:
685 W. Baltimore St.
Phone (Primary):
410 706 2862
Education and Training
| 2004 | BSc., Physics (Major in Fundamental Physics AND Astrophysics), Universidad Complutense de Madrid, Spain |
| 2005 | MSc., Course of Pedagogical Adaptation, Universidad Complutense de Madrid, Spain |
| 2005 |
Research Fellow, Laboratorio de Imagen Médica (Unidad de Medicina y Cirugía Experimental del Hospital General Universitario Gregorio Marañon), Madrid, Spain |
| 2006 | MSc., Physics, Universidad Complutense de Madrid, Spain |
| 2007 | Research Fellow, Grupo Física Nuclear. Dept. Física Atómica, Molecular y Nuclear. Facultad de Ciencias Físicas. Universidad Complutense de Madrid, Spain |
| 2008 |
Pre-Doctoral Fellow, JAE-CSIC program. Instituto de Estructura de la Materia. Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain and Grupo Física Nuclear. Dept. Física Atómica, Molecular y Nuclear. Facultad de Ciencias Físicas. Universidad Complutense de Madrid, Spain |
| 2010 |
Visiting Graduate Research Assistant, Department of Biomedical Engineering, University of California in Davis. Davis, California, USA |
| 2011 | Visiting Graduate Research Assistant, Center for Cancer Research. Molecular Imaging Program, National Institutes of Health (NIH). Bethesda, Maryland, USA |
| 2012 | PhD, Medical Physics, Universidad Complutense de Madrid, Spain |
| 2012 |
Post-Doctoral Fellowship, Grupo Física Nuclear Department, Física Atómica, Molecular y Nuclear. Facultad de Ciencias Físicas. Universidad Complutense de Madrid, Spain |
| 2014 | Post-Doctoral Fellowship, Radiology and Radiological Science. Division of Medical Imaging Physics. Johns Hopkins University. Baltimore, MD, USA |
| 2017 |
Post-Doctoral Fellowship, Department of Radiation Oncology. Division of Medical Physics. University of Maryland School of Medicine. Baltimore, MD, USA |
Biosketch
Dr. Vicente is a nuclear physicist by training working in the field of medical imaging with applications in diagnostic nuclear medicine and in radiation therapy (RT), specifically in the area of stereotactic ablative RT (SAbR or SBRT). Her current work and main research interest are focused on the use of clinical anatomical and functional imaging techniques to improve the state of the art in lung RT treatment planning, in order to preserve post-RT respiratory function. She is developing new lung functional-avoidance RT frameworks which combine virtual bronchoscopy-derived airway maps with lung functional maps (4DCT-derived ventilation maps or SPECT-based ventilation/perfusion maps) to maximize the preservation of both serial and parallel functioning structures of the lung during the RT plan.
Her research background encompasses the study of preclinical and clinical imaging techniques used in diagnostic nuclear medicine. Some of the main lines of research Dr. Vicente was involved are the performance evaluation of preclinical PET/CT systems, the use of Monte Carlo (MC) simulation methods to study and mitigate the sources of error that limit the quality of the preclinical PET images, the investigation of novel preclinical PET scanner designs and reconstruction algorithms for the new geometries, and the analysis of the different factors that determine the repeatability in clinical SPECT by means of patient data, MC simulations and bootstrap techniques.
Research/Clinical Keywords
Medical imaging, airways, dose estimation, lung radiotherapy, stereotactic ablative radiotherapy, SBRT, lung functional-avoidance radiotherapy, motion management.
Highlighted Publications
- E. M. Vicente, A. Modiri, J. Kipritidis, K.C. Yu, K. Sun, J. Cammin, A. Gopal, J. Xu, S. Mossahebi, A. Hagan, Y. Yan, D.R. Owen, P. Mohindra, M.M. Matuszak, R.D. Timmerman, A. Sawant. "Combining Serial and Parallel Functionality in Functional Lung Avoidance Radiation Therapy," Int J Radiat Oncol Biol Phys, 113: 456-468, 2022.
- Kinkopf, A. Modiri, K-C. Yu, Y. Yan, P. Mohindra, R. Timmerman, A. Sawant, E. Vicente, “Virtual bronchoscopy-guided lung SAbR: dosimetric implications of using AAA versus Acuros XB to calculate dose in airways”. Biomed Phys Eng Express, 7(6), 2021.
- E. Vicente, A. Modiri, J. Kipritidis, A. Hagan, K-C. Yu, H. Wibowo, Y. Yan, D.R. Owen, M.M Matuszak, P. Mohindra, R. Timmerman, A. Sawant. “Functionally weighted airway sparing (FWAS): a functional avoidance method for preserving post-treatment ventilation in lung radiotherapy”. Phys Med Biol, 65(16):165010, 2020.
- E. Vicente, A. Modiri, K.C. Yu, H. Wibowo, Y. Yan, R. Timmerman, A. Sawant, “Accounting for respiratory motion in small serial structures during radiotherapy planning: Proof of concept in virtual bronchoscopy–guided lung functional avoidance radiotherapy”, Phys. Med. Biol., 64(22):225011, 2019.
- E. M. Vicente, M.A. Lodge, S.P. Rowe, R.L. Wahl, E.C. Frey, “Simplifying Volume-of-Interest (VOIs) definition in quantitative SPECT: beyond manual definition of 3D whole-organ VOIs”, Med. Phys., 44(5): 1707-1717, 2017.
- E. Mena, S. Sheikhbahaei, M. Taghipour, A.K. Jha, E. Vicente, Jennifer Xiao, and Rathan M. Subramaniam, “18F-FDG PET/CT Metabolic Tumor Volume and Intratumoral Heterogeneity in Pancreatic Adenocarcinomas: Impact of Dual-Time Point and Segmentation Methods”. Clin Nucl Med.;42(1): e16-e21, 2017.
- K. M. Abushab, J. L. Herraiz, E. Vicente, J. Cal-González, S. España, J. J. Vaquero, B. W. Jakoby and J. M. Udías “Evaluation of PeneloPET simulations of Biograph PET/CT scanners”, IEEE Trans. Nucl. Sci. 63(3), pp 1367–1374, 2016.
- L. M. Fraile, J. L. Herraiz, J. M. Udías, J. Cal-González, P. M. G. Corzo, S. España, E. Herranz, M. Pérez-Liva, E. Picado, E. Vicente, A. Muñoz-Martín, and J. J. Vaquero, “Experimental validation of gallium production and isotope-dependent positron range correction in PET”, Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip., vol. 814, pp. 110–116, 2016.
- E. Vicente§, S.P. Rowe§, N. Anizan, H. Wang, J.P. Leal, M.A. Lodge , E.C. Frey, and R.L. Wahl, “Repeatability of Radiotracer Uptake in Normal Abdominal Organs with 111In-Pentetreotide Quantitative SPECT/CT”, J. Nucl. Med. 56 985–8, 2015.
§These authors contributed equally to this work.
- J. Cal-González, E. Lage, E. Herranz, E. Vicente, J. M. Udias, S. C. Moore, M.-A. Park, S. R. Dave, V. Parot, and J. L. Herraiz, “Simulation of triple coincidences in PET,” Phys. Med. Biol., vol. 60, no. 1, p. 117, 2015.
- E. Vicente, J. L. Herraiz, S. España, E. Herranz, M. Desco, J. J. Vaquero, and J. M. Udías, "Improved effective dead-time correction for PET scanners: Application to small-animal PET", Phys Med Biol, 58, 2059-7, 2013.
- E. Vicente§, M. Abella§, A. Rodríguez-Ruano, S. España, E. Lage, M. Desco, J. M. Udias, and J. J. Vaquero, "Misalignments calibration in small-animal PET scanners based on rotating planar detectors and parallel-beam geometry," Phys Med Biol, 57: 7493-518, 2012.
§These authors contributed equally to this work.
- L. Goertzen, Q. Bao, M. Bergeron, E. Blankemeyer, S. Blinder, M. Cañadas, A. F. Chatziioannou, K. Dinelle, E. Elhami, H.-S. Jans, E. Lage, R. Lecomte, V. Sossi, S. Surti, Y.-C. Tai, J. J. Vaquero, E. Vicente, D. A. Williams, and R. Laforest, "NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems," The Journal of Nuclear Medicine 53: 1300-9, 2012.
- J Cal-González, JL Herraiz, S España, E Vicente, E Herranz, M Desco, JJ Vaquero, JM Udías. "Study of CT-based positron range correction in high resolution 3D PET imaging". Nucl Instrum Meth A, S172-S175, 2011.
- S España, JL Herraiz, E Vicente, JJ Vaquero, M Desco, JM Udías. "PeneloPET, a Monte Carlo PET simulation tool based on PENELOPE: features and validation". Phys Med Biol, 54(6): 1723-1742, 2009.
- JL Herráiz, S España, E Vicente, JJ Vaquero, M Desco, JM Udías. "Noise and physical limits to maximum resolution of PET images". Nucl Instrum Meth A, 580(2): 934-937, 2007.
Awards and Affiliations
| 2008-2012 | Pre-Doctoral Fellowship Award, JAE-CSIC program. Instituto de Estructura de la Materia. Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain |
| 2015 | Premios ATI Sistemas a Tesis de Física Nuclear, awards granted to the best Thesis of Nuclear Physics in Spain in 2012 (third position). ATI Sistemas, Grupo Especializado de Fisica Nuclear, and Real Sociedad Española de Física (RSEF) |
| 2019 | 2019 BEST IN PHYSYCS (Therapy) Award granted to the abstract with title “Accounting for Respiration-induced Motion of Peripheral Airways in Virtual Bronchoscopy-guided Lung Stereotactic Ablative Radiotherapy Planning”, 2019 AAPM Annual Meeting, San Antonio, TX. |
| 2019 | 2019 Best Award Travel Fellowship granted to the abstract with title “Accounting for Respiration-induced Motion of Peripheral Airways in Virtual Bronchoscopy-guided Lung Stereotactic Ablative Radiotherapy Planning”, 2019 AAPM Annual Meeting, San Antonio, TX. |
| 2019 | 2019 Basic/Translational Science Award (Senior Investigator, Physics category) granted to the abstract with title “Combining Virtual Bronchoscopy with 4DCT-Based Ventilation Mapping to Preserve Serial- and Parallel-Functioning Lung Elements in Lung SAbR”, 2019 ASTRO Annual Meeting, Chicago, IL. (Abstract awards are only given to the top-scoring abstracts after a peer review; only 44 winners were selected out of over 3,000 abstract submissions). |
| 2021 | 2021 Basic/Translational Science Abstract Award in the Radiation and Cancer Physics category granted to the abstract with title “Accounting for serial and parallel functionality of the lung may minimize post-radiotherapy loss of respiratory function in lung cancer patient”, 2021 ASTRO Annual Meeting, Chicago, IL (Abstract awards are only given to the top-scoring abstracts after a peer review; only 30 winners were selected out nearly 2,000 abstract submissions). |
| 2022 | Michael S. Patterson Publication Impact Prize granted to the paper with title “NEMA NU4-2008 Comparison of Preclinical PET Imaging Systems” (2012) (This prize is awarded by the Canadian Organization of Medical Physicists (COMP) to a publication that represents a significant advance in medical physics. The winner is the eligible paper that has received the most citations in the Web of Science maintained by the Institute for Scientific Information (ISI), including citations from all databases). |
Links of Interest
Patents, Inventions and Copyrights
| 2023 |
US Patent number: 11633623 |