William F. Regine, MD, FACR, FACRO

• State University of New York at Albany, BS, 1983
• State University of New York Health and Science Center at Syracuse, MD, 1987
• Residency, Thomas Jefferson University Hospital, Radiation Oncology, 1991
• Fellowship, Thomas Jefferson University and University of Florida Hospitals, Radiation Oncology-Head and Neck and Gastrointestinal Malignancies, 1992

Dr. Regine leads a department which has achieved a Top 5 national ranking in National Institutes of Health research funding. He is recognized nationally and internationally in the areas of gastrointestinal and central nervous system malignancies and in the use of stereotactic radiosurgery (SRS). As Executive Director of the Maryland Proton Treatment Center, he leads the first and most advanced facility of its kind in the Baltimore-Washington, DC region -- providing nearly 2,000 cancer patients a year with precise, "pencil-beam" technology to treat solid tumors.

Dr. Regine has served as principal or co-principal Investigator in at least four National Cancer Institute (NCI)-sponsored cooperative group clinical trials. He has been a member of the GI and Brain Tumor steering committees for the NCI sponsored national cooperative clinical trials group known as NRG Oncology, and has been the chairman of the GI section of the National Oral Board examination for trainees in radiation oncology. Dr. Regine served as the principal investigator of a study evaluating adjuvant therapy in patients with pancreatic cancer, which defined a new standard of care. He also has been the principal investigator/study chairman for two institutional clinical trials that defined new standards of care for patients with brain metastases and malignant spinal cord compression. Dr. Regine is co-editor of Principles and Practices of Stereotactic Radiosurgery, the first comprehensive textbook of its kind. He is also co-inventor of the first of its kind treatment device completely dedicated to the stereotactic radiation treatment of early stage breast cancer, known as the GammaPod.

Pancreas/Gastrointestinal Cancers, Central Nervous System Malignancies, Brain Metastases/Tumors, Head and Neck Cancers, Sarcomas, Stereotactic Radiosurgery (SRS), Proton Treatment.

Chin LS, Regine WF. Editors. Principles and Practice of Stereotactic Radiosurgery, Second Edition, Springer Publishing, 2015.

Regine WF, Winter K, Abrams R, Safran H, Kessel I, Chen Y, Fugazzi J, Donnelly E, DiPetrillo T, Narayan S, Plastaras J, Gaur R, Delouya G, Suh J, Meyer J, Haddock M, Didolkar M, Padula G, Johnson D, Hoffman J, Crane C. Postresection CA19-9 and margin status as predictors of recurrence after adjuvant treatment for pancreatic carcinoma: Analysis of NRG oncology RTOG trial 9704. Advances in Radiation Oncology, 3(2), p154-162, June 2018.

Remick J, Kowalski E, Khairnar R, Sun K, Morse E, Cherng H, Poirier Y, Lamichhane N, Becker S, Chen S, Patel A, Kwok Y, Nichols E, Mohindra P, Woodworth G, Regine WF, Mishra M. A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery in the treatment of brain metastasis. Clinical Radiation Oncology Journal, Vol 15, Article number: 128 (2020), May 2020.

Snider J, Molitoris J, Shyu S, Diwanji T, Rice S, Kowalski E, Decesaris C, Remick J, Yi B, Zhang B, HallA, Hanna N, Ng V, Regine WF. Spatially Fractionated Radiotherapy (GRID) Prior to Standard Neoadjuvant Conventionally Fractionated Radiotherapy for Bulky, High-Risk Soft Tissue and Osteosarcomas: Feasibility, Safety, and Promising Pathologic Response Rates. Radiation Research, Vol. 194, Issue 6, p. 707–714, October 2020.

Koroulakis A, Molitoris J, Kaiser A, Hanna N, Bafford A, Jiang Y, Bentzen S, Regine WF. Re-Irradiation for Rectal Cancer Using Pencil-Beam Scanning Proton Therapy: A Single Institutional Experience. Advances in Radiation Oncology, Vol. 6, Issue 1, February 2021.

Koroulakis A, Molitoris J, Sullivan M, Jiang Y, Hausner P, Hanna N, Bafford A, Miller R, Regine WF. Radiation Therapy and Malignant Fistulae of Anorectal Cancers. Pract Radiat Oncol.,12(6), p. e517-e521, December 2022.