Research & Projects

Using interdisciplinary approaches, we work at the crossroads of therapeutic concepts and technical developments.

Therapeutic Concepts

The majority of our activities fall under the umbrella of regenerative medicine and neurooncology. We are taking advantage of recent developments in molecular targeting focusing on biological therapeutic agents such cells, vesicles, viruses, proteins, nanoparticles and others. These agents can be highly effective with minimal adverse effects, but their delivery to the CNS is challenging.

Technical Developments

Technical developments focus on three directions, which are essential for full implementation of image-guided neurointerventions.

Labeling and Visualization of Agents

Labeling protocol is optimized taking into account chemical composition of therapeutic agents, disease type, species and other priorities such as spatial and temporal resolution, sensitivity or follow-up duration. Magnetic labeling with iron oxide nanoparticles and ⁸⁹Zr-based radiolabeling are our clinically applicable workhorses. Bioluminescence with excellent reporter genes provides exceptional insight into the dynamics of cellular processes while high resolution intravital two-photon microscopy offers a unique opportunity to examine brain function at the subcellular level.

Device Development

Advancing imaging of neurointerventions requires new types of devices such as catheters, needles, coils or even scanners, which are tuned for the unique requirements of CNS applications, and can be seamlessly incorporated into the workflow of interventional procedures. Safe and precise utilization of these devices for advanced image guided interventions by PET and MRI are of paramount importance.

Image Processing

Image guided neurointerventions require algorithms for robust and instant image processing to provide comprehensive feedback during procedures. We are exploring artificial intelligence-based approaches to address our needs.