Glaucoma Research

Study 1

Focuses on the XyCAM RI, a non-invasive tool designed to assess blood flow in the eye. This innovative approach aims to enhance diagnostic accuracy for early-stage glaucoma, potentially leading to improved treatment outcomes.

Study 2

Focuses on the vascular components of glaucoma, exploring how blood flow to the optic nerve may influence the disease’s progression. By utilizing advanced techniques like erythrocyte-mediated Indocyanine Green angiography and fluorescence-mediated photoplethysmography, we aim to measure blood flow and vasomotion at the optic nerve head, potentially revealing critical insights into the underlying mechanisms of glaucoma.

Study 1

May have:

• Mild glaucoma

Must not have:

• Any other ocular diseases
• Diabetes
• COPD/Asthma
   

Study 2

May have:

• Mild glaucoma

Must not have:

• Any other ocular diseases
• Diabetes
• Hypertension
• COPD/Asthma
• Iodine or shellfish allergy

Study 1

The study will involve a single imaging session that takes approximately 45 minutes at University of Maryland Faculty Physicians, Inc., in downtown Baltimore. If you choose to participate, you will be compensated with a $50 gift card. We offer complimentary transportation to and from the study visits.

Study 2

The study will involve about five to six hours in the General Clinical Research Center at the University of Maryland Medical Center and may involve co-enrollment with a study at the U.S. Food and Drug Administration in Silver Spring, Maryland. 

If you choose to participate, you will be compensated $100 for each study visit. We offer complimentary transportation to and from the study visits.

• Osamah J. Saeedi, MD – Principal Investigator
• Saige Oechsli – Lead Clinical Research Assistant
• Yash Porwal – Research Assistant
• Ibrahim Saleh– Post Doctoral Fellow
• Marlon Diaz – Medical Student
• Priyanka Mann – Post Doctoral Fellow
• Christina Kilby – Clinical Research Coordinator
• Jeong-yoon Wu – Clinical Research Coordinator

• Victoria Y. Chen, Jessica A. Pottenburgh, Shih-En Chen, Sarah Kim, Lakyn Mayo, Aashka Damani, Marvin Cruz, Ashley Park, Lily Im, Laurence Magder, Osamah J. Saeedi; Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2024;65(11):33. https://doi.org/10.1167/iovs.65.11.33.
• Yash Porwal, Mary Ventimiglia, Renad Alhabashi, Shaiza Mansoor, Ria Kapoor, He Eun Forbes, Amrik Gill, Saige Oechsli, Lily Im, Sarah Ullah, Avigyan Sinha, Abhishek Rege, Osamah Saeedi; Impaired Autoregulation of Retinal Blood Flow in Human Glaucoma Subjects Using Laser Speckle Imaging. Invest. Ophthalmol. Vis. Sci. 2024;65(7):1238.
• Avigyan Sinha, Yash Porwal, Mary Ventimiglia, Renad Alhabashi, Shaiza Mansoor, Ria Kapoor, He Eun Forbes, Amrik Gill, Saige Oechsli, Lily Im, Sarah Ullah, Abhishek Rege, Osamah Saeedi; Hyperoxia-induced reactivity of ocular blood flow is altered in glaucoma. Invest. Ophthalmol. Vis. Sci. 2024;65(7):1236.
• Shaiza Mansoor, Amrik Gill, Saige Oechsli, Ria Kapoor, Avigyan Sinha, Abhishek Rege, Osamah Saeedi; Isolating and Estimating Choroidal Blood Flow using Multimodal Imaging. Invest. Ophthalmol. Vis. Sci. 2024;65(7):5897.