PHARMACOLOGY: QUESTIONS BASED ON
SAMPLE DRUG CLASSIFICATION TABLES

DRUGS FOR TREATING HYPERTENSION

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Sympathetic Nervous System Agents
Drug Class Prototype Action
Central clonidine -?- α2 -agonist; causes decreased sympathetic outflow
Peripheral guanethidine
-?- uptake by transmitter vesicles in nerve depletes & replaces norepinephrine in neurosecretory vesicles
prazocin -?- α1-antagonist
propranolol -?- β-antagonist
Central & Peripheral reserpine -?- binds tightly to storage vesicles, which consequently lose their ability to concentrate & store norepinephrine
Vasodilators
Drug Class Prototype Action
Arterial hydralazine -?- unknown
diazoxide -?- opens K+ channels & causes hyperpolarization of smooth muscle
Arterial & Venous nitropusside -?- releases NO, which binds to guanylyl cyclase to generate cGMP
Ca++ Channel-Blockers
Prototype Action
nifedipine -?- Inhibits voltage-dependent "L-type" Ca++ channels
Ace Inhibitors
Prototype Action
catopril -?- Inhibits conversion of angiotensin I to angiotensin II
Diuretics
Drug Class Prototype Action
Thiazides (Benzothiadiazides) hydrochlorothiazide -?- Inhibits Na+ channels in luminal membrane in the proximal segment of the distal tubule
Loop agents furosemide -?- Inhibits cotransporter of Na+, K+, Cl- in the ascending limb of the loop of Henle
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