UM SOM Researchers Discover New Potential Genetic Links to Common Brain Disorder

Five-Year Study Could Lead to Screenings, Therapeutic Options

An international group of researchers has for the first time identified a set of 30 inherited recessive genes that play a role in intellectual disability (ID), a neurodevelopmental disorder that, according to the Centers for Disease Control (CDC), affects as many as 213 million people around the world.

The research team was led in in part by Principal Investigator Saima Riazuddin, PhD, MPH, MBA Professor of Otorhinolaryngology Head & Neck Surgery and Professor of Biochemistry & Molecular Biology at the University of Maryland School of Medicine (UM SOM). Other principal researchers included Hans van Bokhoven, PhD, of the Department of Human Genetics at Radboud University Medical Center in the Netherlands, and Sheikh Riazuddin, PhD, of the Allama Iqbal Medical College, the University of Health Sciences in Pakistan.

Intellectual disability, or ID (previously known as mental retardation), becomes apparent in children before the age of 18. The disorder, which is measured by an intelligence quotient below 70, significantly limits an individual’s intellectual ability and practical skills. ID also can be a significant burden to families, society and the healthcare system. According to CDC, the lifetime cost for caring for a person with an intellectual disability is over $1 million. Currently, about 1-3 percent of the world’s population possess some form of ID. While about half of all ID cases can be linked to environmental causes like poor nutrition, unknown genetic factors, such as gene mutations, are responsible for the remaining 50 percent.

The new study, which was published recently in the online journal Molecular Psychiatry, presents the outcomes of a five-year investigation that was conducted over three continents. In order to identify potential genetic causes for ID, investigators assembled a test group of 121 families in rural Pakistan, in which there was a higher incidence of ID and consanguineous marriages (marriages between blood relations). More than 15,000 DNA samples were collected, which were analyzed both in the Netherlands and at UM SOM’s Institute of Genomic Sciences (IGS), using next-generation genetic sequencing.

From an initial pool of 2,000 possible genes, the study has categorized 30 novel candidate genes possessing a strong potential for causing ID—and possibly other brain disorders as well. In addition, this information now can be applied to DNA screenings in determining the possibility of a couple producing an ID child.

“The implications are enormous,” said Dr. Riazuddin. “The next phase of our study is to come up with therapeutic options and personalized protocols that could help patients improve their intellectual function.”

“This study by Dr. Riazuddin and her colleagues marks a major breakthrough in uncovering new solutions to such crippling brain disorders as ID,” said UM SOM Dean E. Albert Reece, MD, PhD, MBA, who is also Vice President of Medical Affairs at the University of Maryland and the John Z. and Akiko Bowers Distinguished Professor at UM SOM. “Their innovative work now has opened the door to other potential discoveries that will change the way we treat such disabilities in the future.”

About the University of Maryland School of Medicine

The University of Maryland School of Medicine was chartered in 1807 and is the first public medical school in the United States and continues today as an innovative leader in accelerating innovation and discovery in medicine. The School of Medicine is the founding school of the University of Maryland and is an integral part of the 11-campus University System of Maryland. Located on the University of Maryland’s Baltimore campus, the School of Medicine works closely with the University of Maryland Medical Center and Medical System to provide a research-intensive, academic and clinically based education. With 43 academic departments, centers and institutes, and a faculty of more than 3,000 physicians and research scientists and more than $400 million in extramural funding, the School is regarded as one of the leading biomedical research institutions in the U.S. with top-tier faculty and programs in cancer, brain science, surgery and transplantation, trauma and emergency medicine, vaccine development and human genomics, among other centers of excellence. The School is not only concerned with the health of the citizens of Maryland and the nation, but also has a global presence, with research and treatment facilities in more than 35 countries around the world.
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