Publications

Books

• Chemical Biology: Methods and Protocols  Hempel E , Williams H, Hong C, editors. Humana Press; 2015 Jan 1.
• Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies  Hong C, Ao A, Hao J, editors. Wiley; 2014 Aug 1.

2023

• Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Petropoulou E, Jamshidi Y, Benson MD, Keyes MJ, Ngo D, Vasan RS, Yang Q, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, Moskowitz IP, York JD, Wang TJ, Knollmann BC, Roden DM. Circulation. 2023 Mar 7;147(10):824-840. PMID: 36524479
• Longitudinal Echocardiogram Imaging in the First Genetically Modified Porcine to Human Cardiac Xenotransplant. Hong SN, Mohiuddin MM, Ananthram M, Soares C, Goerlich CE, Dickfeld TL, Hanna P, Hong CC, Benitez M, Joseph SM, Gupta A, Grazioli A, Griffith BP. JACC Cardiovasc Imaging. 2023 Apr;16(4):553-557.  PMID: 36813614. 
• Association of Incident Cardiovascular Disease With Time Course and Cumulative Exposure to Multiple Risk Factors. Domanski MJ, Wu CO, Tian X, Hasan AA, Ma X, Huang Y, Miao R, Reis JP, Bae S, Husain A, Jacobs DR Jr, Allen NB, Lee MT, Hong CC, Farkouh ME, Lloyd-Jones DM, Fuster V. J Am Coll Cardiol. 2023 Mar 28;81(12):1151-1161. PMID: 36948731. 
• Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy.  Chun YW, Miyamoto M, Williams CH, Neitzel LR, Silver-Isenstadt M, Cadar AG, Fuller DT, Fong DC, Liu H, Lease R, Kim S, Katagiri M, Durbin MD, Wang KC, Feaster TK, Sheng CC, Neely MD, Sreenivasan U, Cortes-Gutierrez M, Finn AV, Schot R, Mancini GMS, Ament SA, Ess KC, Bowman AB, Han Z, Bichell DP, Su YR, Hong CC. Circulation. 2023 Apr 25;147(17):1291-1303. PMID: 36970983
• Identification of novel genetic variants, including PIM1 and LINC01491, with ICD-10 based diagnosis of pulmonary arterial hypertension in the UK Biobank cohort. Pu A, Ramani G, Chen YJ, Perry JA, Hong CC. Front Drug Discov (Lausanne). 2023;3:1127736. PMID: 37089865

2022

• The grand challenge of discovering new cardiovascular drugs. Hong CC. Front Drug Discov (Lausanne). 2022;2:1027401. PMID: 37123434
• The Social and Natural Environment's Impact on SARS-CoV-2 Infections in the UK Biobank. Scalsky RJ, Chen YJ, Ying Z, Perry JA, Hong CC. Int J Environ Res Public Health. 2022 Jan 4;19(1):533. PMID: 35010792 
• Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment.  Stern S, Liang D, Li L, Kurian R, Lynch C, Sakamuru S, Heyward S, Zhang J, Kareem KA, Chun YW, Huang R, Xia M, Hong CC, Xue F, Wang H. JCI Insight. 2022 Jun 22;7(12): e153868. PMID: 35579950  
• Identification of Novel Genetic Variants and Comorbidities Associated With ICD-10-Based Diagnosis of Hypertrophic Cardiomyopathy Using the UK Biobank Cohort. Gyftopoulos A, Chen YJ, Wang L, Williams CH, Chun YW, O'Connell JR, Perry JA, Hong CC. Front Genet. 2022 May 24;13:866042. PMID: 35685441
• The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon.  Shen C, Nayak A, Neitzel LR, Yang F, Li B, Williams CH, Hong CC, Ahmed Y, Lee E, Robbins DJ. J Biol Chem. 2022 Aug;298(8):102227. PMID: 35780831.
• Identifying genetic variants associated with the ICD10 (International Classification of Diseases10)-based diagnosis of cerebrovascular disease using a large-scale biomedical database. Alkhalfan F, Gyftopoulos A, Chen YJ, Williams CH, Perry JA, Hong CC. PLoS One. 2022 Aug 22;17(8):e0273217. PMID: 35994481  
• Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Halford JL, Morrill VN, Choi SH, Jurgens SJ, Melloni G, Marston NA, Weng LC, Nauffal V, Hall AW, Gunn S, Austin-Tse CA, Pirruccello JP, Khurshid S, Rehm HL, Benjamin EJ, Boerwinkle E, Brody JA, Correa A, Fornwalt BK, Gupta N, Haggerty CM, Harris S, Heckbert SR, Hong CC, Kooperberg C, Lin HJ, Loos RJF, Mitchell BD, Morrison AC, Post W, Psaty BM, Redline S, Rice KM, Rich SS, Rotter JI, Schnatz PF, Soliman EZ, Sotoodehnia N, Wong EK; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Sabatine MS, Ruff CT, Lunetta KL, Ellinor PT, Lubitz SA. Nat Commun. 2022 Aug 30;13(1):5106. PMID: 36042188
• Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke. Jaworek T, Xu H, Gaynor BJ, Cole JW, Rannikmae K, Stanne TM, Tomppo L, Abedi V, Amouyel P, Armstrong ND, Attia J, Bell S, Benavente OR, Boncoraglio GB, Butterworth A; Cervical Artery Dissections and Ischemic Stroke Patients (CADSIP) Consortium; Carcel-Marquez J, Chen Z, Chong M, Cruchaga C, Cushman M, Danesh J, Debette S, Duggan DJ, Durda JP, Engstrom G, Enzinger C, Faul JD, Fecteau NS, Fernandez-Cadenas I, Gieger C, Giese AK, Grewal RP, Grittner U, Havulinna AS, Heitsch L, Hochberg MC, Holliday E, Hu J, Ilinca A; INVENT Consortium; Irvin MR, Jackson RD, Jacob MA, Janssen RR, Jimenez-Conde J, Johnson JA, Kamatani Y, Kardia SL, Koido M, Kubo M, Lange L, Lee JM, Lemmens R, Levi CR, Li J, Li L, Lin K, Lopez H, Luke S, Maguire J, McArdle PF, McDonough CW, Meschia JF, Metso T, Muller-Nurasyid M, O'Connor TD, O'Donnell M, Peddareddygari LR, Pera J, Perry JA, Peters A, Putaala J, Ray D, Rexrode K, Ribases M, Rosand J, Rothwell PM, Rundek T, Ryan KA, Sacco RL, Salomaa V, Sanchez-Mora C, Schmidt R, Sharma P, Slowik A, Smith JA, Smith NL, Wassertheil-Smoller S, Soederholm M, Stine OC, Strbian D, Sudlow CL, Tatlisumak T, Terao C, Thijs V, Torres-Aguila NP, Tregouet DA, Tuladhar AM, Veldink J…Neurology. 2022 Aug 31;99(16):e1738-54. PMID: 36240095
• Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium. Xu H, Nguyen K, Gaynor BJ, Ling H, Zhao W, McArdle PF, O'Connor TD, Stine OC, Ryan KA, Lynch M, Smith JA, Faul JD, Hu Y, Haessler JW, Fornage M, Kooperberg C, On Behalf Of The Trans-Omics For Precision Medicine TOPMed Stroke Working Group, Perry JA, Hong CC, Cole JW, Pugh E, Doheny K, Kardia SLR, Weir DR, Kittner SJ, Mitchell BD; SiGN Consortium. Genes (Basel). 2022 Dec 24;14(1):61. PMID: 36672803

2021

• TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment. Montibus B, Cercy J, Bouschet T, Charras A, Maupetit-Méhouas S, Nury D, Gonthier-Guéret C, Chauveau S, Allegre N, Chariau C, Hong CC, Vaillant I, Marques CJ, Court F, Arnaud P.Cell Mol Life Sci. 2021 Jan;78(2):757-768. PMID: 32405722 
• Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals. Guo L, Torii S, Fernandez R, Braumann RE, Fuller DT, Paek KH, Gadhoke NV, Maloney KA, Harris K, Mayhew CM, Zarpak R, Stevens LM, Gaynor BJ, Jinnouchi H, Sakamoto A, Sato Y, Mori H, Kutyna MD, Lee PJ, Weinstein LM, Collado-Rivera CJ, Ali BB, Atmakuri DR, Dhingra R, Finn ELB, Bell MW, Lynch M, Cornelissen A, Kuntz SH, Park JH, Kutys R, Park JE, Wang L, Hong SN, Gupta A, Hall JL, Kolodgie FD, Romero ME, Jeng LJB, Mitchell BD, Surve D, Fowler DR, Hong CC, Virmani R, Finn AV. JAMA Cardiol. 2021 Sep 1;6(9):1013-1022. PMID: 34076677
• Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort. Ashvetiya T, Fan SX, Chen YJ, Williams CH, O'Connell JR, Perry JA, Hong CC.PLoS One. 2021 Sep 1;16(9):e0247287. PMID: 34469433 
• The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. Nat Commun. 2021 Sep 6;12(1):5263. PMID: 34489457
• Mutagenesis of human genomes by endogenous mobile elements on a population scale. Chuang NT, Gardner EJ, Terry DM, Crabtree J, Mahurkar AA, Rivell GL, Hong CC, Perry JA, Devine SE. Genome Res. 2021 Nov 12;31(12):2225-35. PMID: 34772701 
• Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK.Lasola JJM, Cottingham AL, Scotland BL, Truong N, Hong CC, Shapiro P, Pearson RM. Pharmaceutics. 2021 Nov 2;13(11):1841. PMID: 34834256

2020

• Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes. Cadar AG, Feaster TK, Bersell KR, Wang L, Hong T, Balsamo JA, Zhang Z, Chun YW, Nam YJ, Gotthardt M, Knollmann BC, Roden DM, Lim CC, Hong CC.Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C163-C173. PMID: 31747312
• LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA. Belot A, Gourbeyre O, Fay A, Palin A, Besson-Fournier C, Latour C, Hopkins CR, Tidmarsh GF, Coppin H, Roth MP, Ritter MR, Hong CC, Meynard D. Haematologica. 2020 Aug;105(8):e385-e388. PMID: 31806689
• PEGylated PLGA Nanoparticle Delivery of Eggmanone for T Cell Modulation: Applications in Rheumatic Autoimmunity. Haycook CP, Balsamo JA, Glass EB, Williams CH, Hong CC, Major AS, Giorgio TD. Int J Nanomedicine. 2020 Feb 19;15:1215-1228. PMID: 32110018
• Methods for the reliable induction of heterotopic ossification in the conditional Alk2^Q207D mouse. Pan H, Fleming N, Hong CC, Mishina Y, Perrien DS. J Musculoskelet Neuronal Interact. 2020 Mar 3;20(1):149-159. PMID: 32131380 
•  The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease.Thayer TE, Lino Cardenas CL, Martyn T, Nicholson CJ, Traeger L, Wunderer F, Slocum C, Sigurslid H, Shakartzi HR, O'Rourke C, Shelton G, Buswell MD, Barnes H, Neitzel LR, Ledsky CD, Li JP, Burke MF, Farber-Eger E, Perrien DS, Kumar R, Corey KE, Wells QS, Bloch KD, Hong CC, Bloch DB, Malhotra R. Sci Rep. 2020 Jun 19;10(1):9831. PMID: 32561790
• Should we overcome the resistance to bioelectrical impedance in heart failure? Hankinson SJ, Williams CH, Ton VK, Gottlieb SS, Hong CC. Expert Rev Med Devices. 2020 Aug;17(8):785-794. PMID: 32658589
• Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors. Engers DW, Bollinger SR, Felts AS, Vadukoot AK, Williams CH, Blobaum AL, Lindsley CW, Hong CC, Hopkins CR.Bioorg Med Chem Lett. 2020 Sep 15;30(18):127418. PMID: 32750526
• Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk. Domanski MJ, Tian X, Wu CO, Reis JP, Dey AK, Gu Y, Zhao L, Bae S, Liu K, Hasan AA, Zimrin D, Farkouh ME, Hong CC, Lloyd-Jones DM, Fuster V.J Am Coll Cardiol. 2020 Sep 29;76(13):1507-1516. PMID: 32972526 
• Balancing Service and Safety: Cardiovascular Medicine Divisional Response to the COVID-19 Pandemic. Khan AN, Desai K, Zviman A, Hong SN, Ananthram M, Liu S, Srivastava MC, Benitez M, Hong CC, Dickfeld TM, Jimenez Restrepo A. JACC Case Rep. 2020 Jul 15;2(9):1368-1375. PMID: 33521678 

2019

2018

2017

• Cadar AG, Feaster TK, Durbin MD, Hong CC. Production of Single Contracting Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Matrigel Mattress Technique. Current protocols in stem cell biology. 2017 Aug 14;42. 4A.14.1-4A.14.7. PMID: 28806851 [PubMed].
• Durbin MD, Cadar AG, Williams CH, Guo Y, Bichell DP, Su YR, Hong CC. Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Pediatric cardiology. 2017 Jun 12;6(38). 1232-1240. PMID: 28608148 [PubMed].
• Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. The Journal of Clinical Investigation. 2017 Jun 1;127(6). 2262-2276.
• Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.Assay and drug development technologies. 2017 Apr 5. PMID: 28379727 [PubMed].
• Sheng C, Amiri-Kordestani L, Force T, Hong C, Wu C, Croce K, Kim G, Moslehi J. 21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine Journal of American College of Cardiology: Basic to Translational Science. in press (2017).

2016

• Jiramongkolchai P, Owens P, Hong CC. Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition. Biochemical Society transactions. 2016 Aug 15;44(4). 1117-34. PMID: 27528760 [PubMed].
• Hover LD, Owens P, Munden AL, Wang J, Chambless LB, Hopkins CR, Hong CC, Moses HL, Abel TW. Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma. Neuro-oncology. 2016 Jul;7(18). 928-938. PMID: 26683138 [PubMed].
• Clark CR, Robinson JY, Sanchez NS, Townsend TA, Arrieta JA, Merryman WD, Trykall DZ, Olivey HE, Hong CC, Barnett JV. Common pathways regulate type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells. Cellular signalling. 2016 Mar 9. PMID: 26970186 [PubMed].
• Hempel JE, Cadar AG, Hong CC. Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. Bioorganic & medicinal chemistry letters. 2016 Mar 7. PMID: 26976215 [PubMed].
• Tadokoro T, Gao X, Hong CC, Hotten D, Hogan BL. BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. Development (Cambridge, England). 2016 Jan 25. PMID: 26811382 [PubMed].
• Williams CH, Hong CC. Zebrafish small molecule screens: Taking the phenotypic plunge. Computational and structural biotechnology journal. 14. 350-356. PMID: 27721960 [PubMed].

2015

• Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC. Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full. Journal of molecular and cellular cardiology. 2015 Dec;89(Pt B). 379-80.
• Chun YW, Voyles DE, Rath R, Hofmeister LH, Boire TC, Wilcox H, Lee JH, Bellan LM, Hong* C, Sung* HJ. Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status. Journal of biomechanics. *Co-corresponding authors; 2015 Oct 8.
• Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel J, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC. Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation research. 2015 Oct 1.
• Hover LD, Young CD, Bhola NE, Wilson AJ, Khabele D, Hong CC, Moses HL, Owens P. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer letters. 2015 Jul 30. PMID: 26235139 [PubMed].
• Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC. Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent cell-derived cardiomyocytes. Biomaterials. 2015 Jul 14;67. 52-64.
• Habib A, Polavarapu R, Karmali V, Guo L, Van Dam R, Cheng Q, Akahori H, Saeed O, Nakano M, Pachura K, Hong CC, Shin E, Kolodgie F, Virmani R, Finn AV. Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques. Atherosclerosis. 2015 Jun 19;241(2). 692-700. PMID: 26125411 [PubMed].
• Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong* CC, Moses* HL. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. *Co-senior authors; 2015 May 7;34(19). 2437-49. PMID: 24998846 [PubMed].
• Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell reports. 2015 Apr 7;11(1). 43-50. PMID: 25818300 [PubMed]. PMCID: PMC4394042. NIHMSID: NIHMS669677.
• Williams H, Hong C. High content screening for modulators of cardiovascular or global developmental pathways in zebrafish. In: Chemical Biology: Methods and Protocols. Springer Press; 1263. 167-174. PMID: 25618344 [PubMed].
• Hempel E, Hong C. Practical Strategies for Small Molecule Probe Development in Chemical Biology. In: Chemical Biology: Methods and Protocols. Springer Press; 1263. 209-223. PMID: 25618348 [PubMed]
• Wang X, Chun W, Zhong L, Chiusa M, Balikov A, Frist Y, Lim C, Maltais S, Hong* C, Sung* H. A temperature sensitive, self-adhesive hydrogel to deliver iPSC-derived cardiomyocytes for heart repair International Journal of Cardiology. *Co-corresponding authors; 190. 177-180.
• Hwang S, Kryshtal O, Feaster K, Sanchez-Freire V, Zhang J, Kamp J, Hong C, Wu C, Knollmann C. Comparable Calcium Handling Of Human iPSC-derived Cardiomyocytes Generated By Multiple Laboratories Journal of Molecular and Cellular Cardiology. 85. 79-88.
• Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.PloS one. 10(11). e0143243. PMID: 26600013 [PubMed]. PMCID: PMC4658040.
• Hempel JE, Williams CH, Hong CC. Preface. Chemical biology. Methods in molecular biology (Clifton, N.J.). 1263. v. PMID: 25774396 [PubMed].

2014

• Aboud AA, Tidball AM, Kumar KK, Diana Neely M, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB. PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiology of disease. 2014 Oct 11. PMID: 25315681 [PubMed].
• Tsugawa D, Oya Y, Masuzaki R, Ray KC, Engers DW, Dib M, Do N, Kuramitsu K, Ho KJ, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ. Specific Activin Receptor-Like Kinase 3 Inhibitors Enhance Liver Regeneration. The Journal of pharmacology and experimental therapeutics. 2014 Sep 30. PMID: 25271257 [PubMed].
• Sheng C, Hao J, Hong C. Chemically induced pluripotent stem cells (CiPSC): a potential chemical biological breakthrough in reprogramming? In: Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies. Wiley Press; 2014 Aug.
• Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM. Screening for Acute IKr Block Is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current. Circulation. 2014 Jul 15;130(3). 224-34. PMID: 24895457 [PubMed]. PMCID: PMC4101031.
• West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin DC, Ware LB, Wheeler LA, Hong CC, Meyrick BO, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a Common Wnt Associated Genetic Signature Across Multiple Cell Types in Pulmonary Arterial Hypertension. American journal of physiology. Cell physiology. 2014 May 28. PMID: 24871858 [PubMed].
• Fotinos A, Nagarajan N, Martins AS, Fritz DT, Garsetti D, Lee AT, Hong CC, Rogers MB. Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells. Anticancer research. 2014 May;34(5). 2095-104. PMID: 24778011 [PubMed].
• Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K. BMP pathway regulation of and by macrophages. PloS one. 9(4). e94119. PMID: 24713633 [PubMed]. PMCID: PMC3979749.

2013

• Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell reports. 2013 Sep 12;4(5). 898-904. PMID: 24012757 [PubMed]. PMCID: PMC3923627. NIHMSID: NIHMS514783.
• Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circulation. Cardiovascular genetics. 2013 Aug;6(4). 317-26.
• Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 2013 Jul;28(7). 1733-43. PMID: 23345622 [PubMed]. PMCID: PMC3707526.
• Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & medicinal chemistry letters. 2013 Jun 1;23(11). 3248-52. PMID: 23639540 [PubMed]. PMCID: PMC3677712. NIHMSID: NIHMS466834.
• Engers W, Frist Y, Lindsley W, Hong C, Hopkins R. Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor. Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information; 2013 Apr 12. PMID: 25506972 [PubMed].
• Shelton EL, Galindo CL, Williams CH, Pfaltzgraff E, Hong CC, Bader DM. Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia. PloS one. 8(7). e69712. PMID: 23936085 [PubMed]. PMCID: PMC3723636.
• Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PloS one. 8(6). e67533. PMID: 23840733 [PubMed]. PMCID: PMC3695869.
• Langenfeld E, Hong CC, Lanke G, Langenfeld J. Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. PloS one. 8(4). e61256. PMID: 23593444 [PubMed]. PMCID: PMC3625205.

2012

• Sheng CC, Hong CC. Mixing of the old with the new: nanoparticle-mediated pioglitazone delivery to enhance therapeutic neovascularization. Arteriosclerosis, thrombosis, and vascular biology. 2012 Oct;32(10). 2337-8. PMID: 22972937 [PubMed]. PMCID: PMC3672409.
• Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS chemical neuroscience. 2012 Jun 20;3(6). 482-91. PMID: 22860217 [PubMed]. PMCID: PMC3400384.
• Hill CR, Sanchez NS, Love JD, Arrieta JA, Hong CC, Brown CB, Austin AF, Barnett JV. BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion. Cellular signalling. 2012 May;24(5). 1012-22. PMID: 22237159 [PubMed]. PMCID: PMC3288519.
• Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor WR, Narula J, Kolodgie F, Virmani R, Hong CC, Finn AV. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2012 Feb;32(2). 299-307. PMID: 22095982 [PubMed]. PMCID: PMC3262074. NIHMSID: NIHMS343415
• Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflammatory bowel diseases. 2012 Jan;18(1). 112-9. PMID: 21351217 [PubMed]. PMCID: PMC3139830. NIHMSID: NIHMS265539.
• Ao A, Hao J, Hopkins CR, Hong CC. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PloS one. 7(7). e41627. PMID: 22848549 [PubMed]. PMCID: PMC3407188.

2011

• Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011 Nov 3;118(18). 4977-84. PMID: 21730356 [PubMed]. PMCID: PMC3208302.
• Cross EE, Thomason RT, Martinez M, Hopkins CR, Hong* CC, Bader* DM. Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors. ACS chemical biology. *Co-corresponding authors; 2011 Sep 16;6(9). 952-61. PMID: 21740033 [PubMed]. PMCID: PMC3177035. NIHMSID: NIHMS312854.
• Hao J, Sawyer DB, Hatzopoulos AK, Hong CC. Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis. Recent patents on regenerative medicine. 2011 Sep;1(3). 263-274. PMID: 22787575 [PubMed]. PMCID: PMC3392203.
• Wells QS, Ausborn NL, Funke BH, Pfotenhauer JP, Fredi JL, Baxter S, Disalvo TD, Hong CC. Familial dilated cardiomyopathy associated with congenital defects in the setting of a novel VCL mutation (Lys815Arg) in conjunction with a known MYPBC3 variant. Cardiogenetics. 2011 Aug 22;1(1). PMID: 24062880 [PubMed]. PMCID: PMC3779542.
• Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011 Jul 21;118(3). 747-56. PMID: 21622652 [PubMed]. PMCID: PMC3142910.
• Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology. 2011 Jun;13(6). 686-92. PMID: 21572418 [PubMed]. PMCID: PMC3107371.
• Ao A, Hao J, Hong CC. Regenerative chemical biology: current challenges and future potential. Chemistry & biology. 2011 Apr 22;18(4). 413-24. PMID: 21513877 [PubMed]. PMCID: PMC3082739. NIHMSID: NIHMS285706.
• Wang H, Hao J, Hong CC. Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS chemical biology. 2011 Feb 18;6(2). 192-7. PMID: 21077691 [PubMed]. PMCID: PMC3076310.
• Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950). 2011 Feb 1;186(3). 1369-76. PMID: 21187450 [PubMed]. PMCID: PMC3670585.
• Shi S, Hoogaars WM, De Gorter DJ, Van Heiningen SH, Lin HY, Hong CC, Kemaladewi DU, Aartsma-Rus A, Ten Dijke P, ‘t Hoen PA. BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model. Neurobiology of disease. 2011 Feb;41(2). 353-60. PMID: 20940052 [PubMed]. PMCID: PMC3674857. NIHMSID: NIHMS467999.
• Ao A, Williams CH, Hao J, Hong CC. Modified mouse embryonic stem cell based assay for quantifying cardiogenic induction efficiency. Journal of visualized experiments : JoVE. PMID: 21540823 [PubMed]. PMCID: PMC3169258.
• Gupta MK, Walthall JM, Venkataraman R, Crowder SW, Jung DK, Yu SS, Feaster TK, Wang X, Giorgio TD, Hong CC, Baudenbacher FJ, Hatzopoulos AK, Sung HJ. Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation. PloS one. 6(12). e28935.
• Palmisano BT, Rottman JN, Wells QS, DiSalvo TG, Hong CC. Familial evaluation for diagnosis of arrhythmogenic right ventricular dysplasia. Cardiology. 119(1). 47-53. PMID: 21822014 [PubMed].
• Williams CH, Hong CC. Multi-step usage of in vivo models during rational drug design and discovery.International journal of molecular sciences. 12(4). 2262-74. PMID: 21731440 [PubMed]. PMCID: PMC3127116.

2010

• Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP. sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. The Journal of biological chemistry. 2010 Nov 12;285(46). 35645-53. PMID: 20826809 [PubMed]. PMCID: PMC2975189.
• Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. Journal of the American Society of Nephrology : JASN. 2010 Apr;21(4). 666-77. PMID: 20167703 [PubMed]. PMCID: PMC2844302.
• Kaplan FS, Zasloff MA, Kitterman JA, Shore EM, Hong CC, Rocke DM. Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva. The Journal of bone and joint surgery. American volume. 2010 Mar;92(3). 686-91. PMID: 20194327 [PubMed]. PMCID: PMC2827822.
• Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS chemical biology. 2010 Feb 19;5(2). 245-53. PMID: 20020776 [PubMed]. PMCID: PMC2825290. NIHMSID: NIHMS169068.
• Hao J, Williams CH, Webb ME, Hong CC. Large scale zebrafish-based in vivo small molecule screen. Journal of visualized experiments : JoVE. PMID: 21248690 [PubMed]. PMCID: PMC3159654.
• Harris B, Pfotenhauer JP, Silverstein CA, Markham LW, Schafer K, Exil VJ, Hong CC. Serial observations and mutational analysis of an adoptee with family history of hypertrophic cardiomyopathy. Cardiology research and practice. 2010. 697269 p. PMID: 20309391 [PubMed]. PMCID: PMC2838361.

2009

• Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. The Journal of clinical investigation. 2009 Nov;119(11). 3322-8. PMID: 19809161 [PubMed]. PMCID: PMC2769199.
• Hong CC, Yu PB. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine & growth factor reviews. 20(5-6). 409-18. PMID: 19914855 [PubMed]. PMCID: PMC2813719. NIHMSID: NIHMS154872.
• Hong CC. Large-scale small-molecule screen using zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 486. 43-55. PMID: 19347615 [PubMed].

2008

• Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nature medicine. 2008 Dec;14(12). 1363-9. PMID: 19029982 [PubMed]. PMCID: PMC2846458. NIHMSID: NIHMS187710.
• Hong CC, Kume T, Peterson RT. Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circulation research. 2008 Sep 12;103(6). 573-9. PMID: 18796644 [PubMed]. PMCID: PMC2768581. NIHMSID: NIHMS126759.
• Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. The Journal of biological chemistry. 2008 Feb 15;283(7). 3877-88. PMID: 18042551 [PubMed].
• Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.PloS one. 3(8). e2904. PMID: 18682835 [PubMed]. PMCID: PMC2483414.
• Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology. 2008 Jan;4(1). 33-41. PMID: 18026094 [PubMed]. PMCID: PMC2727650. NIHMSID: NIHMS44146.