Published Molecules
Welcome, below you will find molecules that we have discovered and published.
Dorsomorphin
MW:399.488
Citation: Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism, Nature Chemical Biology, 2007 [DOI: 10.1038/nchembio.2007.54]
Targets
Alk2:107.9nM (IC50)
AMPK: 109nM(Ki)
DMH1
MW:380.442
Citation: Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245 PMID: 20020776
Targets
Alk2:108nM (IC50)
Windorphen
MW:302.751
Citation: Hao J, Ao A, Zhou L et al. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013
Targets
P300:4.2 uM (IC50)
Eggmanone
MW:406.58
Citation: Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300
Targets
PDE4:72nM (IC50)
DMH4
MW:400.47
Citation: Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245 PMID: 20020776
Targets
VEGFR-2:161nM (IC50)