Stroke Prevention in Young Adults

Authors

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Stroke, defined as acute vascular disease of the brain, is the third leading cause of death and the leading cause of major disability. The long-range goal of our research is to characterize the genetic and environmental basis for stroke susceptibility in order to develop more effective prevention and treatment strategies.

Stroke Papers Published

Publications

(updated 5 July 2011)

2010 - In Press or Submitted:

Cheng Y-C, O’Connell JR, Cole, JW, Stine OC, Dueker N, Sparks MJ, Shen J, Laurie CC, Doheny KF, Ling H, Pugh EW, Manolio TA, Kittner SJ, Mitchell BD. Genome-wide association analysis of ischemic stroke in young adults. (submitted)

Hamedani AG, Cole JW, Cheng Y, Sparks MJ, O’Connell JR, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ. Factor V Leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) Study. (submitted)

2010

Anderson CD, Biffi A, Rahman R, Ross OA, Jagiella JM, Kissela B, Cole JW, Cortellini L, Rost NS, Cheng YC, Greenberg SM, de Bakker PI, Brown RD Jr, Brott TG, Mitchell BD, Broderick JP, Worrall BB, Furie KL, Kittner SJ, Woo D, Slowik A, Meschia JF, Saxena R, Rosand J; on behalf of the International Stroke Genetics Consortium. Common mitochondrial sequence variants in ischemic stroke. Ann Neurol. 2010 Sep 13. PMID: 20839239

Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010 Oct 5;75(14):1277-84. PMID: 20921513

Cornelis MC, Agrawal A, Cole JW, Hansel NN, Barnes KC, Beaty TH, Bennett SN, Bierut LJ, Boerwinkle E, Doheny KF, Feenstra B, Feingold E, Fornage M, Haiman CA, Harris EL, Hayes MG, Heit JA, Hu FB, Kang JH, Laurie CC, Ling H, Manolio TA, Marazita ML, Mathias RA, Mirel DB, Paschall J, Pasquale LR, Pugh EW, Rice JP, Udren J, van Dam RM, Wang X, Wiggs JL, Williams K, Yu K; for the GENEVA Consortium. The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genetic Epidemiology 2010 May;34(4)364-72. Jan 20. . PMID: 20091798, PMCID2860056.

Hamedani AG, Cole JW, Mitchell BD, Kittner SJ. Meta-analysis of Factor V Leiden and ischemic stroke in young adults. Stroke 41(8):1599-1603, 2010. PMID: 20616326

Nalls MA, Biffi A, Matarin M, Anderson CD, Chasman DI, Bevan S, Spencer CCA, Gschwendtner A, Sale MM, Wu L, Saleheen D, Deary IJ, Langefeld C, Peddareddygari LR, Cole JW, Arapelli SK, Aucutt-Walter N, Brott TG, Broderick JP, Brown DL, Brown M, Brown RD, Buring JE, Cortellini L, Danesh J, Deka R, Elias GA, Ferrucci L, Frossard P, Furie K, Gibbs JR, Greenberg SM, Gul M, Hardy J, Harris SE, Hernandez DG, Hsu F-C, Indugula S, Jackson C, Kissela B, Liu L, Metter EJ, Mitchell BD, Murphy L, Mychaleckyj JC, O'Connell JR, Paré G, Parker AN, Patel RK, Poole D, Rasheed A, Richie A, Rothwell PM, Rose L, Ross OA, Rost NS, Schwab K, Sen S, Silliman SL, Soto-Ortolaza AI, Starr JM, Stine OC, Stamova B, Xu H, Wichmann HE, Young LE, Young W, Zaidi M, Zhang H, Kittner SJ, Grewal RP, Woo D, Sudlow C, Kamal AK, Wang X, Sharp FR, Worrall BB, Dichgans M, Markus HS, Ridker PM, de Bakker PIW, Wellcome Trust Case-Control Consortium 2, Singleton AB, Meschia JF, Rosand J: Failure to validate association between 12p13 variants and ischemic stroke. New Eng J Med 362:1547-1550, 2010. PMID: 20410525

Wozniak MA, Kittner SJ, Tuhrim S, Cole JW, Stern B, Dobbins M, Grace ME, Nazarenko I, Dobrovolny R, McDade E, Desnick RJ. Frequency of unrecognized Fabry disease among young European-American and African-American men with first ischemic stroke. Stroke. 2010 Jan;41(1):78-81. PMID: 20007919

2009

Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M., Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, Slowik A, Rich SS, Syme PD, MacLeod MJ, Meschia J, Rosand J, Kittner SJ, Markus HS, Müller-Myhsok B, Dichgans M, on behalf of the Ischemic Stroke Genetics Consortium. Sequence Variants on Chromosome 9p21 Confer Risk of Atherosclerotic Stroke. Ann Neurol 2009:65-531-539. PMCID: PMC2702695.

MacClellan LR, Howard TD, Cole JW, Stine OC, Giles WG, O'Connell JR, Wozniak MA, Stern BJ, Mitchell BD and Kittner SJ. Relation of Candidate Genes that Encode for Endothelial Function to Migraine and Stroke. The Stroke Prevention in Young Women Study. Stroke 40:e550-557,2009 PMCID: PMC2753702.

Mez JB, Cole JW, Howard TD, MacClellan LR, Stine OC, O Connell JR, Wozniak MA, Stern BJ, Sorkin JD, Mitchell BD, Kittner SJ. Evaluation of self-reported ethnicity in a case-control population: The Stroke Prevention in Young Women Study. BMC Res Notes 2(1):260, 2009. PMCID: PMC2801514.

2008

Bhat VM, Cole JW, Sorkin JD, Wozniak MA, Malarcher AM, Giles WH, Stern BJ, Kittner SJ. Dose-response relationship between cigarette smoking and risk of ischemic stroke in young women. Stroke. 2008 Sep;39(9):2439-43.

Cole JW, Brown DW, Giles WH, Stine OC, O'Connell JR, Mitchell BD, Sorkin JD, Wozniak MA, Stern BJ, Sparks MJ, Dobbins MT, Shoffner LT, Zappala NK, Reinhart LJ, Kittner SJ. Ischemic Stroke Risk, Smoking, and the Genetics of Inflammation in a Biracial Population: The Stroke Prevention in Young Women Study. Thrombosis J. 2008;6(1):11. PMCID: PMC2533289.

Mitchell, BD Genetic risk to stroke in smokers and nonsmokers. ( Abstract).

2007

Cole JW, Naj AC, O'Connell JR, Stine OC, Mitchell BD, Sorkin J, Wozniak MA, Stern BJ, Yepes M, Lawrence DA, Reinhart LJ , Strickland DK, Kittner SJ. Neuroserpin Polymorphisms and Stroke Risk in a Biracial Population: The Stroke Prevention in Young Women Study. BMC Neurology. 2007 Oct;7:37.

MacClellan LR, Giles WH, Cole JW, Wozniak MA,Stern BJ, Mitchell BD, Kittner SJ. Probable migraine with Visual Symptoms and Risk of Ischemic Stroke: The Stroke Prevention in Young Women Study. Stroke. 2007 Sep;38(9):2438-45.

2006

Brown DW, Dueker N, Jamieson DJ, Cole JW, Wozniak MA, Stern BJ, Giles WH, Kittner SJ. Preeclampsia and the risk of ischemic strokeamong young women. Results from the Stroke Prevention in Young Women Study. Stroke 2006;37(4):1055–1059.

MacClellan LR, Mitchell BD, Cole JW, Wozniak MA, Stern BJ, Giles WH, Brown DW, Sparks MJ, Kittner SJ. Familial aggregation of ischemic stroke in young women: The Stroke Preventioni n Young Women Study. Genet Epidemiol 2006; 30:602-608.

Song Q, Cole JW,O’Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Qin Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4D polymorphisms and the risk of cerebralin farction in a biracial population: The Stroke Prevention in Young WomenStudy. Human Molecular Genetics 2006, 15(16):2468-2478; Epub7/11/06.

2005

Howard TD, Giles WH, Xu J, Wozniak MA, Malarcher AM,Lange LA, Macko RF, Baschore MJ, Meyers DA, Cole JW, Kittner SJ. Promoter Polymorphisms in Endothelial Nitric Oxide Synthase and Risk of Ischemic Stroke: The Stroke Prevention in Young WomenStudy. Stroke 2005;36:1848-1853.

2004

Cole JW, Pinto AN, Hebel JR, Buchholz DW, Earley CJ,Johnson CJ, Macko RF, Price TR, Sloan MA, Stern BJ, Wityk RJ, Wozniak MA, Kittner SJ. Acquired immunodeficiency syndrome and the risk of stroke. Stroke 2004;35:51-6.

Cole JW, Roberts SC, Gallagher M, Giles WH, Mitchell BD, Steinberg KK, Wozniak MA, Macko RF, Reinhart LJ, Kittner SJ. Thrombomodulin Ala455Val polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. BMC Neurology 2004, 4:21 (01 Dec 2004)

2002

Brey RL, Stallworth CL, McGlasson DL, Wozniak MA, Wityk RJ,Stern BJ, Sloan MA, Sherwin R, Price TR, Macko RF, Johnson CJ, Earley CJ, Buchholz DW, Hebel JR,Kittner SJ. Antiphospholipid Antibodies and Stroke in Young Women. Stroke 2002; 33:2396-401.

2001

Malarcher AM, Giles WH, Croft JB, Wozniak MA, Wityk RJ, Stolley PD, Stern BJ, Sloan MA, Sherwin R, Price TR, Macko RF,Johnson CJ, Earley CJ, Buchholz DW, Kittner SJ. Alcohol intake, type of beverage, and the risk of cerebral infarction in young women. Stroke 2001;32:77-83.

2000

Wityk RJ, Kittner SJ, Jenner JL, Hebel JR, Epstein A, Wozniak MA, Stolley PD, Stern BJ, Sloan MA, Price TR, McCarter RJ, Macko RF, Johnson CJ, Earley CJ, Buchholz DW, Schaefer EJ. Lipoprotein(a) and risk of ischemic stroke in young women. Atherosclerosis 2000; 150:389-396.

Before 2000

Earley CJ, Kittner SJ, Feeser BR, Gardner J, Epstein A, Wozniak MA, Wityk R, Stern BJ, Price TR,Macko RF, Johnson C, Sloan MA, Buchholz D. Stroke in children - the importance of sickle cell disease: the Baltimore-Washington Cooperative YoungStroke Study. Neurology 1998;51:169-176.

Giles WH, Kittner SJ, Hebel JR, Losonczy KG, Sherwin RW. Determinants of black-white differences in the risk of cerebral infarction: the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Archives of Internal Medicine 1995;155(12):1319-1324.

Johnson CJ, Kittner SJ, McCarter RJ, Sloan MA, Stern BJ, Buchholz D, Price TR.Interrater reliability of an etiologic classification of ischemic stroke. Stroke 1995;26:46-51.

Kittner SJ, Giles WH, Macko RF, Hebel JR, Wozniak MA, Wityk RJ, Stolley PD, Stern BJ, Sloan MA, Sherwin R, Price TR, McCarter RJ, Johnson CJ, Earley CJ, Buchholz DW,Malinow MR. Homocyst(e)ine and risk of cerebral infarction in a biracial population: The Stroke Prevention in Young Women Study. Stroke 1999 30:1554-60.

Kittner SJ, Malinow MR, Seipp MJ, Upson B, Hebel JR. Stability of bloodhomocyst(e)ine under epidemiological field conditions. Journal of Clinical Laboratory Analysis; 1995;9:75-76.

Kittner SJ, McCarter RJ, Sherwin RW, Sloan MA, Stern BJ, Meyd CJ, Buchholz D, Seipp MJ, Price TR. Black-white differences in stroke risk among young adults. Stroke 1993;24[suppl I]:I 13-I 15.

Kittner SJ, Stern BS, Feeser BR, Hebel JR, Nagey DA, Buchholz DW, Earley CJ, Johnson CJ, Macko RF,Price TR, Sherwin R, Sloan MA, Wityk RJ, Wozniak MA. Pregnancy and the risk of stroke. New England Journal of Medicine 1996: 335:768-774.

Kittner SJ,Stern BJ, Wozniak M, Buchholz DW, Earley CJ, Feeser BR, Johnson CJ, Macko RF,McCarter RJ, Price TR, Sherwin R, Sloan MA, Wityk RJ. Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998;50:890-894.

Macko RF, Kittner SJ, Epstein A, Cox DK, Wozniak MA, Wityk RJ, Stern BJ, Sloan MA,Sherwin R, Price TR, McCarter RJ, Johnson CJ, Earley CJ, Buchholz DW, Stolley PD. Elevated tissue plasminogen activator antigen and stroke risk: the Stroke Prevention in Young Women Study. Stroke 1999;30:7-11.

O'Leary DH, Polak JF, Kronmal RA, Savage PJ, Borhani NO, Kittner SJ, Tracy R, Gardin JM, Price TR,Furberg CD. Thickening of the carotid wall - a marker for atherosclerosis in the elderly. Stroke 1996;27(2):224-231.