The three-bag IV acetylcysteine regimen for acetaminophen overdose is complicated and can result in medication/administration errors. [1] Two recent studies have attempted simplifying the regimen using a two-bag approach and evaluated its effect on adverse effects. [2, 3]

Study 1 [2]

Prospective comparison of cases using a 20 h, two-bag regimen (200 mg/kg over 4 h followed by 100 mg/kg over 16 h) to an historical cohort treated with the 21 h three-bag IV regimen (150 mg/kg over 1 h, 50 mg/kg over 4 h and 100 mg/kg over 16 h).

The two-bag 20 h acetylcysteine regimen was well tolerated and resulted in significantly fewer and milder non-allergic anaphylactic reactions than the standard three-bag regimen.

Study 2 [3]

Prospective observational study of a modified 2-phase acetylcysteine protocol. The first infusion was 200 mg/kg over 4-9 h. The second infusion was 100 mg/kg over 16 h. Pre-defined outcomes were frequency of adverse reactions (systemic hypersensitivity reactions or gastrointestinal); proportion with ALT > 1000 U/L or abnormal ALT.

The 2-phase acetylcysteine infusion protocol resulted in fewer reactions in patients with toxic paracetamol concentrations.

Final word: Two-bag regimens seem to offer advantages compared to the traditional three-bag regimen with regard to reduced adverse drug reactions. Look for more data, particularly on effectiveness, and a potential transition to a two-bag approach in the future.

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• A recent systematic review looked at the prevalence of psychiatric disorders such as anxiety and depressive disorders in patients with traumatic brain injury (TBI).
• They found a substantial number of patients had a history of anxiety disorders (19%) or depressive disorders (13%) prior to their TBI.
• In the first year after TBI, pooled prevalence of anxiety and depressive disorders increased to 21% and 17%.
• Prevalence continued to increase over time, with longterm prevalence of anxiety and depressive disorders of 36% and 43%.
• Females, those without employment, and those with a history of psychiatric disorders or substance abuse prior to TBI were at higher risk for anxiety or depressive disorders following TBI.

Bottom Line: 

• Early recognition and treatment of psychiatric disorders in patients after TBI may improve their outcome, psychosocial functioning and health-related quality of life. 
• Thus we should consider providing appropriate discharge instructions that include psychiatric resources for patients after TBI.

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There are so many variables to monitor during CPR; speed and depth of compressions, rhythm analysis, etc. But how much attention do you give to the ventilations administered?

The right ventricle (RV) fills secondary to the negative pressure created during spontaneously breathing. However, during CPR we administer positive pressure ventilation (PPV), which increase intra-thoracic pressure thus reducing venous return to the RV, decreasing cardiac output, and coronary filling. PPV also increases intracranial pressure by reducing venous return from the brain.

So our goal for ventilations during cardiac arrest should be to minimize the intra-thoracic pressure (ITP); we can do this by remembering to ventilate "low (tidal volumes) and slow (respiratory rates)"

• Low: Use only one-hand while bagging, this will give the patient 500-600cc per breath. Using two-hands provides ~900-1,000cc per squeeze (more than we normally ventilate patients who have a pulse).
• Slow: Ventilate patients at 8-10 breaths per minute. The less you ventilate the less time the patient spends with positive ITP. Observational studies have demonstrated that providers ventilate too fast during code so the use of a metronome or timing light provides critical feedback.

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Question

What’s the name of this CT finding and name two potential causes?

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Sever's disease also known as calcaneal apophysitis, is the most common cause of heel pain in the young adolescent (ages 8 to 12).

It can be thought of as the Achilles tendon equivalent of Osgood-Schlatter's disease (patellar tendon insertion pain).

It is a non inflammatory chronic repetitive injury.

Commonly seen bilaterally in up to two -thirds of cases.

Patients will complain of activity related pain to the heel.

There may be tenderness and local swelling at the Achilles tendon insertion.

Radiographs are not necessary for acute cases.

Treat with activity modification, heel raise, physical therapy.

Caffeine is the most commonly used psychoactive substance in the world. It is widely available in coffee, tea, chocolate,soft drinks, OTC medicines, and energy drinks. The vast majority of people consuming caffeine appear to suffer no harm while enjoying it's stimulating effects. This has led to the widely held perspective that caffeine is a completely benign substance with no adverse health effects exists.

Although, children and adolescents are at particular risk, many caffeine containing products are specifically marketed at them. Alarmingly, statistics demonstrate that caffeine intake among children and adolescents has increased by 70% in the last 30 years. Energy drinks are of special concern as they represent the fastest growing component of the beverage industry, contain significant quantities of caffeine as well as high levels of sugar, and can place children at high risk for caffeine intoxication.

There are many negative health consequences documented with caffeine use which occur in a dose dependent manner with individuals differing in their susceptibility to caffeine-related adverse effects:

• Arrhythmias
• Anxiety
• Agitation
• Seizure
• Nausea,vomiting, diarrhea
• Diuresis
• Metabolic disturbances
• Hypotension
• Rare fatalities

Chronic Effects:

• Insomia
• Palpitations
• Headaches
• Diuresis
• Gastric acid secretion
• Urinary incontinence in women
• Adverse effect on wound healing process, the aging process of the human skin
• Low birth weight babies
• Withdrawal state
• Increased risk of cardiovascular events (heart attack,strokes, peripheral artery disease and kidney failure) in young adults with mild hypertension.

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Every year approximately 265,000 people die from burns

·      The vast majority occur in low- and middle-income countries

o   The rate of child death from burns is 7 times worse in low- and middle-income countries compared to high income countries

·      Almost half of all fatal burns occur in the WHO South-East Asia Region

Non-fatal burns are a leading cause of global morbidity

·      In 2004, almost 11 million individuals worldwide were burned badly enough to require medical attention

Unlike many other unintentional injuries, burns occur:

·      Mainly in the home and workplace

o   Women are at greater risk secondary to open fire cooking

·      Approximately equally among men and women

o   Most other injuries occur more frequently in men

Most burns are preventable.  Developing an effective burn prevention plan involving multiple sectors is important.  Per the WHO, the plan should be broad with efforts to:

·      improve awareness

·      develop and enforce effective policy

·      describe burden and identify risk factors

·      set research priorities with promotion of promising interventions

·      provide burn prevention programmes

·      strengthen burn care

·      strengthen capacities to carry out all of the above.

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Happy New Year!!!

My new year's resolution is to use less antibiotics (and eat more Cap'n Crunch Berries)

Will I be successful?

A multi-center, ICU, observational study looking at over 900 patients from 67 ICUs showed that half of all empiric antibiotics ordered in patients are continued for at least 72 hours in the abscence of adjudicated infection.

• We have been well trained to start antibiotics but stopping or limiting use can be difficult
• The greater the severity of illness, the longer the antibiotics were continued in this study

Things to consider:

The same way we try and limit central line use, we should try and decrease antibiotic usage on a daily basis

Tips to decrease use: daily clinical pharmacist input, ID specialist involvement, automated stop dates, 72 hour vancomycin cessation protocols, incentives for de-escalation, educational resources

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After three failed attempts, the FDA finally granted approval for Merck's non-depolarizing neuromuscular blocker reversal agent sugammadex (Bridion). Though the product has been used in Europe and Asia for several years, hypersensitivity concerns led to the delayed approval in the U.S.

Important points

1. Reverses rocuronium, vecuronium, and to a lesser degree, pancuronium
2. Full reversal obtained about 3 minutes after administration
3. Eliminated entirely by the kidneys in about 8 hours (6 times longer in patients with CrCl < 30 mL/min)
4. Dosing is generally 2-4 mg/kg. Total body weight should be used in obese patients

Application to Clinical Practice

1. Potential for use in situations where a neuro exam is needed shortly after intubation (eg, status epilepticus, ICH)
2. The risk of serious hypersensitivity appears to be < 1% in published literature
3. Cost will most assuredly be high
4. Long duration in patients with reduced kidney function means further attempts to re-paralyze with roc, vec, or pancuronium may be unsuccessful

The EM PharmD blog discusses sugammadex's approval in more detail.

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Many providers may not be familiar with the "J-Tip" (National Medical Products Inc, Irvine, CA) which is a needle-free jet injection system that uses air to push buffered lidocaine into the skin. In theory, it provides quick local anesthesia without a needle, making it an ideal tool to reduce the pain of pediatric venipuncture. Maybe you will consider giving it a try?...but what is the data for it?

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Attachments

• 1601020306_jtip_works.jpg (24 Kb)

In many countries, alcohol is commonly drunk for special occasions, such as New Year’s.  What can be the consequences of drinking too much?

As noted in an article on the validation of the Dutch version of the brief young adult alcohol consequences questionnaire, the most common consequences were:

1. Had a hangover: 74.3%
2. Had less energy or felt tired because of my drinking: 63.9%
3. While drinking, I have said or done embarrassing things: 38.0%
4. Felt very sick to my stomach or thrown up after drinking: 34.1%
5. Ended up drinking on nights when I planned not to drink: 29.2%
6. Not gone to work or missed classes because of drinking: 28.0%
7. Not been able to remember large stretches of time: 26.8%
8. Taken foolish risks: 24.7%
9. Quality of my work or school work has suffered: 21.7%
10. When drinking, I have done impulsive things I regretted later: 21.4%

According to the Alcohol Hangover Research Group Consensus Statement on Best Practice in Alcohol Hangover Research, items 1, 2, 4, 6 and 9 are or may be related to hangovers.

Have an enjoyable, but safe New Year.

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Acute Chest Syndrome

• Acute chest syndrome (ACS) accounts for the most common cause of ICU admission and the most common cause of death in sickle cell patients.
• Important pearls for ACS include:
  • Chlamydophila pneumonia is the most common bacterial cause of ACS in adults, whereas Mycoplasma pneumonia is the most common bacterial cause in children.
  • CXR abnormalities may be absent early in disease.
  • Children are more likely to have middle lobe disease, in contrast to adults who often have lower lobe involvement.
  • Acute RV failure is a well recognized complication of ACS - use ultrasound to evaluate the RV and be careful with fluids.

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Question

79 year-old male with headaches, ataxia, falls, and difficulty urinating. What's the diagnosis?

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Protracted Recovery from Concussion

Age and sex may influence concussion recovery time frame

Methods: 266 adolescent athletes presenting to a sports medicine concussion clinic

Female athletes had a longer recovery course (P=0.002) and required more treatment interventions (p<0.001).

Female athletes were more likely to require academic accommodations (p<0.001), vestibular therapy (P<0.001) and medications (P<0.001).

Be aware that not all concussion patient subgroups with concussions recover in the same manner. Further study is needed to support whether female adolescent athletes require unique management and treatment guidelines.

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HSV infection of the CNS is one of few treatable viral diseases. HSV encephalitis of older children and adults is almost always caused by herpes simplex virus type 1 (HSV-1), and in individuals older than 20, is due to HSV reactivation.

Temporal lobe localization is characteristic for HSV encephalitis in individuals older than 3 months, and is responsible for its characteristic presentation, namely bizarre behavior and expressive aphasia.

CSF analysis will usually reveal an elevated protein level, and a lymphocytic cellular predominance.

CSF protein concentration is a function of disease duration, and will continue to rise even with administration of treatment (acyclovir) and may remain elevated after the completion of therapy.

5% of CSF samples will be totally normal, and the diagnosis will only be revealed with positive PCR detection of viral DNA in the CSF, which is the gold standard for diagnosis.

The sensitivity of MRI is similar to CSF analysis, with 5% of patients with HSV encephalitis having a normal MRI on presentation, and subsequently developing abnormalities.

Of note, HSV-2 tends to cause aseptic meningitis rather than encephalitis in adults, and has a benign course.

Bottom Line? Keep a high index of suspicion for HSV encephalitis, and treat the patient empirically despite a normal CSF/MRI pending PCR results.

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The EuroTherm3235 Trial was a randomized, multi-center trial to study hypothermia (32-35^oC) in severe, traumatic brain injury¹:

• Hypothermia was compared with hyperosmolar therapies (hypertonic saline and mannitol) as "Stage 2" management.
• While hypothermia did successfully reduce ICP, functional outcomes (as measured in Extended Glasgow Outcome Score [GCS-E]) trended towards harm at six months (though not significantly different).
• Take-home: The study design has significant flaws, but the lack of clear benefit of hypothermia is consistent with previous studies² and suggests that fever prevention or controlled normothermia (36^oC) may be ideal for severe TBI patients, but needs further study.

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Quick pearl for those that are trying to complete their holiday shopping.

Mulder's sign is not a sign that there is an extra-terrestial in your ED, But rather a sign that your patient is suffering from a Morton's Neuroma (see pearl from 2012)

Patients will often complain of pain in 3rd and 4th intermetatarsal space and if you can reproduce the pain by compressing the metatarsal heads together then you have a Positive Mulder's sign. Check out the original pearl at https://umem.org/educational_pearls/1684/

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Synthetic cathinones, known as bath salts, are a frequently used street drug in the United States.  They have been discussed in a number of previous pearls.  But from where did cathinone originate?

Khat (Catha edulis) is flowing plant native to the Arabian Peninsula and the Horn of Africa. It contains the monoamine alkaloid cathinone, which is an amphetamine-like stimulant that also causes euphoria. Historically, khat has been chewed for thousands of years and predates the use of coffee.  Khat chewing is particularly popular in Yemen.

Khat contains many different compounds, which cause a number of different effects. Many of these effects are considered harmful to health. Khat chewing primarily impacts the central nervous system and the gastrointestinal system. However, it also has effects on cardiovascular, respiratory, endocrine, and genitourinary systems.  In addition to the amphetamine like central nervous effects, other toxic effects include elevated blood pressure, tachycardia, insomnia, anorexia, constipation and general malaise.

Next time you see a patient with confusion and hallucinations from Yemen, Ethiopia, Somalia and other countries around the Horn of Africa, consider Khat in your differential.

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Question

A patient arrives in acute respiratory distress with left sided chest pain. Ultrasound of the left anterior chest is shown; what's the diagnosis and name one false positive?

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