Analytical Core

Overview

The mission of the Center for Blood Oxygen Transport (CBOTH) analytical core is to support basic science and applied research toward advancing novel therapeutics. Our emphasis is on the process of pharmaceutical, biopharmaceutical and medical device product development that assists investigators and industry-based partners with early pre-clinical proof-of-concept, product refinement and basic safety assessments.

Early phase assistance typically includes analysis of novel products or components, assessment of product identity, purity, potency, and stability as well as to development and validation of assays to define these assessments.

Further, working in synergy with CBOTH core facilities, we assist with ADME and pharmacokinetic, biocompatibility and the exploratory toxicology studies. The ultimate goals of the Analytical Core are to assist core users preparing for regulatory agency interactions, and assist with each step as product candidates move through the development process.

Capabilities

Services Offered

Drug and metabolites identification and analysis of specimen (Plasma/Urine/Tissue) with AND without method development
Protein Analysis and Purification
Analytical size exclusion
Enzyme reaction kinetics
Extinction coefficient determination
Protein-ligand binding studies
Elisa assay of specimen
Membrane fluidity assay
Pharmacokinetics Analysis of parent drug/biologic/metabolite
Self-operated use of core equipment