Core Facilities

• Production of hyperpolarized ¹³C solutions for in vivo and in vitro applications; clinical applications are currently limited to pyruvate
• Simultaneous polarization of up to 4 samples
• Liquid-state polarization of approximately 50% for a 1-g pyruvate sample
• Large volume samples - up to 1mL of concentrated sample production

 Specifications

• Achieve temperatures of  ≤1.0 K within the polarization region
• Nominal magnetic field is 5.0 Tesla
• Motorized sample processing - Mechanical control of multi-sample positioning

Dirk Mayer, Dr. rer. nat.
Phone: 410-706-2720
dmayer@som.umaryland.edu

• Quality Control (QC) module automatically measures pyruvate and residual radical concentrations, pH, temperature, infusion volume, and polarization without compromising the sterile barrier
• Laser welder for preparation of fluid paths for clinical applications

This is a template for the SPINlab Hyperpolarizer, which can be used in the "Facilities and Other Resources" page of NIH applications. Before using this template, please contact your collaborator to ensure the information is correct and up to date.

 "Hyperpolarization of ¹³C-labeled substrates will be performed using a GE SPINlab DNP system within the Center for Metabolic Imaging and Therapeutics on the premises of the University of Maryland Medical Center. The system can simultaneously polarize up to 4 samples and is operating at 5 Tesla and 0.8-1 K. SPINlab, which is fully automated with mechanically controlled vacuum and dissolution systems, can produce, in a sterile manner (using a disposable, sealed sterile fluid path) and after filtering the trityl radical, sample sizes of up to 50 mL of 250-mM ¹³C-pyruvate suitable for human applications. An important feature, in particular for clinical use, is a quality control module that measures pyruvate and residual radical concentrations, pH, temperature, infusion volume, and polarization without compromising the sterile barrier."