The Technology & Drug Development research groups harness cutting-edge instruments and innovative methodologies to address critical challenges in biomedical research. Our team employs advanced techniques such as Cryo-Electron Microscopy and X-ray Crystallography to elucidate the structural intricacies of biomolecules, providing insights essential for drug design and targeted therapies. We utilize Fluorescence Spectroscopy and Single Molecule Fluorescence Spectroscopy to explore dynamic molecular interactions, while Super-Resolution Imaging allows for unprecedented visualization of cellular processes at the nanoscale. Our research also incorporates the principles of Plasmonics to develop novel biosensors and enhance drug delivery systems. In the realm of regenerative medicine, we are pioneering 3D printing technologies, including DeepFreeze-3D printing, to create functional tissue constructs for therapeutic applications and disease modeling.
Faculty
Alexander Drohat, PhD
Keywords: DNA Repair, Epigenetics and DNA methylation, Enzymology, NMR, Structural biology, SUMO modification
Jonathan Fay, PhD
Keywords: Membrane protein, Structure, Structural biology, cryo-EM, GPCR
Saif Hasan, PhD
Keywords: Cryo-Electron microscopy, Infectious Viruses, Inter-organelle trafficking, Membrane proteins, Protein secretion, Structural biology, Vesicular trafficking, Viral structures, X-ray crystallography
Mariusz Karbowski, PhD
Keywords: Mitochondrial membrane dynamics, Impact of ubiquitin and proteasome-dependent control of mitochondria
Joseph Lakowicz, PhD
Keywords: Fluorescence spectroscopy, Radiative decay engineering, Plasmon-controlled fluorescence
Jiayuh Lin, PhD
Keywords: IL-6, IL-11, GP130, STAT3
Krishanu Ray, PhD
Keywords: Single molecule fluorescence spectroscopy, Super-resolution imaging, HIV envelope, Fc gamma receptor, DNA packaging motor, Plasmonics
David Weber, PhD
Keywords: Calcium-signaling, Tumor suppression & Cancer biology, Structural biology
Gerald Wilson, PhD
Keywords: Gene expression, RNA turnover, RNA-binding proteins, Fluorescence spectroscopy, Tumor progression, Inflammatory mediators, Lipoprotein receptors, High-throughput drug screening, Assay development
Michal Zalzman, PhD
Keywords: Stem cells, Embryonic stem cells, ESCs, Induced pluripotent stem cells, iPSCs, Multipotent stem cells, MSCs, Telomere, Cancer stem cells, CSCs, Parkinson's disease, Stroke, Conductive hearing loss, Bone reconstruction, 3D Printing, DeepFeeze-3D printing, Tissue-reconstruction, Regenerative-medicine, Molecular Biology, Biochemistry, RNA-seq, ChIP-seq, Bioengineering, Tissue engineering