Faculty Research
The Department of Biochemistry and Molecular Biology investigators include 19 faculty members who utilize state-of-the-art technology to study the biochemistry and molecular biology of cell and protein structure and function.
Molecular & Cell Biology
In the Molecular and Cell Biology Group, cutting-edge research intersects with the fundamental understanding of life. Our team is dedicated to unraveling the complexities of genetic and epigenetic regulation of gene expression, focusing on cell differentiation in muscle, bone, and adipocytes. We utilize advanced models and innovative techniques to explore the intricate signaling pathways that govern transcriptional regulation.
Cancer Biology
A significant focus of our department is understanding cancer biology, particularly the mechanisms behind cancer development, progression, and metastasis. By examining key molecular players of cell signaling, we aim to uncover novel insights into the DNA damage response and repair mechanisms that allow cancer cells to thrive and resist treatment. Our interdisciplinary approach encompasses enzymology and structural biology to elucidate the dynamic relationships within the cytoskeleton and their implications for signaling transduction in cancer progression.
Muscle Biology
The Muscle Biology group is dedicated to exploring the intricacies of muscle physiology and the underlying mechanisms that contribute to muscle function and disease. Our research utilizes advanced model systems to investigate the roles of globins, nitric oxide, and nitrite in regulating muscle and neuron excitability, delving into the intricate mechanisms of voltage-gated ion channels and calcium signaling pathways essential for skeletal muscle function.
Molecular Biophysics & Structural Biology
Molecular Biophysics & Structural Biology is a dynamic field that integrates advanced technologies to unveil the intricacies of biomolecular structures and their functions. Our department utilizes cutting-edge techniques such as Nuclear Magnetic Resonance (NMR) and Cryo-Electron Microscopy to elucidate the three-dimensional arrangements of proteins and nucleic acids at atomic resolution. By combining these and other powerful methods, our research fosters a deeper understanding of the molecular underpinnings of biological processes.
Molecular Biophysics & Structural Biology >
Technology & Drug Development
The Technology & Drug Development research groups harness innovative methodologies to address critical challenges in biomedical research. Our team strives to elucidate the structural intricacies of biomolecules, providing insights essential for drug design and targeted therapies. We utilize diverse spectroscopic techniques to examine dynamic molecular interactions and visualize cellular processes. Our research also incorporates plasmonics and pioneering 3D-printing technologies to create biosensors and functional tissue constructs for therapeutic applications and disease modeling.