Overview

The research in the Yuan lab (https://www.yuanlaboratory.com/) focuses on integrating molecular biology, bioengineering, and computational biology to investigate the biological mechanisms within the lung vascular microenvironment, aiming to promote functional vascular homeostasis.

There are two main research areas: 1)Leveraging multi-omics and molecular biology tools to delineate molecular mechanisms in the lung vascular microenvironment during homeostasis and diseases; 2) Incorporating decellularization/recellularization, bioreactors, multi-omics, iPSC, and microfluidics to develop vascular and alveolar tissue models for drug screening applications.

Our recent work involved understanding the role of cell-cell and cell-matrix interactions in maintaining vascular homeostasis, with the ultimate goal of developing new therapeutic strategies for lung vascular diseases.

Publications:

• Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski
  N, Herzog EL, Niklason LE. In vitro engineering of the lung alveolus. NPJ Regen Med. 2023 Apr
  28;8(1):22. doi: 10.1038/s41536-023-00295-2. PMID: 37117221.
• Yuan Y. Clinical translation of engineered pulmonary vascular models. Adv Exp Med Biol. 2023:1413:273-
  288. doi: 10.1007/978-3-031-26625-6_14. PMID: 37195536.
• Schupp JC, Adams TS, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M,
  Deluliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB,
  Nawijn MC, Teichmann SA, Banovich N, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer R, Rosas IO, Kaminski
  N. Integrated single-cell atlas of endothelial cells of the human lung. Circulation. 2021 Jul 27;144(4):286-
  302. doi: 10.1161/CIRCULATIONAHA.120.052318. PMID: 34030460.
• Yuan Y, Leiby KL, Greaney AM, Raredon MBS, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH,
  Wang J, Kural M, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A pulmonary vascular model from
  endothelialized whole organ scaffolds. Front Bioeng Biotechnol. 2021 Nov 19:9:760309. doi:
  10.3389/fbioe.2021.760309. eCollection 2021. PMID: 34869270.
• Yuan Y, Khan S, Stewart DJ, Courtman DW. Engineering blood outgrowth endothelial cells to optimize
  endothelial nitric oxide synthase and extracellular matrix production for coating of blood contacting
  surfaces. Acta Biomater. 2020 Jun:109:109-120. doi: 10.1016/j.actbio.2020.04.016. Epub 2020 Apr 14.
  PMID: 32302726.

Please see Dr. Yuan's faculty profile for a complete list of his publications.

You can also see his publications on PubMed.

Contact

Office: (410) 706 4130
Email: Yyuan@som.umaryland.edu