ASTMH2022

58 - COVID-19--An African Perspective

Samba Sow

64 - Late-Breakers in Clinical and Applied Sciences
(Moderated by Sharon Tennant)

LB-5317 - Development of a broad-spectrum semi-synthetic conjugate vaccine for the prevention of Salmonella infections

Scott Baliban

1197 - RNA sequencing with de novo assembly indicates expression of dual-binding PfEMP1s in Malian children with severe malaria

Emily Stucke

131 - The Invisible Burden: Measuring and Evaluating the Impact of Infectious Diseases on Cognition

(Symposium organized by Andrea Buchwald)

131 - Malaria in schoolchildren: impacts on cognition and education

Lauren Cohee

Poster Session A
11:00 AM:

31 - Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for Plasmodium falciparum transmission, Malawi

Authors: Rex B. Mbewe, John B. Keven, Charles Mangani, Mark Wilson, Themba Mzilahowa, Don Mathanga, Clarissa Valim, Miriam K. Laufer, Edward D. Walker, Lauren M. Cohee 

69 - Genomic Characterization of Klebsiella pneumoniae Isolates from deaths in children under 5 years of age identified through the CHAMPS Network

Authors: Eungi Yang, Maureen Diaz, Ashutosh Wadhwa, Muntasir Alam, Mustafizur Rahman, Md Saiful Islam, M Ishrat Jahan, Ikechukwu U. Ogbuanu, Karen Kotloff, Milagritos D. Tapia, Samba O. Sow, Victor Akelo, Dickens Onyango, Shams El Arifeen, Emily Gurley, Dianna M. Blau, Jonas Winchell

244 - Breadth and Abundance of Plasmodium falciparum RIFIN and STEVOR Expression Is Associated with Cerebral Malaria in Malian Children

Authors: Jonathan G. Lawton, Albert E. Zhou, Drissa Coulibaly, Emily M. Stucke, Rafal Sobota, Savy M. Sebastian, Bryan Cummings, Ankit Dwivedi, Antoine Dara, James B. Munro, Abdoulaye K. Koné, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Issa Diarra, Modibo Daou, Youssouf Tolo, Mody Sissoko, Kieran Tebben, Matthew B. Laurens, Amed Ouattara, Bourema Kouriba, Ogobara K. Doumbo, Shannon Takala-Harrison, Christopher V. Plowe, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos 

View supplemental information here: 
Jonathan Lawton ASTMH 2022 poster

Jonathan Lawton ASTMH 2022 Young Investigator

321 - Using Tree-Based Identity-By-Descent Segments to Evaluate the Effect of Directional Selection on the Estimation of Recent Effective Population Size and Population Structure in Plasmodium falciparum

Authors: Bing Guo, Michele D. Spring, Mariusz Wojnarski, Brian A. Vesely, Joana C. Silva, David Serre, Norman C. Waters, Shannon Takala-Harrison, Timothy D. O'Connor

376 - Comparing chemoprevention approaches for school-based malaria control in Machinga District, Malawi

Authors: Alick Sixpence, Wangisani Kumalakwaanthu, Alfred Matengeni, Laurence S. Magder, Karl B. Seydel, Miriam K. Laufer, Don P. Mathanga, Lauren M. Cohee

385 - A Phase 1, Open-Label, Dose Escalation and Route Optimization Trial with Controlled Human Malaria Infection to Evaluate Protective Efficacy of an Anti-Malaria Human Monoclonal Antibody in Healthy Malaria-naïve Adults

Authors: Kirsten E. Lyke, Andrea A. Berry, Kaitlin Mason, Sudhaunshu Joshi, Biraj Shrestha, Kathleen A. Strauss, Matthew Adams, LaSonji A. Holman, Floreliz Mendoza, Ingelise J. Gordon, Jittawadee Murphy, Andrezza Campos Chagas, Emily Coates, Nina M. Berkowitz, Martin Gaudinski, Lesia Dropulic, Robert A. Seder

392 - Protective targets of sporozoite-based whole organism malaria vaccines identified from genome-wide sieve analysis of Plasmodium falciparum isolates from field efficacy trials

Authors: Ankit Dwivedi, Ryan Scalsky, Thomas Stabler, James B. Munro, Olukemi O. Ifeonu, Biraj Shrestha, Sudhaunshu Joshi, Alphonse Ouedraogo, Alfred Tiono, Drissa Coulibaly, Amed Ouattara, Thomas L. Richie, B. Kim Lee Sim, Christopher V. Plowe, Kirsten E. Lyke, Shannon Takala-Harrison, Stephen L. Hoffman, Mahamadou Thera, Sodiomon B. Sirima, Matthew B. Laurens, Joana C. Silva

398 - Recombinant full-length Plasmodium falciparum circumsporozoite protein-based vaccine expressed in Pseudomonas fluorescens and adjuvanted with GLA-LSQ: results of Phase 1 testing with malaria challenge 

Authors: DeAnna J. Friedman-Klabanoff, Andrea A. Berry, Mark A. Travassos, Mallory Shriver, Catherine Cox, Jessica Butts, Jordan S. Lundeen, Annie X. Mo, Effie Y. H. Nomicos, Gregory A. Deye, Marcela F. Pasetti, Matthew B. Laurens

View Supplemental Materials: 13-0088_ASTMH 2022 Poster Supplementary Materials_rev.pdf

423 - Longevity of Anti-Vi IgG and IgA responses in 15-month-old children vaccinated with a typhoid conjugate vaccine in Burkina Faso

Authors: Alphonse Ouedraogo, Amidou Diarra, Issa Nebie, Nouhoun Barry, Jean M. Kabore, Alfred B. Tiono, Shrimati Datta, Yuanyuan Liang, Ifayet Mayo, Jennifer Oshinsky, Kathleen J. Tracy, Tsion Girmay, Marcela Pasetti, Kathleen M. Neuzil, Sodiomon B. Sirima, Matthew B. Laurens

237 - Impact of plasmepsin II copy number on the fitness of piperaquine-resistant PfCRT mutant Plasmodium falciparum in Cambodia

Authors: William Witt, Biraj Shresta, Nonlawat Boonyalai, Paphavee Lertsethtakarn, Sohei Hom, Piyaporn Sai-ngam, Chaiyaporn Chaisatit, Sasikanya Thaloengsok, Lychhea Huot, Brian A. Vesely, Michele D. Spring, John S. Griesenbeck, Dysoley Lek, Mariusz Wojnarski, Norman C. Waters, Shannon Takala Harrison

451 - The choice of reference chart affects the strength of the association between malaria in pregnancy and small for gestational age. An individual participant data meta analysis comparing the Intergrowth 21 with a Tanzanian birthweight chart.

Authors: George Antony Mtove, Daniel T.R Minja, Omari Abdul Msemo, Samwel Gesase, Kenneth Maleta, Titus H. Divala, Noel Patson, Ulla Ashorn, Miriam K. Laufer, Mwayiwawo Madanitsa, Per Ashorn, Don Mathanga, Jobiba Chinkhumba, Julie R. Gutman, Feiko O. ter Kuile, Sofie Lykke Møller, Ib C. Bygbjerg, Michael Alifrangis, Thor Theander, John P. A Lusingu, Christentze Schmiegelow

LB-5061 - Development of a Klebsiella pneumoniae neonatal sepsis rodent model

Authors: Jernelle C. Miller, Scott M. Baliban, Alan S. Cross, Sharon M. Tennant

Poster Session B:
12:00 PM

901 - Overall and gender-specific effects of intermittent preventive treatment of malaria with artemisinin-based combination therapies among schoolchildren in Mali: a three-group open label randomized controlled trial

Authors: Hamma Maiga, Charles Opondo, R. Matthew Chico, Lauren M Cohee, Issaka Sagara, Abdoulaye Djimde

940 - Estimating the potential geospatial malaria exposure risk for different occupation groups in Yala, Thailand

Authors: Yao Li, Natalie Memarsadeghi, Preeyaporn Suida, Sirirporn Sornsakrin, Worachet Kuntawunginn, Mariusz Wojnarski, Norman Waters, Sutchana Tabprasit, John S. Kuntawunginn, Michele Spring, Chokchai Kwanpichit, Shannon Takala-Harrison, Kathleen Stewart 

943 - Application of GC3, a locus read coverage assessment tool, to identify gene duplications of Pfmdr1 and Plasmepsin-2 among Plasmodium falciparum strains

Authors: Thomas C. Stabler, Ankit Dwivedi, Tobias Schindler, Guillermo A. García, Claudia Daubenberger, Joana C. Silva

957 - Characterizing serological responses to variant surface antigens in first Plasmodium falciparum infections in Malawian infants

Authors: Bernadette Hritzo, Rosita Asawa, Amed Ouattara, Andrea A. Berry, Liana R. Andronescu, Biraj Shrestha, Rie Nakajima, Aarti Jain, Omid Taghavian, Algis Jasinkas, Philip L. Felgner, Jobiba Chinkhumba, Don Mathanga, Mark Travassos, Miriam K. Laufer

998 - Epitope-specific differential antibody responses to Plasmodium falciparum circumsporozoite protein are associated with protection from malaria infection in Malian adults

Authors: DeAnna J. Friedman-Klabanoff, Matthew B. Laurens, Drissa Coulibaly, Mahamadou A. Thera, Travis L. Jensen, Casey E. Gelber, Johannes B. Goll, Jigar J. Patel, Richard Pinapati, John C. Tan, Gregory A. Deye, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Mark A. Travassos, Shannon Takala-Harrison, Andrea A. Berry

View Supplemental Materials: FriedmanKlabanoff_CSP peptide array poster_supplementary materials.pdf

1001 - Mapping within-host antigenic escape and allele-specific immunity of Plasmodium falciparum vaccine antigens

Authors: Myo T. Naung, Somya Mehra, Swapnil Tichkule, Andrew J. Guy, Ramin Mazhari, Eamon Conway, Zahra Razook, Somesh Mehra, Paolo Bareng, Matthew Adam, Brendan Ansell, Wilson Wong, Eizo Takashima, Takafumi Tsuboi, Rory Bowden, Shannon Takala Harrison, Ivo Mueller, Alyssa E. Barry

1197 - RNA sequencing with de novo assembly indicates expression of dual-binding PfEMP1s in Malian children with severe malaria

Authors: Emily M. Stucke, Drissa Coulibaly, Rafal Sobota, Jonathan Lawton, Savy M. Sebastian, Matthew Adams, Noah T. Ventimiglia, James B. Munro, Ankit Dwivedi, Antoine Dara, Abdoulaye K. Kone, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Bryan Cummings, Albert E. Zhou, Matthew B. Laurens, Amed Ouattara, Bourema Kouriba, Ogobara K. Doumbo, Shannon Takala Harrison, Christopher V. Plowe, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos

1209 - Three Year Efficacy results from an individually randomized controlled double-blinded trial of a Typhoid Conjugate Vaccine in Malawi

Authors: Priyanka Patel, Yuanyuan Liang, James E. Meiring, Tsion Girmay, Shrimati Datta, Theresa Misiri, Felistas Mwakiseghile, Kathleen J. Tracy, Clemens Masesa, Marc Henrion, Matthew B. Laurens, Robert S. Heyderman, Melita A. Gordon, Kathleen M. Neuzil

LB-5317 - Development of a broad-spectrum semi-synthetic conjugate vaccine for the prevention of Salmonella infections

Authors: Scott M. Baliban, Chang-Xin Huo, Cameron Talbot, Xingling Pan, Sharon M. Tennant, Xuefei Huang

Poster Session C Presentations

Time: 11:00 AM

LB 5370 - Host and parasite gene expression during uncomplicated malaria infections

Authors: Kieran Tebben, Salif Yirampo, Drissa Coulibaly, Mahamadou Thera, Mark Travassos, David Serre

1273 - Identifying and addressing excess burden of neural tube defects from CHAMPS Ethiopia: Transforming data to action

Authors: Lola Madrid, Kartavya J. Vyas, Vijaya Kancherla, Haleluya Leulseged, Parminder S Suchdev, Quique Bassat, Samba O Sow, Shams El Arifeen, Shabir A Madhi, Victor Akelo, Ikechukwu Ogbuanu, J. Anthony G Scott, Dianna Blau, Inacio Mandomando, Adama M. Keita, Emily S Gurley, Sana Mahtab, Erik Kaluma, Yenenesh Tilahun, Rosauro Varo, Uma Onwuchekwa, Beth A. Tippet-Barr Tippet-Barr, Afruna Rahman, Elisio Xerinda, Kazi Munisul Islam, Emily Rogena, Sara Ajanovic, Karen L. Kotloff, Mohammad Zahid Hossain, Portia Mutevedzi, Cynthia G. Whitney, Nega Assefa

 1512 - The changes in malaria epidemiology as we approach malaria elimination: identification of P.cynomolgi and P.knowlesi and P.malaria in Southeast Asia

Authors: Piyaporn Sai-ngam, Kingkan Pidtana, Mariusz Wojnarski, Somethy Sok, Preeyaporn Suida, Siriporn Sornsakrin, Lychhea Huot, Sohei Hom, Pheaktra Oung, Nichapat Uthalmongkol, Chaiyaporn Chaisatit, Sasikanya Thaloengsok, Chadin Thongpiam, Saowaluk Wongarunkochakorn, Kittijarankon Phontham, Brian Vesely, Samandra Demons, Huy Rekol, Shannon Takala Harrison, Norman Waters, John S. Griesenbeck, Paphavee Lertsethtakarn, Sutchana Tabprasit, Chokchai Kwanpichit, Dysoley Lek, Michele D. Spring, Worachet Kuntawunginn

 1526 - Is the Plasmodium falciparum population on Bioko Island, Equatorial Guinea, distinct from those in nearby continental Africa?

Authors: Thomas C. Stabler, Ankit Dwivedi, Biraj Shrestha, Sudhaunshe Joshi, Olivier Tresor Donfack, Carlos Guerra, Mitoha Ondo'o Ayekaba, Guillermo A. García, Joana C. Silva, Claudia Daubenberger

 1529 - Infants born from mothers under DP or SP IPTp have similar serological responses against PfEMP1 proteins

Authors: Amed Ouattara, Liana R. Andronescu, Andrea A. Berry, Biraj Shrestha, Rie Nakajima, Aarti Jain, Omid Taghavian, Algis Jasinskas, Felgner L. Felgner, Jobiba Chinkhumba, Don P. Mathanga, Miriam K. Laufer, Mark Travassos

 1531 - Serological responses to malaria variant surface antigens at birth and risk of malaria during infancy

Authors: Rosita R. Asawa, Bernadette Hritz, Amed Ouattara, Andrea A. Berry, Liana R. Andronescu, Biraj Shrestha, Rie Nakajima, Aarti Jain, Omid Taghavian, Algis Jasinskas, Philip L. Felgne, Jobiba Chinkhumba, Don Mathanga, Mark A. Travassos, Miriam K. Laufer 

1538 - Analysis of the structure and epitope characteristics of novel Plasmodium falciparum antigens

Authors: Ryan Scalsky, Ankit Dwivedi, Olukemi O. Ifeonu, James B. Munro, Biraj Shrestha, Sudhaunshu Joshi, Alphonse Ouedraogo, Alfred Tiono, Drissa Coulibaly, Amed Ouattara, Mahamadou Thera, Sodiomon B. Sirima, Matthew Laurens, Joana C. Silva

1540 - Altered gene expression in gamma delta T cells in children with malaria and schistosomiasis co-infection relative to children infected with malaria alone

Authors: Gillian Mbambo, Marcia Cortés, Holly Bowen, Drissa Coulibaly, Abdoulaye K. Kone, Bourema Kouriba, Charles Arama, Abdoulaye Dabo, Kirsten E. Lyke, Joana C. Silva

1608 - Typhoid conjugate vaccine effectiveness in Malawi - An evaluation of the test-negative design

Authors: Amanda Driscoll, Yuanyuan Liang, Priyanka Patel, Shrimati Datta, Neil French, Marc Henrion, Robert Heyderman, Melita Gordon, Kathleen Neuzil 

1626 - The impact of the community and public health response to COVID-19 on pediatric typhoid surveillance and detection in Malawi

Authors: Helen B. Dale, Priyanka Patel, Esmelda B. Chirwa, Marc Henrion, Donnie Mategula, Richard Wachepa, Maurice Mbewe, George Selemani, Kathleen Neuzil, Melita Gordon