Brian R. Herb, PhD

1995 – 1999    B.A., Biology and Chemistry, Dickinson College                            

2006 – 2013    Ph.D., BCMB, Johns Hopkins University, School of Medicine

2016 – 2018    Postdoctoral Fellow, University of Illinois

Characterizing cell type diversity and function in the brain.

• Herb BR, Glover HJ, Bhaduri A, Colantuoni C, Bale TL, Siletti K, Linnarsson S, Hodge R, Lein E, Kriegstein AR, Doege CA, Ament SA. Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus. Adv. 9, (2023) doi:10.1126/sciadv.adf6251 PMCID: PMC10631741
• Callaway, E. M. et al. (along with the BRAIN Initiative Cell Census Network (BICCN) Consortium, including Herb BR) A multimodal cell census and atlas of the mammalian primary motor cortex. Nature 2021 Oct;598(7879):86-102. doi: 10.1038/s41586-021-03950-0. Epub 2021 Oct 6. PMID: 34616075; PMCID: PMC8494634.
• Yao Z, Liu H, Xie F, Fischer S, Adkins RS, Aldridge AI, et al. A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex. Nature 2021 Oct;598(7879):103-110. doi: 10.1038/s41586-021-03500-8. Epub 2021 Oct 6. PMID: 34616066; PMCID: PMC8494649.

Gene dysregulation in disease states

• Doi, A. Park, I. Wen, B. Murakami, P Aryee, M. Irizarry, R. Herb, B. Ladd-Acosta, C. Rho, J. Loewer, S. Miller, J. Schlaeger, T. Daley, G. Feinberg, A. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 41, 1350-1353, (2009). PMCID: PMC2958040
• Kalra G, Milon B, Casella AM, Herb BR, Humphries E, Song Y, Rose KP, Hertzano R, Ament SA. Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty. PLoS Genet. 2020 Sep 28;16(9):e1009025. PMCID: PMC7544108.
• Malaiya S, Cortes-Gutierrez M, Herb BR, Coffey SR, Legg SRW, Cantle JP, Colantuoni C, Carroll JB, Ament SA. Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington’s Disease Mutations. Journal of Neuroscience 2021 Jun 23;41(25):5534-5552. doi: 10.1523/JNEUROSCI.2074-20.2021. Epub 2021 May 19. PMID: 34011527; PMCID: PMC8221598.

Epigenetic regulation of behavior

• Herb, B. Wolschin, F. Hansen, K. Aryee, M. Langmead, B. Irizarry, R. Amdam, G. and Feinberg A. Reversible switching between epigenetic states in honeybee behavioral subcastes. Nature Neuroscience, 10, 1371-3 (2012)  PMCID: PMC3518384
• Herb, B. R., Shook, M. S., Fields, C. J. & Robinson, G. E. Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain. BMC Genomics 2018 Mar 26;19(1):216. doi: 10.1186/s12864-018-4594-0. PMID: 29580210; PMCID: PMC5870497.
• Herb, B. Epigenetics as an answer to Darwin’s “special difficulty.” Genet. 5:321 (2014). PMCID: PMC4162389